O impacto da ozonioterapia no tratamento da dor crônica não oncológica: Uma revisão integrativa da literatura: The impact of ozone therapy in the treatment of non-cancer chronic pain: An integrative literature review

Objetivo: O objetivo dessa revisão integrativa consiste em apresentar a eficácia da ozonioterapia em patologias que cursam com dor crônica, a partir da reunião de artigos e análise de seus respectivos resultados. Métodos: Trata-se de uma análise analítica e descritiva dos artigos encontrados após aplicação dos critérios de inclusão e exclusão. A inclusão dos artigos foi feita para aqueles que estivessem nos idiomas inglês, português ou espanhol, apresentassem ano de publicação entre 2017 e 2022 e espaço amostral com pacientes acima de 18 anos. Foram excluídos artigos de revisão sistemática, meta-análise, relato de caso e editorial, além daqueles em que a temática após leitura do resumo fugisse do aspecto de terapia de dor crônica não-oncológica. Ao final da triagem metodológica, foram selecionados sete artigos. Resultados e conclusão: A ozonioterapia mostrou-se eficaz no combate a dor crônica, sendo considerado um método seguro, pouco invasivo e sem efeitos colaterais dignos de nota. Porém, pela heterogeneidade dos artigos encontrados, não foi possível avaliar a eficácia para cada patologia isoladamente ou soberania entre as formas de aplicação, necessitando de mais estudos para esse fim

Constituent elements of masculinity taught/learned in childhood and adolescence of men who are being criminally prosecuted for violence against women/partners

O objetivo deste trabalho é compreender os elementos constitutivos da masculinidade ensinados/apreendidos na infância/adolescência e reproduzidos por homens em processo criminal por violência conjugal. Utilizou-se como referencial metodológico a história oral de vida. Foram realizadas entrevistas com 13 homens em processo criminal por violência conjugal. Os dados foram organizados segundo análise de conteúdo temática categorial e interpretados à luz do referencial teórico sobre masculinidade. Com base na oralidade masculina, os elementos constitutivos da masculinidade que foram ensinados/apreendidos na infância e adolescência e reproduzidos por homens em processo criminal por violência conjugal perpassaram pela infidelidade, supervalorização do trabalho, provisão familiar, imposição de normas familiares e detenção de poder em relação a mulher. Considerando que esses elementos se encontram arraigados no modelo hegemônico, urgem ações preventivas com enfoque no comprometimento social, financeiro e para a saúde.info:eu-repo/semantics/publishedVersio

Aminopropyltriethoxysilane functionalized MCM-41 and SBA-15 nanostructured materials for carbon dioxide adsorption

The design of effective CO2 capture materials is a current challenge. Here, we report the synthesis of aminosilanes-functionalized MCM-41 and SBA-15 materials with high efficiency toward carbon dioxide adsorption. The functionalization of the mesoporous silicas involves a post-synthesis method by impregnation with 3-aminopropyltriethoxysilane. The carbon dioxide adsorption capacities for the samples were carried out under ambient pressures. The results evidenced that aminosilanes with a terminal amine were functionalized through covalent coupling of this group onto the channels' surface in the ordered mesoporous silica. It means that the amine is anchored on the surface of the largest pores of the MCM-41 and SBA-15 supports. The Lagergren kinetic model evidenced the enhanced carbon dioxide adsorption capacity and stability of the functionalized ordered mesoporous molecular sieves.Keywords: 3-Aminopropyltriethoxysilane; Carbon dioxide; Functionalization; MCM-41; SBA-15.

Perfil de mortalidade materna por hemorragias do terceiro trimestre no Brasil, no período de 2001 e 2020: Profile of maternal mortality due to third-quarter hemorrhages in Brazil, from 2001 to 2020

Introdução: Destaca-se a hemorragia como uma das maiores causas de mortalidade materna evitável. Dentre os períodos gestacionais, o último trimestre apresenta-se como o período com as principais doenças que representam os quadros hemorrágicos, por importância e frequência: o Descolamento prematuro de placenta (DPP) e a placenta prévia (PP). Metodologia: Os dados foram obtidos a partir do DATASUS, analisando mulheres com idade entre 10-49 anos no período entre 2001-2020 incluindo os óbitos das categorias do CID-10 O43, O44, O45 e O71, de tipo de causa obstétrica direta. Resultados e Discussão: Foram identificados 1993 óbitos por hemorragia do terceiro trimestre no Brasil. Observou-se que a região Norte apresenta a maior média de taxa padronizada de mortalidade, com 4,08 óbitos para cada 100mil (DP=1,43), enquanto que a região Sul apresenta-se com a menor média, no valor de 2,51/100mil (DP=0,92). Destacou-se o DPP com a principal causa de mortalidade, com 57% (1136). Percebeu-se ainda que no Brasil, a faixa etária entre 30-39 anos foi predominante com 913 óbitos (45,8%). Ainda se analisou que o puerpério é o período com maiores índices de óbitos (31,8%). Por fim, a análise de tendência demonstrou que no geral houve uma diminuição da taxa de mortalidade, em concordância com o Nordeste e o Sul, e divergindo do restante das regiões. Conclusão:  Entende-se, portanto, que o Brasil ainda necessita de maiores políticas públicas com a finalidade de diminuir a Razão de Mortalidade Materna por Hemorragia (RMMH)

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe