Whole‐brain dynamics differentiate among cisgender and transgender individuals

How the brain represents gender identity is largely unknown, but some neural differences have recently been discovered. We used an intrinsic ignition framework to investigate whether there are gender differences in the propagation of neural activity across the whole-brain and within resting-state networks. Studying 29 trans men and 17 trans women with gender incongruence, 22 cis women, and 19 cis men, we computed the capability of a given brain area in space to propagate activity to other areas (mean-ignition), and the variability across time for each brain area (node-metastability). We found that both measurements differentiated all groups across the whole brain. At the network level, we found that compared to the other groups, cis men showed higher mean-ignition of the dorsal attention network and node-metastability of the dorsal and ventral attention, executive control, and temporal parietal networks. We also found higher mean-ignition values in cis men than in cis women within the executive control network, but higher mean-ignition in cis women than cis men and trans men for the default mode. Node-metastability was higher in cis men than cis women in the somatomotor network, while both mean-ignition and node-metastability were higher for cis men than trans men in the limbic network. Finally, we computed correlations between these measurements and a body image satisfaction score. Trans men's dissatisfaction as well as cis men's and cis women's satisfaction toward their own body image were distinctively associated with specific networks in each group. Overall, the study of the whole-brain network dynamical complexity discriminates gender identity groups, functional dynamic approaches could help disentangle the complex nature of the gender dimension in the brain

Whole-brain dynamics differentiate among cisgender and transgender individuals

How the brain represents gender identity is largely unknown, but some neural differences have recently been discovered. We used an intrinsic ignition framework to investigate whether there are gender differences in the propagation of neural activity across the whole-brain and within resting-state networks. Studying 29 trans men and 17 trans women with gender incongruence, 22 cis women, and 19 cis men, we computed the capability of a given brain area in space to propagate activity to other areas (mean-ignition), and the variability across time for each brain area (node-metastability). We found that both measurements differentiated all groups across the whole brain. At the network level, we found that compared to the other groups, cis men showed higher mean-ignition of the dorsal attention network and node-metastability of the dorsal and ventral attention, executive control, and temporal parietal networks. We also found higher mean-ignition values in cis men than in cis women within the executive control network, but higher mean-ignition in cis women than cis men and trans men for the default mode. Node-metastability was higher in cis men than cis women in the somatomotor network, while both mean-ignition and node-metastability were higher for cis men than trans men in the limbic network. Finally, we computed correlations between these measurements and a body image satisfaction score. Trans men's dissatisfaction as well as cis men's and cis women's satisfaction toward their own body image were distinctively associated with specific networks in each group. Overall, the study of the whole-brain network dynamical complexity discriminates gender identity groups, functional dynamic approaches could help disentangle the complex nature of the gender dimension in the brain

GENDER FEATURES OF THE COGNITIVE RESERVE

Background: The high risk of cognitive impairment in people of older age groups determines the relevance of the study of factors contributing to the preservation of cognitive potential at a young age, which is necessary to develop a cognitive reserve model aimed at preventi for the formation of a cognitive reserve. Materials and methods: The research material was scientific publications on the topic of work. The general scientific method was applied: analysis of modern scientific literature on the research problem, generalization, comparison, systematization of cognitive functions in the late period of life. The research material was scientific publications on the topic of the work. The General scientific method is applied: analysis of modern scientific literature on the problem of research, generalization, comparison, systematization of theoretical data in relation to factors that contribute to the preservation of normative parameters of cognitive functions in the later period of life. Results: The s of the cognitive reserve at a late age. Scientific novelty: for the first time, a systematic review of scientific literary sources was conducted, devoted to the analysis of the contribution tive reserve. the concept of cognitive reserve is usually used in relation to old age, but there is no doubt that it is the total result of various activities that a person has performed throughout life. Factors that determine the cognitive reserve, acquired factors that are implemented during the life of the individual and biological factors, one of which is the "gender" factor. The "gender" factor has a certain effect on the risk of developing late dementia. The proven Polo-specific differences in the structure of the brain, the dynamics of cognitive functions, which are implemented differently in men and women in ontogenesis, suggest the need for different approaches to the formation and maintenance of the cognitive reserve in men and women

Enhanced dynamic functional connectivity (whole-brain chronnectome) in chess experts

Multidisciplinary approaches have demonstrated that the brain is potentially modulated by the long-term acquisition and practice of specific skills. Chess playing can be considered a paradigm for shaping brain function, with complex interactions among brain networks possibly enhancing cognitive processing. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) can be useful to explore the effect of chess playing on whole-brain fluidity/dynamism (the chronnectome). Dynamic connectivity parameters of 18 professional chess players and 20 beginner chess players were evaluated applying spatial independent component analysis (sICA), sliding-time window correlation, and meta-state approaches to rs-fMRI data. Four indexes of meta-state dynamic fluidity were studied: i) the number of distinct meta-states a subject pass through, ii) the number of switches from one meta-state to another, iii) the span of the realized meta-states (the largest distance between two meta-states that subjects occupied), and iv) the total distance travelled in the state space. Professional chess players exhibited an increased dynamic fluidity, expressed as a higher number of occupied meta-states (meta-state numbers, 75.8 ± 7.9 vs 68.8 ± 12.0, p = 0.043 FDR-corrected) and changes from one meta-state to another (meta-state changes, 77.1 ± 7.3 vs 71.2 ± 11.0, p = 0.043 FDR-corrected) than beginner chess players. Furthermore, professional chess players exhibited an increased dynamic range, with increased traveling between successive meta-states (meta-state total distance, 131.7 ± 17.8 vs 108.7 ± 19.7, p = 0.0004 FDR-corrected). Chess playing may induce changes in brain activity through the modulation of the chronnectome. Future studies are warranted to evaluate if these potential effects lead to enhanced cognitive processing and if "gaming" might be used as a treatment in clinical practice

Diffusion-weighted and functional magnetic resonance imaging of the brain in preterm and term-born adolescents

Magnetic resonance imaging (MRI) is widely used in clinical and research settings in the adolescent population. Technical development has allowed the use of fine-grained methods to assess both the structural and functional properties of the brain. However, the specific technical limitations and improvements are mostly studied in phantom or adult studies, which may have an impact on their reliability as research tools when studying the younger population. Very preterm (VPT) birth is associated with several neurodevelopmental impairments. The present MRI tools provide opportunities to study brain maturation in detail. This thesis is a part of the multidisciplinary longitudinal follow-up study on the development and functioning of very low birth weight infants from infancy to school age (PIPARI). The follow-up cohort consists of infants born VPT (birth weight ≤1500 g and/or gestational age <32 weeks) in Turku University Hospital in 2001–2006 and term-born controls born in 2001–2004 in the same hospital. This thesis includes only children born VPT in 2004–2006 and controls born between 2003–2004 due to an upgrade of the MRI scanner during the recruitment. In Study I, the diffusion-weighted imaging (DWI) metrics at term-equivalent age were compared to the motor outcome at 11 years of age in children born VPT. Study II assessed the effect of the susceptibility correction to the DWI metrics in a healthy adolescent population. In Study III, temporal fluctuation of the resting state brain functioning was compared between 13-year-old adolescents born VPT and at term. The main prematurity-related findings of this thesis were that the DWI metrics of the corpus callosum, left corona radiata and right optic radiation at term are associated with later motor outcome in children born VPT and that adolescents born VPT show a decrease in active time, fluidity and range in brain activation during rest. These findings may reflect the adjustments in brain microstructure and function caused by the VPT birth. Fine-grained MRI methods are reliable tools for studying the mechanisms behind the clinical phenotypes of adolescents when technical limitations and age-appropriate analysis adjustments are considered.Diffuusiopainotteisen ja toiminnallisen aivojen magneettikuvantamisen käyttö nuoruusiässä entisillä pikkukeskosilla ja täysiaikaisilla verrokeilla Magneettikuvaus (MRI) on laajassa kliinisessä ja tieteellisessä käytössä lapsia ja nuoria tutkittaessa. Tekninen kehitys mahdollistaa yhä hienojakoisempia aivojen tutkimuksia. MRI:n teknisiä korjauksia on tutkittu pääosin mallintamalla tai aikuisilla, mikä voi heikentää luotettavuutta alaikäisillä. Hyvin ennenaikaisesti syntyvillä lapsilla neurologisen kehityksen poikkeavuuksien riski on täysiaikaisena syntyviä suurempi. Poikkeavuudet voivat liittyä aivojen kehityksen muutoksiin, joita nykyisillä tekniikoilla voidaan tutkia aiempaa yksityiskohtaisemmin. Väitöskirja on osa PIPARI-tutkimusta (Pienipainoisten riskilasten käyttäytyminen ja toimintakyky imeväisiästä kouluikään). Seurantakohortti koostuu pikkukeskosina (syntymäpaino ≤1500 g ja/tai raskauden kesto <32 viikkoa) Tyksissä vuosina 2001–2006 syntyneistä lapsista sekä täysiaikaisena 2001–2004 syntyneistä verrokeista. MRI-laitteiston päivityksestä johtuen osatyöt käsittelevät pikkukeskosina vuosina 2004–2006 ja verrokkeina vuosina 2003–2004 syntyneitä. Ensimmäisessä osatyössä verrattiin aivojen diffuusiokuvantamistuloksia entisten pikkukeskosten motoriseen toimintakykyyn 11-vuotiaana. Toinen osatyö käsitteli suskeptibiliteettikorjauksen vaikutusta aivojen diffuusiokuvantamisen mittaustuloksiin. Kolmannessa osatyössä vertailtiin 13-vuotiaiden entisten pikkukeskosten ja verrokkien aivojen aktiivisuuden vaihtelua lepotilassa toiminnallisen MRI-kuvauksen aikana. Tämän väitöskirjan keskosuuteen liittyvät päätulokset olivat lasketun syntymäajan corpus callosumin, vasemman corona radiatan ja oikean optisen radaston diffuusiomittaustulosten yhteys motoriseen kehitykseen 11-vuotiaana sekä pikkukeskosina syntyneillä havaittu aivojen vähäisempi aktiivinen aika ja alentunut aktiivisuuden vaihtelun joustavuus 13-vuotiaana. Nämä löydökset saattavat olla seurausta varhaiseen syntymään liittyvistä aivojen mikrorakenteen ja toiminnan muutoksista. Hienojakoiset MRI-menetelmät vaikuttavat olevan luotettavia nuorisoikäisiä tutkittaessa, kunhan tekniset rajoitteet ja ikäsovitukset huomioidaan

Experience-dependent reshaping of body processing: from perception to clinical implications

Starting from the moment we come into the world, we are compelled to pay large attention to the body and its representation, which can be considered as a set of cognitive structures that have the function of tracing and coding our state (de Vignemont, 2010). However, we cannot consider body aside from its image, which can determine the way we emotionally perceive ourselves and other people as well as the way we experience the world. With a brief look to the body, we can identify a persons’ identity, thus catching distinctive elements such as her age or gender; further, by means of body posture and movements we can understand the affective state of others and appropriately shape our social interaction and communication. Several socially significant cues can be detected and provided through the body, but this thesis principally aims to increase the knowledge about how we perceive gender from bodily features and shape. Specifically, I report on a series of behavioral studies designed to investigate the influence of the visual experience on the detection of gender dimension, considering the contribution of brain networks which may also have a role in the development of mental disorders related to body misperception (i.e. Eating Disorders; ED). In the first chapter, I provide evidence for the interdependence of morphologic and dynamic cues in shaping gender judgment. By manipulating various characteristics of virtual-human body stimuli, the experiment I carried out demonstrates the association between stillness and femininity rating, addressing the evolutionary meaning of sexual selection and the influence of cultural norms (D’Argenio et al., 2020). In the second chapter, I present a study that seeks to define the relative role of parvo- and magnocellular visual streams in the identification of both morphologic and dynamic cues of the body. For these experiments, I used the differential tuning of the two streams to low- (LSF) and high-spatial frequencies (HSF) and I tested how the processing of body gender and postures is affected by filtering images to keep only the LSF or HSF (D’Argenio et al., submitted). The third chapter is dedicated to a series of experiments aimed at understanding how gender perception can be biased by the previous exposure to specific body models. I utilized a visual adaptation paradigm to investigate the mechanisms that drives the observers’ perception to a masculinity or femininity judgement (D’Argenio et al., 2021) and manipulates the spatial frequency content of the bodies in order to account for the contribution of parvo- and magnocellular system in in this process. In conclusion, in the last two chapters, I briefly report the preliminary results emerging from two visual adaptation studies. The first one, which is described in the fourth chapter, explored the role of cortical connections in body gender adaptation by means of Transcranial Magnetic Stimulation (TMS), with the aim to investigate neural correlates of dysfunctional body perception. The second represents the intent to explain, at least partially, body misperception disorders by applying adaptation paradigms to ED clinical population. Results were discussed in the fifth chapter.Starting from the moment we come into the world, we are compelled to pay large attention to the body and its representation, which can be considered as a set of cognitive structures that have the function of tracing and coding our state (de Vignemont, 2010). However, we cannot consider body aside from its image, which can determine the way we emotionally perceive ourselves and other people as well as the way we experience the world. With a brief look to the body, we can identify a persons’ identity, thus catching distinctive elements such as her age or gender; further, by means of body posture and movements we can understand the affective state of others and appropriately shape our social interaction and communication. Several socially significant cues can be detected and provided through the body, but this thesis principally aims to increase the knowledge about how we perceive gender from bodily features and shape. Specifically, I report on a series of behavioral studies designed to investigate the influence of the visual experience on the detection of gender dimension, considering the contribution of brain networks which may also have a role in the development of mental disorders related to body misperception (i.e. Eating Disorders; ED). In the first chapter, I provide evidence for the interdependence of morphologic and dynamic cues in shaping gender judgment. By manipulating various characteristics of virtual-human body stimuli, the experiment I carried out demonstrates the association between stillness and femininity rating, addressing the evolutionary meaning of sexual selection and the influence of cultural norms (D’Argenio et al., 2020). In the second chapter, I present a study that seeks to define the relative role of parvo- and magnocellular visual streams in the identification of both morphologic and dynamic cues of the body. For these experiments, I used the differential tuning of the two streams to low- (LSF) and high-spatial frequencies (HSF) and I tested how the processing of body gender and postures is affected by filtering images to keep only the LSF or HSF (D’Argenio et al., submitted). The third chapter is dedicated to a series of experiments aimed at understanding how gender perception can be biased by the previous exposure to specific body models. I utilized a visual adaptation paradigm to investigate the mechanisms that drives the observers’ perception to a masculinity or femininity judgement (D’Argenio et al., 2021) and manipulates the spatial frequency content of the bodies in order to account for the contribution of parvo- and magnocellular system in in this process. In conclusion, in the last two chapters, I briefly report the preliminary results emerging from two visual adaptation studies. The first one, which is described in the fourth chapter, explored the role of cortical connections in body gender adaptation by means of Transcranial Magnetic Stimulation (TMS), with the aim to investigate neural correlates of dysfunctional body perception. The second represents the intent to explain, at least partially, body misperception disorders by applying adaptation paradigms to ED clinical population. Results were discussed in the fifth chapter

The interacting brain::Dynamic functional connectivity among canonical brain networks dissociates cooperative from competitive social interactions

We spend much our lives interacting with others in various social contexts. Although we deal with this myriad of interpersonal exchanges with apparent ease, each one relies upon a broad array of sophisticated cognitive processes. Recent research suggests that the cognitive operations supporting interactive behaviour are themselves underpinned by several canonical functional brain networks (CFNs) that integrate dynamically with one another in response to changing situational demands. Dynamic integrations among these CFNs should therefore play a pivotal role in coordinating interpersonal behaviour. Further, different types of interaction should present different demands on cognitive systems, thereby eliciting distinct patterns of dynamism among these CFNs. To investigate this, the present study performed functional magnetic resonance imaging (fMRI) on 30 individuals while they interacted with one another cooperatively or competitively. By applying a novel combination of analytical techniques to these brain imaging data, we identify six states of dynamic functional connectivity characterised by distinct patterns of integration and segregation among specific CFNs that differ systematically between these opposing types of interaction. Moreover, applying these same states to fMRI data acquired from an independent sample engaged in the same kinds of interaction, we were able to classify interpersonal exchanges as cooperative or competitive. These results provide the first direct evidence for the systematic involvement of CFNs during social interactions, which should guide neurocognitive models of interactive behaviour and investigations into biomarkers for the interpersonal dysfunction characterizing many neurological and psychiatric disorders. [Abstract copyright: Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Human, Nature, Dynamism: The Effects of Content and Movement Perception on Brain Activations during the Aesthetic Judgment of Representational Paintings

Movement perception and its role in aesthetic experience have been often studied, within empirical aesthetics, in relation to the human body. No such specificity has been defined in neuroimaging studies with respect to contents lacking a human form. The aim of this work was to explore, through functional magnetic imaging (f MRI), how perceived movement is processed during the aesthetic judgment of paintings using two types of content: human subjects and scenes of nature. Participants, untutored in the arts, were shown the stimuli and asked to make aesthetic judgments. Additionally, they were instructed to observe the paintings and to rate their perceived movement in separate blocks. Observation highlighted spontaneous processes associated with aesthetic experience, whereas movement judgment outlined activations specifically related to movement processing. The ratings recorded during aesthetic judgment revealed that nature scenes received higher scored than human content paintings. The imaging data showed similar activation, relative to baseline, for all stimuli in the three tasks, including activation of occipito-temporal areas, posterior parietal, and premotor cortices. Contrast analyses within aesthetic judgment task showed that human content activated, relative to nature, precuneus, fusiform gyrus, and posterior temporal areas, whose activation was prominent for dynamic human paintings. In contrast, nature scenes activated, relative to human stimuli, occipital and posterior parietal cortex/precuneus, involved in visuospatial exploration and pragmatic coding of movement, as well as central insula. Static nature paintings further activated, relative to dynamic nature stimuli, central and posterior insula. Besides insular activation, which was specific for aesthetic judgment, we found a large overlap in the activation pattern characterizing each stimulus dimension (content and dynamism) across observation, aesthetic judgment, and movement judgment tasks. These findings support the idea that the aesthetic evaluation of artworks depicting both human subjects and nature scenes involves a motor component, and that the associated neural processes occur quite spontaneously in the viewer. Furthermore, considering the functional roles of posterior and central insula, we suggest that nature paintings may evoke aesthetic processes requiring an additional proprioceptive and sensori-motor component implemented by “motor accessibility” to the represented scenario, which is needed to judge the aesthetic value of the observed painting

Effects of Diversity and Neuropsychological Performance in an NFL Cohort

Objective: The aim of this study was to examine the effect of ethnicity on neuropsychological test performance by comparing scores of white and black former NFL athletes on each subtest of the WMS. Participants and Methods: Data was derived from a de-identified database in South Florida consisting of 63 former NFL white (n=28, 44.4%) and black (n=35, 55.6%) athletes (Mage= 50.38; SD= 11.57). Participants completed the following subtests of the WMS: Logical Memory I and II, Verbal Paired Associates I and II, and Visual Reproduction I and II. Results: A One-Way ANOVA yielded significant effect between ethnicity and performance on several subtests from the WMS-IV. Black athletes had significantly lower scores compared to white athletes on Logical Memory II: F(1,61) = 4.667, p= .035, Verbal Paired Associates I: F(1,61) = 4.536, p = .037, Verbal Paired Associates: II F(1,61) = 4.677, p = .034, and Visual Reproduction I: F(1,61) = 6.562, p = .013. Conclusions: Results suggest significant differences exist between white and black athletes on neuropsychological test performance, necessitating the need for proper normative samples for each ethnic group. It is possible the differences found can be explained by the psychometric properties of the assessment and possibility of a non-representative sample for minorities, or simply individual differences. Previous literature has found white individuals to outperform African-Americans on verbal and non-verbal cognitive tasks after controlling for socioeconomic and other demographic variables (Manly & Jacobs, 2002). This highlights the need for future investigators to identify cultural factors and evaluate how ethnicity specifically plays a role on neuropsychological test performance. Notably, differences between ethnic groups can have significant implications when evaluating a sample of former athletes for cognitive impairment, as these results suggest retired NFL minorities may be more impaired compared to retired NFL white athletes