2,112 research outputs found

    Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates

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    This paper is the second of a three-part series that investigates the architecture of cancellous bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct non-avian species. Cancellous bone is widely known to be highly sensitive to its mechanical environment, and therefore has the potential to provide insight into locomotor biomechanics in extinct tetrapod vertebrates such as dinosaurs. Here in Part II, a new biomechanical modelling approach is outlined, one which mechanistically links cancellous bone architectural patterns with three-dimensional musculoskeletal and finite element modelling of the hindlimb. In particular, the architecture of cancellous bone is used to derive a single ‘characteristic posture’ for a given species—one in which bone continuum-level principal stresses best align with cancellous bone fabric—and thereby clarify hindlimb locomotor biomechanics. The quasi-static approach was validated for an extant theropod, the chicken, and is shown to provide a good estimate of limb posture at around mid-stance. It also provides reasonable predictions of bone loading mechanics, especially for the proximal hindlimb, and also provides a broadly accurate assessment of muscle recruitment insofar as limb stabilization is concerned. In addition to being useful for better understanding locomotor biomechanics in extant species, the approach hence provides a new avenue by which to analyse, test and refine palaeobiomechanical hypotheses, not just for extinct theropods, but potentially many other extinct tetrapod groups as well

    Tissue material properties and computational modelling of the human tibiofemoral joint: a critical review

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    Understanding how structural and functional alterations of individual tissues impact on whole-joint function is challenging, particularly in humans where direct invasive experimentation is difficult. Finite element (FE) computational models produce quantitative predictions of the mechanical and physiological behaviour of multiple tissues simultaneously, thereby providing a means to study changes that occur through healthy ageing and disease such as osteoarthritis (OA). As a result, significant research investment has been placed in developing such models of the human knee. Previous work has highlighted that model predictions are highly sensitive to the various inputs used to build them, particularly the mathematical definition of material properties of biological tissues. The goal of this systematic review is two-fold. First, we provide a comprehensive summation and evaluation of existing linear elastic material property data for human tibiofemoral joint tissues, tabulating numerical values as a reference resource for future studies. Second, we review efforts to model tibiofemoral joint mechanical behaviour through FE modelling with particular focus on how studies have sourced tissue material properties. The last decade has seen a renaissance in material testing fuelled by development of a variety of new engineering techniques that allow the mechanical behaviour of both soft and hard tissues to be characterised at a spectrum of scales from nano- to bulk tissue level. As a result, there now exists an extremely broad range of published values for human tibiofemoral joint tissues. However, our systematic review highlights gaps and ambiguities that mean quantitative understanding of how tissue material properties alter with age and OA is limited. It is therefore currently challenging to construct FE models of the knee that are truly representative of a specific age or disease-state. Consequently, recent tibiofemoral joint FE models have been highly generic in terms of material properties even relying on non-human data from multiple species. We highlight this by critically evaluating current ability to quantitatively compare and model (1) young and old and (2) healthy and OA human tibiofemoral joints. We suggest that future research into both healthy and diseased knee function will benefit greatly from a subject- or cohort-specific approach in which FE models are constructed using material properties, medical imagery and loading data from cohorts with consistent demographics and/or disease states

    Biomechanics

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    Biomechanics is a vast discipline within the field of Biomedical Engineering. It explores the underlying mechanics of how biological and physiological systems move. It encompasses important clinical applications to address questions related to medicine using engineering mechanics principles. Biomechanics includes interdisciplinary concepts from engineers, physicians, therapists, biologists, physicists, and mathematicians. Through their collaborative efforts, biomechanics research is ever changing and expanding, explaining new mechanisms and principles for dynamic human systems. Biomechanics is used to describe how the human body moves, walks, and breathes, in addition to how it responds to injury and rehabilitation. Advanced biomechanical modeling methods, such as inverse dynamics, finite element analysis, and musculoskeletal modeling are used to simulate and investigate human situations in regard to movement and injury. Biomechanical technologies are progressing to answer contemporary medical questions. The future of biomechanics is dependent on interdisciplinary research efforts and the education of tomorrow’s scientists

    Quantitative Computed Tomography Based Finite Element Modeling of Normal and Osteoarthritic Knees: In vivo Precision and Preliminary Comparisons

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    Osteoarthritis (OA) is a debilitating joint disease which affects nearly 85% of the Canadian population over 75 years of age. OA not only affects cartilage, but it also alters subchondral bone (bone underlying cartilage). Altered subchondral bone could be related to OA initiation, progression, and OA-related pain. To help clarify the role of subchondral bone in OA, accurate in vivo methods are needed to monitor subchondral bone mechanical property variations in people living with OA. Subject-specific finite element (FE) modeling has potential to investigate the role of mechanical properties of subchondral bone in OA. However, associated precision errors of FE-derived mechanical properties are not known. The objectives of this study were to 1) develop a subject-specific FE modeling methodology for OA and normal knees, 2) determine the in vivo precision of FE-derived stress/strain distributions and stiffness of the proximal tibia, and 3) determine whether FE-derived metrics discriminate normal and OA knees. Subject-specific FE models were developed for 14 participants (7 OA, 7 normal) with three repeated CT images of knee joint. Von-Mises stress and strain, minimum principal stress and strain, plus structural stiffness outcomes were acquired for each proximal tibia image. Root mean square coefficient of variations (CV%) were used to assess in vivo precision of the FE-based outcomes. Comparisons between OA and normal groups were performed using unpaired t-tests for normally distributed outcomes, and Mann-Whitney U-tests for not normally distributed outcomes. For all the outcomes the average CV% was less than 6.1%. On average, von-Mises stress and minimum principal stress were respectively 65% and 70% higher in OA versus normal knees whereas strain values did not differ. No difference was observed in stiffness values. Thesis results indicate that FE modeling could be used to precisely quantify and differentiate mechanical property variations in normal and OA knees, in vivo. Results suggest that OA and normal bone exhibit dissimilar stress levels but similar strain levels, likely indicating adaptation of bone in response to altered joint mechanics with OA

    Injury Risk Assessment of the Femur in Children with Osteogenesis Imperfecta

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    Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility and decreased bone mass, which leads to high rates of bone fracture. OI has a prevalence of 1/5,000 to 1/10,000 in the United States. About 90% of persons with OI have a genetic mutation in the coding for collagen type I, which is the major protein of connective tissues, including bone. While its prevalence classifies it as a rare disease, it is the most common disorder of bone etiology. Until recently, little was known about the mechanics and materials of OI bone or their impact on fracture risk. Fracture risk is typically characterized by clinical type and radiographs. Finite element (FE) models have recently been developed to examine fracture risk during ambulation and various daily activities of the femur and tibia in children and adolescents with OI. This research aims to provide further information about the impact of OI in children and adolescents during loading conditions. FE models of the femur with normal bone, OI type I (mild) bone and OI type III (severe) bone material properties were developed and analyzed. These models showed the effects of lateral bowing versus increased gluteus medius and gluteus maximus force production on bone injury risk. Lateral bowing and muscle force increase permutations to the standard model of no bowing and normal muscle forces during ambulation showed significant changes to stress levels. Along with FE models, quantitative gait analyses were performed on 10 children with mild OI and ten age- and gender-matched controls to analyze the firing patterns of the gluteus medius and gluteus maximus muscles during normal ambulation. The OI population exhibited a delay in gluteus maximus activation. Additional FE models examined the impact of creating the model directly from a CT scan of a child with severe OI versus scaling a standard model to match the size and shape of and OI femur based on x-ray images alone. Comparison of these two model geometry development techniques resulted in a significant difference in femoral stresses and strains

    Investigation of Subchondral Bone Abnormalities associated with Osteoarthritis using Image-Based Biomechanics

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    Osteoarthritis (OA) is degenerative disease caused by a mechanical failure of bone and cartilage. Common risk factors for developing OA include: being over-weight, female, having joint malalignment, or a history of prior joint injury. Post-traumatic OA is extremely common in the knee as individuals frequently suffer injuries to structures that provide stability to the joint. To enhance our understanding about OA, animal models are employed where the injury can be and monitored in a controlled environment. When used in conjunction with pre-clinical imaging techniques the longitudinal degradation of bone and cartilage can be quantitatively monitored in vivo. Recent evidence has identified cystic lesions within the subchondral bone as the possible source of painful symptoms and accelerated disease progression, but little is known about their etiology. The purpose of this thesis was to improve knowledge regarding the mechanism that causes subchondral cysts. OA was induced in the rodent knee via surgery, and the pathological changes were quantified with micro-CT and MRI. The composition of the cysts was correlated with end-stage histology. Thus, an accurate definition of OA bone cysts was achieved. To assess the effect of cysts in human bone, a study was conducted using a patient data set restrospectively. Using finite element (FE) analysis, higher stress values were found within bone surrounding cysts. Therefore, the probable mechanism of cyst expansion, stress induced resorption, was identified. Finally, the FE models of the bones were combined with soft tissue structures – from a co-registered MRI – to produce comprehensive patient-specific models of the knee
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