Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

Extracellular electrode arrays can reveal the neuronal network correlates of behavior with single-cell, single-spike, and sub-millisecond resolution. However, implantable electrodes are inherently invasive, and efforts to scale up the number and density of recording sites must compromise on device size in order to connect the electrodes. Here, we report on silicon-based neural probes employing nanofabricated, high-density electrical leads. Furthermore, we address the challenge of reading out multichannel data with an application-specific integrated circuit (ASIC) performing signal amplification, band-pass filtering, and multiplexing functions. We demonstrate high spatial resolution extracellular measurements with a fully integrated, low noise 64-channel system weighing just 330 mg. The on-chip multiplexers make possible recordings with substantially fewer external wires than the number of input channels. By combining nanofabricated probes with ASICs we have implemented a system for performing large-scale, high-density electrophysiology in small, freely behaving animals that is both minimally invasive and highly scalable

Oscillation-based DFT for Second-order Bandpass OTA-C Filters

This document is the Accepted Manuscript version. Under embargo until 6 September 2018. The final publication is available at Springer via https://doi.org/10.1007/s00034-017-0648-9.This paper describes a design for testability technique for second-order bandpass operational transconductance amplifier and capacitor filters using an oscillation-based test topology. The oscillation-based test structure is a vectorless output test strategy easily extendable to built-in self-test. The proposed methodology converts filter under test into a quadrature oscillator using very simple techniques and measures the output frequency. Using feedback loops with nonlinear block, the filter-to-oscillator conversion techniques easily convert the bandpass OTA-C filter into an oscillator. With a minimum number of extra components, the proposed scheme requires a negligible area overhead. The validity of the proposed method has been verified using comparison between faulty and fault-free simulation results of Tow-Thomas and KHN OTA-C filters. Simulation results in 0.25μm CMOS technology show that the proposed oscillation-based test strategy for OTA-C filters is suitable for catastrophic and parametric faults testing and also effective in detecting single and multiple faults with high fault coverage.Peer reviewedFinal Accepted Versio

Integrated Circuits and Systems for Smart Sensory Applications

Connected intelligent sensing reshapes our society by empowering people with increasing new ways of mutual interactions. As integration technologies keep their scaling roadmap, the horizon of sensory applications is rapidly widening, thanks to myriad light-weight low-power or, in same cases even self-powered, smart devices with high-connectivity capabilities. CMOS integrated circuits technology is the best candidate to supply the required smartness and to pioneer these emerging sensory systems. As a result, new challenges are arising around the design of these integrated circuits and systems for sensory applications in terms of low-power edge computing, power management strategies, low-range wireless communications, integration with sensing devices. In this Special Issue recent advances in application-specific integrated circuits (ASIC) and systems for smart sensory applications in the following five emerging topics: (I) dedicated short-range communications transceivers; (II) digital smart sensors, (III) implantable neural interfaces, (IV) Power Management Strategies in wireless sensor nodes and (V) neuromorphic hardware

A Low-Power Wireless Multichannel Microsystem for Reliable Neural Recording.

This thesis reports on the development of a reliable, single-chip, multichannel wireless biotelemetry microsystem intended for extracellular neural recording from awake, mobile, and small animal models. The inherently conflicting requirements of low power and reliability are addressed in the proposed microsystem at architectural and circuit levels. Through employing the preliminary microsystems in various in-vivo experiments, the system requirements for reliable neural recording are identified and addressed at architectural level through the analytical tool: signal path co-optimization. The 2.85mm×3.84mm, mixed-signal ASIC integrates a low-noise front-end, programmable digital controller, an RF modulator, and an RF power amplifier (PA) at the ISM band of 433MHz on a single-chip; and is fabricated using a 0.5µm double-poly triple-metal n-well standard CMOS process. The proposed microsystem, incorporating the ASIC, is a 9-channel (8-neural, 1-audio) user programmable reliable wireless neural telemetry microsystem with a weight of 2.2g (including two 1.5V batteries) and size of 2.2×1.1×0.5cm3. The electrical characteristics of this microsystem are extensively characterized via benchtop tests. The transmitter consumes 5mW and has a measured total input referred voltage noise of 4.74µVrms, 6.47µVrms, and 8.27µVrms at transmission distances of 3m, 10m, and 20m, respectively. The measured inter-channel crosstalk is less than 3.5% and battery life is about an hour. To compare the wireless neural telemetry systems, a figure of merit (FoM) is defined as the reciprocal of the power spent on broadcasting one channel over one meter distance. The proposed microsystem’s FoM is an order of magnitude larger compared to all other research and commercial systems. The proposed biotelemetry system has been successfully used in two in-vivo neural recording experiments: i) from a freely roaming South-American cockroach, and ii) from an awake and mobile rat.PhDElectrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/91542/1/aborna_1.pd

Amplifiers in Biomedical Engineering: A Review from Application Perspectives

Continuous monitoring and treatment of various diseases with biomedical technologies and wearable electronics has become significantly important. The healthcare area is an important, evolving field that, among other things, requires electronic and micro-electromechanical technologies. Designed circuits and smart devices can lead to reduced hospitalization time and hospitals equipped with high-quality equipment. Some of these devices can also be implanted inside the body. Recently, various implanted electronic devices for monitoring and diagnosing diseases have been presented. These instruments require communication links through wireless technologies. In the transmitters of these devices, power amplifiers are the most important components and their performance plays important roles. This paper is devoted to collecting and providing a comprehensive review on the various designed implanted amplifiers for advanced biomedical applications. The reported amplifiers vary with respect to the class/type of amplifier, implemented CMOS technology, frequency band, output power, and the overall efficiency of the designs. The purpose of the authors is to provide a general view of the available solutions, and any researcher can obtain suitable circuit designs that can be selected for their problem by reading this survey

Advanced sensors technology survey

This project assesses the state-of-the-art in advanced or 'smart' sensors technology for NASA Life Sciences research applications with an emphasis on those sensors with potential applications on the space station freedom (SSF). The objectives are: (1) to conduct literature reviews on relevant advanced sensor technology; (2) to interview various scientists and engineers in industry, academia, and government who are knowledgeable on this topic; (3) to provide viewpoints and opinions regarding the potential applications of this technology on the SSF; and (4) to provide summary charts of relevant technologies and centers where these technologies are being developed

Modulation Techniques for Biomedical Implanted Devices and Their Challenges

Implanted medical devices are very important electronic devices because of their usefulness in monitoring and diagnosis, safety and comfort for patients. Since 1950s, remarkable efforts have been undertaken for the development of bio-medical implanted and wireless telemetry bio-devices. Issues such as design of suitable modulation methods, use of power and monitoring devices, transfer energy from external to internal parts with high efficiency and high data rates and low power consumption all play an important role in the development of implantable devices. This paper provides a comprehensive survey on various modulation and demodulation techniques such as amplitude shift keying (ASK), frequency shift keying (FSK) and phase shift keying (PSK) of the existing wireless implanted devices. The details of specifications, including carrier frequency, CMOS size, data rate, power consumption and supply, chip area and application of the various modulation schemes of the implanted devices are investigated and summarized in the tables along with the corresponding key references. Current challenges and problems of the typical modulation applications of these technologies are illustrated with a brief suggestions and discussion for the progress of implanted device research in the future. It is observed that the prime requisites for the good quality of the implanted devices and their reliability are the energy transformation, data rate, CMOS size, power consumption and operation frequency. This review will hopefully lead to increasing efforts towards the development of low powered, high efficient, high data rate and reliable implanted devices

Aging-Aware Design Methods for Reliable Analog Integrated Circuits using Operating Point-Dependent Degradation

The focus of this thesis is on the development and implementation of aging-aware design methods, which are suitable to satisfy current needs of analog circuit design. Based on the well known \gm/\ID sizing methodology, an innovative tool-assisted aging-aware design approach is proposed, which is able to estimate shifts in circuit characteristics using mostly hand calculation schemes. The developed concept of an operating point-dependent degradation leads to the definition of an aging-aware sensitivity, which is compared to currently available degradation simulation flows and proves to be efficient in the estimation of circuit degradation. Using the aging-aware sensitivity, several analog circuits are investigated and optimized towards higher reliability. Finally, results are presented for numerous target specifications

Master of Science

thesisFully integrated, implantable, and wireless neural interface systems typically re-quire a forward data link in addition to the telemetry link that transmits data from the chip. One popular way to create this forward data link is to amplitude modulate the magnetic fi eld of the inductive link that provides the device with wireless power. However, the limitations of these channels when loaded with a recti fier and amplitude modulated have not previously been characterized, and this lack of understanding caused previous versions of the Integrated Neural Interface (INI) to have forward data communication issues, which needed to be corrected for the next generation of the device, INIR8. This thesis first develops an analytical method of characterizing this sort of wireless channel. It then shows measurement data that verifies the validity of the model in the desired region of operation. The available bandwidth as determined by this analytical method, and confirmed by simulation, is insufficient for many applications. Therefore, the next subject of this thesis is to increase the data rate beyond what the bandwidth of the system can intrinsically support by using an equalization technique. This technique is shown to support very robust data recovery under a variety of operating conditions and to data rates much higher than otherwise possible. Another way to improve the reliability of data recovery is to develop a robust digital control system with error detection capabilities. This was done for INIR8, and works very reliably. The end result of this eff ort is a very robust forward data communication in INIR8, as well as a new analytical method for characterizing inductively coupled channels with certain loads and modulation techniques

Design and testing of an integrated circuit for multi-electrode neural recording

Journal ArticleWe have developed a single-chip neural recording system with wireless power delivery and telemetry. The 0.5-μm CMOS IC is designed to be bonded to the back of a 100-channel Utah Electrode Array. A pad near each amplifier allows connection of the chip to the MEMS electrode array. The complete Integrated Neural Interface will receive power wirelessly through a 2.64-MHz inductive link. A clock, regulated supply, and commands are derived from the power signal .The neural amplifiers each have a gain of 60 dB. A 10-bit charge-redistribution ADC is used to digitize the signal from one amplifier selected with an analog MUX. Digitizing all channels simultaneously would generate prohibitively high data rates; therefore, we perform data reduction by incorporating one-bit "spike detectors" into each amplifier. Neural data is transmitted off chip using an -integrated 433-MHz FSK transmitter. The chip measures 4.7×5.9 mm2 and consumes 13.5 mW of power