Exploring manycore architectures for next-generation HPC systems through the MANGO approach

[EN] The Horizon 2020 MANGO project aims at exploring deeply heterogeneous accelerators for use in High-Performance Computing systems running multiple applications with different Quality of Service (QoS) levels. The main goal of the project is to exploit customization to adapt computing resources to reach the desired QoS. For this purpose, it explores different but interrelated mechanisms across the architecture and system software. In particular, in this paper we focus on the runtime resource management, the thermal management, and support provided for parallel programming, as well as introducing three applications on which the project foreground will be validated.This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 671668.Flich Cardo, J.; Agosta, G.; Ampletzer, P.; Atienza-Alonso, D.; Brandolese, C.; Cappe, E.; Cilardo, A.... (2018). Exploring manycore architectures for next-generation HPC systems through the MANGO approach. Microprocessors and Microsystems. 61:154-170. https://doi.org/10.1016/j.micpro.2018.05.011S1541706

Agent-based modelling and Swarm Intelligence in systems engineering

El objetivo de la tesis doctoral es evaluar la utilidad de las técnicas Modelado Basado en Agentes, algoritmos de optimización Swarm Intelligence y programación paralela sobre tarjeta gráfica en el campo de la Ingeniería de Sistemas y Automática. Se ha realizado un revisión bibliográfica y desarrollado un marco de desarrollo de la técnica de Modelado Basado en Agentes. Esta técnica se ha empleado para realizar un modelo de un reactor de fangos activados (que se engloba dentro del proceso de depuración de aguas residuales). Se ha desarrollado una notación complementaria para la descripción de modelos basados en agentes desde el punto de vista de la ingeniería de sistemas. Se ha presentado asimismo un algoritmo de optimización basado en agentes bajo la filosofía Swarm Intelligence. Se han trabajado con las técnicas de paralelización sobre tarjeta gráfica para reducir los tiempos de simulación de modelos y algoritmos. Se trata por lo tanto de un tesis de integración de varias tecnologías.Departamento de Ingeniería de Sistemas y Automátic

Deep learning and feature engineering techniques applied to the myoelectric signal for accurate prediction of movements

Técnicas de reconhecimento de padrões no Sinal Mioelétrico (EMG) são empregadas no desenvolvimento de próteses robóticas, e para isso, adotam diversas abordagens de Inteligência Artificial (IA). Esta Tese se propõe a resolver o problema de reconhecimento de padrões EMG através da adoção de técnicas de aprendizado profundo de forma otimizada. Para isso, desenvolveu uma abordagem que realiza a extração da característica a priori, para alimentar os classificadores que supostamente não necessitam dessa etapa. O estudo integrou a plataforma BioPatRec (estudo e desenvolvimento avançado de próteses) a dois algoritmos de classificação (Convolutional Neural Network e Long Short-Term Memory) de forma híbrida, onde a entrada fornecida à rede já possui características que descrevem o movimento (nível de ativação muscular, magnitude, amplitude, potência e outros). Assim, o sinal é rastreado como uma série temporal ao invés de uma imagem, o que nos permite eliminar um conjunto de pontos irrelevantes para o classificador, tornando a informação expressivas. Na sequência, a metodologia desenvolveu um software que implementa o conceito introduzido utilizando uma Unidade de Processamento Gráfico (GPU) de modo paralelo, esse incremento permitiu que o modelo de classificação aliasse alta precisão com um tempo de treinamento inferior a 1 segundo. O modelo paralelizado foi chamado de BioPatRec-Py e empregou algumas técnicas de Engenharia de Features que conseguiram tornar a entrada da rede mais homogênea, reduzindo a variabilidade, o ruído e uniformizando a distribuição. A pesquisa obteve resultados satisfatórios e superou os demais algoritmos de classificação na maioria dos experimentos avaliados. O trabalho também realizou uma análise estatística dos resultados e fez o ajuste fino dos hiper-parâmetros de cada uma das redes. Em última instancia, o BioPatRec-Py forneceu um modelo genérico. A rede foi treinada globalmente entre os indivíduos, permitindo a criação de uma abordagem global, com uma precisão média de 97,83%.Pattern recognition techniques in the Myoelectric Signal (EMG) are employed in the development of robotic prostheses, and for that, they adopt several approaches of Artificial Intelligence (AI). This Thesis proposes to solve the problem of recognition of EMG standards through the adoption of profound learning techniques in an optimized way. The research developed an approach that extracts the characteristic a priori to feed the classifiers that supposedly do not need this step. The study integrated the BioPatRec platform (advanced prosthesis study and development) to two classification algorithms (Convolutional Neural Network and Long Short-Term Memory) in a hybrid way, where the input provided to the network already has characteristics that describe the movement (level of muscle activation, magnitude, amplitude, power, and others). Thus, the signal is tracked as a time series instead of an image, which allows us to eliminate a set of points irrelevant to the classifier, making the information expressive. In the sequence, the methodology developed software that implements the concept introduced using a Graphical Processing Unit (GPU) in parallel this increment allowed the classification model to combine high precision with a training time of less than 1 second. The parallel model was called BioPatRec-Py and employed some Engineering techniques of Features that managed to make the network entry more homogeneous, reducing variability, noise, and standardizing distribution. The research obtained satisfactory results and surpassed the other classification algorithms in most of the evaluated experiments. The work performed a statistical analysis of the outcomes and fine-tuned the hyperparameters of each of the networks. Ultimately, BioPatRec-Py provided a generic model. The network was trained globally between individuals, allowing the creation of a standardized approach, with an average accuracy of 97.83%

A regression framework to head-circumference delineation from US fetal images

Background and Objectives: Measuring head-circumference (HC) length from ultrasound (US) images is a crucial clinical task to assess fetus growth. To lower intra- and inter-operator variability in HC length measuring, several computer-assisted solutions have been proposed in the years. Recently, a large number of deep-learning approaches is addressing the problem of HC delineation through the segmentation of the whole fetal head via convolutional neural networks (CNNs). Since the task is a edge-delineation problem, we propose a different strategy based on regression CNNs. Methods: The proposed framework consists of a region-proposal CNN for head localization and centering, and a regression CNN for accurately delineate the HC. The first CNN is trained exploiting transfer learning, while we propose a training strategy for the regression CNN based on distance fields. Results: The framework was tested on the HC18 Challenge dataset, which consists of 999 training and 335 testing images. A mean absolute difference of 1.90 ( ± 1.76) mm and a Dice similarity coefficient of 97.75 ( ± 1.32) % were achieved, overcoming approaches in the literature. Conclusions: The experimental results showed the effectiveness of the proposed framework, proving its potential in supporting clinicians during the clinical practice

Multi-Agent Systems

A multi-agent system (MAS) is a system composed of multiple interacting intelligent agents. Multi-agent systems can be used to solve problems which are difficult or impossible for an individual agent or monolithic system to solve. Agent systems are open and extensible systems that allow for the deployment of autonomous and proactive software components. Multi-agent systems have been brought up and used in several application domains

Monoclonal Antibodies

Monoclonal antibodies are established in clinical practice for the treatment of cancer, and autoimmune and infectious diseases. The first generation of antibodies has been dominated by classical IgG antibodies, however, in the last decade, the field has advanced, and, nowadays, a large proportion of antibodies in development have been engineered. This Special Issue on "Monoclonal Antibodies" includes original manuscripts and reviews covering various aspects related to the discovery, analytical characterization, manufacturing and development of therapeutic and engineered antibodies

Optimizing deep learning networks using multi-armed bandits

Deep learning has gained significant attention recently following their successful use for applications such as computer vision, speech recognition, and natural language processing. These deep learning models are based on very large neural networks, which can require a significant amount of memory and hence limit the range of applications. Hence, this study explores methods for pruning deep learning models as a way of reducing their size, and computational time, but without sacrificing their accuracy. A literature review was carried out, revealing existing approaches for pruning, their strengths, and weaknesses. A key issue emerging from this review is that there is a trade-off between removing a weight or neuron and the potential reduction in accuracy. Thus, this study develops new algorithms for pruning that utilize a framework, known as a multi-armed bandit, which has been successfully applied in applications where there is a need to learn which option to select given the outcome of trials. There are several different multi-arm bandit methods, and these have been used to develop new algorithms including those based on the following types of multi-arm bandits: (i) Epsilon-Greedy (ii) Upper Confidence Bounds (UCB) (iii) Thompson Sampling and (iv) Exponential Weight Algorithm for Exploration and Exploitation (EXP3). The algorithms were implemented in Python and a comprehensive empirical evaluation of their performance was carried out in comparison to both the original neural network models and existing algorithms for pruning. The existing methods that are compared include: Random Pruning, Greedy Pruning, Optimal Brain Damage (OBD) and Optimal Brain Surgeon (OBS). The thesis also includes an empirical comparison with a number of other learning methods such as KNN, decision trees, SVM, Naïve Bayes, LDA, QDA, logistic regression, Gaussian process classifier, kernel ridge regression, LASSO regression, linear regression, Bayesian Ridge regression, boosting, bagging and random forests. The results on the data sets show that some of the new methods (i) generalize better than the original model and most of the other methods such as KNN and decision trees (ii) outperform OBS and OBD in terms of reduction in size, generalization, and computational time (iii) outperform the greedy algorithm in terms of accuracy