Not all diabetic patients were created equal: How to discriminate risk?

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Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage

Increased arterial stiffness is a marker of vasculopathy in chronic kidney disease (CKD) patients, suggesting a significant cardiovascular damage. Detection of arterial stiffness provides physicians with useful prognostic information independent of traditional cardiovascular (CV) risk factors. In addition, this knowledge may help guide appropriate therapeutic choices and monitor the effectiveness of antihypertensive therapies. We review the relationship between arterial stiffness and CKD, as well as the prognostic implications of increased arterial stiffness and the potential therapeutic strategies to ameliorate arterial compliance and outcome in CKD

Effective runtime resource management using linux control groups with the BarbequeRTRM framework

The extremely high technology process reached by silicon manufacturing (smaller than 32nm) has led to production of computational platforms and SoC, featuring a considerable amount of resources. Whereas from one side such multi- and many-core platforms show growing performance capabilities, from the other side they are more and more affected by power, thermal, and reliability issues. Moreover, the increased computational capabilities allows congested usage scenarios with workloads subject to mixed and time-varying requirements. Effective usage of the resources should take into account both the application requirements and resources availability, with an arbiter, namely a resource manager in charge to solve the resource contention among demanding applications. Current operating systems (OS) have only a limited knowledge about application-specific behaviors and their time-varying requirements. Dedicated system interfaces to collect such inputs and forward them to the OS (e.g., its scheduler) are thus an interesting research area that aims at integrating the OS with an ad hoc resource manager. Such a component can exploit efficient low-level OS interfaces and mechanisms to extend its capabilities of controlling tasks and system resources. Because of the specific tasks and timings of a resource manager, this component can be easily and effectively developed as a user-space extension lying in between the OS and the controlled application. This article, which focuses on multicore Linux systems, shows a portable solution to enforce runtime resource management decisions based on the standard control groups framework. A burst and a mixed workload analysis, performed on a multicore-based NUMA platform, have reported some promising results both in terms of performance and power saving

Urolithiasis associated with atazanavir may mask a metabolic 'channelling' bias.

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Extending a run-time resource management framework to support OpenCL and heterogeneous systems

From Mobile to High-Performance Computing (HPC) systems, performance and energy efficiency are becoming always more challenging requirements. In this regard, heterogeneous systems, made by a general-purpose processor and one or more hardware accelerators, are emerging as affordable solutions. However, the effective exploitation of such platforms requires specific programming languages, like for instance OpenCL, and suitable run-time software layers. This work illustrates the extension of a run-time resource management (RTRM) framework, to support the execution of OpenCL applications on systems featuring a multi-core CPU and multiple GPUs. Early results show how this solution leads to benefits both for the applications, in terms of performance, and for the system, in terms of resource utilization, i.e. load balancing and thermal leveling over the computing devices

Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients

The risk of death in hemodialysis patients treated with calcium-containing phosphate binders or sevelamer is not known. We assessed all-cause mortality in 127 patients new to hemodialysis assigned to calcium-containing binders or sevelamer after a median follow-up of 44 months from randomization. This was a predetermined secondary end point of a randomized clinical trial designed to assess progression of coronary artery calcium (CAC) scores in the two treatment arms. Thirty-four deaths occurred during the follow-up period: 23 in subjects randomized to calcium-containing phosphate binders and 11 in subjects randomized to sevelamer. Baseline CAC score was a significant predictor of mortality after adjustment for age, race, gender, and diabetes with increased mortality proportional to baseline score (P=0.002). Mortality was borderline significantly lower in subjects randomized to sevelamer (5.3/100 patient years, confidence interval (CI) (2.2–8.5) compared to those randomized to calcium-containing binders (10.6/100 patient years, CI 6.3–14.9) (P=0.05). The greater risk of death for patients treated with calcium-containing phosphate binders persisted after full multivariable adjustment (P=0.016, hazard ratio 3.1, CI 1.23–7.61). In subjects new to hemodialysis baseline CAC score was a significant predictor of all-cause mortality. Treatment with sevelamer was associated with a significant survival benefit as compared to the use of calcium-containing phosphate binders

What Are Lake Beaches Made of? An Assessment of Plastic Beach Litter on the Shores of Como Bay (Italy)

Plastic waste dispersion is a well-recognized environmental threat, despite continuous efforts towards improving waste disposal management over the last few decades. Plastic litter is known to strongly impact upon water bodies and shorelines, affecting the health of ecosystems and impacting upon the aesthetic value of sites. Moreover, plastic waste that is abandoned on beaches contributes towards different degradation processes that potentially lead to the formation of secondary microplastics (MPs), with likely cascade effects upon the whole ecosystem. In this view, this study aims to characterize the plastic beach litter found on the shores of the western basin of Como Lake (Italy) to better understand the origin of MPs in littoral sediments, including the recognition of object typologies and the chemical characterization of polymers using Fourier-transformed infrared analysis (FTIR). The results highlighted that the most abundant polymers on beaches are polypropylene (PP) and polyethylene (PE), representing 73% of the collected polymers. This confirms that floating, low-density polymers are more likely to accumulate on beaches. Moreover, almost 66% of litter is represented by commonly used manufactured items (disposable objects, packaging, and everyday items). This evidence, combined with the analysis of the main environmental features of the sampling sites (the main winds, distance to urban areas, and the presence of tributaries) indicate that abundance of beached litter is mainly linked to beach accessibility and the local winds. These results highlight that multiple factors affect the environmental fate of plastic litter and give insights into the assessment of secondary microplastics in beach sediments.publishedVersio

Constrained Collaborative Power Management

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