Continuous blood pressure estimation from PPG signal

Blood pressure (BP) is an indicator of hypertension. We developed a system in which photoplethysmogram (PPG), which is commonly integrated in modern wearables, is used to continuously estimate BP. A preprocessing module was developed and used for cleaning the PPG signal of noise and artefacts, and segmenting it into cycles. A set of features describing the PPG signal was then computed to be used in regression models. The RReliefF algorithm was used to select a subset of relevant features and personalization of the models was considered to further improve the performance of the models. The approach was validated using two distinct datasets, one from a hospital environment, and the other collected during every-day activities. Using the clinical dataset (MIMIC database), the best achieved mean absolute errors (MAE) in a leave-one-subject-out (LOSO) experiment were 5.61 mmHg for systolic and 3.82 mmHg for diastolic BP, at maximum personalization. For everyday-life dataset, the lowest errors were 8.40 mmHg for systolic and 4.20 mmHg for diastolic BP. Deep learning regression and Random Forest algorithm achieved the best results. Our results borderline meet the requirements of the two most well-established standards for BP estimation devices

Continuous blood pressure estimation from PPG signal

Blood pressure (BP) is an indicator of hypertension. We developed a system in which photoplethysmogram (PPG), which is commonly integrated in modern wearables, is used to continuously estimate BP. A preprocessing module was developed and used for cleaning the PPG signal of noise and artefacts, and segmenting it into cycles. A set of features describing the PPG signal was then computed to be used in regression models. The RReliefF algorithm was used to select a subset of relevant features and personalization of the models was considered to further improve the performance of the models. The approach was validated using two distinct datasets, one from a hospital environment, and the other collected during every-day activities. Using the clinical dataset (MIMIC database), the best achieved mean absolute errors (MAE) in a leave-one-subject-out (LOSO) experiment were 5.61 mmHg for systolic and 3.82 mmHg for diastolic BP, at maximum personalization. For everyday-life dataset, the lowest errors were 8.40 mmHg for systolic and 4.20 mmHg for diastolic BP. Deep learning regression and Random Forest algorithm achieved the best results. Our results borderline meet the requirements of the two most well-established standards for BP estimation devices

From data acquisition to data fusion : a comprehensive review and a roadmap for the identification of activities of daily living using mobile devices

This paper focuses on the research on the state of the art for sensor fusion techniques, applied to the sensors embedded in mobile devices, as a means to help identify the mobile device user’s daily activities. Sensor data fusion techniques are used to consolidate the data collected from several sensors, increasing the reliability of the algorithms for the identification of the different activities. However, mobile devices have several constraints, e.g., low memory, low battery life and low processing power, and some data fusion techniques are not suited to this scenario. The main purpose of this paper is to present an overview of the state of the art to identify examples of sensor data fusion techniques that can be applied to the sensors available in mobile devices aiming to identify activities of daily living (ADLs)

Characterization, Classification, and Genesis of Seismocardiographic Signals

Seismocardiographic (SCG) signals are the acoustic and vibration induced by cardiac activity measured non-invasively at the chest surface. These signals may offer a method for diagnosing and monitoring heart function. Successful classification of SCG signals in health and disease depends on accurate signal characterization and feature extraction. In this study, SCG signal features were extracted in the time, frequency, and time-frequency domains. Different methods for estimating time-frequency features of SCG were investigated. Results suggested that the polynomial chirplet transform outperformed wavelet and short time Fourier transforms. Many factors may contribute to increasing intrasubject SCG variability including subject posture and respiratory phase. In this study, the effect of respiration on SCG signal variability was investigated. Results suggested that SCG waveforms can vary with lung volume, respiratory flow direction, or a combination of these criteria. SCG events were classified into groups belonging to these different respiration phases using classifiers, including artificial neural networks, support vector machines, and random forest. Categorizing SCG events into different groups containing similar events allows more accurate estimation of SCG features. SCG feature points were also identified from simultaneous measurements of SCG and other well-known physiologic signals including electrocardiography, phonocardiography, and echocardiography. Future work may use this information to get more insights into the genesis of SCG

Blind Source Separation for the Processing of Contact-Less Biosignals

(Spatio-temporale) Blind Source Separation (BSS) eignet sich für die Verarbeitung von Multikanal-Messungen im Bereich der kontaktlosen Biosignalerfassung. Ziel der BSS ist dabei die Trennung von (z.B. kardialen) Nutzsignalen und Störsignalen typisch für die kontaktlosen Messtechniken. Das Potential der BSS kann praktisch nur ausgeschöpft werden, wenn (1) ein geeignetes BSS-Modell verwendet wird, welches der Komplexität der Multikanal-Messung gerecht wird und (2) die unbestimmte Permutation unter den BSS-Ausgangssignalen gelöst wird, d.h. das Nutzsignal praktisch automatisiert identifiziert werden kann. Die vorliegende Arbeit entwirft ein Framework, mit dessen Hilfe die Effizienz von BSS-Algorithmen im Kontext des kamera-basierten Photoplethysmogramms bewertet werden kann. Empfehlungen zur Auswahl bestimmter Algorithmen im Zusammenhang mit spezifischen Signal-Charakteristiken werden abgeleitet. Außerdem werden im Rahmen der Arbeit Konzepte für die automatisierte Kanalauswahl nach BSS im Bereich der kontaktlosen Messung des Elektrokardiogramms entwickelt und bewertet. Neuartige Algorithmen basierend auf Sparse Coding erwiesen sich dabei als besonders effizient im Vergleich zu Standard-Methoden.(Spatio-temporal) Blind Source Separation (BSS) provides a large potential to process distorted multichannel biosignal measurements in the context of novel contact-less recording techniques for separating distortions from the cardiac signal of interest. This potential can only be practically utilized (1) if a BSS model is applied that matches the complexity of the measurement, i.e. the signal mixture and (2) if permutation indeterminacy is solved among the BSS output components, i.e the component of interest can be practically selected. The present work, first, designs a framework to assess the efficacy of BSS algorithms in the context of the camera-based photoplethysmogram (cbPPG) and characterizes multiple BSS algorithms, accordingly. Algorithm selection recommendations for certain mixture characteristics are derived. Second, the present work develops and evaluates concepts to solve permutation indeterminacy for BSS outputs of contact-less electrocardiogram (ECG) recordings. The novel approach based on sparse coding is shown to outperform the existing concepts of higher order moments and frequency-domain features

Machine learning techniques for the prediction of systolic and diastolic blood pressure utilising the photoplethysmogram

Blood pressure (BP) is one of the four primary vital signs that provides important information regarding patients' cardiovascular system conditions. Continuous and regular blood pressure monitoring is essential for the early diagnosis, prevention and management of cardiovascular disease (CVD) and haemodynamic diseases (hypertension and hypotension). Current clinical blood pressure measurement techniques are either invasive or cuff-based, which can be impractical, intermittent, and uncomfortable for patients during frequent measurements. Considering these challenges, several studies have suggested new non-invasive and cuffless blood pressuring measurement techniques using physiological signals, such as, the Electrocardiogram (ECG) and the Photoplethysmogram (PPG). In particular, indirect cuffless BP measurement techniques using pulse transit time and pulse arrival time have been extensively investigated over the last few decades. However, these techniques require two measurement sensors, frequent calibration, and hence, they are also impractical and inconvenient for continuous BP measurements. More recently, with the advancement of computational techniques, including machine learning and artificial intelligence, a new simple and innovative approach using only PPG signals have been proposed in the literature for cuffless and continuous monitoring of blood pressure. However, the majority of these studies have been unable to achieve acceptable accuracies that comply or satisfy the international standards for cuffless BP monitoring. Thus, further investigations are required to realise this approach. In this research, a total of 52 features have been extracted from the PPG and their individual impact on BP have been rigorously evaluated using several statistical and machine learning techniques. As a result, only the most important features for estimation of BP were selected, effectively reducing the input vector by more than half. Two datasets were created to accommodate the two input feature vectors. The PPG and reference BP signals were derived from the publicly available MIMIC II database. In order to estimate BP, a total of nine machine learning and neural network models have been implemented and evaluated on the two datasets. Out of the nine models, four are widely used classical machine learning models, and five neural network models, three of which are conventional models and two advanced models have been proposed for BP estimation using only one PPG signal. The results of all these models have also been compared against well established studies in the literature. The results obtained using the classical machine learning models, namely, multilinear regression, random forest, adaboost and support vector machine, were poor and inferior to all the neural network models. A slight performance improvement was achieved using the non-recurrent multi-layer perceptron, however, the error was still much higher than the internationally acceptable range. On the other hand, a significant improvement was achieved for the first time by using the recurrent neural network models, namely, Long Short-Term Memory (LSTM) and Gated Recurrent Units (GRU). The two proposed neural network models further enhanced the BP estimation accuracies and were able to reduce the mean absolute error (MAE) to a range below 5 mmHg. In particular, the best performing model was the one bidirectional GRU layer, followed by two unidirectional GRU layers, and an attention layer. The obtained MAE and standard deviation (SD) were 4.79+/-8.08 mmHg for systolic BP (SBP) and 2.77+/-4.72 mmHg for diastolic BP (DBP). Furthermore, the DBP estimation were well below the internationally acceptable limits (referring to the AAMI standards of mean error (ME), ME+/-SD less than 5+/-8), while the ME for the SBP estimation were acceptable but the SD exceeded the limits by only 1.34 mmHg. This research has successfully demonstrated that advanced neural network models can be used for the non-invasive and cuffless prediction of BP utilising the PPG

Open Source Quantitative Stress Prediction Leveraging Wearable Sensing and Machine Learning Methods

The ability to monitor physiological parameters in an individual is paramount for the evaluation of physical health and the detection of many ailments. Wearable technologies are being introduced on a widening scale to address the absence of low-cost and non-invasive health monitoring as compared to medical grade equipment and technologies. By leveraging wearable technologies to supplement or replace traditional gold-standard measurement techniques, the research community can develop a deeper multifaceted understanding of the relationship between specific physiological parameters and particular health conditions. One particular research area in which wearable technologies are beginning to see application is the quantification of physical and mental stress levels in individuals through brainwave and physiological feature monitoring. At present, these methods are time consuming, invasive, expensive, or some combination of the three. This thesis chronicles the development and application of a novel open source wearable sensing platform to the field of stress and fatigue estimation and quantization. More specifically, the garment in its current configuration monitors heart rate, blood oxygen saturation, skin temperature, respiration rate, and skin conductivity parameters to explore the relationship between these parameters and various self-reported stress measures. Utilizing machine-learning methods, subject-specific models were generated in an n=1 study which predicts the self-perceived stress level of the subject with an accuracy of between 92% and 100%. The garment was developed with a modular interface and open source code base to allow and encourage reconfiguration and customization of the sensor array for other research applications. The dataset generated in this effort spans the early stages of the COVID-19 pandemic as the subject experienced increasing levels of isolation and tracks physiological parameters across two months via daily measurements

Multi-sensor data fusion in mobile devices for the identification of Activities of Daily Living

Following the recent advances in technology and the growing use of mobile devices such as smartphones, several solutions may be developed to improve the quality of life of users in the context of Ambient Assisted Living (AAL). Mobile devices have different available sensors, e.g., accelerometer, gyroscope, magnetometer, microphone and Global Positioning System (GPS) receiver, which allow the acquisition of physical and physiological parameters for the recognition of different Activities of Daily Living (ADL) and the environments in which they are performed. The definition of ADL includes a well-known set of tasks, which include basic selfcare tasks, based on the types of skills that people usually learn in early childhood, including feeding, bathing, dressing, grooming, walking, running, jumping, climbing stairs, sleeping, watching TV, working, listening to music, cooking, eating and others. On the context of AAL, some individuals (henceforth called user or users) need particular assistance, either because the user has some sort of impairment, or because the user is old, or simply because users need/want to monitor their lifestyle. The research and development of systems that provide a particular assistance to people is increasing in many areas of application. In particular, in the future, the recognition of ADL will be an important element for the development of a personal digital life coach, providing assistance to different types of users. To support the recognition of ADL, the surrounding environments should be also recognized to increase the reliability of these systems. The main focus of this Thesis is the research on methods for the fusion and classification of the data acquired by the sensors available in off-the-shelf mobile devices in order to recognize ADL in almost real-time, taking into account the large diversity of the capabilities and characteristics of the mobile devices available in the market. In order to achieve this objective, this Thesis started with the review of the existing methods and technologies to define the architecture and modules of the method for the identification of ADL. With this review and based on the knowledge acquired about the sensors available in off-the-shelf mobile devices, a set of tasks that may be reliably identified was defined as a basis for the remaining research and development to be carried out in this Thesis. This review also identified the main stages for the development of a new method for the identification of the ADL using the sensors available in off-the-shelf mobile devices; these stages are data acquisition, data processing, data cleaning, data imputation, feature extraction, data fusion and artificial intelligence. One of the challenges is related to the different types of data acquired from the different sensors, but other challenges were found, including the presence of environmental noise, the positioning of the mobile device during the daily activities, the limited capabilities of the mobile devices and others. Based on the acquired data, the processing was performed, implementing data cleaning and feature extraction methods, in order to define a new framework for the recognition of ADL. The data imputation methods were not applied, because at this stage of the research their implementation does not have influence in the results of the identification of the ADL and environments, as the features are extracted from a set of data acquired during a defined time interval and there are no missing values during this stage. The joint selection of the set of usable sensors and the identifiable set of tasks will then allow the development of a framework that, considering multi-sensor data fusion technologies and context awareness, in coordination with other information available from the user context, such as his/her agenda and the time of the day, will allow to establish a profile of the tasks that the user performs in a regular activity day. The classification method and the algorithm for the fusion of the features for the recognition of ADL and its environments needs to be deployed in a machine with some computational power, while the mobile device that will use the created framework, can perform the identification of the ADL using a much less computational power. Based on the results reported in the literature, the method chosen for the recognition of the ADL is composed by three variants of Artificial Neural Networks (ANN), including simple Multilayer Perceptron (MLP) networks, Feedforward Neural Networks (FNN) with Backpropagation, and Deep Neural Networks (DNN). Data acquisition can be performed with standard methods. After the acquisition, the data must be processed at the data processing stage, which includes data cleaning and feature extraction methods. The data cleaning method used for motion and magnetic sensors is the low pass filter, in order to reduce the noise acquired; but for the acoustic data, the Fast Fourier Transform (FFT) was applied to extract the different frequencies. When the data is clean, several features are then extracted based on the types of sensors used, including the mean, standard deviation, variance, maximum value, minimum value and median of raw data acquired from the motion and magnetic sensors; the mean, standard deviation, variance and median of the maximum peaks calculated with the raw data acquired from the motion and magnetic sensors; the five greatest distances between the maximum peaks calculated with the raw data acquired from the motion and magnetic sensors; the mean, standard deviation, variance, median and 26 Mel- Frequency Cepstral Coefficients (MFCC) of the frequencies obtained with FFT based on the raw data acquired from the microphone data; and the distance travelled calculated with the data acquired from the GPS receiver. After the extraction of the features, these will be grouped in different datasets for the application of the ANN methods and to discover the method and dataset that reports better results. The classification stage was incrementally developed, starting with the identification of the most common ADL (i.e., walking, running, going upstairs, going downstairs and standing activities) with motion and magnetic sensors. Next, the environments were identified with acoustic data, i.e., bedroom, bar, classroom, gym, kitchen, living room, hall, street and library. After the environments are recognized, and based on the different sets of sensors commonly available in the mobile devices, the data acquired from the motion and magnetic sensors were combined with the recognized environment in order to differentiate some activities without motion, i.e., sleeping and watching TV. The number of recognized activities in this stage was increased with the use of the distance travelled, extracted from the GPS receiver data, allowing also to recognize the driving activity. After the implementation of the three classification methods with different numbers of iterations, datasets and remaining configurations in a machine with high processing capabilities, the reported results proved that the best method for the recognition of the most common ADL and activities without motion is the DNN method, but the best method for the recognition of environments is the FNN method with Backpropagation. Depending on the number of sensors used, this implementation reports a mean accuracy between 85.89% and 89.51% for the recognition of the most common ADL, equals to 86.50% for the recognition of environments, and equals to 100% for the recognition of activities without motion, reporting an overall accuracy between 85.89% and 92.00%. The last stage of this research work was the implementation of the structured framework for the mobile devices, verifying that the FNN method requires a high processing power for the recognition of environments and the results reported with the mobile application are lower than the results reported with the machine with high processing capabilities used. Thus, the DNN method was also implemented for the recognition of the environments with the mobile devices. Finally, the results reported with the mobile devices show an accuracy between 86.39% and 89.15% for the recognition of the most common ADL, equal to 45.68% for the recognition of environments, and equal to 100% for the recognition of activities without motion, reporting an overall accuracy between 58.02% and 89.15%. Compared with the literature, the results returned by the implemented framework show only a residual improvement. However, the results reported in this research work comprehend the identification of more ADL than the ones described in other studies. The improvement in the recognition of ADL based on the mean of the accuracies is equal to 2.93%, but the maximum number of ADL and environments previously recognized was 13, while the number of ADL and environments recognized with the framework resulting from this research is 16. In conclusion, the framework developed has a mean improvement of 2.93% in the accuracy of the recognition for a larger number of ADL and environments than previously reported. In the future, the achievements reported by this PhD research may be considered as a start point of the development of a personal digital life coach, but the number of ADL and environments recognized by the framework should be increased and the experiments should be performed with different types of devices (i.e., smartphones and smartwatches), and the data imputation and other machine learning methods should be explored in order to attempt to increase the reliability of the framework for the recognition of ADL and its environments.Após os recentes avanços tecnológicos e o crescente uso dos dispositivos móveis, como por exemplo os smartphones, várias soluções podem ser desenvolvidas para melhorar a qualidade de vida dos utilizadores no contexto de Ambientes de Vida Assistida (AVA) ou Ambient Assisted Living (AAL). Os dispositivos móveis integram vários sensores, tais como acelerómetro, giroscópio, magnetómetro, microfone e recetor de Sistema de Posicionamento Global (GPS), que permitem a aquisição de vários parâmetros físicos e fisiológicos para o reconhecimento de diferentes Atividades da Vida Diária (AVD) e os seus ambientes. A definição de AVD inclui um conjunto bem conhecido de tarefas que são tarefas básicas de autocuidado, baseadas nos tipos de habilidades que as pessoas geralmente aprendem na infância. Essas tarefas incluem alimentar-se, tomar banho, vestir-se, fazer os cuidados pessoais, caminhar, correr, pular, subir escadas, dormir, ver televisão, trabalhar, ouvir música, cozinhar, comer, entre outras. No contexto de AVA, alguns indivíduos (comumente chamados de utilizadores) precisam de assistência particular, seja porque o utilizador tem algum tipo de deficiência, seja porque é idoso, ou simplesmente porque o utilizador precisa/quer monitorizar e treinar o seu estilo de vida. A investigação e desenvolvimento de sistemas que fornecem algum tipo de assistência particular está em crescente em muitas áreas de aplicação. Em particular, no futuro, o reconhecimento das AVD é uma parte importante para o desenvolvimento de um assistente pessoal digital, fornecendo uma assistência pessoal de baixo custo aos diferentes tipos de pessoas. pessoas. Para ajudar no reconhecimento das AVD, os ambientes em que estas se desenrolam devem ser reconhecidos para aumentar a fiabilidade destes sistemas. O foco principal desta Tese é o desenvolvimento de métodos para a fusão e classificação dos dados adquiridos a partir dos sensores disponíveis nos dispositivos móveis, para o reconhecimento quase em tempo real das AVD, tendo em consideração a grande diversidade das características dos dispositivos móveis disponíveis no mercado. Para atingir este objetivo, esta Tese iniciou-se com a revisão dos métodos e tecnologias existentes para definir a arquitetura e os módulos do novo método de identificação das AVD. Com esta revisão da literatura e com base no conhecimento adquirido sobre os sensores disponíveis nos dispositivos móveis disponíveis no mercado, um conjunto de tarefas que podem ser identificadas foi definido para as pesquisas e desenvolvimentos desta Tese. Esta revisão também identifica os principais conceitos para o desenvolvimento do novo método de identificação das AVD, utilizando os sensores, são eles: aquisição de dados, processamento de dados, correção de dados, imputação de dados, extração de características, fusão de dados e extração de resultados recorrendo a métodos de inteligência artificial. Um dos desafios está relacionado aos diferentes tipos de dados adquiridos pelos diferentes sensores, mas outros desafios foram encontrados, sendo os mais relevantes o ruído ambiental, o posicionamento do dispositivo durante a realização das atividades diárias, as capacidades limitadas dos dispositivos móveis. As diferentes características das pessoas podem igualmente influenciar a criação dos métodos, escolhendo pessoas com diferentes estilos de vida e características físicas para a aquisição e identificação dos dados adquiridos a partir de sensores. Com base nos dados adquiridos, realizou-se o processamento dos dados, implementando-se métodos de correção dos dados e a extração de características, para iniciar a criação do novo método para o reconhecimento das AVD. Os métodos de imputação de dados foram excluídos da implementação, pois não iriam influenciar os resultados da identificação das AVD e dos ambientes, na medida em que são utilizadas as características extraídas de um conjunto de dados adquiridos durante um intervalo de tempo definido. A seleção dos sensores utilizáveis, bem como das AVD identificáveis, permitirá o desenvolvimento de um método que, considerando o uso de tecnologias para a fusão de dados adquiridos com múltiplos sensores em coordenação com outras informações relativas ao contexto do utilizador, tais como a agenda do utilizador, permitindo estabelecer um perfil de tarefas que o utilizador realiza diariamente. Com base nos resultados obtidos na literatura, o método escolhido para o reconhecimento das AVD são as diferentes variantes das Redes Neuronais Artificiais (RNA), incluindo Multilayer Perceptron (MLP), Feedforward Neural Networks (FNN) with Backpropagation and Deep Neural Networks (DNN). No final, após a criação dos métodos para cada fase do método para o reconhecimento das AVD e ambientes, a implementação sequencial dos diferentes métodos foi realizada num dispositivo móvel para testes adicionais. Após a definição da estrutura do método para o reconhecimento de AVD e ambientes usando dispositivos móveis, verificou-se que a aquisição de dados pode ser realizada com os métodos comuns. Após a aquisição de dados, os mesmos devem ser processados no módulo de processamento de dados, que inclui os métodos de correção de dados e de extração de características. O método de correção de dados utilizado para sensores de movimento e magnéticos é o filtro passa-baixo de modo a reduzir o ruído, mas para os dados acústicos, a Transformada Rápida de Fourier (FFT) foi aplicada para extrair as diferentes frequências. Após a correção dos dados, as diferentes características foram extraídas com base nos tipos de sensores usados, sendo a média, desvio padrão, variância, valor máximo, valor mínimo e mediana de dados adquiridos pelos sensores magnéticos e de movimento, a média, desvio padrão, variância e mediana dos picos máximos calculados com base nos dados adquiridos pelos sensores magnéticos e de movimento, as cinco maiores distâncias entre os picos máximos calculados com os dados adquiridos dos sensores de movimento e magnéticos, a média, desvio padrão, variância e 26 Mel-Frequency Cepstral Coefficients (MFCC) das frequências obtidas com FFT com base nos dados obtidos a partir do microfone, e a distância calculada com os dados adquiridos pelo recetor de GPS. Após a extração das características, as mesmas são agrupadas em diferentes conjuntos de dados para a aplicação dos métodos de RNA de modo a descobrir o método e o conjunto de características que reporta melhores resultados. O módulo de classificação de dados foi incrementalmente desenvolvido, começando com a identificação das AVD comuns com sensores magnéticos e de movimento, i.e., andar, correr, subir escadas, descer escadas e parado. Em seguida, os ambientes são identificados com dados de sensores acústicos, i.e., quarto, bar, sala de aula, ginásio, cozinha, sala de estar, hall, rua e biblioteca. Com base nos ambientes reconhecidos e os restantes sensores disponíveis nos dispositivos móveis, os dados adquiridos dos sensores magnéticos e de movimento foram combinados com o ambiente reconhecido para diferenciar algumas atividades sem movimento (i.e., dormir e ver televisão), onde o número de atividades reconhecidas nesta fase aumenta com a fusão da distância percorrida, extraída a partir dos dados do recetor GPS, permitindo também reconhecer a atividade de conduzir. Após a implementação dos três métodos de classificação com diferentes números de iterações, conjuntos de dados e configurações numa máquina com alta capacidade de processamento, os resultados relatados provaram que o melhor método para o reconhecimento das atividades comuns de AVD e atividades sem movimento é o método DNN, mas o melhor método para o reconhecimento de ambientes é o método FNN with Backpropagation. Dependendo do número de sensores utilizados, esta implementação reporta uma exatidão média entre 85,89% e 89,51% para o reconhecimento das AVD comuns, igual a 86,50% para o reconhecimento de ambientes, e igual a 100% para o reconhecimento de atividades sem movimento, reportando uma exatidão global entre 85,89% e 92,00%. A última etapa desta Tese foi a implementação do método nos dispositivos móveis, verificando que o método FNN requer um alto poder de processamento para o reconhecimento de ambientes e os resultados reportados com estes dispositivos são inferiores aos resultados reportados com a máquina com alta capacidade de processamento utilizada no desenvolvimento do método. Assim, o método DNN foi igualmente implementado para o reconhecimento dos ambientes com os dispositivos móveis. Finalmente, os resultados relatados com os dispositivos móveis reportam uma exatidão entre 86,39% e 89,15% para o reconhecimento das AVD comuns, igual a 45,68% para o reconhecimento de ambientes, e igual a 100% para o reconhecimento de atividades sem movimento, reportando uma exatidão geral entre 58,02% e 89,15%. Com base nos resultados relatados na literatura, os resultados do método desenvolvido mostram uma melhoria residual, mas os resultados desta Tese identificam mais AVD que os demais estudos disponíveis na literatura. A melhoria no reconhecimento das AVD com base na média das exatidões é igual a 2,93%, mas o número máximo de AVD e ambientes reconhecidos pelos estudos disponíveis na literatura é 13, enquanto o número de AVD e ambientes reconhecidos com o método implementado é 16. Assim, o método desenvolvido tem uma melhoria de 2,93% na exatidão do reconhecimento num maior número de AVD e ambientes. Como trabalho futuro, os resultados reportados nesta Tese podem ser considerados um ponto de partida para o desenvolvimento de um assistente digital pessoal, mas o número de ADL e ambientes reconhecidos pelo método deve ser aumentado e as experiências devem ser repetidas com diferentes tipos de dispositivos móveis (i.e., smartphones e smartwatches), e os métodos de imputação e outros métodos de classificação de dados devem ser explorados de modo a tentar aumentar a confiabilidade do método para o reconhecimento das AVD e ambientes

Intelligent Biosignal Processing in Wearable and Implantable Sensors

This reprint provides a collection of papers illustrating the state-of-the-art of smart processing of data coming from wearable, implantable or portable sensors. Each paper presents the design, databases used, methodological background, obtained results, and their interpretation for biomedical applications. Revealing examples are brain–machine interfaces for medical rehabilitation, the evaluation of sympathetic nerve activity, a novel automated diagnostic tool based on ECG data to diagnose COVID-19, machine learning-based hypertension risk assessment by means of photoplethysmography and electrocardiography signals, Parkinsonian gait assessment using machine learning tools, thorough analysis of compressive sensing of ECG signals, development of a nanotechnology application for decoding vagus-nerve activity, detection of liver dysfunction using a wearable electronic nose system, prosthetic hand control using surface electromyography, epileptic seizure detection using a CNN, and premature ventricular contraction detection using deep metric learning. Thus, this reprint presents significant clinical applications as well as valuable new research issues, providing current illustrations of this new field of research by addressing the promises, challenges, and hurdles associated with the synergy of biosignal processing and AI through 16 different pertinent studies. Covering a wide range of research and application areas, this book is an excellent resource for researchers, physicians, academics, and PhD or master students working on (bio)signal and image processing, AI, biomaterials, biomechanics, and biotechnology with applications in medicine

Acoustic sensing as a novel approach for cardiovascular monitoring at the wrist

Cardiovascular diseases are the number one cause of deaths globally. An increased cardiovascular risk can be detected by a regular monitoring of the vital signs including the heart rate, the heart rate variability (HRV) and the blood pressure. For a user to undergo continuous vital sign monitoring, wearable systems prove to be very useful as the device can be integrated into the user's lifestyle without affecting the daily activities. However, the main challenge associated with the monitoring of these cardiovascular parameters is the requirement of different sensing mechanisms at different measurement sites. There is not a single wearable device that can provide sufficient physiological information to track the vital signs from a single site on the body. This thesis proposes a novel concept of using acoustic sensing over the radial artery to extract cardiac parameters for vital sign monitoring. A wearable system consisting of a microphone is designed to allow the detection of the heart sounds together with the pulse wave, an attribute not possible with existing wrist-based sensing methods. Methods: The acoustic signals recorded from the radial artery are a continuous reflection of the instantaneous cardiac activity. These signals are studied and characterised using different algorithms to extract cardiovascular parameters. The validity of the proposed principle is firstly demonstrated using a novel algorithm to extract the heart rate from these signals. The algorithm utilises the power spectral analysis of the acoustic pulse signal to detect the S1 sounds and additionally, the K-means method to remove motion artifacts for an accurate heartbeat detection. The HRV in the short-term acoustic recordings is found by extracting the S1 events using the relative information between the short- and long-term energies of the signal. The S1 events are localised using three different characteristic points and the best representation is found by comparing the instantaneous heart rate profiles. The possibility of measuring the blood pressure using the wearable device is shown by recording the acoustic signal under the influence of external pressure applied on the arterial branch. The temporal and spectral characteristics of the acoustic signal are utilised to extract the feature signals and obtain a relationship with the systolic blood pressure (SBP) and diastolic blood pressure (DBP) respectively. Results: This thesis proposes three different algorithms to find the heart rate, the HRV and the SBP/ DBP readings from the acoustic signals recorded at the wrist. The results obtained by each algorithm are as follows: 1. The heart rate algorithm is validated on a dataset consisting of 12 subjects with a data length of 6 hours. The results demonstrate an accuracy of 98.78%, mean absolute error of 0.28 bpm, limits of agreement between -1.68 and 1.69 bpm, and a correlation coefficient of 0.998 with reference to a state-of-the-art PPG-based commercial device. A high statistical agreement between the heart rate obtained from the acoustic signal and the photoplethysmography (PPG) signal is observed. 2. The HRV algorithm is validated on the short-term acoustic signals of 5-minutes duration recorded from each of the 12 subjects. A comparison is established with the simultaneously recorded electrocardiography (ECG) and PPG signals respectively. The instantaneous heart rate for all the subjects combined together achieves an accuracy of 98.50% and 98.96% with respect to the ECG and PPG signals respectively. The results for the time-domain and frequency-domain HRV parameters also demonstrate high statistical agreement with the ECG and PPG signals respectively. 3. The algorithm proposed for the SBP/ DBP determination is validated on 104 acoustic signals recorded from 40 adult subjects. The experimental outputs when compared with the reference arm- and wrist-based monitors produce a mean error of less than 2 mmHg and a standard deviation of error around 6 mmHg. Based on these results, this thesis shows the potential of this new sensing modality to be used as an alternative, or to complement existing methods, for the continuous monitoring of heart rate and HRV, and spot measurement of the blood pressure at the wrist.Open Acces