Genetic programming for mining DNA chip data from cancer patients

In machine learning terms DNA (gene) chip data is unusual in having thousands of attributes (the gene expression values) but few (<100) records (the patients). A GP based method for both feature selection and generating simple models based on a few genes is demonstrated on cancer data

Radar and RGB-depth sensors for fall detection: a review

This paper reviews recent works in the literature on the use of systems based on radar and RGB-Depth (RGB-D) sensors for fall detection, and discusses outstanding research challenges and trends related to this research field. Systems to detect reliably fall events and promptly alert carers and first responders have gained significant interest in the past few years in order to address the societal issue of an increasing number of elderly people living alone, with the associated risk of them falling and the consequences in terms of health treatments, reduced well-being, and costs. The interest in radar and RGB-D sensors is related to their capability to enable contactless and non-intrusive monitoring, which is an advantage for practical deployment and users’ acceptance and compliance, compared with other sensor technologies, such as video-cameras, or wearables. Furthermore, the possibility of combining and fusing information from The heterogeneous types of sensors is expected to improve the overall performance of practical fall detection systems. Researchers from different fields can benefit from multidisciplinary knowledge and awareness of the latest developments in radar and RGB-D sensors that this paper is discussing

Genetic programming in data mining for drug discovery

Genetic programming (GP) is used to extract from rat oral bioavailability (OB) measurements simple, interpretable and predictive QSAR models which both generalise to rats and to marketed drugs in humans. Receiver Operating Characteristics (ROC) curves for the binary classier produced by machine learning show no statistical dierence between rats (albeit without known clearance dierences) and man. Thus evolutionary computing oers the prospect of in silico ADME screening, e.g. for \virtual" chemicals, for pharmaceutical drug discovery

Plastid proteome prediction for diatoms and other algae with secondary plastids of the red lineage

The plastids of ecologically and economically important algae from phyla such as stramenopiles, dinoflagellates and cryptophytes were acquired via a secondary endosymbiosis and are surrounded by three or four membranes. Nuclear-encoded plastid-localized proteins contain N-terminal bipartite targeting peptides with the conserved amino acid sequence motif ‘ASAFAP’. Here we identify the plastid proteomes of two diatoms, Thalassiosira pseudonana and Phaeodactylum tricornutum, using a customized prediction tool (ASAFind) that identifies nuclear-encoded plastid proteins in algae with secondary plastids of the red lineage based on the output of SignalP and the identification of conserved ‘ASAFAP’ motifs and transit peptides. We tested ASAFind against a large reference dataset of diatom proteins with experimentally confirmed subcellular localization and found that the tool accurately identified plastid-localized proteins with both high sensitivity and high specificity. To identify nucleus-encoded plastid proteins of T. pseudonana and P. tricornutum we generated optimized sets of gene models for both whole genomes, to increase the percentage of full-length proteins compared with previous assembly model sets. ASAFind applied to these optimized sets revealed that about 8% of the proteins encoded in their nuclear genomes were predicted to be plastid localized and therefore represent the putative plastid proteomes of these algae

Multimodal decision-level fusion for person authentication

In this paper, the use of clustering algorithms for decision-level data fusion is proposed. Person authentication results coming from several modalities (e.g., still image, speech), are combined by using fuzzy k-means (FKM), fuzzy vector quantization (FVQ) algorithms, and median radial basis function (MRBF) network. The quality measure of the modalities data is used for fuzzification. Two modifications of the FKM and FVQ algorithms, based on a novel fuzzy vector distance definition, are proposed to handle the fuzzy data and utilize the quality measure. Simulations show that fuzzy clustering algorithms have better performance compared to the classical clustering algorithms and other known fusion algorithms. MRBF has better performance especially when two modalities are combined. Moreover, the use of the quality via the proposed modified algorithms increases the performance of the fusion system

Spatial Identification Methods and Systems for RFID Tags

Disertační práce je zaměřena na metody a systémy pro měření vzdálenosti a lokalizaci RFID tagů pracujících v pásmu UHF. Úvod je věnován popisu současného stavu vědeckého poznání v oblasti RFID prostorové identifikace a stručnému shrnutí problematiky modelování a návrhu prototypů těchto systémů. Po specifikaci cílů disertace pokračuje práce popisem teorie modelování degenerovaného kanálu pro RFID komunikaci. Detailně jsou rozebrány metody měření vzdálenosti a odhadu směru příchodu signálu založené na zpracování fázové informace. Pro účely lokalizace je navrženo několik scénářů rozmístění antén. Modely degenerovaného kanálu jsou simulovány v systému MATLAB. Významná část této práce je věnována konceptu softwarově definovaného rádia (SDR) a specifikům jeho adaptace na UHF RFID, která využití běžných SDR systémů značně omezují. Diskutována je zejména problematika průniku nosné vysílače do přijímací cesty a požadavky na signál lokálního oscilátoru používaný pro směšování. Prezentovány jsou tři vyvinuté prototypy: experimentální dotazovač EXIN-1, měřicí systém založený na platformě Ettus USRP a anténní přepínací matice pro emulaci SIMO systému. Závěrečná část je zaměřena na testování a zhodnocení popisovaných lokalizačních technik, založených na měření komplexní přenosové funkce RFID kanálu. Popisuje úzkopásmové/širokopásmové měření vzdálenosti a metody odhadu směru signálu. Oba navržené scénáře rozmístění antén jsou v závěru ověřeny lokalizačním měřením v reálných podmínkách.The doctoral thesis is focused on methods and systems for ranging and localization of RFID tags operating in the UHF band. It begins with a description of the state of the art in the field of RFID positioning with short extension to the area of modeling and prototyping of such systems. After a brief specification of dissertation objectives, the thesis overviews the theory of degenerate channel modeling for RFID communication. Details are given about phase-based ranging and direction of arrival finding methods. Several antenna placement scenarios are proposed for localization purposes. The degenerate channel models are simulated in MATLAB. A significant part of the thesis is devoted to software defined radio (SDR) concept and its adaptation for UHF RFID operation, as it has its specialties which make the usage of standard SDR test equipment very disputable. Transmit carrier leakage into receiver path and requirements on local oscillator signals for mixing are discussed. The development of three experimental prototypes is also presented there: experimental interrogator EXIN-1, measurement system based on Ettus USRP platform, and antenna switching matrix for an emulation of SIMO system. The final part is focused on testing and evaluation of described positioning techniques based on complex backscatter channel transfer function measurement. Both narrowband/wideband ranging and direction of arrival methods are validated. Finally, both proposed antenna placement scenarios are evaluated with real-world measurements.

Techno-economic projections for advanced small solar thermal electric power plants to years 1990-2000

Advanced technologies applicable to solar thermal electric power systems in the 1990-200 time-frame are delineated for power applications that fulfill a wide spectrum of small power needs with primary emphasis on power ratings less than 10MWe. Projections of power system characteristics (energy and capital costs as a function of capacity factor) are made based on development of identified promising technologies and are used as the basis for comparing technology development options and combinations of these options to determine developmental directions offering potential for significant improvements. Stirling engines, Brayton/Rankine combined cycles and storage/transport concepts encompassing liquid metals, and reversible-reaction chemical systems are considered for two-axis tracking systems such as the central receiver or power tower concept and distributed parabolic dish receivers which can provide efficient low-cost solar energy collection while achieving high temperatures for efficient energy conversion. Pursuit of advanced technology across a broad front can result in post-1985 solar thermal systems having the potential of approaching the goal of competitiveness with conventional power systems

Multi-Target Detection Capability of Linear Fusion Approach Under Different Swerling Models of Target Fluctuation

In evolving radar systems, detection is regarded as a fundamental stage in their receiving end. Consequently, detection performance enhancement of a CFAR variant represents the basic requirement of these systems, since the CFAR strategy plays a key role in automatic detection process. Most existing CFAR variants need to estimate the background level before constructing the detection threshold. In a multi-target state, the existence of spurious targets could cause inaccurate estimation of background level. The occurrence of this effect will result in severely degrading the performance of the CFAR algorithm. Lots of research in the CFAR design have been achieved. However, the gap in the previous works is that there is no CFAR technique that can operate in all or most environmental varieties. To overcome this challenge, the linear fusion (LF) architecture, which can operate with the most environmental and target situations, has been presented