Order-of-Magnitude Influence Diagrams

In this paper, we develop a qualitative theory of influence diagrams that can be used to model and solve sequential decision making tasks when only qualitative (or imprecise) information is available. Our approach is based on an order-of-magnitude approximation of both probabilities and utilities and allows for specifying partially ordered preferences via sets of utility values. We also propose a dedicated variable elimination algorithm that can be applied for solving order-of-magnitude influence diagrams

Trapped surfaces and spherical closed cosmologies

This article gives necessary and sufficient conditions for the formation of trapped surfaces in spherically symmetric initial data defined on a closed manifold. Such trapped surfaces surround a region in which there occurs an enhancement of matter over the average. The conditions are posed directly in terms of physical variables and show that what one needs is a relatively large amount of excess matter confined to a small volume. The expansion of the universe and an outward flow of matter oppose the formation of trapped surfaces; an inward flow of matter helps. The model can be regarded as a Friedmann-Lema\^\i tre-Walker cosmology with localized spherical inhomogeneities. We show that the total excess mass cannot be too large.Comment: 36 page

Quantum reservoirs with ion chains

Ion chains are promising platforms for studying and simulating quantum reservoirs. One interesting feature is that their vibrational modes can mediate entanglement between two objects which are coupled through the vibrational modes of the chain. In this work we analyse entanglement between the transverse vibrations of two heavy impurity defects embedded in an ion chain, which is generated by the coupling with the chain vibrations. We verify general scaling properties of the defects dynamics and demonstrate that entanglement between the defects can be a stationary feature of these dynamics. We then analyse entanglement in chains composed of tens of ions and propose a measurement scheme which allows one to verify the existence of the predicted entangled state.Comment: 14 pages, 12 figure

Evaluation of the Efficacy and Safety of a Marine-Derived Bacillus Strain for Use as an In-Feed Probiotic for Newly Weaned Pigs

peer-reviewedForty eight individual pigs (8.7±0.26 kg) weaned at 28±1 d of age were used in a 22-d study to evaluate the effect of oral administration of a Bacillus pumilus spore suspension on growth performance and health indicators. Treatments (n = 16) were: (1) non-medicated diet; (2) medicated diet with apramycin (200 mg/kg) and pharmacological levels of zinc oxide (2,500 mg zinc/kg) and (3) B. pumilus diet (non-medicated diet + 1010 spores/day B. pumilus). Final body weight and average daily gain tended to be lower (P = 0.07) and feed conversion ratio was worsened (P<0.05) for the medicated treatment compared to the B. pumilus treatment. Ileal E. coli counts were lower for the B. pumilus and medicated treatments compared to the non-medicated treatment (P<0.05), perhaps as a result of increased ileal propionic acid concentrations (P<0.001). However, the medicated treatment reduced fecal (P<0.001) and cecal (P<0.05) Lactobacillus counts and tended to reduce the total cecal short chain fatty acid (SCFA) concentration (P = 0.10). Liver weights were lighter and concentrations of liver enzymes higher (P<0.05) in pigs on the medicated treatment compared to those on the non-medicated or B. pumilus treatments. Pigs on the B. pumilus treatment had lower overall lymphocyte and higher granulocyte percentages (P<0.001) and higher numbers of jejunal goblet cells (P<0.01) than pigs on either of the other two treatments or the non-medicated treatment, respectively. However, histopathological examination of the small intestine, kidneys and liver revealed no abnormalities. Overall, the B. pumilus treatment decreased ileal E. coli counts in a manner similar to the medicated treatment but without the adverse effects on growth performance, Lactobacillus counts, cecal SCFA concentration and possible liver toxicity experienced with the medicated treatment.The study was funded by the Higher Education Authority/Institutes of Technology Ireland Technological Sector Research Strand III Programme

In-vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia

Antihypertensive drugs lower the maternal blood pressure in pre-eclampsia (PE) by direct or central vasodilatory mechanisms but little is known about the direct effects of these drugs on placental functions

Baseline and stress-induced levels of corticosterone in male and female Afrotropical and European temperate stonechats during breeding

Background: Latitudinal variation in avian life histories falls along a slow-fast pace of life continuum: tropical species produce small clutches, but have a high survival probability, while in temperate species the opposite pattern is found. This study investigated whether differential investment into reproduction and survival of tropical and temperate species is paralleled by differences in the secretion of the vertebrate hormone corticosterone (CORT). Depending on circulating concentrations, CORT can both act as a metabolic (low to medium levels) and a stress hormone (high levels) and, thereby, influence reproductive decisions. Baseline and stress-induced CORT was measured across sequential stages of the breeding season in males and females of closely related taxa of stonechats (Saxicola spp) from a wide distribution area. We compared stonechats from 13 sites, representing Canary Islands, European temperate and East African tropical areas. Stonechats are highly seasonal breeders at all these sites, but vary between tropical and temperate regions with regard to reproductive investment and presumably also survival. Results: In accordance with life-history theory, during parental stages, post-capture (baseline) CORT was overall lower in tropical than in temperate stonechats. However, during mating stages, tropical males had elevated post-capture (baseline) CORT concentrations, which did not differ from those of temperate males. Female and male mates of a pair showed correlated levels of post-capture CORT when sampled after simulated territorial intrusions. In contrast to the hypothesis that species with low reproduction and high annual survival should be more risk-sensitive, tropical stonechats had lower stress-induced CORT concentrations than temperate stonechats. We also found relatively high post-capture (baseline) and stress-induced CORT concentrations, in slow-paced Canary Islands stonechats. Conclusions: Our data support and refine the view that baseline CORT facilitates energetically demanding activities in males and females and reflects investment into reproduction. Low parental workload was associated with lower post-capture (baseline) CORT as expected for a slow pace of life in tropical species. On a finer resolution, however, this tropical-temperate contrast did not generally hold. Post-capture (baseline) CORT was higher during mating stages in particular in tropical males, possibly to support the energetic needs of mate-guarding. Counter to predictions based on life history theory, our data do not confirm the hypothesis that long-lived tropical populations have higher stress-induced CORT concentrations than short-lived temperate populations. Instead, in the predator-rich tropical environments of African stonechats, a dampened stress response during parental stages may increase survival probabilities of young. Overall our data further support an association between life history and baseline CORT, but challenge the role of stress-induced CORT as a mediator of tropical-temperate variation in life history

Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs

peer-reviewedBackground: Carotid body (peripheral oxygen sensor) sensitisation is pivotal in the development of chronic intermittent hypoxia (CIH)-induced hypertension. We sought to determine if exposure to CIH, modelling human sleep apnoea, adversely affects cardiorespiratory control in guinea-pigs, a species with hypoxia-insensitive carotid bodies. We reasoned that CIH-induced disruption of gut microbiota would evoke cardiorespiratory morbidity. Methods: Adult male guinea-pigs were exposed to CIH (6.5% O2 at nadir, 6 cycles.hour−1) for 8 h.day−1 for 12 consecutive days. Findings: CIH-exposed animals established reduced faecal microbiota species richness, with increased relative abundance of Bacteroidetes and reduced relative abundance of Firmicutes bacteria. Urinary corticosterone and noradrenaline levels were unchanged in CIH-exposed animals, but brainstem noradrenaline concentrations were lower compared with sham. Baseline ventilation was equivalent in CIH-exposed and sham animals; however, respiratory timing variability, sigh frequency and ventilation during hypoxic breathing were all lower in CIH-exposed animals. Baseline arterial blood pressure was unaffected by exposure to CIH, but β-adrenoceptor-dependent tachycardia and blunted bradycardia during phenylephrine-induced pressor responses was evident compared with sham controls. Interpretation: Increased carotid body chemo-afferent signalling appears obligatory for the development of CIH-induced hypertension and elevated chemoreflex control of breathing commonly reported in mammals, with hypoxia-sensitive carotid bodies. However, we reveal that exposure to modest CIH alters gut microbiota richness and composition, brainstem neurochemistry, and autonomic control of heart rate, independent of carotid body sensitisation, suggesting modulation of breathing and autonomic homeostasis via the microbiota-gut-brainstem axis. The findings have relevance to human sleep-disordered breathing

Enhanced Bragg reflections from size-matched heterostructure photonic crystal thin films prepared by the Langmuir-Blodgett method

The Langmuir-Blodgett method was used to engineer photonic crystal thin films of an AB architecture. Structures were studied by transmittance and reflectance spectroscopies. For an AB structure in which the silica particle diameter B is twice that of A, reflectance features associated with the first order Bragg peak for the ``A'' domain are only observed when the structure is probed from the A side of the structure. Furthermore, this feature is enhanced in intensity compared to that for a structure consisting solely of A particles. These findings are attributed to a matching of first and second order Bragg processes

On the stability of self-gravitating accreting flows

Analytic methods show stability of the stationary accretion of test fluids but they are inconclusive in the case of self-gravitating stationary flows. We investigate numerically stability of those stationary flows onto compact objects that are transonic and rich in gas. In all studied examples solutions appear stable. Numerical investigation suggests also that the analogy between sonic and event horizons holds for small perturbations of compact support but fails in the case of finite perturbations.Comment: 10 pages, accepted for publication in PR

Surprising Evolution of the Parsec-scale Faraday Rotation Gradients in the Jet of the BL Lac Object B1803+784

Several multi-frequency polarization studies have shown the presence of systematic Faraday Rotation gradients across the parsec-scale jets of Active Galactic Nuclei (AGN), taken to be due to the systematic variation of the line-of-sight component of a helical magnetic (B) field across the jet. Other studies have confirmed the presence and sense of these gradients in several sources, thus providing evidence that these gradients persist over time and over large distances from the core. However, we find surprising new evidence for a reversal in the direction of the Faraday Rotation gradient across the jet of B1803+784, for which multi-frequency polarization observations are available at four epochs. At our three epochs and the epoch of Zavala & Taylor (2003), we observe transverse Rotation Measure (RM) gradients across the jet, consistent with the presence of a helical magnetic field wrapped around the jet. However, we also observe a "flip" in the direction of the gradient between June 2000 and August 2002. Although the origins of this phenomena are not entirely clear, possibly explanations include (i) the sense of rotation of the central supermassive black hole and accretion disc has remained the same, but the dominant magnetic pole facing the Earth has changed from North to South; (ii) a change in the direction of the azimuthal B field component as a result of torsional oscillations of the jet; and (iii) a change in the relative contributions to the observed rotation measures of the "inner" and "outer" helical fields in a magnetic-tower model. Although we cannot entirely rule out the possibility that the observed changes in the RM distribution are associated instead with changes in the thermal-electron distribution in the vicinity of the jet, we argue that this explanation is unlikely.Comment: 21 pages, 10 figures. Accepted for publication in MNRA