183 research outputs found
Treatment of cognitive deficits in brain tumour patients:Current status and future directions
Purpose of review Increased life expectancy in brain tumour patients had led to the need for strategies that preserve and improve cognitive functioning, as many patients suffer from cognitive deficits. The tumour itself, as well as antitumor treatment including surgery, radiotherapy and chemotherapy, supportive treatment and individual patient factors are associated with cognitive problems. Here, we review the recent literature on approaches that preserve and improve cognitive functioning, including pharmacological agents and rehabilitation programs. Recent findings Minimizing cognitive dysfunction and improving cognitive functioning in brain tumour patients may be achieved both by preserving cognitive functioning during antitumor treatment, including techniques such as awake brain surgery, less invasive radiation therapies such as stereotactic radiotherapy and proton therapy, as well as with interventions including cognitive rehabilitation programmes. Novel rehabilitation programs including computer-based cognitive rehabilitation therapy (CRT) programmes that can be adjusted to the specific patient needs and can be administered at home are promising. Furthermore, personalized/precision medicine approaches to identify patients who are at risk for cognitive decline may facilitate effective treatment strategies in the future. Cognitive functioning has gained greater awareness in the neuro-oncological community, and methods to preserve and improve cognitive functioning have been explored. Rehabilitation programmes for brain tumour patients should be further developed and referred to in clinical practice.Neurolog
Prevalence and correlates of fatigue in patients with meningioma before and after surgery
Background Fatigue is a common symptom in patients with brain tumors, but comprehensive studies on fatigue in patients with meningioma specifically are lacking. This study examined the prevalence and correlates of fatigue in meningioma patients. Methods Patients with grade I meningioma completed the Multidimensional Fatigue Inventory (MFI-20) before and 1 year after neurosurgery. The MFI consists of 5 subscales: General Fatigue, Physical Fatigue, Mental Fatigue, Reduced Motivation, and Reduced Activity. Patients’ scores were compared with normative data. Preoperative fatigue was compared with postoperative fatigue. Correlations with sex, age, education, tumor hemisphere, preoperative tumor volume, antiepileptic drugs (AEDs), symptoms of anxiety/depression, and self-reported cognitive complaints were explored. Results Questionnaires were completed by 65 patients preoperatively, and 53 patients postoperatively. Of 34 patients, data from both time points were available. Patients had significantly higher fatigue levels on all subscales compared to normative values at both time points. Mean scores on General Fatigue, Physical Fatigue, and Mental Fatigue remained stable over time and improvements were observed on Reduced Motivation and Reduced Activity. Preoperatively, the prevalence of high fatigue (Z-score ≥ 1.3) varied between 34% for Reduced Motivation and 43% for General Fatigue/Mental Fatigue. The postoperative prevalence ranged from 19% for Reduced Activity to 49% on Mental Fatigue. Fatigue was associated with cognitive complaints, anxiety and depression, but not with education, tumor lateralization, tumor volume, or AEDs. Conclusion Fatigue is a common and persistent symptom in patients with meningioma undergoing neurosurgery. Findings emphasize the need for more research and appropriate care targeting fatigue for meningioma patients
Subjective cognitive functioning in patients with a meningioma:Its course and association with objective cognitive functioning and psychological symptoms
Objective: Although meningioma patients show deficits in objective cognitive functioning (OCF) measured with neuropsychological tests, subjective cognitive functioning (SCF) has received little attention. We investigate SCF from pre- to post-surgery and its associations with OCF, psychological, sociodemographic, and clinical characteristics.Methods: SCF was measured using the Cognitive Failures Questionnaire (CFQ) one day before (T0), and three (T3) and twelve months (T12) after surgery. Patients' scores were compared to normative data and changes over time were assessed. The neuropsychological battery CNS Vital Signs and the Hospital Anxiety and Depression Scale were administered. Correlations of SCF with OCF, psychological, sociodemographic, and clinical characteristics were explored.Results: Patients reported significantly better SCF as compared with controls at T0 (N=54) and T3 (N=242), but not at T12 (N=50). A significant decrease in group level SCF was observed from T0 to T12 (n=24, p<.001). SCF was associated with anxiety at all time points (rs=-0.543 to -0.352) and with depression at T3 and T12 (r=-0.338 and -0.574), but not with OCF, sociodemographic, or clinical characteristics (rs=-0.202 to 0.288).Conclusions: Meningioma patients experienced better SCF as compared to controls before and three months after surgery, which might be the result of phenomena related to disease and recovery. As the findings suggest that cognitive symptoms might increase later on, future studies should further investigate the course of SCF in meningioma patients. In clinical practice, measurements of SCF should be combined with those of OCF and psychological distress in order to determine whether and which interventions are needed.</p
Myxoid hepatocellular adenoma, a rare variant of hepatocellular adenoma with distinct imaging features : a case report with immunohistochemical and molecular analysis and literature review
Preoperative imaging and histopathology, immunohistochemistry and molecular analysis after resection of 2 hepatocellular adenomas (HCAs) (20 and 2cm) in a 53-year-old female patient were performed. On imaging, the large lesion resembled a myxoid HCA, while the small lesion resembled a more conventional HCA with a small myxoid/fluid area. On microscopy, the large lesion showed cords and nests of hepatocytes embedded in abundant myxoid matrix, while the small lesion resembled a conventional HCA with small foci of myxoid change and serosities; both consistent with a myxoid HCA. Immunophenotyping and molecular subtyping excluded inflammatory HCA, CTNNB1 mutated HCA and sonic hedgehog HCA, and was consistent with HNF1A mutated HCA. The myxoid change as well as the serosities may allow imaging diagnosis of myxoid HCA. As fluid vacuoles can also be present in ASS1+HCA, sonic hedgehog HCA has to be considered in the differential diagnosis. (C) 2020 Les Auteurs. Publie par Elsevier Masson SAS
Содовые подземные воды юга-востока Западной Сибири: определение и распространение
Дается определение понятия "содовые воды", приводятся условия локализации подземных содовых вод на юго-востоке Западной Сибири и некоторые их химические особенности. Definition of the term "soda water", the conditions of localization of underground soda waters on the South-East of Western Siberia and some of their chemical features are given
Ecoliteracy through imagery: a close reading of two wordless picture books
The purpose of this paper is to propose some ways of reading two
wordless picture storybooks which have recently been published, by Suzy Lee and
Bernardo Carvalho respectively. The objective is to analyse the ways in which the
visual discourse can create an effective narrative using a variety of pictorial strategies.
These works were not idly chosen, however. Both are concerned with
ecoliteracy, having narratives that tell a story about a specific relationship between
humans and the sea. Depicting maritime scenarios, the two picture books promote a
special and symbolic approach to the natural environment. The narratives help to
configure the environment as more than merely an undifferentiated space inhabited
by living beings, this being the most elementary concept of ‘‘environment’’; rather,
it is seen as an ecological arena involving the interaction between the landscape and
the living beings it harbours. As such, the books assume the role of promoting not
only habits of proto-literacy, but of ecoliteracy too.CIEC – FCT research unit 31
Positive and Negative Urgency as a single coherent construct: Evidence from a large‐scale network analysis in clinical and non‐clinical samples
Aims: Negative and positive urgency are emotion-related
impulsivity traits that are
thought to be transdiagnostic factors in psychopathology. However, it has recently
been claimed that these two traits are closely related to each other and that considering
them separately might have limited conceptual and methodological value. The
present study aimed to examine whether positive and negative urgency constructs
constitute separate impulsivity traits.
Methods: In contrast to previous studies that have used latent variable approaches,
this study employed an item-based
network analysis conducted in two different samples:
a large sample of non-clinical
participants (N = 18,568) and a sample of clinical
participants with psychiatric disorders (N = 385).
Results: The network analysis demonstrated that items denoting both positive and
negative urgency cohere as a single cluster of items termed “general urgency” in both
clinical and non-clinical
samples, thereby suggesting that differentiating positive and
negative urgency as separate constructs is not necessary.
Conclusion: These findings have important implications for the conceptualization
and assessment of urgency and, more broadly, for future research on impulsivity,
personality, and psychopathology
Widespread drying of European peatlands in recent centuries
This is the author accepted manuscript. The final version is available from Nature Research via the DOI in this record Climate warming and human impacts are thought to be causing peatlands to dry,potentially converting them from sinks to sources of carbon. However, it is unclear whether the hydrological status of peatlands has moved beyond their natural envelope.
Here we show that European peatlands have undergone substantial, widespread drying during the last ~300 years. We analyse testate amoeba-derived hydrological reconstructions from 31 peatlands across Britain, Ireland, Scandinavia and continental Europe to examine changes in peatland surface wetness during the last 2000 years.
60% of our study sites were drier during the period CE 1800-2000 than they have been for the last 600 years; 40% of sites were drier than they have been for 1000 years; and 24% of sites were drier than they have been for 2000 years. This marked recent transition in the hydrology of European peatlands is concurrent with compound pressures including climatic drying, warming and direct human impacts on peatlands, although these factors vary between regions and individual sites. Our results suggest that the wetness of many European peatlands may now be moving away from natural baselines. Our findings highlight the need for effective management and restoration of European peatlands.Natural Environment Research Council (NERC
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