The Lantern, 2009-2010

• I\u27m Pregnant. It\u27s Yours • The Nightmare • What Death Became After Cyparissus • Substances • Ain\u27t That a Man? • Portrait • The 100th Chemo • Looking into Her Toy Box with a Lover • They Used to Talk About Burning Cities • MESSAGE: Absence for Allen Ginsberg • Lunch with Candide • Behold! Man of Unbelief! Behold! • Dream #1 Final Strophe • Patience (Things You Will Discover) • Four Years • He Falls Like Leaves • The Quilt • Ariel (Turning Tricks at Fisherman\u27s Wharf, Monterey, California) • Extranjera • The Taste of Morning • Fear of Glory • The Rum Bottle\u27s Fortune • While Thinking of What to Write • Dying in Spring • Tutte le Eta di Firenze • Token • A House Grows Into Itself • Gravity • Father with the Skyy • He Says He Dreams of Me • Myth • Sun-Veins and Wishbones • Attempts at Bravery • One Boy in Four Parts • Blacktop Rollin\u27 • Getting My Feet Wet • The Long Ride After Ending • Wet Tongues and Sweaty Cotton • Norman Bates is My Mother • Sims Trek • Tomorrow Comes Today • The Writer\u27s Process • This Too Was Real • Venus from the Waves • Shark • Monday\u27s Expectations • Recognition • The Black Shoes • Climax • Andrew • Bottles • Calle de Cusco • God in the Machine • The 26th of December • Lollipop Lollipop • When Dinosaurs Roamed the Earth • Meaning • Jeffrey • Looking • Jagged Edges • Fading Storm • Shoes • Cover Image: Death by Chocolatehttps://digitalcommons.ursinus.edu/lantern/1175/thumbnail.jp

Adipose depots differ in cellularity, adipokines produced, gene expression, and cell systems

The race to manage the health concerns related to excess fat deposition has spawned a proliferation of clinical and basic research efforts to understand variables including dietary uptake, metabolism, and lipid deposition by adipocytes. A full appreciation of these variables must also include a depot-specific understanding of content and location in order to elucidate mechanisms governing cellular development and regulation of fat deposition. Because adipose tissue depots contain various cell types, differences in the cellularity among and within adipose depots are presently being documented to ascertain functional differences. This has led to the possibility of there being, within any one adipose depot, cellular distinctions that essentially result in adipose depots within depots. The papers comprising this issue will underscore numerous differences in cellularity (development, histogenesis, growth, metabolic function, regulation) of different adipose depots. Such information is useful in deciphering adipose depot involvement both in normal physiology and in pathology. Obesity, diabetes, metabolic syndrome, carcass composition of meat animals, performance of elite athletes, physiology/pathophysiology of aging, and numerous other diseases might be altered with a greater understanding of adipose depots and the cells that comprise them—including stem cells—during initial development and subsequent periods of normal/abnormal growth into senescence. Once thought to be dormant and innocuous, the adipocyte is emerging as a dynamic and influential cell and research will continue to identify complex physiologic regulation of processes involved in adipose depot physiology

Sentinel node biopsy in cancer of the oral cavity

Sentinel lymph node biopsy represents a less invasive technique for detecting subclinical lymphatic metastases in patients with a known primary malignancy. This procedure was developed to address the management of the lymphatics for cutaneous lesions, especially malignant melanoma. For melanoma, lymphatic drainage patterns are very unpredictable, and the therapeutic value of extensive formal lymphadenectomies remains controversial. The technique is increasingly being applied to other malignancies. Multiple small patient series have been published evaluating the application of lymphatic mapping and sentinel lymph node biopsy to cancer of the oral cavity. The technique requires the selection of patients without clinical or radiologic evidence of gross lymphatic cancer who are at risk for subclinical metastases. Subsequently, primary tumors are injected with a radioactive tracer, followed by radiologic imaging, and then gamma probe-guided lymph node excision through a small incision. Rigorous serial sectioning and immunohistochemistry is essential. Sentinel lymph node biopsy has not yet been validated as safe for oral cavity cancer, and a multi-institutional trial is currently completing accrual to correlate the histopathologic results of sentinel lymph node biopsy and subsequent selective neck dissection. The goal is to establish the predictive value of the less invasive procedure relative to formal lymphadenectomy. In this article, the authors describe the details of their surgical technique for sentinel lymphadenectomy as applied to oral squamous cell carcinomas