3,981 research outputs found
Adoptive immunotherapy against allogeneic kidney grafts in dogs with stable hematopoietic trichimerism.
Dogs given nonmyeloablative conditioning and marrow grafts from 2 dog leukocyte antigen (DLA)-identical littermate donors developed stable trichimerism and stably accepted a subsequent kidney graft from one of the marrow donors without the need for immunosuppression. In this study, we used trichimeras to evaluate strategies for adoptive immunotherapy to solid tumors, using the kidney as a tumor surrogate. Three DLA-identical trichimeric recipients were established by simultaneously infusing marrow from 2 DLA-identical donor dogs into a DLA-identical recipient conditioned with 2 Gy of total body irradiation (TBI) and given a short course of postgraft immunosuppression. After stable hematopoietic engraftment was confirmed, a kidney was transplanted from 1 of the 2 marrow donors into each respective trichimeric recipient. Peripheral blood lymphocytes from each kidney donor were then used to sensitize the alternate marrow donor. The trichimeric recipients were given donor lymphocyte infusions (DLIs) from the sensitized dogs and monitored for chimerism, graft-versus-host disease (GVHD), and kidney rejection. After DLI, we observed both prompt rejection of the transplanted marrow and donor kidney and disappearance of corresponding hematopoietic chimerism. Presumably due to shared minor histocompatibility antigens, host chimerism also disappeared, and GVHD in skin, gut, and liver developed. The native kidneys, although exhibiting lymphocytic infiltration, remained functionally normal. This study demonstrates that under certain experimental conditions, the kidney--an organ ordinarily not involved in graft-versus-host reactions--can be targeted by sensitized donor lymphocytes
An Intense Gamma-Ray Flare of PKS1622-297
We report the observation by the Compton Gamma Ray Observatory of a
spectacular flare of radio source PKS 1622-297. A peak flux of 17E-6 cm^-2 s^-1
(E > 100 MeV) was observed. The corresponding isotropic luminosity is 2.9E49
erg/s. We find that PKS 1622-297 exhibits gamma-ray intra-day variability. A
flux increase by a factor of at least 3.6 was observed to occur in less than
7.1 hours (with 99% confidence). Assuming an exponential rise, the
corresponding doubling time is less than 3.8 hours. A significant flux decrease
by a factor of ~2 in 9.7 hours was also observed. Without beaming, the rapid
flux change and large isotropic luminosity are inconsistent with the
Elliot-Shapiro condition (assuming that gas accretion is the immediate source
of power for the gamma-rays). This inconsistency suggests that the gamma-ray
emission is beamed. A minimum Doppler factor of 8.1 is implied by the observed
lack of pair-production opacity (assuming x-rays are emitted co-spatially with
the gamma-rays). Simultaneous observation by EGRET and OSSE finds a spectrum
adequately fit by a power law with photon index of -1.9. Although the
significance is not sufficient to establish this beyond doubt, the high-energy
gamma-ray spectrum appears to evolve from hard to soft as a flare progresses.Comment: 14 pages, 4 figures, 1 tabl
Search for Pair Production of Scalar Top Quarks Decaying to a tau Lepton and a b Quark in ppbar Collisions at sqrt{s}=1.96 TeV
We search for pair production of supersymmetric top quarks (~t_1), followed
by R-parity violating decay ~t_1 -> tau b with a branching ratio beta, using
322 pb^-1 of ppbar collisions at sqrt{s}=1.96 TeV collected by the CDF II
detector at Fermilab. Two candidate events pass our final selection criteria,
consistent with the standard model expectation. We set upper limits on the
cross section sigma(~t_1 ~tbar_1)*beta^2 as a function of the stop mass
m(~t_1). Assuming beta=1, we set a 95% confidence level limit m(~t_1)>153
GeV/c^2. The limits are also applicable to the case of a third generation
scalar leptoquark (LQ_3) decaying LQ_3 -> tau b.Comment: 7 pages, 2 eps figure
Search for the Higgs boson in events with missing transverse energy and b quark jets produced in proton-antiproton collisions at s**(1/2)=1.96 TeV
We search for the standard model Higgs boson produced in association with an
electroweak vector boson in events with no identified charged leptons, large
imbalance in transverse momentum, and two jets where at least one contains a
secondary vertex consistent with the decay of b hadrons. We use ~1 fb-1
integrated luminosity of proton-antiproton collisions at s**(1/2)=1.96 TeV
recorded by the CDF II experiment at the Tevatron. We find 268 (16) single
(double) b-tagged candidate events, where 248 +/- 43 (14.4 +/- 2.7) are
expected from standard model background processes. We place 95% confidence
level upper limits on the Higgs boson production cross section for several
Higgs boson masses ranging from 110 GeV/c2 to 140 GeV/c2. For a mass of 115
GeV/c2 the observed (expected) limit is 20.4 (14.2) times the standard model
prediction.Comment: 8 pages, 2 figures, submitted to Phys. Rev. Let
Observation of
We report the first observation of the decays . The data sample of fb used in this analysis corresponds
to million pairs, collected at the resonance by
the Belle detector at the KEKB asymmetric-energy collider. We
observe and excesses of events for the two decay
modes and measure the branching fractions of and to be
and ,
respectively, where the first uncertainties are statistical and the second are
systematic. These results are not compatible with the predictions based on the
generalized factorization approach. In addition, a threshold enhancement in the
di-baryon () system is observed, consistent with that observed
in similar decays.Comment: 16 pages, 3 figures and 3 tables, submitted to PR
Search for and a measurement of the branching fraction for
We search for the decay and measure the
branching fraction for using
121.4~ of data collected at the
resonance with the Belle detector at the KEKB asymmetric-energy
collider. The branching fraction is measured
to be , where is the fraction of
in events. Our result is in good
agreement with the theoretical predictions as well as with a recent measurement
from LHCb. We observe no statistically significant signal for the decay
and set a confidence-level upper
limit on its branching fraction at . This constitutes a
significant improvement over the previous result.Comment: 6 pages, 3 figure
Observation of Mixing in Collisions
We observe mixing in the decay
using a data sample of integrated luminosity 976 fb collected with the
Belle detector at the KEKB asymmetric-energy collider. We measure the
mixing parameters and and the ratio of doubly Cabibbo-suppressed to
Cabibbo-favored decay rates , where the
uncertainties are statistical and systematic combined. Our measurement excludes
the no-mixing hypothesis at the 5.1 standard deviation level.Comment: 6 pages, 4 figure
Measurement of Ratios of Fragmentation Fractions for Bottom Hadrons in p-pbar Collisions at sqrt{s}=1.96 TeV
This paper describes the first measurement of b-quark fragmentation fractions
into bottom hadrons in Run II of the Tevatron Collider at Fermilab. The result
is based on a 360 pb-1 sample of data collected with the CDF II detector in
p-pbar collisions at sqrt{s}=1.96 TeV. Semileptonic decays of B0, B+, and B_s
mesons, as well as Lambda_b baryons, are reconstructed. For an effective bottom
hadron p_T threshold of 7 GeV/c, the fragmentation fractions are measured to be
f_u/f_d=1.054 +/- 0.018 (stat) +0.025-0.045(sys) +/- 0.058 (Br),
f_s/(f_u+f_d)=0.160 +/- 0.005 (stat) +0.011-0.010 (sys) +0.057-0.034 (Br), and
f_{Lambda_b}/(f_u+f_d)=0.281\pm0.012 (stat) +0.058-0.056 (sys) +0.128-0.086
(Br), where the uncertainty (Br) is due to uncertainties on measured branching
ratios. The value of f_s/(f_u+f_d) agrees within one standard deviation with
previous CDF measurements and the world average of this quantity, which is
dominated by LEP measurements. However, the ratio f_{Lambda_b}/(f_u+f_d) is
approximately twice the value previously measured at LEP. The approximately 2
sigma discrepancy is examined in terms of kinematic differences between the two
production environments.Comment: Submitted to PRD, 54 pages, 53 plot
Search for a Higgs Boson Produced in Association with a W Boson in pbar-p Collisions at sqrt{s} = 1.96 TeV
We present a search for a standard model Higgs boson produced in association
with a W boson using 2.7 1/fb of integrated luminosity of pbar-p collision data
taken at sqrt{s} = 1.96 TeV. Limits on the Higgs boson production rate are
obtained for masses between 100 GeV and 150 GeV. Through the use of
multivariate techniques, the analysis achieves an observed (expected) 95%
confidence level upper limit of 5.6 (4.8) times the theoretically expected
production cross section for a standard model Higgs boson with a mass of 115
GeV.Comment: submitted to Phys. Rev. Let
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