1,129 research outputs found
Continued need for non-human primate neuroscience research.
Neuroscience research in non-human primates (NHPs) has delivered fundamental knowledge about human brain function as well as some valuable therapies that have improved the lives of human patients with a variety of brain disorders. Research using NHPs, although it is facing serious challenges, continues to complement studies in human volunteers and patients, and will continue to be needed as the burdens of mental health problems and neurodegenerative diseases increase. At the same time, research into the 3Rs is helping to ameliorate the harms experienced by NHPs in experimental procedures, allowing the effective combination of optimal welfare conditions for the NHPs and high quality research
Habitat corridors facilitate genetic resilience irrespective of species dispersal abilities or population sizes
Corridors are frequently proposed to connect patches of habitat that have become isolated due to human‐mediated alterations to the landscape. While it is understood that corridors can facilitate dispersal between patches, it remains unknown whether corridors can mitigate the negative genetic effects for entire communities modified by habitat fragmentation. These negative genetic effects, which include reduced genetic diversity, limit the potential for populations to respond to selective agents such as disease epidemics and global climate change. We provide clear evidence from a forward‐time, agent‐based model (ABM) that corridors can facilitate genetic resilience in fragmented habitats across a broad range of species dispersal abilities and population sizes. Our results demonstrate that even modest increases in corridor width decreased the genetic differentiation between patches and increased the genetic diversity and effective population size within patches. Furthermore, we document a trade‐off between corridor quality and corridor design whereby populations connected by high‐quality habitat (i.e., low corridor mortality) are more resilient to suboptimal corridor design (e.g., long and narrow corridors). The ABM also revealed that species interactions can play a greater role than corridor design in shaping the genetic responses of populations to corridors. These results demonstrate how corridors can provide long‐term conservation benefits that extend beyond targeted taxa and scale up to entire communities irrespective of species dispersal abilities or population sizes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111750/1/eva12255.pd
The Millennium Galaxy Catalogue: the photometric accuracy, completeness and contamination of the 2dFGRS and SDSS-EDR/DR1 data sets
The Millennium Galaxy Catalogue (MGC) is a deep (μB,lim = 26 mag arcsec−2), wide-field, charge-coupled device imaging survey, covering 37.5 deg2. The MGC survey region is completely contained within the Two-Degree Field Galaxy Redshift Survey (2dFGRS) and the Sloan Digital Sky Survey Early Data Release (SDSS-EDR). We compare the photometry and completeness of the 2dFGRS and the SDSS-EDR with the MGC over the range 16 < B < 20 mag. We have also undertaken a photometric comparison to SuperCosmos (SCOS) and the Sloan Digital Sky Survey First Data Release (SDSS-DR1). We find that BMGC−B2dF = (0.035 ± 0.005) mag with an uncertainty of 0.142 mag per galaxy; BMGC−BSCOS = (0.032 ± 0.005) mag with an uncertainty of 0.108 mag; BMGC−BSDSS-EDR = (0.032 ± 0.005) mag with an uncertainty of 0.094 mag; and BMGC−BSDSS-DR1 = (0.039 ± 0.005) mag with an uncertainty of 0.086 mag. We find that high surface brightness 2dFGRS galaxies are systematically too faint, which leads to a significant scale error in magnitude. This effect is significantly reduced with the SCOS photometry. In the SDSS there is a weak non-linear scale error, which is negligible for faint galaxies. Low surface brightness galaxies in the SDSS are systematically fainter, consistent with the relative shallowness of this survey. We find that the 2dFGRS catalogue has (5.2 ± 0.3) per cent stellar contamination, (7.0 ± 0.4) per cent of objects resolved into two or more by the MGC, and is (8.7 ± 0.6) per cent incomplete compared to the MGC. From our all-object spectroscopic survey we find that the MGC is itself misclassifying (5.6 ± 1.3) per cent of galaxies as stars, and hence the 2dFGRS misses (14.3 ± 1.4) per cent of the galaxy population. The SDSS-EDR galaxy catalogue has (1.3 ± 0.1) per cent stellar contamination and (5.3 ± 1.0) per cent of galaxies misclassified as stars, with (0.18 ± 0.04) per cent of objects resolved into two or more by the MGC, and is (1.8 ± 0.1) per cent incomplete compared to the MGC. The total fraction of galaxies missing from the SDSS-EDR galaxy catalogue to BMGC = 20 mag, from incompleteness and misclassification, is (7.1 ± 1.0) per cen
Some Remarks on the Question of Charge Densities in Stationary-Current-Carrying Conductors
Recently, some discussions arose as to the definition of charge and the value
of the density of charge in stationary-current-carrying conductors. We stress
that the problem of charge definition comes from a misunderstanding of the
usual definition. We provide some theoretical elements which suggest that
positive and negative charge densities are equal in the frame of the positive
ions.Comment: 14 pages, TeX, macro newsym.tex include
Superconducting-coil--resistor circuit with electric field quadratic in the current
It is shown for the first time that the observed [Phys. Lett. A 162 (1992)
105] potential difference Phi_t between the resistor and the screen surrounding
the circuit is caused by polarization of the resistor because of the kinetic
energy of the electrons of the superconducting coil. The proportionality of
Phi_t to the square of the current and to the length of the superconducting
wire is explained. It is pointed out that measuring Phi_t makes it possible to
determine the Fermi quasimomentum of the electrons of a metal resistor.Comment: 2 pages, 1 figur
Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy.
BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease of right ventricular morphology, as well as in a rodent model of right ventricular hypertrophy (RVH).MethodsHomogenates of right ventricle (RV) explants from non-failing controls and children born with a SV were assayed for HDAC catalytic activity and HDAC isoform expression. Postnatal 1-day-old rat pups were placed in hypoxic conditions, and echocardiographic analysis, gene expression, HDAC catalytic activity, and isoform expression studies of the RV were performed.ResultsClass I, IIa, and IIb HDAC catalytic activity and protein expression were elevated in the hearts of children born with a SV. Hypoxic neonatal rats demonstrated RVH, abnormal gene expression, elevated class I and class IIb HDAC catalytic activity, and protein expression in the RV compared with those in the control.ConclusionsThese data suggest that myocardial HDAC adaptations occur in the SV heart and could represent a novel therapeutic target. Although further characterization of the hypoxic neonatal rat is needed, this animal model may be suitable for preclinical investigations of pediatric RV disease and could serve as a useful model for future mechanistic studies
The Millennium Galaxy Catalogue: 16 < B_MGC < 24 galaxy counts and the calibration of the local galaxy luminosity function
The Millennium Galaxy Catalogue (MGC) is a 37.5 deg^2, medium-deep, B-band
imaging survey along the celestial equator, taken with the Wide Field Camera on
the Isaac Newton Telescope. The survey region is contained within the regions
of both the Two Degree Field Galaxy Redshift Survey (2dFGRS) and the Sloan
Digital Sky Survey Early Data Release (SDSS-EDR). The survey has a uniform
isophotal detection limit of 26 mag arcsec^-2 and it provides a robust,
well-defined catalogue of stars and galaxies in the range 16 <= B_MGC < 24 mag.
Here we describe the survey strategy, the photometric and astrometric
calibration, source detection and analysis, and present the galaxy number
counts that connect the bright and faint galaxy populations within a single
survey. We argue that these counts represent the state of the art and use them
to constrain the normalizations (phi*) of a number of recent estimates of the
local galaxy luminosity function. We find that the 2dFGRS, SDSS Commissioning
Data (CD), ESO Slice Project, Century Survey, Durham/UKST, Mt Stromlo/APM,
SSRS2, and NOG luminosity functions require a revision of their published phi*
values by factors of 1.05 +/- 0.05, 0.76 +/- 0.10, 1.02 +/- 0.22, 1.02 +/-
0.16, 1.16 +/- 0.28, 1.75 +/- 0.37, 1.40 +/- 0.26 and 1.01 +/- 0.39,
respectively. After renormalizing the galaxy luminosity functions we find a
mean local \bj luminosity density of j_{b_J} = (1.986 +/- 0.031) x 10^8 h
L_{\odot} Mpc^-3.Comment: 20 pages, LaTeX, 20 Postscript figures (some low resolution), MNRAS,
in press; considerably revised versio
What factors determine the severity of hepatitis A‐related acute liver failure?
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87020/1/j.1365-2893.2010.01410.x.pd
Early Fasting Is Long Lasting: Differences in Early Nutritional Conditions Reappear under Stressful Conditions in Adult Female Zebra Finches
Conditions experienced during early life can have profound effects on individual development and condition in adulthood. Differences in nutritional provisioning in birds during the first month of life can lead to differences in growth, reproductive success and survival. Yet, under natural conditions shorter periods of nutritional stress will be more prevalent. Individuals may respond differently, depending on the period of development during which nutritional stress was experienced. Such differences may surface specifically when poor environmental conditions challenge individuals again as adults. Here, we investigated long term consequences of differences in nutritional conditions experienced during different periods of early development by female zebra finches (Taeniopygia guttata) on measures of management and acquisition of body reserves. As nestlings or fledglings, subjects were raised under different nutritional conditions, a low or high quality diet. After subjects reached sexual maturity, we measured their sensitivity to periods of food restriction, their exploration and foraging behaviour as well as adult resting metabolic rate (RMR). During a short period of food restriction, subjects from the poor nutritional conditions had a higher body mass loss than those raised under qualitatively superior nutritional conditions. Moreover, subjects that were raised under poor nutritional conditions were faster to engage in exploratory and foraging behaviour. But RMR did not differ among treatments. These results reveal that early nutritional conditions affect adult exploratory behaviour, a representative personality trait, foraging and adult's physiological condition. As early nutritional conditions are reflected in adult phenotypic plasticity specifically when stressful situations reappear, the results suggest that costs for poor developmental conditions are paid when environmental conditions deteriorate
Cerebral activations related to ballistic, stepwise interrupted and gradually modulated movements in parkinson patients
Patients with Parkinson's disease (PD) experience impaired initiation and inhibition of movements such as difficulty to start/stop walking. At single-joint level this is accompanied by reduced inhibition of antagonist muscle activity. While normal basal ganglia (BG) contributions to motor control include selecting appropriate muscles by inhibiting others, it is unclear how PD-related changes in BG function cause impaired movement initiation and inhibition at single-joint level. To further elucidate these changes we studied 4 right-hand movement tasks with fMRI, by dissociating activations related to abrupt movement initiation, inhibition and gradual movement modulation. Initiation and inhibition were inferred from ballistic and stepwise interrupted movement, respectively, while smooth wrist circumduction enabled the assessment of gradually modulated movement. Task-related activations were compared between PD patients (N = 12) and healthy subjects (N = 18). In healthy subjects, movement initiation was characterized by antero-ventral striatum, substantia nigra (SN) and premotor activations while inhibition was dominated by subthalamic nucleus (STN) and pallidal activations, in line with the known role of these areas in simple movement. Gradual movement mainly involved antero-dorsal putamen and pallidum. Compared to healthy subjects, patients showed reduced striatal/SN and increased pallidal activation for initiation, whereas for inhibition STN activation was reduced and striatal-thalamo-cortical activation increased. For gradual movement patients showed reduced pallidal and increased thalamo-cortical activation. We conclude that PD-related changes during movement initiation fit the (rather static) model of alterations in direct and indirect BG pathways. Reduced STN activation and regional cortical increased activation in PD during inhibition and gradual movement modulation are better explained by a dynamic model that also takes into account enhanced responsiveness to external stimuli in this disease and the effects of hyper-fluctuating cortical inputs to the striatum and STN in particular
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