Image Reconstruction in Optical Interferometry

This tutorial paper describes the problem of image reconstruction from interferometric data with a particular focus on the specific problems encountered at optical (visible/IR) wavelengths. The challenging issues in image reconstruction from interferometric data are introduced in the general framework of inverse problem approach. This framework is then used to describe existing image reconstruction algorithms in radio interferometry and the new methods specifically developed for optical interferometry.Comment: accepted for publication in IEEE Signal Processing Magazin

Immunological markers after long-term treatment interruption in chronically HIV-1 infected patients with CD4 cell count above 400 x 10(6) cells/l.

OBJECTIVE: To analyse immunological markers associated with CD4+ lymphocyte T-cell count (CD4+) evolution during 12-month follow-up after treatment discontinuation. METHOD: Prospective observational study of chronically HIV-1 infected patients with CD4+ above 400 x 10(6) cells/l. RESULTS: CD4+ changes took place in two phases: an initial rapid decrease in the first month (-142 x 10(6) cells/l on average), followed by a slow decline (-17 x 10(6) cells/l on average) The second slope of CD4+ decline was not correlated with the first and only baseline plasma HIV RNA was associated with it. The decline in CD4+ during the first month was steeper in patients with higher CD4+ and weaker plasma HIV RNA baseline levels. Moreover, the decline was less pronounced (P < 10(-4)) in patients with CD4+ nadir above 350 x 10(6) cells/l (-65 x 10(6) cells/l per month) in comparison with those below 350 x 10(6) cells/l (-200 x 10(6) cells/l per month). A high number of dendritic cells (DCs) whatever the type was associated with high CD4+ at the time of treatment interruption and its steeper decline over the first month. Moreover, the myeloid DC level was stable whereas the lymphoid DC count, which tended to decrease in association with decrease in CD4+, was negatively correlated with the HIV RNA load slope. CONCLUSIONS: The results support the use of the CD4+ nadir to predict the CD4+ dynamic after treatment interruption and consideration of the CD4+ count after 1-month of interruption merely reflects the 12-month level of CD4+. Although DCs seem to be associated with the CD4+ dynamic, the benefit of monitoring them has still to be defined

Reverse- Engineering et copiage rapide de nuage de points numérisés

Dans cette communication nous nous intéressons à démontrer la faisabilité d'une démarche copiage rapide de forme vis-à-vis d'une approche classique de reproduction de forme s'appuyant sur une démarche de Reverse Engineering. Nous montrons au travers d'une analyse des formes réelles et par simulation que le copiage direct est plus performant en termes de fidélité à la forme dans le cadre de l'usinage à 3 axes. De même, le copiage rapide forme permettant de s'affranchir de l'étape de reconstruction il est également beaucoup plus rapide et simple à mettre en oeuvre

Bayesian estimation of regularization and point spread function parameters for Wiener-Hunt deconvolution

International audienceThis paper tackles the problem of image deconvolution with joint estimation of point spread function (PSF) parameters and hyperparameters. Within a Bayesian framework, the solution is inferred via a global a posteriori law for unknown parameters and object. The estimate is chosen as the posterior mean, numerically calculated by means of a Monte Carlo Markov chain algorithm. The estimates are efficiently computed in the Fourier domain, and the effectiveness of the method is shown on simulated examples. Results show precise estimates for PSF parameters and hyperparameters as well as precise image estimates including restoration of high frequencies and spatial details, within a global and coherent approach

Sequential Dirichlet Process Mixtures of Multivariate Skew t-distributions for Model-based Clustering of Flow Cytometry Data

39 pages, 11 figuresInternational audienceFlow cytometry is a high-throughput technology used to quantify multiple surface and intracellular markers at the level of a single cell. This enables to identify cell sub-types, and to determine their relative proportions. Improvements of this technology allow to describe millions of individual cells from a blood sample using multiple markers. This results in high-dimensional datasets, whose manual analysis is highly time-consuming and poorly reproducible. While several methods have been developed to perform automatic recognition of cell populations, most of them treat and analyze each sample independently. However, in practice, individual samples are rarely independent (e.g. longitudinal studies). Here, we propose to use a Bayesian nonparametric approach with Dirichlet process mixture (DPM) of multivariate skew $t$-distributions to perform model based clustering of flow-cytometry data. DPM models directly estimate the number of cell populations from the data, avoiding model selection issues, and skew $t$-distributions provides robustness to outliers and non-elliptical shape of cell populations. To accommodate repeated measurements, we propose a sequential strategy relying on a parametric approximation of the posterior. We illustrate the good performance of our method on simulated data, on an experimental benchmark dataset, and on new longitudinal data from the DALIA-1 trial which evaluates a therapeutic vaccine against HIV. On the benchmark dataset, the sequential strategy outperforms all other methods evaluated, and similarly, leads to improved performance on the DALIA-1 data. We have made the method available for the community in the R package NPflow

Use of mathematical modeling for optimizing and adapting immunotherapy protocols in HIV-infected patients

International audienc

Études de taphonomie archéologique en milieu périglaciaire actuel : le Projet Gavarnie

Un programme d’archéologie expérimentale a été initié en milieu périglaciaire actuel. Le site sélectionné est localisé dans les Pyrénées centrales, sur le versant sud du Massif du Taillon, secteur de Gavarnie. Les expériences entreprises traitent des points suivants : (1) vitesse de déplacement des vestiges et évolution des structures anthropiques – amas de taille – par solifluxion et par reptation sur talus gravitaire ; (2) fragmentation des ossements et altération des états de surface ; (3) vitesse d’acquisition d’une orientation préférentielle des vestiges lithiques déplacés par solifluxion ou reptation. Après un an de fonctionnement, certains paramètres contrôlant la nature et la vitesse des modifications peuvent être identifiés. Pour les ossements, le caractère frais ou sec détermine les déplacements, tandis que le caractère brûlé / non brûlé apparaît prééminent par rapport à leur fragmentation. Dans le cas des vestiges lithiques déposés sur coulée de solifluxion, les déplacements diffèrent selon la disposition initiale des objets – en amas ou dispersés –. Ces premiers résultats permettent de réexaminer la validité des précédentes expériences de taphonomie archéologique en contexte périglaciaire.A set of long-term experiments have been initiated in an active periglacial environment. The experimental site is located on the south slope of the Taillon Mountain, near Gavarnie, Spain. Experiments address the following points: 1) the rate of displacement of archaeological particles and the disturbance of archaeological features on solifluction sheets and by creep on rockfall screes; 2) the fragmentation of bones and their surface alteration, with emphasis on cutmark disappearance; 3) the rate of linear fabric acquisition of knapped flint displaced by solifluction or creep. After one year, disturbances are observed. Considering bones, factors responsible for the changes noted are 1) green versus dry nature of items with regard to displacements 2) burnt versus unburnt status in respect of alteration. For lithic assemblage, we observe that initial artifact distribution – in regimented intervals or replicating knapping spot – controls the rate of displacement. This last point is crucial to the application of experimental data to archaeological sites. Previous experiments can be discussed in light of these preliminary results

Etudes de taphonomie archéologique en milieu périglaciaire actuel : le projet Gavarnie.

A set of long-term experiments have been initiated in active periglacial environment. The experimental site is located on the south slope of Taillon Mountain, near Gavarnie, Spain. Experiments address the following points: 1) rate of displacement of archaeological particles and disturbance of archaeological features on solifluction sheet and by creep on rockfall screes; 2) fragmentation of bones and their surface alteration, with emphasis on cutmarks disappearance; 3) the rate of linear fabric acquisition of knapped flint displaced by solifluction or creep. After one year, disturbances are observed. Considering bones, factors responsible for the changes noted are 1) green versus dry nature of items with regard to displacements 2) burnt versus unburnt status in respect of alteration. For lithic assemblage, we observe that initial setting of artifacts - in regimented intervals or replicating knapping spot - controls the rate of displacement. This last point is crucial in the application of experimental data to the application of experimental data to archaeological sites. Previous experiments can be discussed in light of these preliminary results.Un programme d'archéologie expérimentale a été entrepris en milieu périglaciaire actuel. Le site sélectionné est localisé dans les Pyrénées centrales, sur le versant sud du Massif du Taillon, secteur de Gavarnie. Les expériences entreprises traitent des points suivants : 1) vitesse de déplacement des vestiges et évolution des structures anthropiques - amas de taille - par solifluxion et par reptation sur talus gravitaire ; 2) fragmentation des ossements et altération des états de surface ; 3) vitesse d'acquisition d'une orientation préférentielle des vestiges lithiques déplacés par solifluxion ou reptation. Après un an de fonctionnement, certains paramètres contrôlant la nature et la vitesse des modifications peuvent être identifiés. Pour les ossements, le caractère frais ou sec détermine les déplacements, tandis que le caractère brûlé / non brûlé apparaît prééminent par rapport à leur fragmentation. Dans le cas des vestiges lithiques déposés sur coulées de solifluxion, les déplacements diffèrent selon la disposition initiale des objets - en amas ou dispersés -. Ces premiers résultats permettent de réexaminer la validité des précédentes expériences de taphonomie archéologique en contexte périglaciaire

Immunologic response in treatment-naïve HIV-2-infected patients:the IeDEA West Africa cohort

Introduction: Response to antiretroviral therapy (ART) among individuals infected with HIV-2 is poorly described. We compared the immunological response among patients treated with three nucleoside reverse-transcriptase inhibitors (NRTIs) to boosted protease inhibitor (PI) and unboosted PI-based regimens in West Africa. Methods: This prospective cohort study enrolled treatment-naïve HIV-2-infected patients within the International Epidemiological Databases to Evaluate AIDS collaboration in West Africa. We used mixed models to compare the CD4 count response to treatment over 12 months between regimens. Results: Of 422 HIV-2-infected patients, 285 (67.5%) were treated with a boosted PI-based regimen, 104 (24.6%) with an unboosted PI-based regimen and 33 (7.8%) with three NRTIs. Treatment groups were comparable with regard to gender (54.5% female) and median age at ART initiation (45.3 years; interquartile range 38.3 to 51.8). Treatment groups differed by clinical stage (21.2%, 16.8% and 17.3% at CDC Stage C or World Health Organization Stage IV for the triple NRTI, boosted PI and unboosted PI groups, respectively, p=0.02), median length of follow-up (12.9, 17.7 and 44.0 months for the triple NRTI, the boosted PI and the unboosted PI groups, respectively, p<0.001) and baseline median CD4 count (192, 173 and 129 cells/µl in the triple NRTI, the boosted PI and the unboosted PI-based regimen groups, respectively, p=0.003). CD4 count recovery at 12 months was higher for patients treated with boosted PI-based regimens than those treated with three NRTIs or with unboosted PI-based regimens (191 cells/µl, 95% CI 142 to 241; 110 cells/µl, 95% CI 29 to 192; 133 cells/µl, 95% CI 80 to 186, respectively, p=0.004). Conclusions: In this observational study using African data, boosted PI-containing regimens had better immunological response compared to triple NRTI combinations and unboosted PI-based regimens at 12 months. A randomized clinical trial is still required to determine the best initial regimen for treating HIV-2 infected patients