Personal Well-Being and Family Interactions of Working Couples With Preschool Children: A Correlational Study

O estudo teve por objetivo verificar a existência de relação entre a avaliação do bem estar pessoal, práticas parentais e interações com filhos pré-escolares declaradas por pais e mães ( n = 120, 60 casais) trabalhadores de uma cidade do interior de São Paulo. Os dados foram coletados por meio do Questionário sobre vida familiar e profissional . Para a análise dos dados foram selecionadas três escalas do instrumento: bem-estar, interações entre pais e filhos e vida familiar. Por meio de testes estatísticos ( One-Way ANOVA e Teste de Correlação de Pearson) foram observadas correlações negativas entre as práticas educativas adotadas e os problemas de saúde declarados pelos pais, além de correlações positivas entre as interações dos pais e as práticas educativas declaradas. Foi verificado ainda as práticas parentais declaradas e as interações entre pais e filhos variaram em função do número de filhos (um ou dois).El estudio tuvo como objetivo verificar la existencia de relación entre la evaluación del bienestar personal, prácticas educativas de los padres y la interacción con sus hijos en edad preescolar, por padres y madres ( n = 120; 60 parejas) trabajadores de una ciudad del interior de Sao Paulo-Brasil. Los datos fueron colectados a través de un Cuestionario sobre el trabajo y la vida familiar . Para análisis de los datos se seleccionaron tres escalas: bienestar, interacciones entre padres e hijos y vida familiar. Por medio de pruebas estadísticas ( One-Way ANOVA y correlación de Pearson) se encontraron correlaciones negativas entre las prácticas educativas adoptadas por los padres y los problemas de salud informados, y correlaciones positivas entre las interacciones de los padres y las prácticas educativas declaradas. También se verificó que las prácticas educativas de los padres y la interacción entre padres e hijos variaron según el número de niños (un o dos).This study’s objective was to verify potential relationships among personal well-being, parental practices, and interactions between parents and preschool children reported by working fathers and mothers ( n = 120, 60 couples) from a city in the interior of São Paulo, Brazil. Data were collected using the Questionnaire on family and professional lives. Three scales were selected for data analysis: well-being; interaction between parents and children; and family life. Statistical tests (One-Way ANOVA and Pearson’s correlation coefficient) showed negative correlations between child-rearing practices and health problems reported by parents. Positive correlations were also found between reported parental interactions and child-rearing practices. Parental practices and interactions between parents and children varied according to the number of children (one or two)

Talidomida : validação de método analítico por espectrofotometria no ultravioleta e avaliação preliminar da complexação com ciclodextrinas

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Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015:a systematic review and modelling study

Background: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. Methods: We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. Findings: We estimated that globally in 2015, 33·1 million (uncertainty range [UR] 21·6–50·3) episodes of RSV-ALRI, resulted in about 3·2 million (2·7–3·8) hospital admissions, and 59 600 (48 000–74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1·4 million (UR 1·2–1·7) hospital admissions, and 27 300 (UR 20 700–36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600–149 400). Incidence and mortality varied substantially from year to year in any given population. Interpretation: Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Personal Well-Being and Family Interactions of Working Couples With Preschool Children: A Correlational Study

This study’s objective was to verify potential relationships among personal well-being, parental practices, and interactions between parents and preschool children reported by working fathers and mothers ( n = 120, 60 couples) from a city in the interior of São Paulo, Brazil. Data were collected using the Questionnaire on family and professional lives. Three scales were selected for data analysis: well-being; interaction between parents and children; and family life. Statistical tests (One-Way ANOVA and Pearson’s correlation coefficient) showed negative correlations between child-rearing practices and health problems reported by parents. Positive correlations were also found between reported parental interactions and child-rearing practices. Parental practices and interactions between parents and children varied according to the number of children (one or two)

An hplc-uv method for the measurement of permeability of marker drugs in the caco-2 cell assay

The Caco-2 cell line has been used as a model to predict the in vitro permeability of the human intestinal barrier. The predictive potential of the assay relies on an appropriate in-house validation of the method. The objective of the present study was to develop a single HPLC-UV method for the identification and quantitation of marker drugs and to determine the suitability of the Caco-2 cell permeability assay. A simple chromatographic method was developed for the simultaneous determination of both passively (propranolol, carbamazepine, acyclovir, and hydrochlorothiazide) and actively transported drugs (vinblastine and verapamil). Separation was achieved on a C18 column with step-gradient elution (acetonitrile and aqueous solution of ammonium acetate, pH 3.0) at a flow rate of 1.0 mL/min and UV detection at 275 nm during the total run time of 35 min. The method was validated and found to be specific, linear, precise, and accurate. This chromatographic system can be readily used on a routine basis and its utilization can be extended to other permeability models. The results obtained in the Caco-2 bi-directional transport experiments confirmed the validity of the assay, given that high and low permeability profiles were identified, and Pglycoprotein functionality was established

Desenvolvimento de um método analítico para caracterização dos complexos de talidomida com hidroxipropil-beta-ciclodextrina (HPβCD) e metil-beta-ciclodextrina (MeβCD) por cromatografia líquida de alta eficiência

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Desenvolvimento de um método analítico para caracterização dos complexos de talidomida com hidroxipropil-beta-ciclodextrina (HPβCD) e metil-beta-ciclodextrina (MeβCD) por cromatografia líquida de alta eficiência

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