Examination on total ozone column retrievals by Brewer spectrophotometry using different processing software

The availability of long-term records of the total ozone content (TOC) represents a valuable source of information for studies on the assessment of short-and long-term atmospheric changes and their impact on the terrestrial ecosystem. In particular, ground-based observations represent a valuable tool for validating satellite-derived products. To our knowledge, details about software packages for processing Brewer spectrophotometer measurements and for retrieving the TOC are seldom specified in studies using such datasets. The sources of the differences among retrieved TOCs from the Brewer instruments located at the Italian stations of Rome and Aosta, using three freely available codes (Brewer Processing Software, BPS; O3Brewer software; and European Brewer Network (EUBREWNET) level 1.5 products) are investigated here. Ground-based TOCs are also compared with Ozone Monitoring Instrument (OMI) TOC retrievals used as an independent dataset since no other instruments near the Brewer sites are available. The overall agreement of the BPS and O3Brewer TOC data with EUBREWNET data is within the estimated total uncertainty in the retrieval of total ozone from a Brewer spectrophotometer (1%). However, differences can be found depending on the software in use. Such differences become larger when the instrumental sensitivity exhibits a fast and dramatic drift which can affect the ozone retrievals significantly. Moreover, if daily mean values are directly generated by the software, differences can be observed due to the configuration set by the users to process single ozone measurement and the rejection rules applied to data to calculate the daily value. This work aims to provide useful information both for scientists engaged in ozone measurements with Brewer spectrophotometers and for stakeholders of the Brewer data products available on Web-based platforms

Holocene Event Record of Aysen Fjord (Chilean Patagonia): An Interplay of Volcanic Eruptions and Crustal and Megathrust Earthquakes

In the first months of 2007, the Aysen region in southern Chile was affected by a crustal seismic swarm. Its largest earthquake (M-w 6.2) occurred in April and had its epicenter in Aysen Fjord. Seismic intensities became so high that hundreds of onshore mass movements were triggered, several of which entered into the fjord, resulting in mass transport deposits (MTDs) preserved at the fjord bottom. Here we present a Holocene record of paleo-earthquakes in the previously unstudied Patagonian fjordland based on MTD stratigraphy. High-resolution seismic data retrieved using two different seismic systems (sparker and TOPAS) reveal multiple older MTDs on different stratigraphic levels. Correlation of the seismic stratigraphy with sedimentological data obtained from a long Calypso core (MD07-3117) allows conclusion on the seismic origin of these deposits. Additionally, radiocarbon dating permits constructing an age model, validated by tephrochronology, providing an age for the different MTD levels. We thus present a highly detailed paleoseismological history of the Aysen region, including at least six major Holocene earthquakes, one of which is likely related to a known megathrust earthquake. Other earthquakes are related to activity of the Liquine-Ofqui Fault Zone (LOFZ), forming the main source of seismic hazard in the area. We can infer a general average recurrence time for LOFZ earthquakes of -2,100years in the vicinity of Aysen Fjord with clustered events during the early and late Holocene. Finally, we argue that cascading events (causal link between volcanic and seismic events) may be a frequent phenomenon along the LOFZ

Review on Occupational Personal Solar UV Exposure Measurements

During leisure time, people can decide if they want to expose themselves to solar ultraviolet (UV) radiation and to which extent. During occupation, people do not have this choice. Outdoor workers are exposed to solar UV radiation (UVR) on a daily basis. This may hold a certain health risk, which can be estimated when the personal solar UVR exposure (PE) is known. During the past decades, a variety of studies was conducted to measure PE of outdoor workers and our knowledge on the PE of outdoor workers has remarkably increased. As shown by this review, studies clearly indicate that PE of most of outdoor workers exceeds the internationally proposed threshold limit value, which is comparable to 1.0 to 1.3 SED, respectively to 1.1 to 1.5 UV Index received over one hour. Besides working in a high UVR environment, monotonic workflow (limited movement, nearly static posture) is a risk factor. In such cases, PE can be higher than ambient UVR. In this review, we provide also a list of milestone, depicting the progress and the most important findings in this field during the past 45 years. However, in many respects our knowledge is still rudimentary, because of several reasons. Different measuring positions have been used so that measured PE is not comparable. Few studies were designed to enable extension of measured PE to other locations or dates. Although the importance of a proper calibration of the measuring devices in respect to the changing solar spectrum was pointed out from the beginning, this is often not performed, which leads to high uncertainties in the presented PE levels. At the end of our review, we provide some key points, which can be used to evaluate the quality of a study respectively to support the design of future studies

Seismo‐turbidites in Aysén Fjord (Southern Chile) reveal a complex pattern of rupture modes along the 1960 megathrust earthquake segment

Grainsize analysis and end‐member modeling of a long sediment core from Aysén Fjord (southern Chile) allows to identify over 25 seismo‐turbidites in the last 9,000 years. Considering the shaking intensities required to trigger these turbidites (V½‐VI½), the majority can be related to megathrust earthquakes. Multiple studies in south‐central Chile have aimed at finding traces of giant, tsunamigenic megathrust earthquakes leading to the current 5,500‐year‐long paleoseismological record of the Valdivia segment. However, none of these cover the southern third of the segment. Aysén Fjord allows to fill this data gap and presents the first, crucial paleoseismic data to demonstrate that the 1960 event was not unique for the Valdivia segment, yielding a recurrence rate of 321 ± 116 years in the last two millennia. Moreover, the oldest identified events in Aysén Fjord date back to 9,000 cal years BP and, thus, also extend the regional paleoseismological record in time. We infer a large temporal variability in rupture modes, with successions of full‐segment ruptures alternating with partial and cascading ruptures. The latter seems to significantly postpone the occurrence of another full rupture when consecutively occurring in different parts of the segment. Additionally, one outstanding period of seismic quiescence ¿during which no megathrust earthquake evidence has been found at any paleoseismic site¿occurred after a full rupture in AD ~745 that presents an unusual uplift/subsidence pattern. Such variability makes it highly speculative to anticipate the rupture mode of the next megathrust earthquake along the Valdivia segment

Preliminary Analysis of the Effects of Ad26.COV2.S Vaccination on CT Findings and High Intensive Care Admission Rates of COVID-19 Patients

On 27 February 2021, the Food and Drug Administration(FDA) authorized the administration of the adenovirus-based Ad26.COV2-S vaccine (J&J-Janssen) for the prevention of COVID-19, a viral pandemic that, to date, has killed more than 5.5 million people. Performed during the early phase of the COVID-19 4th wave, this retrospective observational study aims to report the computerized tomography (CT) findings and intensive care unit admission rates of Ad26.COV2-S-vaccinated vs. unvaccinated COVID-19 patients. From the 1st to the 23rd of December 2021, all confirmed COVID-19 patients that had been subjected to chest non-contrast CT scan analysis were enrolled in the study. These were divided into Ad26.COV2.S-vaccinated (group 1) and unvaccinated patients (group 2). The RSNA severity score was calculated for each patient and correlated to CT findings and type of admission to a healthcare setting after CT-i.e., home care, ordinary hospitalization, sub-intensive care, and intensive care. Descriptive and inference statistical analyses were performed by comparing the data from the two groups. Data from a total of 71 patients were collected: 10 patients in group 1 (4M, 6F, mean age 63.5 years, SD ± 4.2) and 61 patients in group 2 (32M, 29F, mean age 64.7 years, SD ± 3.7). Statistical analysis showed lower values of RSNA severity in group 1 compared to group 2 (mean value 14.1 vs. 15.7, p = 0.009, respectively). Furthermore, vaccinated patients were less frequently admitted to both sub-intensive and high-intensive care units than group 2, with an odds ratio of 0.45 [95%CI (0.01; 3.92)]. Ad26.COV2.S vaccination protects from severe COVID-19 based on CT severity scores. As a result, Ad26.COV2.S-vaccinated COVID-19 patients are more frequently admitted to home in comparison with unvaccinated patients

First national intercomparison of solar ultraviolet radiometers in Italy

A blind intercomparison of ground-based ultraviolet (UV) instruments has been organized for the first time in Italy. The campaign was coordinated by the Environmental Protection Agency of Aosta Valley (ARPA Valle d'Aosta) and took place in Saint-Christophe (45.8 degrees N, 7.4 degrees E, 570 m a.s.l.), in the Alpine region, from 8 to 23 June 2010. It involved 8 institutions, 10 broadband radiometers, 2 filter radiometers and 2 spectroradiometers. Synchronized measurements of downward global solar UV irradiance at the ground were collected and the raw series were then individually processed by the respective operators on the base of their own procedures and calibration data. A radiative transfer model was successfully applied as an interpretative tool. The input parameters and output results are described in detail. The comparison was performed in terms of global solar UV Index and integrated UV-A irradiance against a well-calibrated double monochromator spectroradiometer as reference. An improved algorithm for comparing broadband data and spectra has been developed and is discussed in detail. For some instruments, we found average deviations ranging from -16% up to 20% relative to the reference and diurnal variations as large as 15% even in clear days. Remarkable deviations were found for the instruments calibrated in the manufacturers' facilities and never involved in field intercomparison. Finally, some recommendations to the UV operators based on the campaign results are proposed

Safety and efficacy of vacuum assisted thrombo-aspiration in patients with acute lower limb ischaemia: The INDIAN Trial

Objective: The aim was to evaluate the short term safety and effectiveness of the Penumbra/Indigo aspiration thrombectomy Systems (Penumbra Inc.) in patients with acute lower limb ischaemia. (ALLI). Recently, endovascular vacuum assisted thrombectomy devices, similar to those used in the management of acute ischaemic stroke, have become available for peripheral arteries, but data are still scarce.Methods: To assess vessel patency, a modified Thrombolysis in Myocardial Infarction (TIMI) classification, called TIPI (Thrombo-aspiration In Peripheral Ischaemia), is proposed. The TIPI flow is assessed at presentation, immediately after treatment with the study device, and after all adjuvant procedures. The primary outcome is the technical success of the thrombo-aspiration with the investigative system, defined as near complete or complete revascularisation TIPI 2 - 3. Safety and clinical success rate were collected at one month.Results: One hundred and fifty patients were enrolled. The mean age was 72.4 years and 73.3% were male. Rutherford grade on enrolment was I in 16%, IIa in 40.7%, and IIb in 43.3% with a mean ankle brachial index of 0.19. Primary technical success (TIPI 2 - 3 flow) was achieved in 88.7% of patients. Adjunctive procedures included angioplasty/stenting of chronic atherosclerotic lesions (n = 39), thrombolysis (n = 31), covered stenting (n = 15), and supplementary Fogarty embolectomy (n = 6). After all interventions, assisted primary technical success was 95.3% (TIPI 2 - 3 in 143/150). No systemic bleeding complications or device related serious adverse events were reported. At one month follow up, one death, and one below the knee amputation were recorded. Primary patency was 92% (138/150), and the re-intervention rate was 7.33%, resulting in an assisted primary and secondary patency of 94% and 99.33%, respectively.Conclusion: Results from the INDIAN registry reveal that mechanical thrombectomy using the Indigo system is safe and effective for revascularisation of ALLI as a primary therapy

The Non-Invasive Diagnosis of Chronic Coronary Syndrome: A Focus on Stress Computed Tomography Perfusion and Stress Cardiac Magnetic Resonance

Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were made in response to the request for non-invasive diagnostic tools with better sensitivity and specificity. To date, clinicians have at their disposal a wide range of stress-imaging techniques. Among others, stress cardiac magnetic resonance (S-CMR) and computed tomography perfusion (CTP) techniques both demonstrated their diagnostic efficacy and prognostic value in clinical trials when compared to other non-invasive ischemia-assessing techniques and invasive fractional flow reserve measurement techniques. Standardized protocols for both S-CMR and CTP usually imply the administration of vasodilator agents to induce hyperemia and contrast agents to depict perfusion defects. However, both methods have their own limitations, meaning that optimizing their performance still requires a patient-tailored approach. This review focuses on the characteristics, drawbacks, and future perspectives of these two techniques

Clinicians' adherence versus non adherence to practice guidelines in the management of patients with sarcoma: a cost-effectiveness assessment in two European regions

International audienceABSTRACT: BACKGROUND: Although the management of sarcoma is improving, non adherence to clinical practice guidelines (CPGs) remains high, mainly because of the low incidence of the disease and the variety of histological subtypes. Since little is known about the health economics of sarcoma, we undertook a cost-effectiveness analysis (within the CONnective TIssue CAncer NETwork, CONTICANET) comparing costs and outcomes when clinicians adhered to CPGs and when they did not. METHODS: Patients studied had a histological diagnosis of sarcoma, were older than 15 years, and had been treated in the Rhone-Alpes region of France (in 2005/2006) or in the Veneto region of Italy (in 2007). Data collected retrospectively for the three years after diagnosis were used to determine relapse free survival and health costs (adopting the hospital's perspective and a microcosting approach). All costs were expressed in euros at their 2009 value. A 4% annual discount rate was applied to both costs and effects. The incremental cost-effectiveness ratio (ICER) was expressed as cost per relapse-free year gained when management was compliant with CPGs compared with when it was not. To capture uncertainty surrounding ICER, a probabilistic sensitivity analysis was performed based on a non-parametric bootstrap method. RESULTS: A total of 219 patients were included in the study. Compliance with CPGs was observed for 118 patients (54%). Average total costs reached 23,571 euros when treatment was in accordance with CPGs and 27,313 euros when it was not. In relation to relapse-free survival, compliance with CPGs strictly dominates non compliance, i.e. it is both less costly and more effective. Taking uncertainty into account, the probability that compliance with CPGs still strictly dominates was 75%. CONCLUSIONS: Our findings should encourage physicians to increase their compliance with CPGs and healthcare administrators to invest in the implementation of CPGs in the management of sarcoma