Social Integration of Sorority Women Living in Residence Halls

College students find a sense of belonging at institutions in multiple ways. For college women, the relationships they form through their campus involvements are important. The purpose of this study was to gain an understanding of the social integration experiences of sorority women living in residence halls. The researchers found sorority women had positive community experiences and enriched relationship opportunities through their involvement in sororities and residence halls. The women felt more connected to people through the relationships they formed because of sorority membership, whereas they felt more connected to campus as a whole because they lived in the halls

Monitoring of transiting exoplanets and their host stars with small aperture telescopes

Exoplanet research is now target rich with a wide diversity of systems making it difficult for high demand observatories to undertake follow up observations over extended periods of time. We investigate the effectiveness of using 0.4m-class telescopes for monitoring transiting hot Jupiters and their host stars. We consider two representative case studies: WASP-52b with 13 new transits, and HAT-P-23b with 17 new transits and concurrent photometric monitoring covering 78 days. We present updated system parameters and combine our new transit times with previously published results to calculate new ephemerides for both systems. Our analysis of transit mid-times for WASP52b results in a slight preference for a quadratic ephemeris (∆χ2ν = 0.07, ∆BIC = 1.53 over a linear ephemeris. We discuss the reality of this quadratic ephemeris indicating a period change of δP/δt = −38.6 ± 4 ms yr−1 and consider possible causes. WASP-52 is known to be an active star with previous publications reporting many spot crossing events, however no such events are seen in our new photometry. Our analysis shows that WASP-52 is still active and that the latitude of the spots has likely migrated away from the transit chord. We confirm the inflated nature and circular orbit for HAT-P-23b. Our monitoring of HAT-P-23 reveals a periodicity of 7.015 days with an amplitude of 0.011 mag which we interpret as the rotation period of HAT-P-23. The photometric and transit timing precision achieved in the case studies shows that this class of telescope is capable of precise characterisation and long-term monitoring of transiting hot Jupiters in support of dedicated ongoing and future ground and space based observations

The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26-27 October 2016, Oxford, UK

Typhoid fever is estimated to cause between 11.9–26.9 million infections globally each year with 129,000–216,510 deaths. Access to improved water sources have reduced disease incidence in parts of the world but the use of efficacious vaccines is seen as an important public health tool for countries with a high disease burden. A new generation of Vi typhoid conjugate vaccines (TCVs), licensed for use in young children and expected to provide longer lasting protection than previous vaccines, are now available. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has convened a working group to review the evidence on TCVs and produce an updated WHO position paper for all typhoid vaccines in 2018 that will inform Gavi, the Vaccine Alliance's future vaccine investment strategies for TCVs. The Typhoid Vaccine Acceleration Consortium (TyVAC) has been formed through a $36.9 million funding program from the Bill & Melinda Gates Foundation to accelerate the introduction of TCVs into Gavi-eligible countries. In October 2016, a meeting was held to initiate planning of TCV effectiveness studies that will provide the data required by policy makers and stakeholders to support decisions on TCV use in countries with a high typhoid burden. Discussion topics included (1) the latest evidence and data gaps in typhoid epidemiology; (2) WHO and Gavi methods and data requirements; (3) data on TCV efficacy; (4) cost effectiveness analysis for TCVs from mathematical models; (5) TCV delivery and effectiveness study design. Specifically, participants were asked to comment on study design in 3 sites for which population-based typhoid surveillance is underway. The conclusion of the meeting was that country-level decision making would best be informed by the respective selected sites in Africa and Asia vaccinating children aged from 9-months to 15-years-old, employing either an individual or cluster randomized design with design influenced by population characteristics, transmission dynamics, and statistical considerations

AD51B in Familial Breast Cancer

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of RAD51B variants in breast cancer predisposition, particularly in the context of familial breast cancer in Finland. We sequenced the coding region of RAD51B in 168 Finnish breast cancer patients from the Helsinki region for identification of possible recurrent founder mutations. In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and RAD51B haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast Cancer Association Consortium (BCAC) that were genotyped on a custom chip (iCOGS). We identified one putatively pathogenic missense mutation c.541C>T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus. No significant association with breast cancer risk was seen in the meta-analysis of the Finnish datasets or in the large BCAC dataset. The association with previously identified risk variants rs999737, rs2588809, and rs1314913 was replicated among all breast cancer cases and also among familial cases in the BCAC dataset. The most significant association was observed for the haplotype carrying the risk-alleles of all the three SNPs both among all cases (odds ratio (OR): 1.15, 95% confidence interval (CI): 1.11–1.19, P = 8.88 x 10−16) and among familial cases (OR: 1.24, 95% CI: 1.16–1.32, P = 6.19 x 10−11), compared to the haplotype with the respective protective alleles. Our results suggest that loss-of-function mutations in RAD51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk

Een proefsleuvenonderzoek (IVO-P)

Rapportage proefsleuvenonderzoek aan de Otmansweg 5 te Ommen

Een bureau- en verkennend booronderzoek (IVO-O)

Rapport archeologisch booronderzoek aan de Anna van Burenlaan 8 te Santpoort-Zuid

Een karterend booronderzoek (IVO-O)

Booronderzoek aan de Koelenbergsteeg 1 te Onnen