From Big Bang to Galactic Civilizations

Each scientific study emerges in its own particular time and marks a new step in the development of human thought.1 Big History materialized to satisfy the human need for a unified vision of our existence. It came together in the waning decades of the twentieth century, in part, as a reaction to the specialization of scholarship and education that had taken hold around the world. While this specialization had great results, it created barriers that stood in contrast to a growing unity among our global communities. These barriers were increasingly awkward to bridge, and, thus, Big History emerged as a successful new framework

Cultural Trigonometry of Franco-American Stereotypes

The life of Franco-American Tom Plant represents a group of lost Francos who came to the United States prior to the great migrations of 1870-1920. His experience differed from that of the archetypical French-Canadians who found work in a textile mill and settled into one of New England\u27s many petits Canadas. Plant\u27s life adds another facet to a story much richer and more complex than most scholars of Franco-American have documented

Introduction: From Big Bang to Galactic Civilizations - An Introduction to Big History

Each scientific study emerges in its own particular time and marks a new step in the development of human thought.1 Big History materialized to satisfy the human need for a unified vision of our existence. It came together in the waning decades of the twentieth century, in part, as a reaction to the specialization of scholarship and education that had taken hold around the world. While this specialization had great results, it created barriers that stood in contrast to a growing unity among our global communities. These barriers were increasingly awkward to bridge, and, thus, Big History emerged as a successful new framework

University of Maine at Orono Franco Series Letter with Attachments

Letter from Barry H. Rodrigue, a graduate student writing on behalf of the Franco-American Centre at the University of Maine at Orono, to Giguère inviting her to participate in the series Beyond the French and Indian Wars: The impact of warfare on the Franco and Native communities of North America.https://digitalcommons.usm.maine.edu/giguere-conferences-and-presentations-1968-1997/1057/thumbnail.jp

Towards Visual Feedback Loops for Robot-Controlled Additive Manufacturing

Robotic additive manufacturing methods have enabled the design and fabrication of novel forms and material systems that represent an important step forward for architectural fabrication. However, a common problem in additive manufacturing is to predict and incorporate the dynamic behavior of the material that is the result of the complex confluence of forces and material properties that occur during fabrication. While there have been some approaches towards verification systems, to date most robotic additive manufacturing processes lack verification to ensure deposition accuracy. Inaccuracies, or in some instances critical errors, can occur due to robot dynamics, material self-deflection, material coiling, or timing shifts in the case of multi-material prints. This paper addresses that gap by presenting an approach that uses vision-based sensing systems to assist robotic additive manufacturing processes. Using online image analysis techniques, occupancy maps can be created and updated during the fabrication process to document the actual position of the previously deposited material. This development is an intermediary step towards closed-loop robotic control systems that combine workspace sensing capabilities with decision-making algorithms to adjust toolpaths to correct for errors or inaccuracies if necessary. The occupancy grid map provides a complete representation of the print that can be analyzed to determine various key aspects, such as, print quality, extrusion diameter, adhesion between printed parts, and intersections within the meshes. This valuable quantitative information regarding system robustness can be used to influence the system’s future actions. This approach will help ensure consistent print quality and sound tectonics in robotic additive manufacturing processes, improving on current techniques and extending the possibilities of robotic fabrication in architecture

Nickel and platinum group metal nanoparticle production by <i>Desulfovibrio alaskensis</i> G20

Desulfovibrio alaskensis G20 is an anaerobic sulfate reducing bacteria. While Desulfovibrio species have previously been shown to reduce palladium and platinum to the zero-state, forming nanoparticles in the process; there have been no reports that D. alaskensis is able to form these nanoparticles. Metal nanoparticles have properties that make them ideal for use in many industrial and medical applications, such as their size and shape giving them higher catalytic activity than the bulk form of the same metal. Nanoparticles of the platinum group metals in particular are highly sought after for their catalytic ability and herein we report the formation of both palladium and platinum nanoparticles by D. alaskensis and the biotransformation of solvated nickel ions to nanoparticle form

Reprogramming the Mycobacterium tuberculosis transcriptome during pathogenesis

Transcriptional profiling has revealed that Mycobacterium tuberculosis adapts both its metabolic and respiratory states during infection, utilising lipids as a carbon source and switching to alternative electron acceptors. These global gene expression datasets may be exploited to identify virulence determinants and to screen for new targets for rational drug design. Characterising the changing physiological predicament of distinct M. tb populations during infection will help expose the fundamental biology of M. tb highlighting mechanisms that influence tuberculosis pathogenicity

Community engagement for successful COVID-19 pandemic response: 10 lessons from Ebola outbreak responses in Africa

Publisher's version (útgefin grein)[No abstract available]The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.Peer Reviewe

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

The Mre11–Rad50–Nbs1 (MRN) complex functions in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) at postreplicative stages of the cell cycle. During HR, the MRN complex functions directly in the repair of DNA DSBs and in the initiation of DSB responses through activation of the ataxia telangiectasia-mutated (ATM) serine-threonine kinase. Whether MRN functions in DNA damage responses before DNA replication in G0/G1 phase cells has been less clear. In developing G1-phase lymphocytes, DNA DSBs are generated by the Rag endonuclease and repaired during the assembly of antigen receptor genes by the process of V(D)J recombination. Mice and humans deficient in MRN function exhibit lymphoid phenotypes that are suggestive of defects in V(D)J recombination. We show that during V(D)J recombination, MRN deficiency leads to the aberrant joining of Rag DSBs and to the accumulation of unrepaired coding ends, thus establishing a functional role for MRN in the repair of Rag-mediated DNA DSBs. Moreover, these defects in V(D)J recombination are remarkably similar to those observed in ATM-deficient lymphocytes, suggesting that ATM and MRN function in the same DNA DSB response pathways during lymphocyte antigen receptor gene assembly

Communications and Transport: The mobility of information, people and commodities

In a context where the study of communications tends to focus only on the mobility of information, to the neglect of that of people and commodities, this article explores the potential for a closer integration between the fields of communications and transport studies. Against the presumption that the emergence of virtuality means that material geographies are no longer of consequence, the role of mediated ‘technologies of distance’ is considered here in the broader contexts of the construction (and regulation) of a variety of physical forms of mobility and the changing modes of articulation of the virtual and material worlds