Measurement of Dynamic Properties of Clay Using the Downhole Freestanding Shear Device

The Downhole Freestanding Shear Device is a new, in situ tool for measuring the dynamic properties of cohesive soil deposits. It has been designed and developed to perform cyclic torsional shear tests on freestanding specimens beneath the bottom of a cased borehole, with the goal of measuring local strains on soil which has not been significantly disturbed by the drilling, sampling, or unloading/reloading processes associated with conventional laboratory testing. The research team has completed the device, and is now in the process of validating its performance, first in a laboratory setting. The current paper presents results from the initial tests on soil, illustrating that this new device is capable of measuring shear modulus and damping over a wide range of shear strains, from 10-3 % to nearly 1%

Liquefaction of Soils in the 1989 Loma Prieta Earthquake

The Loma Prieta Earthquake of October 17, 1989 was the most costly single natural disaster in U.S. history, resulting in losses of $7 to$9 billion, and claiming 63 lives. These damages were concentrated mainly at a number of distinct sites comprising a relatively small fraction of the affected region, as local site conditions and related geotechnical factors exerted a major influence on damage patterns and loss of life in this catastrophic event. This paper discusses one of these geotechnical factors, the widespread occurrence of soil liquefaction during the earthquake, as well as the associated damages and the resulting lessons learned. Additional significant geotechnical factors which exerted a strong influence on damage patterns during this event, including site-dependent dynamic response and seismically-induced slope instability, are discussed in companion papers in these proceedings

Origin of Metals around Galaxies. I. Catalogs of Metal-line Absorption Doublets from High-resolution Quasar Spectra

We present the first paper of the series Origin of Metals around Galaxies, which aims to explore the origin of the metals observed in the circumgalactic and intergalactic media. In this work we extract and build catalogs of metal absorbers that will be used in future analyses, and make our results publicly available to the community. We design a fully automatic algorithm to search for absorption metal-line doublets of the species C IV, N V, Si IV, and Mg II in high-resolution (R >=30,000) quasar spectra without human intervention, and apply it to the high-resolution and signal-to-noise ratio spectra of 690 quasars, observed with the UVES and HIRES instruments. We obtain 5656 C IV doublets, 7919 doublets of Mg II, 2258 of Si IV, and 239 of N V, constituting the largest high-resolution metaldoublet samples to date, and estimate the dependence of their completeness and purity on various doublet parameters such as equivalent width and redshift, using real and artificial quasar spectra. The catalogs include doublets with rest-frame line-equivalent widths down to a few mÅ, all detected at a significance above 3σ, and covering the redshifts between 1 < z =<5, properties that make them useful for a wide range of chemical evolution studies

The Astropy Problem

The Astropy Project (http://astropy.org) is, in its own words, "a community effort to develop a single core package for Astronomy in Python and foster interoperability between Python astronomy packages." For five years this project has been managed, written, and operated as a grassroots, self-organized, almost entirely volunteer effort while the software is used by the majority of the astronomical community. Despite this, the project has always been and remains to this day effectively unfunded. Further, contributors receive little or no formal recognition for creating and supporting what is now critical software. This paper explores the problem in detail, outlines possible solutions to correct this, and presents a few suggestions on how to address the sustainability of general purpose astronomical software

Investigation of the Performance of the New Orleans Flood Protection System in Hurricane Katrina on August 29, 2005: Volume 1

This report presents the results of an investigation of the performance of the New Orleans regional flood protection system during and after Hurricane Katrina, which struck the New Orleans region on August 29, 2005. This event resulted in the single most costly catastrophic failure of an engineered system in history. Current damage estimates at the time of this writing are on the order of $100 to$200 billion in the greater New Orleans area, and the official death count in New Orleans and southern Louisiana at the time of this writing stands at 1,293, with an additional 306 deaths in nearby southern Mississippi. An additional approximately 300 people are currently still listed as “missing”; it is expected that some of these missing were temporarily lost in the shuffle of the regional evacuation, but some of these are expected to have been carried out into the swamps and the Gulf of Mexico by the storm’s floodwaters, and some are expected to be recovered in the ongoing sifting through the debris of wrecked homes and businesses, so the current overall regional death count of 1,599 is expected to continue to rise a bit further. More than 450,000 people were initially displaced by this catastrophe, and at the time of this writing more than 200,000 residents of the greater New Orleans metropolitan area continue to be displaced from their homes by the floodwater damages from this storm event. This investigation has targeted three main questions as follow: (1) What happened?, (2) Why?, and (3) What types of changes are necessary to prevent recurrence of a disaster of this scale again in the future? To address these questions, this investigation has involved: (1) an initial field reconnaissance, forensic study and data gathering effort performed quickly after the arrival of Hurricanes Katrina (August 29, 2005) and Rita (September 24, 2005), (2) a review of the history of the regional flood protection system and its development, (3) a review of the challenging regional geology, (4) detailed studies of the events during Hurricanes Katrina and Rita, as well as the causes and mechanisms of the principal failures, (4) studies of the organizational and institutional issues affecting the performance of the flood protection system, (5) observations regarding the emergency repair and ongoing interim levee reconstruction efforts, and (6) development of findings and preliminary recommendations regarding changes that appear warranted in order to prevent recurrence of this type of catastrophe in the future. In the end, it is concluded that many things went wrong with the New Orleans flood protection system during Hurricane Katrina, and that the resulting catastrophe had it roots in three main causes: (1) a major natural disaster (the Hurricane itself), (2) the poor performance of the flood protection system, due to localized engineering failures, questionable judgments, errors, etc. involved in the detailed design, construction, operation and maintenance of the system, and (3) more global “organizational” and institutional problems associated with the governmental and local organizations responsible for the design, construction, operation, maintenance and funding of the overall flood protection system

A pervasive role for biomass burning in tropical high ozone/low water structures.

Air parcels with mixing ratios of high O3 and low H2O (HOLW) are common features in the tropical western Pacific (TWP) mid-troposphere (300-700 hPa). Here, using data collected during aircraft sampling of the TWP in winter 2014, we find strong, positive correlations of O3 with multiple biomass burning tracers in these HOLW structures. Ozone levels in these structures are about a factor of three larger than background. Models, satellite data and aircraft observations are used to show fires in tropical Africa and Southeast Asia are the dominant source of high O3 and that low H2O results from large-scale descent within the tropical troposphere. Previous explanations that attribute HOLW structures to transport from the stratosphere or mid-latitude troposphere are inconsistent with our observations. This study suggest a larger role for biomass burning in the radiative forcing of climate in the remote TWP than is commonly appreciated.We thank L. Pan for coordinating the CONTRAST flights and her constructive criticism of an early version of the manuscript; S. Schauffler, V. Donets and R. Lueb for collecting and analysing AWAS samples; T. Robinson and O. Shieh for providing meteorology forecasts in the field; and the pilots and crews of the CAST BAe-146 and CONTRAST Gulfstream V aircrafts for their dedication and professionalism. CAST was funded by the Natural Environment Research Council; CONTRAST was funded by the National Science Foundation. Research at the Jet Propulsion Laboratory, California Institute of Technology, is performed under contract with the National Aeronautics and Space Administration (NASA). A number of the US-based investigators also benefitted from the support of NASA as well as the National Oceanic and Atmospheric Administration. The views, opinions, and findings contained in this report are those of the author(s) and should not be construed as an official National Oceanic and Atmospheric Administration or US Government position, policy or decision. We would like to acknowledge high-performance computing support from Yellowstone (ark:/85065/d7wd3xhc) provided by NCAR's Computational and Information Systems Laboratory. NCAR is sponsored by the National Science Foundation.This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/ncomms1026

Inducing Cross-Clade Neutralizing Antibodies against HIV-1 by Immunofocusing

Background: Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We sought to test whether HIV-1 Env mimics may serve as immunogens. Methodology/Principal Findings: Using random peptide phage display libraries, we identified the epitopes recognized by polyclonal antibodies of a rhesus monkey that had developed high-titer, broadly reactive nAbs after infection with a simianhuman immunodeficiency virus (SHIV) encoding env of a recently transmitted HIV-1 clade C (HIV-C). Phage peptide inserts were analyzed for conformational and linear homology using computational analysis; some peptides mimicked various domains of the original HIV-C Env, such as conformational V3 loop epitopes and the conserved linear region of the gp120 C-terminus. Next, we devised a novel prime/boost strategy to test the immunogenicity of such phage-displayed peptides and primed mice only once with HIV-C gp160 DNA followed by boosting with mixtures of recombinant phages. Conclusions/Significance: This strategy, which was designed to focus the immune system on a few Env epitopes (immunofocusing), not only induced HIV-C gp160 binding antibodies and cross-clade nAbs, but also linked a conserved HIV Env region for the first time to the induction of nAbs: the C-terminus of gp120. The identification of conserved antige

Recent Advances in Soil Liquefaction Engineering: A Unified and Consistent Framework

Over the past decade, major advances have occurred in both understanding and practice with regard to assessment and mitigation of hazard associated with seismically induced soil liquefaction. Soil liquefaction engineering has evolved into a sub-field in its own right, and engineering assessment and mitigation of seismic soil liquefaction hazard is increasingly well addressed in both research and practice. This rapid evolution in the treatment of liquefaction has been pushed largely by a confluence of lessons and data provided by a series of major earthquakes over the past dozen years, as well as by the research and professional/political will engendered by these major seismic events. The overall field of soil liquefaction engineering is now beginning to coalesce into an internally consistent and comprehensive framework, and one in which the various elements are increasingly mutually supportive of each other. Although the rate of progress has been laudable, further advances are occurring, and more remains to be done. As we enter a “new millenium”, engineers are increasingly well able to deal with important aspects of soil liquefaction engineering. This paper will highlight a number of important recent and ongoing developments in soil liquefaction engineering, and will offer insights regarding research in progress, as well as suggestions regarding further advances needed

Accelerated Prion Replication in, but Prolonged Survival Times of, Prion-Infected CXCR3−/− Mice▿

Prion diseases have a significant inflammatory component. Glia activation, which is associated with increased production of cytokines and chemokines, may play an important role in disease development. Among the chemokines upregulated highly and early upregulated during scrapie infections are ligands of CXCR3. To gain more insight into the role of CXCR3 in a prion model, CXCR3-deficient (CXCR3−/−) mice were infected intracerebrally with scrapie strain 139A and characterized in comparison to similarly infected wild-type controls. CXCR3−/− mice showed significantly prolonged survival times of up to 30 days on average. Surprisingly, however, they displayed accelerated accumulation of misfolded proteinase K-resistant prion protein PrPSc and 20 times higher infectious prion titers than wild-type mice at the asymptomatic stage of the disease, indicating that these PrP isoforms may not be critical determinants of survival times. As demonstrated by immunohistochemistry, Western blotting, and gene expression analysis, CXCR3-deficient animals develop an excessive astrocytosis. However, microglia activation is reduced. Quantitative analysis of gliosis-associated gene expression alterations demonstrated reduced mRNA levels for a number of proinflammatory factors in CXCR3−/− compared to wild-type mice, indicating a weaker inflammatory response in the knockout mice. Taken together, this murine prion model identifies CXCR3 as disease-modifying host factor and indicates that inflammatory glial responses may act in concert with PrPSc in disease development. Moreover, the results indicate that targeting CXCR3 for treatment of prion infections could prolong survival times, but the results also raise the concern that impairment of microglial migration by ablation or inhibition of CXCR3 could result in increased accumulation of misfolded PrPSc

Origin of Metals around Galaxies. I. Catalogs of Metal-line Absorption Doublets from High-resolution Quasar Spectra

11 pages, 7 figures. Version matching the published one at ApJ. Metal-line doublet catalogs publicly available at \url{https://github.com/lluism/OMG}International audienceWe present the first paper of the series Origin of Metals around Galaxies (OMG) aimed to study the origin of the metals observed in the circumgalactic and intergalactic media. In this work we extract and build the catalogs of metal absorbers that will be used in future analyses, and make our results publicly available to the community. We design a fully automatic algorithm to search for absorption metal-line doublets of the species CIV, NV, SiIV and MgII in high-resolution ($R\gtrsim30\,000$) quasar spectra without human intervention, and apply it to the high-resolution and signal-to-noise ratio spectra of 690 quasars, observed with the UVES and HIRES instruments. We obtain $5\,656$ CIV doublets, $7\,919$ doublets of MgII, $2\,258$ of SiIV, and 239 of NV, constituting the largest high-resolution metal-doublet samples to date, and estimate the dependence of their completeness and purity on various doublet parameters such as equivalent width and redshift, using real and artificial quasar spectra. The catalogs include doublets with rest-frame line equivalent widths down to a few ${\rm m\AA}$, all detected at a significance above 3$\sigma$, and covering the redshifts between $1<z \lesssim 5$, properties that make them useful for a wide range of chemical evolution studies