The effect of parallel static and microwave electric fields on excited hydrogen atoms

Motivated by recent experiments we analyse the classical dynamics of a hydrogen atom in parallel static and microwave electric fields. Using an appropriate representation and averaging approximations we show that resonant ionisation is controlled by a separatrix, and provide necessary conditions for a dynamical resonance to affect the ionisation probability. The position of the dynamical resonance is computed using a high-order perturbation series, and estimate its radius of convergence. We show that the position of the dynamical resonance does not coincide precisely with the ionisation maxima, and that the field switch-on time can dramatically affect the ionisation signal which, for long switch times, reflects the shape of an incipient homoclinic. Similarly, the resonance ionisation time can reflect the time-scale of the separatrix motion, which is therefore longer than conventional static field Stark ionisation. We explain why these effects should be observed in the quantum dynamics. PACs: 32.80.Rm, 33.40.+f, 34.10.+x, 05.45.Ac, 05.45.MtComment: 47 pages, 20 figure

Magnetic dipoles and electric currents

We discuss several similarities and differences between the concepts of electric and magnetic dipoles. We then consider the relation between the magnetic dipole and a current loop and show that in the limit of a pointlike circuit, their magnetic fields coincide. The presentation is accessible to undergraduate students with a knowledge of the basic ideas of classical electromagnetism.Comment: 7 pages, 1 figur

Adjusting farm production in Cheshire County, N.H., to market demands, Bulletin, no. 217

The Bulletin is a publication of the New Hampshire Agricultural Experiment Station, College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire

The Nicotine Metabolite, Cotinine, Alters the Assembly and Trafficking of a Subset of Nicotinic Acetylcholine Receptors

Exposure to nicotine alters the trafficking and assembly of nicotinic receptors (nAChRs), leading to their up-regulation on the plasma membrane. Although the mechanism is not fully understood, nicotine-induced up-regulation is believed to contribute to nicotine addiction. The effect of cotinine, the primary metabolite of nicotine, on nAChR trafficking and assembly has not been extensively investigated. We utilize a pH-sensitive variant of GFP, super ecliptic pHluorin, to differentiate between intracellular nAChRs and those expressed on the plasma membrane to quantify changes resulting from cotinine and nicotine exposure. Similar to nicotine, exposure to cotinine increases the number of α4β2 receptors on the plasma membrane and causes a redistribution of intracellular receptors. In contrast to this, cotinine exposure down-regulates α6β2β3 receptors. We also used single molecule fluorescence studies to show that cotinine and nicotine both alter the assembly of α4β2 receptors to favor the high sensitivity (α4)2(β2)3 stoichiometry

AGN and starbursts at high redshift: High resolution EVN radio observations of the Hubble Deep Field

We present deep, wide-field European VLBI Network (EVN) 1.6 GHz observations of the Hubble Deep Field (HDF) region with a resolution of 0.025 arcseconds. Above the 210 microJy/beam (5sigma) detection level, the EVN clearly detects two radio sources in a field that encompasses the HDF and part of the Hubble Flanking Fields (HFF). The sources detected are: VLA J123644+621133 (a z=1.013, low-luminosity FR-I radio source located within the HDF itself) and VLA J123642+621331 (a dust enshrouded, optically faint, z=4.424 starburst system). A third radio source, J123646+621404, is detected at the 4sigma level. The VLBI detections of all three sources suggest that most of the radio emission of these particular sources (including the dusty starburst) is generated by an embedded AGN.Comment: 4 pages, 1 figure; Accepted by Astron. & Astrophys Letters ... See http://www.nfra.nl/~mag/hdf_evn.htm

An ALMA 3mm continuum census of Westerlund 1

Context. Massive stars play an important role in both cluster and galactic evolution and the rate at which they lose mass is a key driver of both their own evolution and their interaction with the environment up to and including their terminal SNe explosions. Young massive clusters provide an ideal opportunity to study a co-eval population of massive stars, where both their individual properties and the interaction with their environment can be studied in detail. Aims. We aim to study the constituent stars of the Galactic cluster Westerlund 1 in order to determine mass-loss rates for the diverse post-main sequence population of massive stars. Methods. To accomplish this we made 3mm continuum observations with the Atacama Large Millimetre/submillimetre Array. Results. We detected emission from 50 stars in Westerlund 1, comprising all 21 Wolf-Rayets within the field of view, plus eight cool and 21 OB super-/hypergiants. Emission nebulae were associated with a number of the cool hypergiants while, unexpectedly, a number of hot stars also appear spatially resolved. Conclusions. We were able to measure the mass-loss rates for a unique population of massive post-main sequence stars at every stage of evolution, confirming a significant increase as stars transitioned from OB supergiant to WR states via LBV and/or cool hypergiant phases. Fortuitously, the range of spectral types exhibited by the OB supergiants provides a critical test of radiatively-driven wind theory and in particular the reality of the bi-stability jump. The extreme mass-loss rate inferred for the interacting binary Wd1-9 in comparison to other cluster members confirmed the key role binarity plays in massive stellar evolution. The presence of compact nebulae around a number of OB and WR stars is unexpected; by analogy to the cool super-/hypergiants we attribute this to confinement and sculpting of the stellar wind via interaction with the intra-cluster medium/wind. Given the morphology of core collapse SNe depend on the nature of the pre-explosion circumstellar environment, if this hypothesis is correct then the properties of the explosion depend not just on the progenitor, but also the environment in which it is located

Organelle-Specific Single-Molecule Imaging of \u3cem\u3eα\u3c/em\u3e4\u3cem\u3eβ\u3c/em\u3e2 Nicotinic Receptors Reveals the Effect of Nicotine on Receptor Assembly and Cell-Surface Trafficking

Nicotinic acetylcholine receptors (nAChRs) assemble in the endoplasmic reticulum (ER) and traffic to the cell surface as pentamers composed of α and β subunits. Many nAChR subtypes can assemble with varying subunit ratios, giving rise to multiple stoichiometries exhibiting different subcellular localization and functional properties. In addition to the endogenous neurotransmitter acetylcholine, nicotine also binds and activates nAChRs and influences their trafficking and expression on the cell surface. Currently, no available technique can specifically elucidate the stoichiometry of nAChRs in the ER versus those in the plasma membrane. Here, we report a method involving single-molecule fluorescence measurements to determine the structural properties of these membrane proteins after isolation in nanoscale vesicles derived from specific organelles. These cell-derived nanovesicles allowed us to separate single membrane receptors while maintaining them in their physiological environment. Sorting the vesicles according to the organelle of origin enabled us to determine localized differences in receptor structural properties, structural influence on transport between organelles, and changes in receptor assembly within intracellular organelles. These organelle-specific nanovesicles revealed that one structural isoform of the α4β2 nAChR was preferentially trafficked to the cell surface. Moreover, nicotine altered nAChR assembly in the ER, resulting in increased production of the receptor isoform that traffics more efficiently to the cell surface. We conclude that the combined effects of the increased assembly of one nAChR stoichiometry and its preferential trafficking likely drive the up-regulation of nAChRs on the cell surface upon nicotine exposure

Economic inequalities in burden of illness, diagnosis and treatment of five long-term conditions in England: panel study

We compared the distribution by wealth of self-reported illness burden (estimated from validated scales, biomarker and reported symptoms) for angina, cataract, depression, diabetes and osteoarthritis, with the distribution of self-reported medical diagnosis and treatment. We aimed to determine if the greater illness burden borne by poorer participants was matched by appropriately higher levels of diagnosis and treatment

Site-selective quantum correlations revealed by magnetic anisotropy in the tetramer system SeCuO3

We present the investigation of a monoclinic compound SeCuO3 using x-ray powder diffraction, magnetization, torque and electron-spin-resonance (ESR). Structurally based analysis suggests that SeCuO3 can be considered as a 3D network of tetramers. The values of intra-tetramer exchange interactions are extracted from the temperature dependence of the susceptibility and amount to ~200 K. The inter-tetramer coupling leads to the development of long-range antiferromagnetic order at TN = 8 K. An unusual temperature dependence of the effective g-tensors is observed, accompanied with a rotation of macroscopic magnetic axes. We explain this unique observation as due to site-selective quantum correlations