15 research outputs found
A global assembly of adult female mosquito mark-release-recapture data to inform the control of mosquito-borne pathogens
Ingested Salmonella enterica, Cronobacter sakazakii, Escherichia coli O157:H7, and Listeria monocytogenes: transmission dynamics from adult house flies to their eggs and first filial (F1) generation adults
Assessing degradation of nano drug carriers - Magnetic particle imaging as a solution
Stimulus-triggered drug release by magnetic actuation of nano drug carriers is of high interest for targeted therapies. Most promising candidates are nano formulations based on biodegradable polymers and magnetic nanoparticles (MNP) because they have low side effects and customizable degradation properties. For the control drug release in vivo, monitoring of degradation dynamics play an important role. In this study, we demonstrate the feasibility of measuring degradation state of poly-(lactic-co-glycolic) acid magnetic nanoparticles (PLGA-MNP) using magnetic particle imaging (MPI). We show that due that the immobilization state of MNP during degradation leads to changes in image quality. Further, we test the influence of magnetic fluid hyperthermia on degradation of PLGA-MNP carriers and discuss the effects of degradation on MPI signal
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A global assembly of adult female mosquito mark-release-recapture data to inform the control of mosquito-borne pathogens.
BackgroundPathogen transmission by mosquitos is known to be highly sensitive to mosquito bionomic parameters. Mosquito mark-release-recapture (MMRR) experiments are a standard method for estimating such parameters including dispersal, population size and density, survival, blood feeding frequency and blood meal host preferences.MethodsWe assembled a comprehensive database describing adult female MMRR experiments. Bibliographic searches were used to build a digital library of MMRR studies and selected data describing the reported outcomes were extracted.ResultsThe resulting database contained 774 unique adult female MMRR experiments involving 58 vector mosquito species from the three main genera of importance to human health: Aedes, Anopheles and Culex. Crude examination of these data revealed patterns associated with geography as well as mosquito genus, consistent with bionomics varying by species-specific life history and ecological context. Recapture success varied considerably and was significantly different amongst genera, with 8, 4 and 1% of adult females recaptured for Aedes, Anopheles and Culex species, respectively. A large proportion of experiments (59%) investigated dispersal and survival and many allowed disaggregation of the release and recapture data. Geographic coverage was limited to just 143 localities around the world.ConclusionsThis MMRR database is a substantial contribution to the compilation of global data that can be used to better inform basic research and public health interventions, to identify and fill knowledge gaps and to enrich theory and evidence-based ecological and epidemiological studies of mosquito vectors, pathogen transmission and disease prevention. The database revealed limited geographic coverage and a relative scarcity of information for vector species of substantial public health relevance. It represents, however, a wealth of entomological information not previously compiled and of particular interest for mosquito-borne pathogen transmission models