Viagem à Fragilândia: um projeto comunitário com pessoas da Cerci-Feira

Mestrado em Ensino de MúsicaO presente Relatório Final da componente de Prática de Ensino Supervisionada do Mestrado em Ensino da Música encontra-se dividido em duas secções. A primeira fundamenta e relata a implementação do Projeto Educativo desenvolvido ao longo de 6 meses com 13 elementos da Cerci de Santa Maria da Feira. As sessões semanais realizadas durante todo este percurso centraram-se na criação de instrumentos adaptados às necessidades inerentes às condições físicas / mentais de cada um dos participantes resultando na apresentação do espetáculo final Viagem à Fragilândia. A segunda é constituída pelo Relatório de Estágio realizado durante o ano letivo 2016/2017 no Conservatório Regional de Música de Viseu Dr. José de Azevedo Perdigão.The present final report of the Supervised Teaching Practice component of the Masters degree in Music Education is divided into two sections. The first part describes the educational project developed over 5 months with 13 elements of the Cerci in Santa Maria da Feira. The weekly sessions held throughout this period, focused on creating instruments adapted to the physical and mental conditions of each participant, resulting in a final public presentation called “Viagem à Fragilândia”. The second part reports the internship held during the academic year 2016/2017 at the Conservatório de Música de Viseu Dr. José de Azevedo Perdigão

A review

Women have a number of specificities that differentiate them from men. In particular, the role of sex steroid hormones and the menstrual cycle (MC) significantly impact women’s physiology. The literature has shown nonlinear relationships between MC, exercise, and nutritional intake. Notably, these relationships are bidirectional and less straightforward than one would suppose. For example, the theoretical implications of the MC’s phases on exercise performance do not always translate into relevant practical effects. There is often a disconnect between internal measures (e.g., levels of hormone concentrations) and external performance. Furthermore, it is not entirely clear how nutritional intake varies across the MC’s phases and whether these variations impact on exercise performance. Therefore, a thorough review of the existing knowledge could help in framing these complex relationships and potentially contribute to the optimization of exercise prescription and nutritional intake according to the naturally occurring phases of the MC. Throughout this re-view, an emerging trend is the lack of generalizability and the need to individualize interventions, since the consequences of the MC’s phases and their relationships with exercise and nutritional intake seem to vary greatly from person to person. In this sense, average data are probably not relevant and could potentially be misleading.publishersversionpublishe

Feasibility and acceptability of psychosocial care for unsuccessful fertility treatment

Introduction: Many people undergo fertility treatment to have biological children, but around four in ten patients complete all treatment cycles without having the children they desire. This triggers intense grief from which patients report taking on average 2 years to recover. Fertility guidelines and regulators stress the need to support patients through this process, but there is a scarcity of evaluated interventions to this end and evidence about when and how to offer care is lacking. This study explored patients' and healthcare professionals' (HCPs) experiences of and views about provision of psychosocial care (to patients facing unsuccessful fertility treatment, i.e., care provided by a mental health professional to address the emotional, cognitive, behavioural, relational and social needs that patients have at this stage of treatment). Methods: Five qualitative online focus groups were conducted with Portuguese participants: three with patients waiting to initiate or undergoing their last cycle of in vitro fertilization/intracytoplasmic sperm injection or having completed it within the last 2 months without achieving a pregnancy and two with HCPs working at fertility clinics. Focus groups were recorded and transcribed verbatim, and data were analysed with Framework Analysis. Results: Thirteen patients and nine HCPs participated. Analysis resulted in 1293 codes, systematically organized into 13 categories, 4 themes and 1 metatheme. The latter showed high consensus about the need for psychosocial care for unsuccessful treatment, but perceived challenges in its implementation. Themes reflected (1) consensual demand for psychosocial care at all stages of treatment but particularly at the end, (2) high perceived acceptability of integrating preventive care initiated during treatment with early psychosocial care only for those patients who experience unsuccessful treatment, (3) perceived challenges of implementing psychosocial care for unsuccessful treatment at clinics and (4) suggestions to promote its acceptability and feasibility. Conclusion: Patients and HCPs perceive that clinics should improve care provision across the whole treatment pathway and in particular for unsuccessful fertility treatment. Suggestions were made to inform future research focusing on the development and evaluation of psychosocial interventions to this end. Patient or Public Contribution: Patients and HCPs participated in the focus groups. Two HCPs also revised the manuscript

Evaluation of bone turnover markers and serum minerals variations for predicting fracture healing versus non-union processes in adult sheep as a model for orthopedic research

Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers SOH namely the total alkaline phosphatase (ALP) and its bone-specific isoform (BALP), serum concentration of intact osteocalcin (OC), N-terminal propeptide type III procollagen (PIIINP) and of bone resorption markers â  namely tartrate resistant acid phosphatase (TRAP) and deoxypyridinoline crosslink (DPD) during the first stages of a normal fracture healing process and of a segmental critical size defect (CSD), which progresses to a non-union process. Thirty healthy female sheep (Portuguese Churra-da-Terra- Quente breed), approximately 4-years-old, were enrolled in this study. Jugular venous blood samples were collected pre-operatively and at 1, 2, 3, 4, 6, 8, 10 and 12 post-operative weeks. The animals of the CSD group showed significant lower serum levels of BALP, OC and significant higher serum PIIINP levels at early stages of the fracture healing process, compared with animals that progressed in a normal fracture healing process. Serum BALP, OC and PIIINP levels could be useful as non-invasive auxiliary tools with other complementary methods for predicting the outcome of traumatic bone fractures.Cristina P. Sousa acknowledges the Portuguese Foundation for Science and Technology (FCT) for her PhD scholarship (Grant No SFRH/BD/45018/2008).info:eu-repo/semantics/publishedVersio

Livro Vermelho dos Peixes Dulciaquícolas e Diádromos de Portugal Continental

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Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome.As técnicas imagiológicas são o método convencional para a avaliação dos processos de cicatrização das fraturas. No entanto, estes métodos não são talvez totalmente confiáveis para a deteção precoce de complicações, as mais frequentes destas sendo o atraso da união e a não-união. Um diagnóstico eficaz destas desordens poderia prevenir a dor e a incapacidade prolongada do paciente. Esforços devem ser dirigidos no sentido do desenvolvimento de novas tecnologias para melhorar a exatidão no diagnóstico de complicações após fraturas ósseas. A variação nos níveis dos marcadores do turnover ósseo (BTMs) têm sido avaliados com vista à sua capacidade para prever o comprometimento da cicatrização das fraturas numa fase inicial, no entanto, as conclusões de alguns estudos não são consensuais. Neste artigo os autores fizeram uma revisão do potencial dos BTMs como fatores de previsibilidade precoce do prognóstico em doentes adultos que apresentavam fraturas ósseas traumáticas mas que não sofriam de osteopenia ou osteoporose pós-menopausa. A informação disponível nos diferentes estudos realizados neste campo foi sistematizada com vista a evidenciar-se os BTMs mais promissores para a avaliação da evolução da cicatrização das fraturas.SFRH/BD/45018/200

Arte Nova e Eclectismo no palacete projectado por Ernesto Korrodi para a família Bouhon

In the early twentieth century, Interior Design resulted from the work of architects, decorators, painters and carvers. Although then integrated into the world of decorative arts, we believe that already existed as a profession regulated by a coherent network design principles and the understanding of interior space as global web of relationships established between plans, ornament, lighting and furniture solutions. At the end of the previous century, before the need for a reform of industrial training, the Portuguese Government opened a tender for hiring of foreign teachers. We emphasize the role of Ernesto Korrodi (1870-1944). His works arise from an attitude paradoxically modern and eclectic, leaning one hand on a reinterpretation of solutions referenced in the medieval period or the Renaissance, on the other, based on formulas from Arts and Crafts movement, Art Nouveau or Secession. In his projects certain rooms and hierarchies remain, but these are intersect with the needs aroused by technical innovations, which causes an attempt to answer to the emergence of new functions and features in the house, along with the hygienists demands of the moment. This article consists in the analysis of Bouhon home, located in the city of Covilhã, Portugal. If Art Nouveau is visible in the elevations, inside we find a cleaner space, marked by decorative notes which we can find in tiles and embedded in the stucco or coffered ceilings. The ornament thus contributes to the dignity of the walls, wainscots and ceiling plans, assuming a key role in the spatial composition.No início do século XX, o design de interiores resultava do trabalho desenvolvido por arquitectos, decoradores, pintores ou entalhadores. Embora então integrado no universo das artes decorativas, acreditamos que já existia como prática profissional regulada por uma rede coerente de princípios de concepção e pelo entendimento do espaço interior como teia global de relações que se estabelece entre planos, ornamento, iluminação e mobiliário. No final do século anterior, perante a necessidade de proceder a uma reforma do ensino industrial, o governo português abrira um concurso para contratação de professores estrangeiros. Evidenciamos o papel de Ernesto Korrodi (1870-1944). As suas obras decorrem de uma atitude paradoxalmente ecléctica e moderna, apoiando-se por um lado, numa reinterpretação de soluções referenciadas no período medieval ou na Renascença; por outro, em fórmulas sediadas nos movimentos Arts and Crafts, Arte Nova (Art Nouveau) ou Secessão. Nos seus projectos persistem determinadas dependências e hierarquias, mas estas se cruzam com as necessidades despertadas pelas inovações técnicas, o que faz com que se preocupe também com a resposta à eclosão de novas funções e mobiliário na casa, a par das exigências higienistas do momento. O presente artigo consiste na análise da casa da família Bouhon, localizada na cidade da Covilhã, Portugal. Se a Arte Nova marca as suas fachadas, no interior deparamo-nos com espaços mais depurados, marcados por apontamentos decorativos, incorporados na azulejaria e nos tectos estucados ou em caixotões. O ornamento contribui, deste modo, para a dignificação dos planos das paredes, lambris e tectos, assumindo um papel fundamental na composição espacial

Sinus node disfunction in an adolescent with systemic lupus erythematosus

Copyright © 2020 by SAGE Publications.Cardiac involvement in systemic lupus erythematosus (SLE) is well documented. The pericardium, myocardium and endocardium, as well as the coronary arteries, the valves and the conduction system can all be affected. While pericarditis is common, arrythmias are less frequently described.We present a 13-year-old male, who had fatigue, anorexia, weight loss, myalgias and arthralgias for four months. On physical examination, we identified bradycardia (heart rate 31-50 bpm), oral and nasal ulcers and polyarthritis. The laboratory results showed hemolytic anemia, hypocomplementemia, antinuclear and anti-dsDNA antibodies, hematuria and non-nephrotic proteinuria. Renal function was normal. Lupus nephritis class II was diagnosed by kidney biopsy. On the transthoracic echocardiogram we identified a minimal pericardial effusion, suggesting pericarditis, and, on the electrocardiogram, we detected sinus arrest with junctional rhythm, denoting sinus node dysfunction. The patient was diagnosed with juvenile SLE with cardiac, renal, musculoskeletal and hematologic involvement. Disease remission and cardiac rhythm control were obtained with steroids and mycophenolate mofetil. Currently, the patient is asymptomatic, with normal sinus rhythm.We described an adolescent with SLE who had sinus node dysfunction upon diagnosis. Other cases have been reported in adults but none in juvenile SLE. All SLE patients should have a thorough cardiac examination to promptly diagnose and treat the innumerous cardiac manifestations of this disease.info:eu-repo/semantics/publishedVersio

Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection

Regeneration of adult mammalian central nervous system (CNS) axons is abortive, resulting in inability to recover function after CNS lesion, including spinal cord injury (SCI). Here, we show that the spiny mouse (Acomys) is an exception to other mammals, being capable of spontaneous and fast restoration of function after severe SCI, re-establishing hind limb coordination. Remarkably, Acomys assembles a scarless pro-regenerative tissue at the injury site, providing a unique structural continuity of the initial spinal cord geometry. The Acomys SCI site shows robust axon regeneration of multiple tracts, synapse formation, and electrophysiological signal propagation. Transcriptomic analysis of the spinal cord following transcriptome reconstruction revealed that Acomys rewires glycosylation biosynthetic pathways, culminating in a specific pro-regenerative proteoglycan signature at SCI site. Our work uncovers that a glycosylation switch is critical for axon regeneration after SCI and identifies beta 3gnt7, a crucial enzyme of keratan sulfate biosynthesis, as an enhancer of axon growth.Santa Casa da Misericordia de Lisboa MC-39-2019, Wings for Life WFL-PT-21/20, Portuguese Foundation for Science and Technology UID/BIM/04773/2013/CBMRinfo:eu-repo/semantics/publishedVersio