Combination Olanzapine and Samidorphan for the Management of Schizophrenia and Bipolar 1 Disorder in Adults: A Narrative Review

Schizophrenia is a debilitating psychotic disorder characterized by positive symptoms such as delusions, hallucinations, and disorganized thoughts, and negative symptoms like lack of effect or motivation. Bipolar 1 disorder (B1D) is a psychiatric illness characterized by recurrent manic episodes in alternation with depressive episodes and interspersed periods of euthymia, ultimately resulting in psychological distress and impairment of daily functioning. Effective treatments are needed for both schizophrenia and B1D to reach the treatment goals of reducing the debilitating symptomology, improving social functioning and quality of life, and increasing the chances of recovery and more favorable long-term outcomes. To date, olanzapine is one of the most efficacious atypical antipsychotics (AAPs) for the treatment of both schizophrenia and B1D and is associated with fewer extrapyramidal effects compared to other treatments. However, compared to other AAPs, olanzapine is associated with a greater chance of metabolic syndrome, limiting its clinical use and affecting treatment compliance. Samidorphan mitigates the weight gain side effects of olanzapine by antagonizing μ-, κ-, and δ-opioid receptors. The use of combination drugs to treat psychiatric conditions is an emerging field with the goal of increasing therapeutic efficacy and decreasing undesirable side effects. Clinical trials have demonstrated combination on olanzapine and samidorphan (OLZ/SAM) treatment resulted in significantly less weight gain than olanzapine monotherapy. Clinical trial patients reported improvements in symptoms of psychosis, reduced weight gain, and overall satisfaction with their treatment. OLZ/SAM has been as shown to be a safe and effective pharmaceutical option for the clinical management of schizophrenia and B1D

From Incineration to Sterilisation of Solid Hospital Waste in Low-income Contexts: a Gradual Sustainable Transition.

Open burning and incineration are the two most common treatments for hospital solid waste in low-income countries. Due to the absence of limits on emissions and the lack of technical capacity or funding, obsolete incinerators do not guarantee neither a low environmental and economic impact nor people health. The SIRSU Project, co-financed by the Italian Agency for Sustainable Development and Newster Group, aims to substitute the incinerator in Beira Central Hospital (Mozambique) with an electric sterilizer, an environmentally friendly machine that is also safe for workers. However, it is not sufficient to import this new technology and train the staff. First, an assessment of the quantities and types of biomedical waste produced in the different hospitals is necessary, as well as a careful analysis of the waste management system of all hospitals in the city. If the technology is suitable for the context, then, after the training of technicians for maintenance and operation, a period of accompaniment and monitoring is necessary to optimise performances. The transition cannot be immediate, and a period of coexistence of the two plants (steriliser and incinerator) is necessary. To facilitate the gradual transition, the SIRSU project foresees the foundation of a local start-up to manage the steriliser and offer a waste full transport service for smaller hospitals to the Central Hospital where the machine is installed. This experience could be an opportunity to set guidelines comprehensive of the concepts of safety and security during all the steps of the transition. This aspect can be an important element for defining 1) the most appropriate technical solutions, evaluating the implementations on the control and regulation systems in order to minimize the risks associated with the process, 2) management and above all operational methods in order to guarantee not only compliance with the most precautionary technical legislations, but also modern and advanced operating standards

Synthesis and Photophysical Properties of Au(III)-Ag(I) Aggregates

Cyclometallated gold (III) complexes of the type (C^N^C)AuX [HC^N^CH = 2,6-bis(4-ButC6H4)pyrazine; 2,6-bis(4-ButC6H4)pyridine, or 2,6-bis(4-ButC6H4)4-Butpyridine; X = CN, CH(COMe)2 or CH(CN)2] have been used as building blocks for the construction of the first family of AuIII/AgI aggregates. The crystal structures of these aggregates reveal the formation of complex architectures in which the Ag+ cations are stabilized by the basic centers present on each of the Au precursors. The photophysical properties of these aggregates are reported. Compared to mononuclear pincer complexes, a general red-shift and an increase in the emission intensity are observed. In agreement with DFT calculations the lowest energy absorption and the emission are assigned to 1IL(C^N^C) and 3IL(C^N^C) transitions dominated by the HOMO and the LUMO orbitals

Assessing the sustainability dimension at local scale: Case study of Spanish cities

Nowadays, cities host most of the world population. As a result of human activities within their boundaries, most greenhouse gases emissions, natural resources consumption and waste generation are concentrated in urban areas. For these reasons, studies focusing on assessing the sustainability of cities have increased in recent decades. Bearing in mind the three pillars of sustainability (social, economic and environmental), this study aims to evaluate the level of sustainability of 31 representative Spanish cities through multiple sustainability indicators, which have been aggregated into a composite sustainability indicator that is reported by a three-letter code. Thus, each pillar of sustainability is represented by a letter A, B or C in the three-letter code, so that the letter A corresponds to the best rate and C to the worst. Within the geographical and socio-demographic framework of Spain, the results show considerable differences between the cities in the south and the north of the country. Accordingly, most of the cities with the best sustainability scores according to the award of at least two A in the three-letters code are located in the north of the country. Examples of this category are Pamplona and L’Hospitalet de Llobregat (both ranked as AAA). Cities such as Murcia, Gijon, Badajoz and Huelva obtained the worst ranking with the CCC rating. For this group of cities, actions for the improvement of sustainability have been identifiedThis research was supported by a project granted by the Spanish Government and FEDER/Ministry of Science and Innovation – Spanish National Research Agency (CTQ2016-75136-P) and by a project granted by Xunta de Galicia (project ref. ED431F 2016/001). Dr. S.G.-G. would like to express her gratitude to the Spanish Ministry of Economy and Competitiveness for financial support (Grant reference RYC-2014-14984). The authors belong to the Galician Competitive Research Group GRC ED431C 2017/29 and to the CRETUS Strategic Partnership (ED431E2018/01). All these programs are co-funded by FEDER (UE)S

From In Vitro to Perioperative Vascular Tissue Engineering: Shortening Production Time by Traceable Textile-Reinforcement

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Teachers’Coordination within the Framework of the EHEA: the Case of the Faculty of Business and Tourism in Ourense

[ES] En los últimos años, la tecnología se ha ido incorporando a la enseñanza, dando lugar a la aparición de nuevos escenarios educativos, al mismo tiempo que ha permitido la puesta en marcha de procesos de mejora de la calidad en la misma. Con este trabajo se expone la experiencia de coordinación docente desarrollada en la Facultad de Ciencias Empresariales y Turismo de Ourense, consistente en la elaboración de un cronograma que recoge las principales actividades evaluables de las diferentes materias durante un cuatrimestre. Dos eran los principales objetivos de esta experiencia: por un lado, facilitar al estudiante la planificación de sus tareas dentro del proceso de evaluación continua, y por otro, detectar por parte de los Coordinadores de Curso solapamientos y sobrecargas de trabajo. Para alcanzar estos fines se utilizó una herramienta tecnológica como el Google Calendar alcanzando unos resultados que pueden ser considerados como satisfactorios.[EN] Recently, technology has been incorporated into higher education, leading to the appearance of new educational scenarios. At the same time, this fact has set up several processes aimed at quality improvement. In this paper, we look at the teaching coordination experience carried out in the Faculty of Business Sciences and Tourism in Ourense. This experience consisted in the ellaboration of an activity schedule that shows the main activities for subject assessment during a semester. This experience had two main objectives: first, to facilitate the students’planning of their tasks in continuous assessment; second, to detect possible overlaps and work overloads. The Google Calendar was used to achieve these objectives, and the results obtained can be regarded as satisfactory.Sanchez Fernandez, P.; Rivo López, E.; Del Rio Rama, MC. (2012). La coordinación de la docencia de grado en el marco del EEES: El caso de la Facultad de Ciencias Empresariales y Turismo de Ourense. REDU. Revista de Docencia Universitaria. 10(3):285-299. https://doi.org/10.4995/redu.2012.6024OJS285299103ABDOULAYE, A. (2003). Conceptualisation et dissemination des bonnes pratiques en Éducation: Essai d'une approche internationale à partir d'enseignements tirés d'un projet. Disponible en http://portal.unesco.org/education/en/file_download.php/f1685fde2633dd9b3b2 0fd828d6bfa92abdoulaye.pdf (última consulta 10 de enero de 2012)ALMENAR, V., MALDONADO, M. H. F. (2009). Una aproximación didáctica a la contratación bursátil a través de un juego de rol en google‐docs. Red‐U. Revista De Docencia Universitaria. Número, 4, 29. REDU - Revista de Docencia Universitaria; publicado en http://redeaberta.usc.es/reduCABERO ALMENARA, J. (Coord.) (2007): Nuevas Tecnologías Aplicadas a la Educación. Madrid: Mc Graw Hill.DE JUAN HERRERO, J.; PÉREZ‐CAÑAVERAS, R. M.; GÓMEZ‐TORRES, M. J.; VIZCAYA MORENO, M. F.; MORA‐PASCUAL, J. M. (2007). Buenas prácticas en la evaluación de la docencia y del profesorado universitario en: A. Martínez Ruiz; V. Carrasco Embuena (Eds.) La multidimensionalidad de la Educación Universitaria (155‐182). Redes de investigación Docente‐Espacio Europeo de Enseñanza Superior. Alcoy: Editorial Marfil.Declaración de Bolonia. 19 de Junio de 1999. Comunicado de la Conferencia de Ministros Europeos responsables de la Educación Superior.Declaración de La Sorbona. 25 de Mayo de 1998. Declaración conjunta para la armonización del diseño del Sistema de Educación Superior.ESTEVE MON, F. M., GISBERT CERVET, M. (2011). El nuevo paradigma de aprendizaje y nuevas tecnologías. REDU. Revista de Docencia Universitaria, 9(3), 55‐73 publicado en http://redeaberta.usc.es/reduLey Orgánica 6/2001, de 21 de diciembre, de Universidades.GONZÁLEZ, L. (2003). Aproximación a una formación académica de calidad: el punto de vista de los estudiantes universitarios. Electronic Journal of Research in Educational Psychology, 1(1):20‐42.MARTÍN‐LABORDA, R. (2005). Las nuevas Tecnologías en la Educación. Madrid: Fundación Auna.PAPERT, S. (1981). Desafío a la mente. Computadoras y educación. Argentina (Buenos Aires): Ed. Galápago.Real Decreto 1393/2007, de 29 de octubre, por el que se establece la Ordenación de las Enseñanzas Universitarias Oficiales.Real Decreto 861/2010, de 2 de julio, por el que se modifica el Real Decreto 1393/2007, de 29 de octubre, por el que se establece la ordenación de las enseñanzas universitarias oficiales.RUE, J. (2007). Enseñar en la Universidad: El EEES como reto para la Educación Superior. Madrid: Narcea