APOSENTADORIA DOS TRANSEXUAIS NO BRASIL

Este artigo apresenta a situação da aposentadoria dos transexuais no Brasil. A Seguridade Social brasileira é um meio de amparar e zelar pela vida do cidadão, a partir da Assistência Social, Saúde e Previdência Social. A Previdência Social, no âmbito mundial, evoluiu, a partir da Lei dos Pobres na Inglaterra em 1601 e, no Brasil, com a Lei Eloy Chaves e a Constituição Federal de 1988. Em relação à leis que garantem os direitos previdenciários dos transexuais no Brasil, é necessária a atuação do judiciário para a resolução dessas questões, pela falta de leis específicas. Na Inglaterra, um cidadão transexual, dois anos após a cirurgia de mudança de sexo, pediu a aposentadoria no sexo atual, que só foi concedida após decisão judicial. Ao redor do mundo, não há tanta analogia ao Brasil, pois muitos países apresentam idades iguais para aposentadoria em ambos os sexos

Composted sewage sludge as an alternative substrate for forest seedlings production

The production of forest seedlings with adequate morphological and physiological characteristics is essential for the success of plantations. Substrates and irrigation are the major factors determining seedlings’ growth. Substrates made of urban and agricultural residues are a sustainable alternative to peat-based substrates. In this study, we evaluated how composted sewage sludge substrates affect the growth and gas exchange in seedlings of Cedrela fissilis Vell. Seedlings were produced under daily irrigation depths of 6, 9, and 12 mm, and on different substrates. The substrates were based on sewage sludge composted with Eucalyptus bark or sugarcane bagasse, and a commercial substrate based on peat, involving a double factorial design with 12 treatments (3 irrigation depths × 3 substrates). Both physical and chemical characteristics of substrates were analyzed, and morphological traits and gas exchanges of seedlings were measured. Sewage sludge-based substrates presented different characteristics according to the material it was mixed. Eucalyptus bark provided higher bulk density (0.19 g cm-3) and lower total porosity (75%) to the substrate, while sugarcane bagasse increased macroporosity up to 60%. Seedlings produced in sewage sludge-based substrates presented a height up to 17.8 cm and stem diameters of between 8.39-10.29 mm. Higher shoot and root dry mass was obtained in sewage sludge-based substrates with irrigation depth of 9 mm, which were 3.71 and 2.01 g, respectively. Photosynthetic carbon assimilation varied between 2.26 and 3.23 µmol CO2 m-2 s-1, and water use efficiency varied from 2.058 to 3.395 µmol CO2 (mol H2O)-1, with the highest values being obtained in seedlings produced in sewage sludge-based substrates with irrigation depth of 6 mm. Our results demonstrate that sewage sludge-based substrates are an efficient alternative to commercial peat-based substrates for seedling production

Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts

Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia

Background: Cancer-cachexia induces a variety of metabolic disorders, including skeletal muscle imbalance. Alternative therapy, as nutritional supplementation with leucine, shows a modulatory effect over tumour damage in vivo and in vitro. Method: Adult rats distributed into Control (C), Walker tumour-bearing (W), control fed a leucine-rich diet (L), and tumour-bearing fed a leucine-rich diet (WL) groups had the gastrocnemius muscle metabolomic and proteomic assays performed in parallel to in vitro assays. Results: W group presented an affected muscle metabolomic and proteomic profile mainly related to energy generation and carbohydrates catabolic processes, but leucine-supplemented group (WL) recovered the energy production. In vitro assay showed that cell proliferation, mitochondria number and oxygen consumption were higher under leucine effect than the tumour influence. Muscle proteomics results showed that the main affected cell component was mitochondria, leading to an impacted energy generation, including impairment in proteins of the tricarboxylic cycle and carbohydrates catabolic processes, which were modulated and improved by leucine treatment. Conclusion: In summary, we showed a beneficial effect of leucine upon mitochondria, providing information about the muscle glycolytic pathways used by this amino acid, where it can be associated with the preservation of morphometric parameters and consequent protection against the effects of cachexia

Análise estratégica da cadeia produtiva de leite ovino no Brasil: uma abordagem pela metodologia SWOT

O leite ovino é utilizado em escala global para a produção de queijos e outros derivados, ou para consumo in natura. A produção de leite e de seus derivados, seja formal ou informal, faz parte de uma cadeia produtiva, com menor ou maior grau de organização dependendo do desenvolvimento regional da atividade. O objetivo deste estudo foi descrever e discutir os elementos da cadeia produtiva de leite ovino no Brasil utilizando a metodologia SWOT. Este estudo foi desenvolvido em 2017 a partir de pesquisa direta com agentes ligados ao setor produtivo de leite ovino de 15 propriedades distribuídas em sete Estados do Brasil. Os agentes apontaram e descreveram os pontos fortes e fracos, as oportunidades e ameaças dos segmentos de insumos, produção, processamento, e venda e distribuição de produtos e, posteriormente, esses elementos foram organizados em uma matriz SWOT. No segmento produção, a baixa adoção de técnicas adequadas de produção, controle de dados e conhecimento dos custos de produção são fatores críticos. No segmento processamento, aspectos positivos foram apontados para as características físico-químicas do leite ovino, enquanto aspectos relacionados com a legislação foram considerados pontos críticos. A falta de cultura e conhecimento do consumidor sobre os produtos derivados do leite ovino são pontos críticos que afetam o segmento de venda e distribuição. A pequena escala de produção e a baixa demanda pelo leite e seus derivados, assim como a falta de insumos específicos para a atividade, também são pontos críticos da cadeia produtiva. Entretanto, o uso de insumos de outras atividades pecuárias (principalmente da bovinocultura leiteira) é uma opção importante para reduzir os custos de produção e otimizar o uso dos recursos na ovinocultura leiteira. Técnicas adequadas de produção e de processamento do leite ovino devem ser implementadas, assim como o controle de dados e de custos da produção. Apesar dos sistemas de produção estudados serem heterogêneos, alguns apresentam indicadores econômicos positivos, o que demonstra o potencial produtivo e econômico da atividade. Nesse cenário, a produção intensiva de produtos com maior valor agregado e o crescimento do mercado consumidor são fatores que estimulam o crescimento da ovinocultura leiteira, e são considerados oportunidades, de modo que campanhas de marketing para promover o consumo de derivados do leite devem ser realizadas. O pequeno volume de leite produzido gera oportunidades ao setor pela falta de concorrência e pelo grande mercado potencial a ser explorado, especialmente nos grandes centros, com maior poder aquisitivo

The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by zika virus

The northeast (NE) region of Brazil commonly goes through drought periods, which favor cyanobacterial blooms, capable of producing neurotoxins with implications for human and animal health. The most severe dry spell in the history of Brazil occurred between 2012 and 2016. Coincidently, the highest incidence of microcephaly associated with the Zika virus (ZIKV) outbreak took place in the NE region of Brazil during the same years. In this work, we tested the hypothesis that saxitoxin (STX), a neurotoxin produced in South America by the freshwater cyanobacteria Raphidiopsis raciborskii, could have contributed to the most severe Congenital Zika Syndrome (CZS) profile described worldwide. Quality surveillance showed higher cyanobacteria amounts and STX occurrence in human drinking water sup-plies of NE compared to other regions of Brazil. Experimentally, we described that STX dou-bled the quantity of ZIKV-induced neural cell death in progenitor areas of human brain organoids, while the chronic ingestion of water contaminated with STX before and during gestation caused brain abnormalities in offspring of ZIKV-infected immunocompetent C57BL/6J mice. Our data indicate that saxitoxin-producing cyanobacteria is overspread in water reservoirs of the NE and might have acted as a co-insult to ZIKV infection in Brazil. These results raise a public health concern regarding the consequences of arbovirus outbreaks happening in areas with droughts and/or frequent freshwater cyanobacterial blooms.Fil: Pedrosa, Carolina da S. G.. D’Or Institute for Research and Education; BrasilFil: Souza, Leticia R. Q.. D’Or Institute for Research and Education; BrasilFil: Gomes, Tiago A.. Universidade Federal do Rio de Janeiro; Brasil. Instituto Oswaldo Cruz; BrasilFil: de Lima, Caroline V. F.. D’Or Institute for Research and Education; BrasilFil: Ledur, Pitia F.. D’Or Institute for Research and Education; BrasilFil: Karmirian, Karina. D’Or Institute for Research and Education; Brasil. Universidade Federal do Rio de Janeiro; BrasilFil: Barbeito Andrés, Jimena. Universidade Federal do Rio de Janeiro; Brasil. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Costa, Marcelo do N.. Universidade Federal do Rio de Janeiro; BrasilFil: Higa, Luiza M.. Universidade Federal do Rio de Janeiro; BrasilFil: Rossi, Átila D.. Universidade Federal do Rio de Janeiro; BrasilFil: Bellio, Maria. Universidade Federal do Rio de Janeiro; BrasilFil: Tanuri, Amilcar. Universidade Federal do Rio de Janeiro; BrasilFil: Prata Barbosa, Arnaldo. D’Or Institute for Research and Education; BrasilFil: Tovar Moll, Fernanda. D’Or Institute for Research and Education; Brasil. Universidade Federal do Rio de Janeiro; BrasilFil: Garcez, Patricia P.. Universidade Federal do Rio de Janeiro; BrasilFil: Lara, Flavio A.. Instituto Oswaldo Cruz; BrasilFil: Molica, Renato J. R.. Universidad Federal Rural Pernambuco; BrasilFil: Rehen, Stevens K.. D’Or Institute for Research and Education; Brasil. Universidade Federal do Rio de Janeiro; Brasi

ANÁLISE E COMPARAÇÃO DO PERFIL ANTROPOMÉTRICO E POSTURAL DE ADOLESCENTES COM SÍNDROME DE DOWN

O objetivo deste estudo foi analisar e comparar o perfil antropométrico e postural de adolescentes com Síndrome de Down (SD). A amostra foi composta por 36 indivíduos divididos em: Grupo Experimental (GE) com 18 sujeitos com SD (média de idade de 15,16±3,51 anos) e um Grupo Controle (GC) com 18 indivíduos com desenvolvimento típico (média de idade de 13,05±2,26 anos). Para classificação dos dados antropométricos foi utilizado o índice de massa corpórea pela idade (IMC/idade) e para análise da postura o Instrumento de Avaliação Postural. Ao comparar a classificação do IMC/idade entre os grupos, constatou-se que 66,67% do GC foram considerados eutróficos e 33,33% no GE como obesos. Ambos os grupos apresentaram alterações posturais, sendo significativa a presença de joelhos valgos e tronco em rotação à esquerda na vista anterior no GE. Enfatiza-se a importância da avaliação postural na SD para que possíveis alterações posturais sejam evitadas e minimizadas

Age, Successive Waves, Immunization, and Mortality in Elderly COVID-19 Haematological Patients: EPICOVIDEHA Findings

Introduction: elderly patients with haematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection impact in different age groups remains unstudied in detail. Methods: We analysed elderly patients (age groups: 65-70, 71-75, 76-80 and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with haematological malignancy. results: the study included data from 3,603 elderly patients (aged 65 or older) with haematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves.tThe 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukaemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusions: These data underscore the heterogeneity of elderly haematological patients, highlight the different impact of COVID waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts