269 research outputs found
Sub-100 attoseconds optics-to-microwave synchronization
We use two fiber-based femtosecond frequency combs and a low-noise carrier
suppression phase detection system to characterize the optical to microwave
synchronization achievable with such frequency divider systems. By applying
specific noise reduction strategies, a residual phase noise as low as -120
dBc/Hz at 1 Hz offset frequency from a 11.55 GHz carrier is measured. The
fractional frequency instability from a single optical-to-frequency divider is
1.1E-16 at 1 s averaging down to below 2E-19 after only 1000 s. The
corresponding rms time deviation is lower than 100 attoseconds up to 1000 s
averaging duration.Comment: 4 pages, 3 figure
AC Stark-shift in CPT-based Cs miniature atomic clocks
We report on studies on the light-shift in caesium miniature atomic clocks based on coherent population trapping (CPT) using a micro-fabricated buffer-gas cell (MEMS cell). The CPT signal is observed on the Cs D1-line by coupling the two hyperfine ground-state Zeeman sublevels involved in the clock transition to a common excited state, using two coherent electromagnetic fields. These light fields are created with a distributed feedback laser and an electro-optical modulator. We study the light-shift phenomena at different cell temperatures and laser wavelengths around 894.6nm. By adjusting the cell temperature, conditions are identified where a miniature CPT atomic clock can be operated with simultaneously low temperature coefficient and suppressed light-shift. The impact of the light-shift on the clock frequency stability is evaluated. These results are relevant for improving the long-term frequency stability of CPT-based Cs vapour-cell clock
Ultra-Low Noise Microwave Extraction from Fiber-Based Optical Frequency Comb
In this letter, we report on all-optical fiber approach to the generation of
ultra-low noise microwave signals. We make use of two erbium fiber mode-locked
lasers phase locked to a common ultra-stable laser source to generate an 11.55
GHz signal with an unprecedented relative phase noise of -111 dBc/Hz at 1 Hz
from the carrier.The residual frequency instability of the microwave signals
derived from the two optical frequency combs is below 2.3 10^(-16) at 1s and
about 4 10^(-19) at 6.5 10^(4)s (in 5 Hz bandwidth, three days continuous
operation).Comment: 12 pages, 3 figure
Reduction of helium permeation in microfabricated cells using aluminosilicate glass substrates and AlO coatings
The stability and accuracy of atomic devices can be degraded by the evolution
of their cell inner atmosphere. Hence, the undesired entrance or leakage of
background or buffer gas, respectively, that can permeate through the cell
walls, should be slowed down. In this work, we investigate helium permeation in
microfabricated alkali vapor cells filled with He and whose windows are made of
borosilicate glass (BSG) or aluminosilicate glass (ASG). The permeation is then
derived from routine measurements of the pressure-shifted hyperfine transition
frequency of an atomic clock. We first confirm that ASG reduces He permeation
rate by more than two orders of magnitude, in comparison with BSG. In addition,
we demonstrate that AlO thin-film coatings, known to avoid alkali
consumption in vapor cells, can also significantly reduce He permeation. The
permeation through BSG is thereby reduced by a factor 110 whereas the one
through ASG is decreased by a factor up to 5.8 compared to uncoated substrates.
These results may contribute to the development of miniaturized atomic clocks
and sensors with improved long-term stability or sensitivity.Comment: 7 pages, 5 figure
White-faced Darter distribution is associated with coniferous forests in Great Britain
Abstract
1) Understanding of dragonfly distributions is often geographically comprehensive but less so in ecological terms.
2) White-faced darter (Leucorhinnia dubia) is a lowland peatbog specialist dragonfly which has experienced population declines in Great Britain. White-faced darter are thought to rely on peat-rich pool complexes within woodland but this has not yet been empirically tested.
3) We used dragonfly recording data collected by volunteers of the British Dragonfly Society from 2005 to 2018 to model habitat preference for white-faced darter using species distribution models across Great Britain and, with a more detailed landcover dataset, specifically in the North of Scotland.
4) Across the whole of Great Britain our models used the proportion of coniferous forest within 1km as the most important predictor of habitat suitability but were not able to predict all current populations in England.
5) In the North of Scotland our models were more successful and suggest that habitats characterised by native coniferous forest and areas high potential evapotranspiration represent the most suitable habitat for white-faced darter.
6) We recommend that future white-faced darter monitoring should be expanded to include areas currently poorly surveyed but with high suitability in the North of Scotland.
7) Our results also suggest that white-faced darter management should concentrate on maintaining Sphagnum rich pool complexes and the maintenance and restoration of native forests in which these pool complexes occur
Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptorâpositive breast cancers
Introduction
Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by intersecting global gene transcription data from patients treated presurgically with the aromatase inhibitor anastrazole with those from MCF7 cells adapted to long-term oestrogen deprivation (LTED) (2) to assess the clinical value of selected genes in public clinical data sets and (3) to determine the impact of targeting these genes with novel agents.
Methods
Gene expression and Ki67 data were available from 69 postmenopausal women with oestrogen receptorâpositive (ER+) early BC, at baseline and 2 weeks after anastrazole treatment, and from cell lines adapted to LTED. The functional consequences of target genes on proliferation, ER-mediated transcription and downstream cell signalling were assessed.
Results
By intersecting genes predictive of a poor change in Ki67 with those upregulated in LTED cells, we identified 32 genes strongly correlated with poor antiproliferative response that were associated with inflammation and/or immunity. In a panel of LTED cell lines, C-X-C chemokine receptor type 7 (CXCR7) and CXCR4 were upregulated compared to their wild types (wt), and CXCR7, but not CXCR4, was associated with reduced relapse-free survival in patients with ER+ BC. The CXCR4 small interfering RNA variant (siCXCR4) had no specific effect on the proliferation of wt-SUM44, wt-MCF7 and their LTED derivatives. In contrast, siCXCR7, as well as CCX733, a CXCR7 antagonist, specifically suppressed the proliferation of MCF7-LTED cells. siCXCR7 suppressed proteins associated with G1/S transition and inhibited ER transactivation in MCF7-LTED, but not wt-MCF7, by impeding association between ER and proline-, glutamic acidâ and leucine-rich protein 1, an ER coactivator.
Conclusions
These data highlight CXCR7 as a potential therapeutic target warranting clinical investigation in endocrine-resistant BC
Additive Combinatorics and Discrete Logarithm Based Range Protocols
We show how to express an arbitrary integer interval as a sumset of smaller integer intervals for some small values , , and , where and . We show how to derive such expression of as a sumset for any value of , and in particular, how the coefficients can be found by using a nontrivial but efficient algorithm. This result may be interesting by itself in the context of additive combinatorics. Given the sumset-representation of , we show how to decrease both the communication complexity and the computational complexity of the recent pairing-based range proof of Camenisch, Chaabouni and shelat from ASIACRYPT 2008 by a factor of . Our results are important in applications like e-voting where a voting server has to verify thousands of proofs of e-vote correctness per hour. Therefore, our new result in additive combinatorics has direct relevance in practice
Sorptive stabilization of organic matter by amorphous Al hydroxide
Amorphous Al hydroxides (am-Al(OH)3) strongly sorb and by this means likely protect dissolved organic matter (OM) against microbial decay in soils. We carried out batch sorption experiments (pH 4.5; 40 mg organic C L-1) with OM extracted from organic horizons under a Norway spruce and a European beech forest. The stabilization of OM by sorption was analyzed by comparing the CO2 mineralized during the incubation of sorbed and non-sorbed OM. The mineralization of OM was evaluated based in terms of (i) the availability of the am-Al(OH)3, thus surface OM loadings, (ii) spectral properties of OM, and (iii) the presence of phosphate as a competitor for OM. This was done by varying the solid-to-solution ratio (SSR = 0.02-1.2 g L-1) during sorption. At low SSRs, hence limited am-Al(OH)3 availability, only small portions of dissolved OM were sorbed; for OM from Oa horizons, the mineralization of the sorbed fraction exceeded that of the original dissolved OM. The likely reason is competition with phosphate for sorption sites favouring the formation of weak mineral-organic bindings and the surface accumulation of N-rich, less aromatic and less complex OM. This small fraction controlled the mineralization of sorbed OM even at higher SSRs. At higher SSRs, i.e., with am-Al(OH)3 more available, competition of phosphate decreased and aromatic compounds were sorbed selectively, which resulted in pronounced resistance of sorbed OM against decay. The combined OC mineralization of sorbed and non-sorbed OM was 12-65% less than that of the original DOM. Sorbed OM contributed only little to the overall OC mineralization. Stabilization of OC increased in direct proportion to am-Al(OH)3 availability, despite constant aromatic C (~30%). The strong stabilization at higher mineral availability is primarily governed by strong Al-OM bonds formed under less competitive conditions. Due to these strong bonds and the resulting strong stabilization, the surface loading, a proxy for the mineral's occupation by OM, was not a factor in the mineralization of sorbed OM over a wide range of C sorption (0.2-1.1 mg C m-2). This study demonstrates that sorption to am-Al(OH)3 results in stabilization of OM. The mineral availability as well as the inorganic solution chemistry control sorptive interactions, thereby the properties of sorbed OM, and the stability of OM against microbial decay
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