Heavy MSSM Higgs production at the LHC and decays to WW,ZZ at higher orders

In this paper we discuss the production of a heavy scalar MSSM Higgs boson H and its subsequent decays into pairs of electroweak gauge bosons WW and ZZ. We perform a scan over the relevant MSSM parameters, using constraints from direct Higgs searches and several low-energy observables. We then compare the possible size of the pp -> H -> WW,ZZ cross sections with corresponding Standard Model cross sections. We also include the full MSSM vertex corrections to the H -> WW,ZZ decay and combine them with the Higgs propagator corrections, paying special attention to the IR-divergent contributions. We find that the vertex corrections can be as large as -30% in MSSM parameter space regions which are currently probed by Higgs searches at the LHC. Once the sensitivity of these searches reaches two percent of the SM signal strength the vertex corrections can be numerically as important as the leading order and Higgs self-energy corrections and have to be considered when setting limits on MSSM parameters

Determining the Effectiveness of Gender-based Integrated Care for Women Veterans: An Integrative Review

As the Veterans Health Administration (VHA) improves their services to keep up with the needs of the rapidly-rising population of minority veterans, the aspects of gender-sensitive care must be tailored to the needs of women veterans. The purpose of this integrative review was to discover and critique evidence-based research studies of women veterans to determine the state of gender-sensitive care for improving access and coordination care, specifically to enhance mental health approaches needed at VA settings. The women veterans minority population is the fastest growing group of patients in the Department of Veterans Affairs (VA). Women veterans are less likely than their male counterpart to access mental health care or gender-sensitive care services at the VA. Results revealed that twelve research studies are significantly limited for the current state of transforming the care for women veterans, and there are substantial gaps in gender analysis to assess whether the VA’s programs, policies, and initiatives are geared toward integrated issues for this minority group of veterans. The top priorities of improving delivery of gender-sensitive comprehensive care in VA settings must be further explored

The Potential of Goat Meat Acceptance by Young Adults in South Africa

Recent global meat consumption trends report an increase in goat meat consumption as a protein source; however, consumption is not popular in South Africa. Despite goat meat being a nutritious and sustainable source, the willingness to consume goat meat as an acceptable protein source among young adults is not known. The study aims to explore factors that may prevent goat meat consumption and determine the potential for goat meat consumption among young adults from a rural and urban university in KwaZulu-Natal, South Africa. An online meat consumption survey was developed and disseminated through email to students (n=416). Goat meat consumption by young adults was reported to be mainly due to cultural practices. Although most of the participants consumed goat meat, the frequency of consumption was lower than that of chicken, beef and pork. Key barriers to goat meat consumption included a lack of availability, unappealing aroma and allergies. The findings indicated the potential to promote goat meat availability at retail outlets in South Africa, specifically through value-added convenience products. An integrated approach, including consumer education and the increasing availability of goat meat and value-added products, will improve the consumption of this sustainable and nutritious protein source

The Potential of Goat Meat Acceptance by Young Adults in South Africa

Recent global meat consumption trends report an increase in goat meat consumption as a protein source; however, consumption is not popular in South Africa. Despite goat meat being a nutritious and sustainable source, the willingness to consume goat meat as an acceptable protein source among young adults is not known. The study aims to explore factors that may prevent goat meat consumption and determine the potential for goat meat consumption among young adults from a rural and urban university in KwaZulu-Natal, South Africa. An online meat consumption survey was developed and disseminated through email to students (n=416). Goat meat consumption by young adults was reported to be mainly due to cultural practices. Although most of the participants consumed goat meat, the frequency of consumption was lower than that of chicken, beef and pork. Key barriers to goat meat consumption included a lack of availability, unappealing aroma and allergies. The findings indicated the potential to promote goat meat availability at retail outlets in South Africa, specifically through value-added convenience products. An integrated approach, including consumer education and the increasing availability of goat meat and value-added products, will improve the consumption of this sustainable and nutritious protein source

The Potential of Goat Meat Acceptance by Young Adults in South Africa

Recent global meat consumption trends report an increase in goat meat consumption as a protein source; however, consumption is not popular in South Africa. Despite goat meat being a nutritious and sustainable source, the willingness to consume goat meat as an acceptable protein source among young adults is not known. The study aims to explore factors that may prevent goat meat consumption and determine the potential for goat meat consumption among young adults from a rural and urban university in KwaZulu-Natal, South Africa. An online meat consumption survey was developed and disseminated through email to students (n=416). Goat meat consumption by young adults was reported to be mainly due to cultural practices. Although most of the participants consumed goat meat, the frequency of consumption was lower than that of chicken, beef and pork. Key barriers to goat meat consumption included a lack of availability, unappealing aroma and allergies. The findings indicated the potential to promote goat meat availability at retail outlets in South Africa, specifically through value-added convenience products. An integrated approach, including consumer education and the increasing availability of goat meat and value-added products, will improve the consumption of this sustainable and nutritious protein source

A randomised controlled trial of computerised cognitive behaviour therapy for the treatment of depression in primary care: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial.

BACKGROUND: Computerised cognitive behaviour therapy (cCBT) has been developed as an efficient form of therapy delivery with the potential to enhance access to psychological care. Independent research is needed which examines both the clinical effectiveness and cost-effectiveness of cCBT over the short and longer term. OBJECTIVES: To compare the clinical effectiveness and cost-effectiveness of cCBT as an adjunct to usual general practitioner (GP) care against usual GP care alone, for a free-to-use cCBT program (MoodGYM; National Institute for Mental Health Research, Australian National University, Canberra, Australia) and a commercial pay-to-use cCBT program (Beating the Blues(®); Ultrasis, London, UK) for adults with depression, and to determine the acceptability of cCBT and the experiences of users. DESIGN: A pragmatic, multicentre, three-armed, parallel, randomised controlled trial (RCT) with concurrent economic and qualitative evaluations. Simple randomisation was used. Participants and researchers were not blind to treatment allocation. SETTING: Primary care in England. PARTICIPANTS: Adults with depression who scored ≥ 10 on the Patient Health Questionnaire-9 (PHQ-9). INTERVENTIONS: Participants who were randomised to either of the two intervention groups received cCBT (Beating the Blues or MoodGYM) in addition to usual GP care. Participants who were randomised to the control group were offered usual GP care. MAIN OUTCOME MEASURES: The primary outcome was depression at 4 months (PHQ-9). Secondary outcomes were depression at 12 and 24 months; measures of mental health and health-related quality of life at 4, 12 and 24 months; treatment preference; and the acceptability of cCBT and experiences of users. RESULTS: Clinical effectiveness: 210 patients were randomised to Beating the Blues, 242 patients were randomised to MoodGYM and 239 patients were randomised to usual GP care (total 691). There was no difference in the primary outcome (depression measured at 4 months) either between Beating the Blues and usual GP care [odds ratio (OR) 1.19, 95% confidence interval (CI) 0.75 to 1.88] or between MoodGYM and usual GP care (OR 0.98, 95% CI 0.62 to 1.56). There was no overall difference across all time points for either intervention compared with usual GP care in a mixed model (Beating the Blues versus usual GP care, p = 0.96; and MoodGYM versus usual GP care, p = 0.11). However, a small but statistically significant difference between MoodGYM and usual GP care at 12 months was found (OR 0.56, 95% CI 0.34 to 0.93). Free-to-use cCBT (MoodGYM) was not inferior to pay-to-use cCBT (Beating the Blues) (OR 0.91, 90% CI 0.62 to 1.34; p = 0.69). There were no consistent benefits of either intervention when secondary outcomes were examined. There were no serious adverse events thought likely to be related to the trial intervention. Despite the provision of regular technical telephone support, there was low uptake of the cCBT programs. Cost-effectiveness: cost-effectiveness analyses suggest that neither Beating the Blues nor MoodGYM appeared cost-effective compared with usual GP care alone. Qualitative evaluation: participants were often demotivated to access the computer programs, by reason of depression. Some expressed the view that a greater level of therapeutic input would be needed to promote engagement. CONCLUSIONS: The benefits that have previously been observed in developer-led trials were not found in this large pragmatic RCT. The benefits of cCBT when added to routine primary care were minimal, and uptake of this mode of therapy was relatively low. There remains a clinical and economic need for effective low-intensity psychological treatments for depression with improved patient engagement. TRIAL REGISTRATION: This trial is registered as ISRCTN91947481. FUNDING: This project was funded by the National Institute for Health Research Health Technology Assessment programme

Measuring global ocean heat content to estimate the earth energy imbalance

The energy radiated by the Earth toward space does not compensate the incoming radiation from the Sun leading to a small positive energy imbalance at the top of the atmosphere (0.4–1 Wm–2). This imbalance is coined Earth’s Energy Imbalance (EEI). It is mostly caused by anthropogenic greenhouse gas emissions and is driving the current warming of the planet. Precise monitoring of EEI is critical to assess the current status of climate change and the future evolution of climate. But the monitoring of EEI is challenging as EEI is two orders of magnitude smaller than the radiation fluxes in and out of the Earth system. Over 93% of the excess energy that is gained by the Earth in response to the positive EEI accumulates into the ocean in the form of heat. This accumulation of heat can be tracked with the ocean observing system such that today, the monitoring of Ocean Heat Content (OHC) and its long-term change provide the most efficient approach to estimate EEI. In this community paper we review the current four state-of-the-art methods to estimate global OHC changes and evaluate their relevance to derive EEI estimates on different time scales. These four methods make use of: (1) direct observations of in situ temperature; (2) satellite-based measurements of the ocean surface net heat fluxes; (3) satellite-based estimates of the thermal expansion of the ocean and (4) ocean reanalyses that assimilate observations from both satellite and in situ instruments. For each method we review the potential and the uncertainty of the method to estimate global OHC changes. We also analyze gaps in the current capability of each method and identify ways of progress for the future to fulfill the requirements of EEI monitoring. Achieving the observation of EEI with sufficient accuracy will depend on merging the remote sensing techniques with in situ measurements of key variables as an integral part of the Ocean Observing System

Heat stored in the Earth system:where does the energy go?

Human-induced atmospheric composition changes cause a radiative imbalance at the top of the atmosphere which is driving global warming. This Earth energy imbalance (EEI) is the most critical number defining the prospects for continued global warming and climate change. Understanding the heat gain of the Earth system – and particularly how much and where the heat is distributed – is fundamental to understanding how this affects warming ocean, atmosphere and land; rising surface temperature; sea level; and loss of grounded and floating ice, which are fundamental concerns for society. This study is a Global Climate Observing System (GCOS) concerted international effort to update the Earth heat inventory and presents an updated assessment of ocean warming estimates as well as new and updated estimates of heat gain in the atmosphere, cryosphere and land over the period 1960–2018. The study obtains a consistent long-term Earth system heat gain over the period 1971–2018, with a total heat gain of 358±37 ZJ, which is equivalent to a global heating rate of 0.47±0.1 W m−2. Over the period 1971–2018 (2010–2018), the majority of heat gain is reported for the global ocean with 89 % (90 %), with 52 % for both periods in the upper 700 m depth, 28 % (30 %) for the 700–2000 m depth layer and 9 % (8 %) below 2000 m depth. Heat gain over land amounts to 6 % (5 %) over these periods, 4 % (3 %) is available for the melting of grounded and floating ice, and 1 % (2 %) is available for atmospheric warming. Our results also show that EEI is not only continuing, but also increasing: the EEI amounts to 0.87±0.12 W m−2 during 2010–2018. Stabilization of climate, the goal of the universally agreed United Nations Framework Convention on Climate Change (UNFCCC) in 1992 and the Paris Agreement in 2015, requires that EEI be reduced to approximately zero to achieve Earth's system quasi-equilibrium. The amount of CO2 in the atmosphere would need to be reduced from 410 to 353 ppm to increase heat radiation to space by 0.87 W m−2, bringing Earth back towards energy balance. This simple number, EEI, is the most fundamental metric that the scientific community and public must be aware of as the measure of how well the world is doing in the task of bringing climate change under control, and we call for an implementation of the EEI into the global stocktake based on best available science. Continued quantification and reduced uncertainties in the Earth heat inventory can be best achieved through the maintenance of the current global climate observing system, its extension into areas of gaps in the sampling, and the establishment of an international framework for concerted multidisciplinary research of the Earth heat inventory as presented in this study. This Earth heat inventory is published at the German Climate Computing Centre (DKRZ, https://www.dkrz.de/, last access: 7 August 2020) under the DOI https://doi.org/10.26050/WDCC/GCOS_EHI_EXP_v2 (von Schuckmann et al., 2020)

Evolving the Physical Global Ocean Observing System for Research and Application Services Through International Coordination

Climate change and variability are major societal challenges, and the ocean is an integral part of this complex and variable system. Key to the understanding of the ocean's role in the Earth's climate system is the study of ocean and sea-ice physical processes, including its interactions with the atmosphere, cryosphere, land and biosphere. These processes include those linked to ocean circulation; the storage and redistribution of heat, carbon, salt and other water properties; and air-sea exchanges of heat, momentum, freshwater, carbon and other gasses. Measurements of ocean physics variables are fundamental to reliable earth prediction systems for a range of applications and users. In addition, knowledge of the physical environment is fundamental to growing understanding of the ocean's biogeochemistry and biological/ecosystem variability and function. Through the progress from OceanObs'99 to OceanObs'09, the ocean observing system has evolved from a platform centric perspective to an integrated observing system. The challenge now is for the observing system to evolve to respond to an increasingly diverse end user group. The Ocean Observations Physics and Climate panel (OOPC), formed in 1995, has undertaken many activities that led to observing system-related agreements. Here, OOPC will explore the opportunities and challenges for the development of a fit-for-purpose, sustained and prioritized ocean observing system, focusing on physical variables that maximize support for fundamental research, climate monitoring, forecasting on different timescales, and society. OOPC recommendations are guided by the Framework for Ocean Observing (Lindstrom et al. 2012) which emphasizes identifying user requirements by considering time and space scales of the Essential Ocean Variables. This approach provides a framework for reviewing the adequacy of the observing system, looking for synergies in delivering an integrated observing system for a range of applications and focusing innovation in areas where existing technologies do not meet these requirement

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth