4,790 research outputs found
Assessing seismic efficiency from scalar Moment-rates: an application to Mt. Etna volcano (Italy)
Here we propose an improved estimation of the scalar seismic (from instrumental and historical catalogues), geodetic and geologic moment-rates for the eastern flank of Mt. Etna. The estimated moment-rates have been compared in terms of seismic efficiency. Results show that all the calculated efficiency values are lower than 40%, i.e., the geodetic moment-rate estimations are generally larger than the seismic and the geologic ones. Although a number of reasons may account for the observed discrepancy, we are confident that a large amount of the deformation affecting the eastern flank occurs aseismically
Study of the reaction pbar p -> phi phi from 1.1 to 2.0 GeV/c
A study has been performed of the reaction pbar p -> 4K using in-flight
antiprotons from 1.1 to 2.0 GeV/c incident momentum interacting with a hydrogen
jet target. The reaction is dominated by the production of a pair of phi
mesons. The pbar p -> phi phi cross section rises sharply above threshold and
then falls continuously as a function of increasing antiproton momentum. The
overall magnitude of the cross section exceeds expectations from a simple
application of the OZI rule by two orders of magnitude. In a fine scan around
the xi/f_J(2230) resonance, no structure is observed. A limit is set for the
double branching ratio B(xi -> pbar p) * B(xi -> phi phi) < 6e-5 for a spin 2
resonance of M = 2.235 GeV and Width = 15 MeV.Comment: 13 pages, 13 figures, 2 tables, Latex. To be published in Phys. Rev.
Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance
Multiple myeloma is still incurable due to an intrinsic aggressiveness or, more frequently, to the interactions of malignant plasma cells with bone marrow microenvironment. Myeloma cells educate bone marrow cells to support neoplastic cell growth, survival, acquisition of drug resistance resulting in disease relapse. Myeloma microenvironment is characterized by Notch signaling hyperactivation due to the increased expression of Notch1 and 2 and the ligands Jagged1 and 2 in tumor cells. Notch activation influences myeloma cell biology and promotes the reprogramming of bone marrow stromal cells. In this work we demonstrate, by in vitro, ex vivo and using a zebrafish multiple myeloma model, that Jagged inhibition causes a decrease in both myeloma-intrinsic and stromal cell-induced resistance to currently used drugs, i.e. bortezomib, lenalidomide and melphalan. The molecular mechanism of drug resistance involves the chemokine system CXCR4/SDF1\u3b1. Myeloma cell-derived Jagged ligands trigger Notch activity in bone marrow stromal cells. These, in turn, secrete higher levels of SDF1\u3b1 in the bone marrow microenvironment increasing CXCR4 activation in myeloma cells, which is further potentiated by the concomitant increased expression of this receptor induced by Notch activation. Consistently with the augmented pharmacological resistance, SDF1\u3b1 boosts the expression of BCL2, Survivin and ABCC1. These results indicate that a Jagged-tailored approach may contribute to disrupting the pharmacological resistance due to intrinsic myeloma cell features or to the pathological interplay with bone marrow stromal cells and, conceivably, improve patients' response to standard-of-care therapies
On the influence of the cosmological constant on gravitational lensing in small systems
The cosmological constant Lambda affects gravitational lensing phenomena. The
contribution of Lambda to the observable angular positions of multiple images
and to their amplification and time delay is here computed through a study in
the weak deflection limit of the equations of motion in the Schwarzschild-de
Sitter metric. Due to Lambda the unresolved images are slightly demagnified,
the radius of the Einstein ring decreases and the time delay increases. The
effect is however negligible for near lenses. In the case of null cosmological
constant, we provide some updated results on lensing by a Schwarzschild black
hole.Comment: 8 pages, 1 figure; v2: extended discussion on the lens equation,
references added, results unchanged, in press on PR
Measurement of Branching Fractions and Rate Asymmetries in the Rare Decays B -> K(*) l+ l-
In a sample of 471 million BB events collected with the BABAR detector at the
PEP-II e+e- collider we study the rare decays B -> K(*) l+ l-, where l+ l- is
either e+e- or mu+mu-. We report results on partial branching fractions and
isospin asymmetries in seven bins of di-lepton mass-squared. We further present
CP and lepton-flavor asymmetries for di-lepton masses below and above the J/psi
resonance. We find no evidence for CP or lepton-flavor violation. The partial
branching fractions and isospin asymmetries are consistent with the Standard
Model predictions and with results from other experiments.Comment: 16 pages, 14 figures, accepted by Phys. Rev.
Measurement of the mass and lifetime of the baryon
A proton-proton collision data sample, corresponding to an integrated
luminosity of 3 fb collected by LHCb at and 8 TeV, is used
to reconstruct , decays. Using the , decay mode for calibration, the lifetime ratio and absolute
lifetime of the baryon are measured to be \begin{align*}
\frac{\tau_{\Omega_b^-}}{\tau_{\Xi_b^-}} &= 1.11\pm0.16\pm0.03, \\
\tau_{\Omega_b^-} &= 1.78\pm0.26\pm0.05\pm0.06~{\rm ps}, \end{align*} where the
uncertainties are statistical, systematic and from the calibration mode (for
only). A measurement is also made of the mass difference,
, and the corresponding mass, which
yields \begin{align*} m_{\Omega_b^-}-m_{\Xi_b^-} &= 247.4\pm3.2\pm0.5~{\rm
MeV}/c^2, \\ m_{\Omega_b^-} &= 6045.1\pm3.2\pm 0.5\pm0.6~{\rm MeV}/c^2.
\end{align*} These results are consistent with previous measurements.Comment: 11 pages, 5 figures, All figures and tables, along with any
supplementary material and additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-008.htm
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