ANALISIS PENGARUH MOTIVASI KERJA DAN FAKTOR KOGNISI PEKERJA TERHADAP KEMAMPUAN KERJA SERTA DAMPAKNYA TERHADAP PERFORMANSI KERJA (STUDI KASUS DI PT. SANKEN INDONESIA-BEKASI)

Makalah ini bertujuan untuk memperkirakan berapa besar pengaruh yang diberikan dari variabel Motivasi Kerja dan Kognisi Pekerja terhadap Kemampuan Kerja serta dampaknya terhadap Performansi di PT. SANKEN INDONESIA dengan menggunakan analisis jalur (Path Analysis), dengan tujuan menerangkan akibat langsung dan tidak langsung seperangkat variabel sebagai variabel penyebab (eksogenus) terhadap seperangkat variabel lainnya yang merupakan variabel akibat (endogenus). Berdasarkan pengolahan data dengan menggunakan analisis jalur menunjukkan bahwa pengaruh antara variabel Motivasi Kerja dan Kognisi Pekerja terhadap Kemampuan Kerja memberikan kontribusi sebesar 38 %, sedangkan faktor lain diluar variabel penelitian yang tidak teridentifikasi oleh model penelitian dan dapat mempengaruhi peningkatan serta penurunan Kemampuan Kerja adalah sebesar 62%. Sedangkan pengaruh antara variabel Motivasi Kerja (X1), Kognisi Pekerja (X2) dan Kemampuan Kerja (Y) terhadap Performansi Kerja (Z) adalah sebesar 56%, sedangkan faktor lain diluar variabel penelitian yang tidak teridentifikasi oleh model penelitian dan dapat mempengaruhi peningkatan serta penurunan Performansi Kerja (Z) adalah sebesar 44 %. Kata Kunci : Ergonomi Industri, Analisis Jalur, Faktor Kognisi, Ergonomi Kogniti

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Glossina palpalis palpalis populations from Equatorial Guinea belong to distinct allopatric clades

[Background] Luba is one of the four historical foci of Human African Trypanosomiasis (HAT) on Bioko Island, in Equatorial Guinea. Although no human cases have been detected since 1995, T. b. gambiense was recently observed in the vector Glossina palpalis palpalis. The existence of cryptic species within this vector taxon has been previously suggested, although no data are available regarding the evolutionary history of tsetse flies populations in Bioko.[Methods] A phylogenetic analysis of 60 G. p. palpalis from Luba was performed sequencing three mitochondrial (COI, ND2 and 16S) and one nuclear (rDNA-ITS1) DNA markers. Phylogeny reconstruction was performed by Distance Based, Maximum Likelihood and Bayesian Inference methods.[Results] The COI and ND2 mitochondrial genes were concatenated and revealed 10 closely related haplotypes with a dominant one found in 61.1% of the flies. The sequence homology of the other 9 haplotypes compared to the former ranged from 99.6 to 99.9%. Phylogenetic analysis clearly clustered all island samples with flies coming from the Western African Clade (WAC), and separated from the flies belonging to the Central Africa Clade (CAC), including samples from Mbini and Kogo, two foci of mainland Equatorial Guinea. Consistent with mitochondrial data, analysis of the microsatellite motif present in the ITS1 sequence exhibited two closely related genotypes, clearly divergent from the genotypes previously identified in Mbini and Kogo.[Conclusions] We report herein that tsetse flies populations circulating in Equatorial Guinea are composed of two allopatric subspecies, one insular and the other continental. The presence of these two G. p. palpalis cryptic taxa in Equatorial Guinea should be taken into account to accurately manage vector control strategy, in a country where trypanosomiasis transmission is controlled but not definitively eliminated yet.This work has been supported by ‘Fondo de Investigacion Sanitaria (FIS)’ (PI10/01128) and by VI PN de I + D + I 2008–2011, ISCIII -Subdirección General de Redes y Centros de Investigación Cooperativa RD12/0018/0001 and RD12/0018/0015 (RICET). JMB is supported by Miguel Servet Fellowship CP09/00300.Peer Reviewe

Uso de la rapamicina y derivados para el tratamiento de la tripanosomiasis africana

[EN] Use of a composition that comprises a TbTOR-inhibiting agent, rapamycin or any of the salts, prodrugs, derivatives or analogues thereof, for the preparation of a drug to prevent and treat African trypanosomiasis.[ES] Uso de una composición que comprende un agente inhibidor de TbTOR, la rapamicina o cualquiera de sus sales, profármacos, derivados o análogos, para la elaboración de un medicamento para la prevención o el tratamiento de Ia tripanosomiasis africana.Peer reviewedConsejo Superior de Investigaciones Científicas (España)A1 Solicitud de patentes con informe sobre el estado de la técnic

Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity

Trypanosoma brucei gambiense infection is widely considered an anthroponosis, although it has also been found in wild and domestic animals. Thus, fauna could act as reservoir, constraining the elimination of the parasite in hypo-endemic foci. To better understand the possible maintenance of T. b. gambiense in local fauna and investigate the molecular mechanisms underlying adaptation, we generated adapted cells lines (ACLs) by in vitro culture of the parasites in different mammalian sera. Using specific antibodies against the Variant Surface Glycoproteins (VSGs) we found that serum ACLs exhibited different VSG variants when maintained in pig, goat or human sera. Although newly detected VSGs were independent of the sera used, the consistent appearance of different VSGs suggested remodelling of the co-transcribed genes at the telomeric Expression Site (VSG-ES). Thus, Expression Site Associated Genes (ESAGs) sequences were analysed to investigate possible polymorphism selection. ESAGs 6 and 7 genotypes, encoding the transferrin receptor (TfR), expressed in different ACLs were characterised. In addition, we quantified the ESAG6/7 mRNA levels and analysed transferrin (Tf) uptake. Interestingly, the best growth occurred in pig and human serum ACLs, which consistently exhibited a predominant ESAG7 genotype and higher Tf uptake than those obtained in calf and goat sera. We also detected an apparent selection of specific ESAG3 genotypes in the pig and human serum ACLs, suggesting that other ESAGs could be involved in the host adaptation processes. Altogether, these results suggest a model whereby VSG-ES remodelling allows the parasite to express a specific set of ESAGs to provide selective advantages in different hosts. Finally, pig serum ACLs display phenotypic adaptation parameters closely related to human serum ACLs but distinct to parasites grown in calf and goat sera. These results suggest a better suitability of swine to maintain T. b. gambiense infection supporting previous epidemiological results. Figures 12 Citation: Cordon-Obras C, Cano J, González-Pacanowska D, Benito A, Navarro M, et al. (2013) Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity. PLoS ONE 8(12): e85072. doi:10.1371/journal.pone.0085072 Editor: Mauricio Martins Rodrigues, Federal University of São Paulo, Brazil Received: July 31, 2013; Accepted: November 21, 2013; Published: December 23, 2013 Copyright: © 2013 Cordon-Obras et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by grants from the Spanish Ministerio de Ciencia e Innovación, Plan Nacional (SAF2012-40029), Junta de Andalucia (CTS-5841), Fondo de Investigación Sanitaria (FIS) PI10/01128 and VI PN de I+D+I 2008-2011, ISCIII -Subdirección General de Redes y Centros de Investigación Cooperativa (RICET) RD12/0018/0001 and RD12/0018/0015. JMB is supported by a Miguel Servet Fellowship CP09/00300. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.Peer reviewe

Selection of thermoplastic polymers for use as bipolar plates in direct methanol fuel cell applications

The use of polymers in direct methanol fuel cells (DMFCs) would reduce their density and cost, thereby enhanc-ing their commercialization. This work aims to select the most appropriate materials among seven thermoplasticpolymers (ABS, CPE, CPE+, Nylon, PC, PLA and TPU 95A) for use as bipolar plates (BPs) for different applicationsof DMFCs. For that purpose, four multi-criteria decision-making (MCDM) methods (TOPSIS, COPRAS, SAW andAHP) are applied to resolve the problems of material selection. In addition, long-term experiments with thesepolymers have been carried out in a simulated environment that reproduces the conditions inside DMFCs inorder to collect reliable data on the behaviour of the materials during the selection process. According to the re-sults of the experiments, PLA is not an appropriate material for DMFCs because of its extreme degradation in ashort period of time. On the contrary, ABS, CPE+ and PC exhibit promising properties, but identifying the propermaterial for a concrete application with confidence evidently requires the use of MCDM methods. By applyingsuch methods, it is concluded that ABS is the preferred material for stationary and small portable DMFC applica-tions whereas PC is the most appropriate material for DMFCs on board UAVs

New electrodes prepared by Pt/Ru e-beam evaporation for application in fuel cell

Direct methanol fuel cells (DMFC), as environmentally friendly energy devices, are being intensively studied due to their numerous advantages with respect to other energy storing systems, including low environmental impact, high-energy density, high-efficiency and low noise, portable applications. One of the main problems of these fuel cells is the cost of the MEA due to the platinum content as catalyst. The Pt-Rub binary alloy electrocatalyst appears as the most promising formulation to oxidize the methanol at DMFC anodes. Pt sites in Pt-Ru alloys are especially involved in both the methanol dehydrogenation step and strong chemisorption of methanol residues. The aim of this work is to investigate the electron beam evaporation for preparing Pt/Ru layers deposited on the un-catalysed gas diffussion layers for DMFC, Freudenberg H2215 T10A. Pt/Ruf films in atomic ratio 1:1(50.4µg Pt cm2, 26.1 µg Ru cm2) were evaporated in a vacuum chamber using an e-beam evaporator QUAD-EV-C, Mantis. Electrochemical measurements were carried out in a three electrode cell with a Pt wire used as auxiliary electrode connected to a Schlumbeger 1286 potentiostast/galvanostat connected to a frequency analyser Solarton 1255B. The prepared e-beam PtRu electrode and a commercial of 3 mg PtRu cm2, BC-M100-30F T10A were measured using membrane electrode assemblies (MEAs) in a single DMFC of 3.8 cm2 of active area. A commercial cathode: Quintech H2315 IX91CX320 containing 1mgPt cm2 has been used to fabricate the MEAs. Polarization curves were registered at different temperatures and methanol concentrations with each DMFC. The electrochemical behaviour of the catalyst support and the electrodes has been studied by cyclicvoltammetry in 0.5M H2SO4 and O.5M H2SO4+1M MeOH medium. The electrochemical active surfaces were determined and their morphological characteristics were examined by SEM. Low Pt/Ru electrodes shows more electroactivity than carbon paper without e-beam evaporation and they are also comparable with commercial ones. The e-beam MEA maximum power density (Wm, mW per mg of PtRu at the anode) is higher than that of the commercial MEA. At 80ºC and 1M of methanol the ratio between Wm of e-beam and commercial MEAs is 3.5. This ratio decreases when the temperature decreases, but it is always greater than 1. Thus, PtRu e-beam electrode makes better use of the catalyst. Therefore, at low Pt-Ru loadings, the e-beam evaporation technique seems to be an easily scalable preparation method for fuel cell electrodes

Long-term corrosion tests of stainless steel and aluminium alloys in simulated direct methanol fuel cell environments

Estudio de materiales para placas bipolares

Study of a DMFC crossover at different temperatures using a polarization curve model

The study of the fuel crossover is one of the most sensi-tive aspects to consider when designing a power generation system of which a DMFC is part, especially during low power operation, when the significance of this phenomenon in the reduction of the electric efficiency of the fuel cell is maxi-mum