298 research outputs found
Location-independent and location-linked representations of sound objects.
For the recognition of sounds to benefit perception and action, their neural representations should also encode their current spatial position and their changes in position over time. The dual-stream model of auditory processing postulates separate (albeit interacting) processing streams for sound meaning and for sound location. Using a repetition priming paradigm in conjunction with distributed source modeling of auditory evoked potentials, we determined how individual sound objects are represented within these streams. Changes in perceived location were induced by interaural intensity differences, and sound location was either held constant or shifted across initial and repeated presentations (from one hemispace to the other in the main experiment or between locations within the right hemispace in a follow-up experiment). Location-linked representations were characterized by differences in priming effects between pairs presented to the same vs. different simulated lateralizations. These effects were significant at 20-39 ms post-stimulus onset within a cluster on the posterior part of the left superior and middle temporal gyri; and at 143-162 ms within a cluster on the left inferior and middle frontal gyri. Location-independent representations were characterized by a difference between initial and repeated presentations, independently of whether or not their simulated lateralization was held constant across repetitions. This effect was significant at 42-63 ms within three clusters on the right temporo-frontal region; and at 165-215 ms in a large cluster on the left temporo-parietal convexity. Our results reveal two varieties of representations of sound objects within the ventral/What stream: one location-independent, as initially postulated in the dual-stream model, and the other location-linked
Neural plasticity associated with recently versus often heard objects.
In natural settings the same sound source is often heard repeatedly, with variations in spectro-temporal and spatial characteristics. We investigated how such repetitions influence sound representations and in particular how auditory cortices keep track of recently vs. often heard objects. A set of 40 environmental sounds was presented twice, i.e. as prime and as repeat, while subjects categorized the corresponding sound sources as living vs. non-living. Electrical neuroimaging analyses were applied to auditory evoked potentials (AEPs) comparing primes vs. repeats (effect of presentation) and the four experimental sections. Dynamic analysis of distributed source estimations revealed i) a significant main effect of presentation within the left temporal convexity at 164-215ms post-stimulus onset; and ii) a significant main effect of section in the right temporo-parietal junction at 166-213ms. A 3-way repeated measures ANOVA (hemisphere×presentation×section) applied to neural activity of the above clusters during the common time window confirmed the specificity of the left hemisphere for the effect of presentation, but not that of the right hemisphere for the effect of section. In conclusion, spatio-temporal dynamics of neural activity encode the temporal history of exposure to sound objects. Rapidly occurring plastic changes within the semantic representations of the left hemisphere keep track of objects heard a few seconds before, independent of the more general sound exposure history. Progressively occurring and more long-lasting plastic changes occurring predominantly within right hemispheric networks, which are known to code for perceptual, semantic and spatial aspects of sound objects, keep track of multiple exposures
Assessment of resolution and accuracy of the Moving Window Cross Spectral technique for monitoring crustal temporal variations using ambient seismic noise.
International audienceTemporal variations in the elastic behaviour of the Earth's crust can be monitored through the analysis of the Earth's seismic response and its evolution with time. This kind of analysis is particularly interesting when combined with the reconstruction of seismic Green's functions from the cross-correlation of ambient seismic noise, which circumvents the limitations imposed by a dependence on the occurrence of seismic events. In fact, because seismic noise is recorded continuously and does not depend on earthquake sources, these cross-correlation functions can be considered analogously to records from continuously repeating doublet sources placed at each station, and can be used to extract observations of variations in seismic velocities. These variations, however, are typically very small: of the order of 0.1 per cent. Such accuracy can be only achieved through the analysis of the full reconstructed waveforms, including later scattered arrivals. We focus on the method known as Moving-Window Cross-Spectral Analysis that has the advantage of operating in the frequency domain, where the bandwidth of coherent signal in the correlation function can be clearly defined. We investigate the sensitivity of this method by applying it to microseismic noise cross-correlations which have been perturbed by small synthetic velocity variations and which have been randomly contaminated. We propose threshold signal-to-noise ratios above which these perturbations can be reliably observed. Such values are a proxy for cross-correlation convergence, and so can be used as a guideline when determining the length of microseismic noise records that are required before they can be used for monitoring with the moving-window cross-spectral technique
Representation of Sound Objects within Early-Stage Auditory Areas: A Repetition Effect Study Using 7T fMRI.
Environmental sounds are highly complex stimuli whose recognition depends on the interaction of top-down and bottom-up processes in the brain. Their semantic representations were shown to yield repetition suppression effects, i. e. a decrease in activity during exposure to a sound that is perceived as belonging to the same source as a preceding sound. Making use of the high spatial resolution of 7T fMRI we have investigated the representations of sound objects within early-stage auditory areas on the supratemporal plane. The primary auditory cortex was identified by means of tonotopic mapping and the non-primary areas by comparison with previous histological studies. Repeated presentations of different exemplars of the same sound source, as compared to the presentation of different sound sources, yielded significant repetition suppression effects within a subset of early-stage areas. This effect was found within the right hemisphere in primary areas A1 and R as well as two non-primary areas on the antero-medial part of the planum temporale, and within the left hemisphere in A1 and a non-primary area on the medial part of Heschl's gyrus. Thus, several, but not all early-stage auditory areas encode the meaning of environmental sounds
Skeletal Immaturity, Rostral Sparing, and Disparate Hip Morphologies as Biomechanical Causes for Legg-Calve-Perthes’ Disease
Legg-Calvé-Perthes’ (Perthes’) disease is a developmental disease of the hip joint that may result
in numerous short and long term problems. The aetiology of the disease remains largely unknown, but
the mechanism is believed to be vascular and/or biomechanical in nature. There are several anatomical
characteristics that tend to be prevalent in children with Perthes’ disease, namely: skeletal immaturity,
reduced height and rostral sparing. We present an overview of the literature, summarising the current
understanding of the pathogenesis, particularly related to how the formation of the vasculature to the
femoral epiphysis places children aged 5-8 at a higher risk for Perthes’ disease, how skeletal immaturity
and rostral sparing could increase the probability of developing Perthes’ disease, and how animal
models have aided our understanding of the disease. In doing so, we also explore why Perthes’ disease
is correlated to latitude, with populations at higher latitudes having higher incidence rates than
populations closer to the Equator. Finally, we present five hypotheses detailing how Perthes’ disease
could have a biomechanical cause
B(E1) Strengths from Coulomb Excitation of 11Be
The (E1;) strength for Be has been extracted from
intermediate energy Coulomb excitation measurements, over a range of beam
energies using a new reaction model, the extended continuum discretized coupled
channels (XCDCC) method. In addition, a measurement of the excitation cross
section for Be+Pb at 38.6 MeV/nucleon is reported. The (E1)
strength of 0.105(12) efm derived from this measurement is consistent
with those made previously at 60 and 64 MeV/nucleon, i n contrast to an
anomalously low result obtained at 43 MeV/nucleon. By coupling a
multi-configuration description of the projectile structure with realistic
reaction theory, the XCDCC model provides for the first time a fully quantum
mechanical description of Coulomb excitation. The XCDCC calculations reveal
that the excitation process involves significant contributions from nuclear,
continuum, and higher-order effects. An analysis of the present and two earlier
intermediate energy measurements yields a combined B(E1) strength of 0.105(7)
efm. This value is in good agreement with the value deduced
independently from the lifetime of the state in Be, and has a
comparable p recision.Comment: 5 pages, 2 figures, accepted for publication in Phys. Lett.
Single-Proton Removal Reaction Study of 16B
The low-lying level structure of the unbound system B has been
investigated via single-proton removal from a 35 MeV/nucleon C beam. The
coincident detection of the beam velocity B fragment and neutron allowed
the relative energy of the in-flight decay of B to be reconstructed. The
resulting spectrum exhibited a narrow peak some 85 keV above threshold. It is
argued that this feature corresponds to a very narrow (100 keV)
resonance, or an unresolved multiplet, with a dominant + configuration which decays by d-wave neutron
emission.Comment: 16 pages, 5 figures, 1 table, submitted to Phys. Lett.
Helium Clustering in Neutron-Rich Be Isotopes
Measurements of the helium-cluster breakup and neutron removal cross sections
for neutron-rich Be isotopes A=10-12,14 are presented. These have been studied
in the 30 to 42 MeV/u energy range where reaction measurements are proposed to
be sensitive to the cluster content of the ground-state wave-function. These
measurements provide a comprehensive survey of the decay processes of the Be
isotopes by which the valence neutrons are removed revealing the underlying
alpha-alpha core-cluster structure. The measurements indicate that clustering
in the Be isotopes remains important up to the drip-line nucleus 14^Be and that
the dominant helium-cluster structure in the neutron-rich Be isotopes
corresponds to alpha-Xn-alpha.Comment: 5 pages, 2 tables and 3 figure
One-neutron removal reactions on neutron-rich psd-shell nuclei
A systematic study of high energy, one-neutron removal reactions on 23
neutron-rich, psd--shell nuclei (Z=5-9, A=12-25) has been carried out. The
longitudinal momentum distributions of the core fragments and corresponding
single-neutron removal cross sections are reported for reactions on a carbon
target. Extended Glauber model calculations, weighted by the spectroscopic
factors obtained from shell model calculations, are compared to the
experimental results. Conclusions are drawn regarding the use of such reactions
as a spectroscopic tool and spin-parity assignments are proposed for 15B, 17C,
19-21N, 21,23O, 23-25F. The nature of the weakly bound systems 14B and 15,17C
is discussed.Comment: 11 pages + 2 figure
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