Potencial productivo y calidad de chile serrano autóctono en el municipio de Tlaola, Puebla

"El proyecto de investigación se realizó en los municipios de Tlaola y Tlapacoya de la sierra norte del Estado de Puebla y en la ciudad de Puebla, previo a los ensayos de campo se realizó una encuesta a productores de chile serrano de los dos municipios. El objetivo general del proyecto fue estudiar el comportamiento productivo y la calidad de dos ecotipos de chile serrano a campo abierto e invernadero. Para el experimento de ecotipos de chile serrano (Tlaola y Tlapacoya) se empleó un diseño monofactorial completamente al azar con nueve repeticiones. El experimento de dosis de fertilización se utilizó un diseño monofactorial de cuatro tratamientos (T1: 80-60-15 T2: 160-120- 30, T3: 240-180-45 y T4: 320-240-60), en bloques al azar con tres repeticiones, y para el experimento en invernadero se utilizó un diseño factorial para ecotipos 2 x 2 x 2, con dos soluciones nutritivas (S1 y S2), dos dosis de riego (V1 y V2) y dos tratamientos foliares (Ca y Testigo), con tres repeticiones de ocho plantas cada una. En los tres experimentos se evaluó el comportamiento productivo y calidad de frutos en chile serrano"

Mejoramiento de la gestión administrativa, determinación de costos de los procesos y organización de almacenes de Industrias Fervill Ltda. /

DURANTE LOS ÚLTIMOS DOS AÑOS EL SECTOR METALMECÁNICO Y METALÚRGICO EN COLOMBIA HA PASADO POR UNA DIFÍCIL SITUACIÓN. EN OPINIÓN DE MUCHOS EMPRESARIOS DEL SECTOR LA TENDENCIA RECESIVA ES CONSECUENCIA DE LA CAÍDA DE LA DEMANDA, LAS ALTAS TASAS DE INTERÉS, LA ROTACIÓN DE LA CARTERA, Y LA CRISIS POLÍTICA, PRINCIPALMENTE. EN LA CIUDAD DE CARTAGENA, UNA EMPRESA DE ESTE GENERO CREADA HACE NUEVE (9) AÑOS, INDUSTRIAS FERVILL LTDA, HA DADO ENCOMIABLES MUESTRAS DE ESFUERZO POR MANTENERSE EN EL DURO MERCADO DE ESTE SECTOR EN PROBLEMAS. SU CRECIMIENTO, LUEGO DE SU FUNDACIÓN, HA SIDO VERTIGINOSO, Y SUS DIRECTIVOS ESTÁN BUSCANDO, CADA VEZ CON MÁS AHÍNCO FORMULAS PARA CONTINUAR MEJORANDOIncluye bibliografí

Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES) : comprehensive genetic analysis by next-generation sequencing of 480 patients

Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses. The need for molecular and clinical characterization of von Willebrand disease in Spain prompted the creation of a multicenter project (PCM-EVW-ES) that resulted in the largest prospective cohort study of patients with all types of von Willebrand disease. Molecular analysis of relevant regions of the VWF, including intronic and promoter regions, was achieved in the 556 individuals recruited via the development of a simple, innovative, relatively low-cost protocol based on microfluidic technology and next-generation sequencing. A total of 704 variants (237 different) were identified along VWF, 155 of which had not been previously recorded in the international mutation database. The potential pathogenic effect of these variants was assessed by in silico analysis. Furthermore, four short tandem repeats were analyzed in order to evaluate the ancestral origin of recurrent mutations. The outcome of genetic analysis allowed for the reclassification of 110 patients, identification of 37 asymptomatic carriers (important for genetic counseling) and re-inclusion of 43 patients previously excluded by phenotyping results. In total, 480 patients were definitively diagnosed. Candidate mutations were identified in all patients except 13 type 1 von Willebrand disease, yielding a high genotype-phenotype correlation. Our data reinforce the capital importance and usefulness of genetics in von Willebrand disease diagnostics. The progressive implementation of molecular study as the first-line test for routine diagnosis of this condition will lead to increasingly more personalized and effective care for this patient population

Gestión del conocimiento: perspectiva multidisciplinaria. Volumen 11

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 11, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro cuenta con el apoyo de los grupos de investigación: Universidad Sur del Lago “Jesús María Semprúm” (UNESUR), Zulia – Venezuela; Universidad Politécnica Territorial de Falcón Alonso Gamero (UPTAG), Falcón – Venezuela; Universidad Politécnica Territorial de Mérida Kleber Ramírez (UPTM), Mérida – Venezuela; Universidad Guanajuato (UG) - Campus Celaya - Salvatierra - Cuerpo Académico de Biodesarrollo y Bioeconomía en las Organizaciones y Políticas Públicas (C.A.B.B.O.P.P), Guanajuato – México; Centro de Altos Estudios de Venezuela (CEALEVE), Zulia – Venezuela, Centro Integral de Formación Educativa Especializada del Sur (CIFE - SUR) - Zulia - Venezuela, Centro de Investigaciones Internacionales SAS (CIN), Antioquia - Colombia.y diferentes grupos de investigación del ámbito nacional e internacional que hoy se unen para estrechar vínculos investigativos, para que sus aportes científicos formen parte de los libros que se publiquen en formatos digital e impreso

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Dietary Patterns and Fitness Level in Mexican Teenagers

Background. Nowadays, the term “physical fitness” has evolved from sports performance to health status, and it has been considered a strong predictor of cardiovascular disease. In this sense, test batteries have been developed to evaluate physical fitness such as the ALPHA-FIT battery. On the other hand, the analysis of dietary patterns has emerged as an alternative method to study the relationship between diet and chronic noncommunicable diseases. However, the association between dietary patterns and the physical fitness level has not been evaluated in both adults and adolescents. This association is most important in adolescents due to the fact that establishing healthy dietary behaviors and a favorable nutritional profile in early stages of life prevents various chronic-degenerative diseases. Objective. To analyze the association between dietary patterns and the level of fitness in Mexican teenagers. Methods. We analyzed the relationship between dietary patterns and the fitness level of 42 teenage students in Toluca, Mexico. Students were weighed and measured, and their food intake was recorded for 2 weekdays and one weekend day. Dietary patterns were obtained by factorial analysis. The ALPHA-FIT battery was used to measure the fitness level. Results. Fifty percent of the students were found to have a low fitness level (62.1% men; 37.9% women). There was no association (X2 = 0.83) between the dietary patterns “high in fat and sugar,” “high in protein”, and “low in fat and protein” and the level of physical condition in teens. Conclusions. In this study, all of teenagers with a very low level of fitness obtained a high dietary pattern in protein; however, 40% with a high level of physical condition resulted in the same pattern; that is why we did not find a relationship between the fitness level and the patterns investigated in this study