The Luminosity Function Evolution of Soft X--ray selected AGN in the RIXOS survey

A sample of 198 soft X--ray selected active galactic nuclei (AGN) from the ROSAT International X--ray Optical Survey (RIXOS), is used to investigate the X--ray luminosity function and its evolution. RIXOS, with a flux limit of 3E-14 erg s-1 cm-2 (0.5 to 2.0 keV), samples a broad range in redshift over 20 deg^2 of sky, and is almost completely identified; it is used in combination with the Einstein Extended Medium Sensitivity Survey (EMSS), to give a total sample of over 600 AGN. We find the evolution of AGN with redshift to be consistent with pure luminosity evolution (PLE) models in which the rate of evolution slows markedly or stops at high redshifts z>1.8. We find that this result is not affected by the inclusion, or exclusion, of narrow emission line galaxies at low redshift in the RIXOS and EMSS samples, and is insensitive to uncertainties in the conversion between flux values measured with ROSAT and Einstein. We confirm, using a model independent Ve/Va test, that our survey is consistent with no evolution at high redshifts.Comment: 10 pages, LaTeX file, PS figures and mn.sty. Accepted in MNRA

Clustering of X-ray selected Active Galactic Nuclei

A total of 235 Active Galactic Nuclei (AGN) from two different soft X-ray surveys (the ROSAT Deep Survey -DRS- and the ROSAT International X-ray Optical Survey -RIXOS-) with redshifts between 0 and 3.5 are used to study the clustering of X-ray selected AGN and its evolution. A 2 sigma significant detection of clustering of such objects is found on scales <40-80/h Mpc in the RIXOS sample, while no clustering is detected on any scales in the DRS sample. Assuming a single power law model for the spatial correlation function (SCF), quantitative limits on the AGN clustering have been obtained: a comoving correlation length 1.5<~ r_0 <~ 3.3/h Mpc is implied for comoving evolution, while 1.9 <~ r_0 <~ 4.8 for stable clustering and 2.2 <~ r_0 <~ 5.5 for linear evolution. These values are consistent with the correlation lengths and evolutions obtained for galaxy samples, but imply smaller amplitude or faster evolution than recent UV and optically selected AGN samples. We also constrain the ratio of bias parameters between X-ray selected AGN and IRAS galaxies to be <~1.7 on scales <~ 10/h Mpc, a significantly smaller value than is inferred from local large-scale dynamical studies.Comment: LaTeX file, 9 pages with 7 figures. To be published in MNRA

X-ray spectra of XMM-Newton serendipitous medium flux sources

We report on the results of a detailed analysis of the X-ray spectral properties of a large sample of sources detected serendipitously with the XMM-Newton observatory in 25 selected fields. The survey covers a total solid angle of ~3.5 deg2 and contains 1137 sources with ~10E-15 < S0.5-10 < 10E-12 erg cm-2 s-1. We find evidence for hardening of the average X-ray spectra of the sources towards fainter fluxes. We interpret this as indicating a higher degree of photoelectric absorption amongst the fainter population. Absorption is detected at 95% confidence in 20% of the sources, but it could certainly be present in many other sources below our detection capabilities. For Broad Line AGNs (BLAGNs), we detect absorption in ~10% of the sources with column densities in the range 10E21 - 10E22 cm-2. The fraction of absorbed Narrow Emission Line galaxies (NELGs, most with intrinsic X-ray luminosities >10E43 erg s-1, and therefore classified as type 2 AGNs) is significantly higher (40%), with a hint of moderately higher columns. We do not find evidence for a redshift evolution of the underlying power law index of BLAGNs, which stays roughly constant at Gamma ~1.9, with intrinsic dispersion of 0.4. A small fraction (~7%) of BLAGNs and NELGs require the presence of a soft excess, that we model as a black body with temperature ranging from 0.1 to 0.3 keV. Comparing our results on absorption to popular X-ray background synthesis models, we find absorption in only ~40% of the sources expected. This is due to a deficiency of heavily absorbed sources (with NH ~10E22 - 10E24 cm-2) in our sample in comparison with the models. We therefore conclude that the synthesis models require some revision in their specific parameters.Comment: 20 pages, 30 Postscript figures, A&A in pres

Numerical simulations of the Warm-Hot Intergalactic Medium

In this paper we review the current predictions of numerical simulations for the origin and observability of the warm hot intergalactic medium (WHIM), the diffuse gas that contains up to 50 per cent of the baryons at z~0. During structure formation, gravitational accretion shocks emerging from collapsing regions gradually heat the intergalactic medium (IGM) to temperatures in the range T~10^5-10^7 K. The WHIM is predicted to radiate most of its energy in the ultraviolet (UV) and X-ray bands and to contribute a significant fraction of the soft X-ray background emission. While O VI and C IV absorption systems arising in the cooler fraction of the WHIM with T~10^5-10^5.5 K are seen in FUSE and HST observations, models agree that current X-ray telescopes such as Chandra and XMM-Newton do not have enough sensitivity to detect the hotter WHIM. However, future missions such as Constellation-X and XEUS might be able to detect both emission lines and absorption systems from highly ionised atoms such as O VII, O VIII and Fe XVII.Comment: 18 pages, 5 figures, accepted for publication in Space Science Reviews, special issue "Clusters of galaxies: beyond the thermal view", Editor J.S. Kaastra, Chapter 14; work done by an international team at the International Space Science Institute (ISSI), Bern, organised by J.S. Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke

Simulating the Soft X-ray excess in clusters of galaxies

The detection of excess of soft X-ray or Extreme Ultraviolet (EUV) radiation, above the thermal contribution from the hot intracluster medium (ICM), has been a controversial subject ever since the initial discovery of this phenomenon. We use a large--scale hydrodynamical simulation of a concordance $\Lambda$CDM model, to investigate the possible thermal origin for such an excess in a set of 20 simulated clusters having temperatures in the range 1--7 keV. Simulated clusters are analysed by mimicking the observational procedure applied to ROSAT--PSPC data, which for the first time showed evidences for the soft X-ray excess. For cluster--centric distances $0.4< R/R_{\rm vir}< 0.7$ we detect a significant excess in most of the simulated clusters, whose relative amount changes from cluster to cluster and, for the same cluster, by changing the projection direction. In about 30 per cent of the cases, the soft X-ray flux is measured to be at least 50 per cent larger than predicted by the one--temperature plasma model. We find that this excess is generated in most cases within the cluster virialized regions. It is mainly contributed by low--entropy and high--density gas associated with merging sub--halos, rather than to diffuse warm gas. Only in a few cases the excess arises from fore/background groups observed in projection, while no evidence is found for a significant contribution from gas lying within large--scale filaments. We compute the distribution of the relative soft excess, as a function of the cluster--centric distance, and compare it with the observational result by Bonamente et al. (2003) for the Coma cluster. Similar to observations, we find that the relative excess increases with the distance from the cluster center, with no significant excess detected for $R<0.4R_{\rm vir}$. (abridged)Comment: 10 pages, to appear in A&

The ROSAT International X-ray/Optical Survey (RIXOS): source catalogue

We describe the ROSAT International X-ray/Optical Survey (RIXOS), a medium-sensitivity survey and optical identification of X-ray sources discovered in ROSAT high Galactic latitude fields (|b|>28°) and observed with the Position Sensitive Proportional Counter (PSPC) detector. The survey made use of the central 17 arcmin of each ROSAT field. A flux limit of 3×10−14 erg cm−2 s−1 (0.5–2 keV) was adopted for the survey, and a minimum exposure time of 8000 s was required for qualifying ROSAT observations. X-ray sources in the survey are therefore substantially above the detection threshold of each field used, and many contain enough counts to allow the X-ray spectral slope to be estimated. Spectroscopic observations of potential counterparts were obtained of all sources down to the survey limit in 64 fields, totalling a sky area of 15.77 deg2. Positive optical identifications are made for 94 per cent of the 296 sources thus examined. A further 18 fields (4.44 deg2), containing 105 sources above the 3×10−14 erg cm−2 s−1 survey limit, are completely optically identified to a higher flux of 8×10−14 erg cm−2 s−1 (0.5–2 keV). Optical spectroscopic data are supplemented by deep CCD imaging of many sources to reveal the morphology of the optical counterparts, and objects too faint to register on Sky Survey plates. The faintest optical counterparts have R∼22. This paper describes the survey method, and presents a catalogue of the RIXOS sources and their optical identifications. Finding charts based on Sky Survey data are given for each source, supplemented by CCD imaging where necessary

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology. The human family includes 19 members that can be sub-grouped on the basis of their known substrates, namely the aggrecanases or proteoglycanases (ADAMTS1, 4, 5, 8, 9, 15 and 20), the procollagen N-propeptidases (ADAMTS2, 3 and 14), the cartilage oligomeric matrix protein-cleaving enzymes (ADAMTS7 and 12), the von-Willebrand Factor proteinase (ADAMTS13) and a group of orphan enzymes (ADAMTS6, 10, 16, 17, 18 and 19). Control of the structure and function of the extracellular matrix (ECM) is a central theme of the biology of the ADAMTS, as exemplified by the actions of the procollagen-N-propeptidases in collagen fibril assembly and of the aggrecanases in the cleavage or modification of ECM proteoglycans. Defects in certain family members give rise to inherited genetic disorders, while the aberrant expression or function of others is associated with arthritis, cancer and cardiovascular disease. In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on tumorigenesis and metastasis, with both metalloproteinase-dependent and -independent actions known to occur. The basic ADAMTS structure comprises a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain, the latter determining substrate specificity and the localization of the protease and its interaction partners; ancillary domains probably also have independent biological functions. Focusing primarily on the aggrecanases and proteoglycanases, this review provides a perspective on the evolution of the ADAMTS family, their links with developmental and disease mechanisms, and key questions for the future

Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

The authors wish to acknowledge excellent technical assistance from A. Kurioka, L. Swadling, C. de Lara, J. Ussher, R. Townsend, S. Lionikaite, A.S. Lionikiene, R. Wolswinkel and I. van der Made. We would like to thank T.M. Keane and A.G. Doran for their help in annotating variants and adding the FVB/NJ strain to the MGP. We thank the High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics and the Wellcome Trust Sanger Institute for the generation of the sequencing data. This work was funded by Wellcome Trust grant 090532/Z/09/Z (J.F.). Primary phenotyping of the mice was supported by the Mary Lyon Centre and Mammalian Genetics Unit (Medical Research Council, UK Hub grant G0900747 91070 and Medical Research Council, UK grant MC U142684172). D.A.B. acknowledges support from NIH R01AR056280. The sleep work was supported by the state of Vaud (Switzerland) and the Swiss National Science Foundation (SNF 14694 and 136201 to P.F.). The ECG work was supported by the Netherlands CardioVascular Research Initiative (Dutch Heart Foundation, Dutch Federation of University Medical Centres, Netherlands Organization for Health Research and Development and the Royal Netherlands Academy of Sciences) PREDICT project, InterUniversity Cardiology Institute of the Netherlands (ICIN; 061.02; C.A.R. and C.R.B.). N.C. is supported by the Agency of Science, Technology and Research (A*STAR) Graduate Academy. R.W.D. is supported by a grant from the Wellcome Trust (097308/Z/11/Z).Peer reviewedPostprin