18 research outputs found
A two-arm parallel-group individually randomised prison pilot study of a male remand alcohol intervention for self-efficacy enhancement:The APPRAISE study protocol
- Author
- Publication venue
- 'BMJ'
- Publication date
- 01/04/2021
- Field of study
Introduction The prevalence of at-risk drinking is far higher among those in contact with the criminal justice system (73%) than the general population (35%). However, there is little evidence on the effectiveness of alcohol brief interventions (ABIs) in reducing risky drinking among those in the criminal justice system, including the prison system and, in particular, those on remand. Building on earlier work, A two-arm parallel group individually randomised Prison Pilot study of a male Remand Alcohol Intervention for Self-efficacy Enhancement (APPRAISE) is a pilot study designed to assess the feasibility and acceptability of an ABI, delivered to male prisoners on remand. The findings of APPRAISE should provide the information required to design a future definitive randomised controlled trial (RCT). Methods and analysis APPRAISE will use mixed methods, with two linked phases, across two prisons in the UK, recruiting 180 adult men on remand: 90 from Scotland and 90 from England. Phase I will involve a two-arm, parallel-group, individually randomised pilot study. The pilot evaluation will provide data on the likely impact of A two-arm parallel group individually randomised Prison Pilot study of a male Remand Alcohol Intervention for Self-efficacy Enhancement (APPRAISE), which will be used to inform a future definitive multicentre RCT. Phase II will be a process evaluation assessing how the ABI has been implemented to explore the change mechanisms underpinning the ABI (figure 1) and to assess the context within which the ABI is delivered. Ethics and dissemination The APPRAISE protocol has been approved by the East of Scotland Research Ethics Committee (19/ES/0068), National Offender Management System (2019-240), Health Board Research and Development (2019/0268), Scottish Prison Service research and ethics committee, and by the University of Edinburgh’s internal ethics department. The findings will be disseminated via peer-reviewed journal publications, presentations at local, national and international conferences, infographics and shared with relevant stakeholders through meetings and events.Additional co-authors: Jeremy Bray, Jennifer Ferguson, Arun Sondhi, Kieran Lynch, Jessica Rees, Dorothy Newbury-Birc
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- Zhang Xiuqing
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- Zhang Yilin
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- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
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- Angeslis Fragkiskos
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- Athamneh Tayseer
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- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
- Uyanık Mustafa Safa
- Uzair Ahmad
- Uzel Kadir
- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
- Valverde-Vazquez Rocio
- Vance Lucille
- Vanguardia Kristina
- Vanguardia Maria Kristina
- Vanzuylekom Katie
- Varesano Marco
- Varghese Chris
- Varghese Chris
- Velenciuc Natalia
- Vermeulen Wikus
- Vidanagama Sasini
- Vimalan Vineeth
- Virani Sehar Salim
- Vollenhoven Beverley
- Vong Crystal
- Vrakopoulou Gavriella Zoi
- Vu Jennifer
- Vu Jennifer
- Waaka Nicholas
- Wadhwa Sanya
- Wagaarachchi Prabhath
- Waheed Ayesha Akbar
- Waldin Lucy
- Walsh Eamon
- Walters Chris
- Wang Bill
- Wang Christine
- Wang Erica
- Wang Grace
- Wang Katie
- Wang Nicole Qiwen
- Wang Pengnan
- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- Agnès Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de Jesús Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Šuput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali Kağnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana Alícia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sánchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana María De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell Fernández
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas Stübner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
- Andréa Maria Laizner
- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
- Anisette Hoegenhaven
- Anita Alias
- Anita Jans
- Anita Vuković
- Anita-Chrysolyte Kusi-Appiah
- Anja Diers
- Anja Hansen
- Ann-Sofie Malvemyr
- Anna Alexandrou
- Anna Diaz
- Anna Efthymiou
- Anna Kyriakoudi
- Anna Leonova
- Anna Vita Bruno
- Anne Fishman
- Anne Langvad
- Anne Marie Kodal
- Anne Sofie Bomholt Pedersen
- Anne Williams
- Anne-Sophie Debue
- Annette Carey
- Annette Toellefsen
- Anthony Adenekan
- Anthony Radavidson
- Antigoni Karathanou
- Anton Turčan
- Antonella Cotoia
- Antonella Mo
- Antoni Margarit Ribas
- Antonia Liarmakopoulou
- Antonija Petosic
- Antonino Rizzo
- Antonio Abdala
- Antonio Barone
- Antonio Landaverde
- Antonio Manzo
- Antonio Margarit Ribas
- Antony Eneas
- Apostolos Bakas
- Arena Raimondo
- Arif Moghal
- Aristeidis Vakalos
- Arlette Van Den Elst
- Armanda Bozena
- Armando Schmukler
- Armorel Salberg
- Artemis Patsalos
- Arturo Briva
- Arvind Baronia
- Asbjorn Blondal
- Ascanio Tridente
- Ashish K Khanna
- Ashish K Khanna
- Ashish Khanna
- Ashley Szabo Eltorai
- Ashok Sundai Raj
- Ashwaq Ali
- Asmah Zainudin
- Asu Ozgultekin
- Ata Mahmoodpoor
- Athena Lavrentieva
- Attilio Quaini
- Audrey Fioretti
- Audrey Massard
- Auke Reidinga
- Auli Palmu
- Avşar Zerman
- Aya Alabuzidi
- Ayako Noguchi
- Ayça Gümüş
- Azmin Huda Abdul Rahim
- Babangida John Sankey
- Badiola Hilario
- Banu Taşdemir
- Baoke Zhang
- Barbara Garcia
- Barbro Meland
- Bart Ramaker
- Basri Mat Nor
- Battsetseg Baasanjav
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- Başar Erdivanli
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- Belen Burgos Conde
- Belinda Guadi-Gosh
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- Benjamin Bongiorno
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- Benoît Chinardet
- Berenice Navarro
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- Betty Star Kampayana
- Beverley Thomas
- Beysim Özcan
- Beysim Özcan
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- Biljana Kuzmanovska
- Bindu Thankamma
- Bing Song
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- Caiju Song
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- Enas Soula
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- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ágoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ângela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
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- Aydemir Semih
- Aydin Demet Tok
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- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
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- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
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- Vymazal Tamas
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- Wahab Sherliza
- Wahlbom Ewa
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- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
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- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
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- Wijnands Patricia
- Wilby Liz
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- Williams Lynne
- Wilting Rob
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- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
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- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Towards quantifying uncertainty in predictions of Amazon "dieback".
- Author
- Publication venue
- 'The Royal Society'
- Publication date
- 01/01/2008
- Field of study
Simulations with the Hadley Centre general circulation model (HadCM3), including carbon cycle
model and forced by a ‘business-as-usual’ emissions scenario, predict a rapid loss of Amazonian
rainforest from the middle of this century onwards. The robustness of this projection to both
uncertainty in physical climate drivers and the formulation of the land surface scheme is investigated.
We analyse how the modelled vegetation cover in Amazonia responds to (i) uncertainty in the
parameters specified in the atmosphere component of HadCM3 and their associated influence on
predicted surface climate. We then enhance the land surface description and (ii) implement a
multilayer canopy light interception model and compare with the simple ‘big-leaf ’ approach used in
the original simulations. Finally, (iii) we investigate the effect of changing the method of simulating
vegetation dynamics from an area-based model (TRIFFID) to a more complex size- and agestructured
approximation of an individual-based model (ecosystem demography).
We find that the loss of Amazonian rainforest is robust across the climate uncertainty explored by
perturbed physics simulations covering a wide range of global climate sensitivity. The introduction of
the refined light interception model leads to an increase in simulated gross plant carbon uptake for
the present day, but, with altered respiration, the net effect is a decrease in net primary productivity.
However, this does not significantly affect the carbon loss from vegetation and soil as a consequence
of future simulated depletion in soil moisture; the Amazon forest is still lost. The introduction of the
more sophisticated dynamic vegetation model reduces but does not halt the rate of forest dieback.
The potential for human-induced climate change to trigger the loss of Amazon rainforest appears
robust within the context of the uncertainties explored in this paper. Some further uncertainties
should be explored, particularly with respect to the representation of rooting depth
Facebook Live: Mental Health and BIPOC Social & Cultural Differences
- Publication venue
- Providence St. Joseph Health Digital Commons
- Publication date
- 11/12/2020
- Field of study
Speaking out about the inequities surrounding mental health services for minorities is a beginning to finding solutions. In this discussion, our panelists will talk about how their own communities and lives have been affected, and ideas for how we can work together to make it better
Understanding, recognizing, and sharing energy poverty knowledge and gaps in Latin America and the Caribbean – because conocer es resolver
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2022
- Field of study
Despite specific historical, geographical, sociodemographic, and infrastructural conditions that in combination could produce very high levels of energy vulnerability, there are significant and enduring knowledge gaps concerning energy poverty in Latin America and the Caribbean. Bringing together a multi-disciplinary and multi-national team, we focus on establishing the state-of-the-art in knowledge and policy for 5 diverse case studies - Argentina, Brazil, Colombia, Cuba, and Mexico - as well as for the wider region. Our article has three specific aims: to establish the range of approaches used to research energy poverty across the region; to examine national and supranational policy obligations; and to lay the framework for new research and policy agendas. In combination, our extensive academic and grey literature reviews, and accompanying scientometric, legal and statistical analyses, confirm that energy poverty is a relatively nascent topic, with only 62 scientific articles on the region published since 1991. From this body of knowledge, we identify key differences in the geographies of energy poverty identified by different metrics, with energy services-based approaches generally indicating higher vulnerability within rural areas, while energy expenditure metrics point towards higher risk in urban areas. We also find a dominance of quantitative approaches that tend to use existing (and often limited) forms of survey data, and a relative absence of detailed qualitative research. As such, we argue there is an urgent need for transformative research and policy activities within Latin America and the Caribbean, in order to support access to clean, reliable, and affordable energy services for all.Fil: Thomson, Harriet. The University Of Birmingham (tub);Fil: Day, Rosie. The University Of Birmingham (tub);Fil: Ricalde, Karla. Independent Researcher; Reino UnidoFil: Brand-Correa, Lina. The University Of Birmingham (tub);Fil: Cedano, Karla. Universidad Nacional Autónoma de México; MéxicoFil: Martinez, Manuel. Universidad Nacional Autónoma de México; MéxicoFil: Santillán, Oscar. Universidad Nacional Autónoma de México; MéxicoFil: Delgado Triana, Yanelys. Universidad Central Marta Abreu de Las Villas; CubaFil: Luis Cordova, José Grabiel. Universidad Central Marta Abreu de Las Villas; CubaFil: Milian Gómez, Jorge Freddy. Universidad Central Marta Abreu de Las Villas; CubaFil: Garcia Torres, David. Universidad del Norte; ColombiaFil: Mercado, Cesar. Universidad del Norte; ColombiaFil: Castelao Caruana, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro de Estudios Urbanos y Regionales. Grupo Vinculado Instituto de Investigación de Vivienda y Hábitat al Ceur; ArgentinaFil: Giannini Pereira, Marcio. Universidade Federal do Rio de Janeiro; Brasi
Towards quantifying uncertainty in predictions of Amazon ‘dieback’
- Author
- Publication venue
- 'The Royal Society'
- Publication date
- Field of study