Metamorfic evolution P-T-d-t and geodinamic meaning of the eclogitic unit of the Cabo Ortegal complex (NW of Spain)

Se presentan los resultados obtenidos a partir del estudio petrológico detallado de las eclogitas que componen la unidad eclogítica del Complejo de Cabo Ortegal estableciéndose un modelo para la evolución metamórfica de la misma. Desde el punto de vistapetrológico se han reconocido tres tipos de eclogitas: comunes, con distena y ferrotitaníferas, definiéndose las características de afloramiento y estructurales de las mismas. La unidad eclogítica está compuesta por diversas láminas de eclogitas comunes limitadas por importantes zonas de cizalla en las que afloran principalmente las eclogitas con distena. Se han reconocido y cuantificado (condiciones P-T) los distintos estadios en la evolución metamórfica de estas rocas, los cuales se han relacionado con los datos estructurales y geocronológicos disponibles para obtener una idea global de la evolución P-T-deformación-tiempo que han seguido las eclogitas. Los datos obtenidos indican condiciones de 780-800 °C y c. 22 kbar para el máximo metamórfico asociado a la primera fase de deformación reconocida, D1, relacionada con un proceso de subducción.Posteriormente se produjo una segunda fase de deformación en condiciones todavía eclogíticas, a 660 - 700 °C y 20 kbar, relacionada con el apilamiento de las unidades y probablemente con el comienzo de la exhumación tectónica de estas rocas. La evolución retrógrada se caracteriza por un primer estadio de descompresión casi isotérmica con un posterior enfriamiento más importante. Durante este periodo tuvieron lugar las fases de deformación D3 y D4 en condiciones extensionales y relacionadas con el emplazamiento final del complejo. El ascenso de las rocas de la unidad eclogítica habría sido fundamentalmente tectónico lo que permitió una preservación considerable durante los posteriores eventos metamórfico-deformativos de menor grado. La evolución de la unidad eclogítica constituye un ejemplo de un fragmento de corteza oceánica subducida hasta profundidades superiores a 70 km con formación de una cuña orogénica relacionada con la superposición tectónica de las diferentes unidades estructurales que componen el alóctono superior del complejo. Este proceso se considera que marcó el comienzo de la Orogénesis Hercínica en este sector hace unos 390-400 Ma

Semantic-based Context Modeling for Quality of Service Support in IoT Platforms

The Internet of Things (IoT) envisions billions of devices seamlessly connected to information systems, thus providing a sensing platform for applications. The availability of such a huge number of smart things will entail a multiplicity of devices collecting overlapping data and/or providing similar functionalities. In this scenario, efficient discovery and appropriate selection of things through proper context acquisition and management will represent a critical requirement and a challenge for future IoT platforms. In this work we present a practical approach to model and manage context, and how this information can be exploited to implement QoS-aware thing service selection. In particular, it is shown how context can be used to infer knowledge on the equivalence of thing services through semantic reasoning, and how such information can be exploited to allocate thing services to applications while meeting QoS requirements even in case of failures. The proposed approach is demonstrated through a simple yet illustrative experiment in a smart home scenario.European Commission's FP

HPLC–(Q)-TOF-MS-Based Study of Plasma Metabolic Profile Differences Associated with Age in Pediatric Population Using an Animal Model

[EN] A deep knowledge about the biological development of children is essential for appropriate drug administration and dosage in pediatrics. In this sense, the best approximation to study organ maturation is the analysis of tissue samples, but it requires invasive methods. For this reason, surrogate matrices should be explored. Among them, plasma emerges as a potential alternative since it represents a snapshot of global organ metabolism. In this work, plasma metabolic profiles from piglets of different ages (newborns, infants, and children) obtained by HPLC–(Q)-TOF-MS at positive and negative ionization modes were studied. Improved clustering within groups was achieved using multiblock principal component analysis compared to classical principal component analysis. Furthermore, the separation observed among groups was better resolved by using partial least squares-discriminant analysis, which was validated by bootstrapping and permutation testing. Thanks to univariate analysis, 13 metabolites in positive and 21 in negative ionization modes were found to be significant to discriminate the three groups of piglets. From these features, an acylcarnitine and eight glycerophospholipids were annotated and identified as metabolites of interest. The findings indicate that there is a relevant change with age in lipid metabolism in which lysophosphatidylcholines and lysophoshatidylethanolamines play an important role.This research was funded by UPV/EHU (Project GIU16/04) and the Spanish Ministry of Economy and Competitiveness (Project CTQ2013-46179-R)

PRECIPITATION STRENGTHENING PRODUCED BY THE FORMATION IN FERRITE OF Nb CARBIDES

A Nb microalloyed steel has been thermomechanically processed at laboratory through the use of plane straincompression sequences followed by simulated coiling. Tensile samples have been machined from the obtainedspecimens in order to investigate the effect of different variables: recrystallisation or accumulated strain beforetransformation, holding in austenite and coiling temperature on the final mechanical behaviour. Transmissionelectron microscopy observation of the precipitates has been carried out after coiling at different temperatures.It has been shown that when Nb remains in solution in austenite after hot deformation, it can precipitate inferrite, leading to an important strengthening effect which is directly related to the concentration of Nb insolution before transformation and coiling temperature

20 years of alveolar distraction : a systematic review of the literature

The Vertical Alveolar Distraction Osteogenesis (VADO) technique is an excellent solution for bone and soft tissue neoformation in areas in which there has been significant bone atrophy that hinders normal rehabilitation using dental implants. The goal of this systematic review is to analyze the most relevant articles published on VADO in the literature over the past 20 years. The review was performed by using the keywords: ?alveolar ridge?, ?distraction ostegenesis? and ?dental implant?. This search produced a total result of 240 articles. The clinical studies and cases reported in humans amounted to 113 articles, 18 articles referred to studies developed on animals and 33 review articles. The presentation of this systematic analysis follows the criteria described in the PRISMA declaration. 22 articles complied with the inclusion criteria and 7 articles more were added manually, reaching a total sample of 29 studies. Following the analysis of the studies, they were classified into 18 high-quality, 10 mediumquality and 1 low-quality study. Only 4 studies achieved a maximum score of 9 (according to NewCastle Ottawa Scale, NOS). VADO is a technique with greater potential in vertical gain. The performance of dental implants has a success and survival rate similar to dental implants placed on bones that are not subject to increase techniques

Diagnostic yield of sentinel lymph node biopsy in oral squamous cell carcinoma T1/T2-N0: systematic review and meta-analysis

The objective of this study was to conduct a systematic review and meta-analysis on the efficacy of sentinel lymph node biopsy (SLNB) in T1/T2-N0 oral squamous cell carcinoma (OSCC). A systematic review of the literature on SLNB until March 2019 was conducted. The review was organized according to the PRISMA protocol, considering the following PICO (population, intervention, comparison, outcome) question: What is the sensitivity of sentinel lymph node biopsy in OSCC? ‘P’ was patients with head and neck squamous cell carcinoma T1/2-N0; ‘I’ was SLNB; ‘C’ was neck treated with elective neck dissection and haematoxylin–eosin histopathology; ‘O’ was sensitivity and specificity. A meta-analysis and meta-regression were performed on the selected studies. The sensitivity of SLNB was up to 88% (95% confidence interval (CI) 72–96%) and specificity was up to 99% (95% CI 96–100%). The area under the summary receiver operating characteristic curve was 0.99 (95% CI 0.98–1.00). In the four studies where immunohistochemistry was performed, both the sensitivity and specificity were higher than in the studies without immunohistochemistry: 93% (95% CI 88–97%) and 98% (95% CI 96–100%), respectively. In conclusion, SLNB is an effective technique for treating patients with some types of stage T1/2-N0 OSCC. Some parameters such as immunohistochemistry could determine the level of diagnostic accuracyS

Importance of Magnesium Status in COVID-19

A large amount of published research points to the interesting concept (hypothesis) that magnesium (Mg) status may have relevance for the outcome of COVID-19 and that Mg could be protective during the COVID disease course. As an essential element, Mg plays basic biochemical, cellular, and physiological roles required for cardiovascular, immunological, respiratory, and neurological functions. Both low serum and dietary Mg have been associated with the severity of COVID-19 outcomes, including mortality; both are also associated with COVID-19 risk factors such as older age, obesity, type 2 diabetes, kidney disease, cardiovascular disease, hypertension, and asthma. In addition, populations with high rates of COVID-19 mortality and hospitalization tend to consume diets high in modern processed foods, which are generally low in Mg. In this review, we review the research to describe and consider the possible impact of Mg and Mg status on COVID-19 showing that (1) serum Mg between 2.19 and 2.26 mg/dL and dietary Mg intakes > 329 mg/day could be protective during the disease course and (2) inhaled Mg may improve oxygenation of hypoxic COVID-19 patients. In spite of such promise, oral Mg for COVID-19 has thus far been studied only in combination with other nutrients. Mg deficiency is involved in the occurrence and aggravation of neuropsychiatric complications of COVID-19, including memory loss, cognition, loss of taste and smell, ataxia, confusion, dizziness, and headache. Potential of zinc and/or Mg as useful for increasing drug therapy effectiveness or reducing adverse effect of anti-COVID-19 drugs is reviewed. Oral Mg trials of patients with COVID-19 are warranted

Outstanding performance of PIM-1 membranes towards the separation of fluorinated refrigerant gases

The recycling of depleted high global warming mixtures of fluorinated gases (F-gases) with close-boiling or azeotropic behavior requires advanced separation processes to obtain effectively the pure components. Herein, several types of PIM-1 membranes were tested for the first time towards the separation of hydrofluorocarbons and hydrofluoroolefins, showing extraordinarily high permeability coefficients for the value-added difluoromethane (R-32), up to 4100 barrer, coupled with high selectivity for the F-gas pairs of interest. Additionally, the solubility of selected F-gases in PIM-1 was measured and fitted to the dual-mode and Guggenheim, Anderson and de Boer sorption models. The separation performance of the standard PIM-1 and a highly branched PIM-1 was examined with the mixture R-410A (containing R-32 and pentafluoroethane R-125) to assess the influence of the membrane topology on the mixed-gas permeation properties over time (physical aging). Considering that the branched PIM-1 membrane was the least impacted by the aging phenomena, it was used to recover high purity R-32 (concentration in the permeate side as high as 98.9 vol % was achieved) from refrigerant gas mixtures R-410A and R-454B (mixture of R-32 and R-1234yf) in continuous long-term experiments. Results showed the great potential of PIM-1 membranes for the separation of R-32 from refrigerant mixtures collected from end-of-life equipment.This research is supported by project PID2019-105827RB-I00 funded by MCIN/AEI/10.13039/501100011033. F.P. and S.V.G.H. acknowledge the support of the Spanish State Research Agency and the Spanish Ministry of Science and Innovation (grants IJC2020-043134-I and PRE2020-093568, respectively). A.B.F and P.M.B acknowledge EPSRC Grant ep/v047078/1 (SynHiSel). P.G. is supported by Grant RYC2019-027060-I funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8–13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05–6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50–75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life. Funding Pfizer, Amgen, Merck Sharp & Dohme, Sanofi–Aventis, Daiichi Sankyo, and Regeneron

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life