159 research outputs found
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
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- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
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- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
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- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
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- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
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- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
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- Arnaoutoglou E
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- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
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- Arustei M
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- Arya S
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- Attrill E
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- Avila Sanchez FJ
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- Christoforidis D
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- Dumitrascu CO
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- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
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- Abdel-Aziz AK
- Abdelfatah S
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
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- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eric E Schadt
- Eriksson Johan G.
- Eriksson Per
- Esko Tõnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
- Gardezi Ali
- Gejman Pablo V.
- Geus Eco J C
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gjesing Anette P.
- Glass Daniel
- Glazer Nicole L.
- Gloyn Anna L.
- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
- Green Fiona
- Green Todd
- Greenawalt Danielle M.
- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
- Hazen Stanley L.
- Heard-Costa Nancy L.
- Heath Andrew C.
- Hebebrand Johannes
- Hedman Åsa K.
- Hei Iris M.
- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C.
- Horikoshi Momoko
- Horne Benjamin D.
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Huikuri Heikki V.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Ida Chen Yii Der
- Igl Wilmar
- Illig Thomas
- Ingelsson Erik
- Ingle Catherine
- Iribarren Carlos
- Ishaq Muhammad
- Isomaa Bo
- Jackso Anne U.
- Jackson Anne U.
- Jacobs Kevin B.
- James Alan L.
- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
- Johansson Åsa
- John Ulrich
- Johnson Paul
- Johnson Paul R V
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
- Kajantie Eero
- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
- Kerr-Conte Julie
- Ketkar Shamika
- Kettunen Johannes
- Khaw Kay Tee
- Kiemeney Lambertus A.
- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
- Langenberg Claudia
- Lango Allen Hana
- Lantieri Olivier
- Lanzani Chiara
- Launer Lenore J.
- Lauritzen Torsten
- Lawlor Debbie A.
- Lawrence Robert W.
- Leander Karin
- Lecoeur Cecile
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
- Li Mingyao
- Li Shengxu
- Lian Liming
- Liang Liming
- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
- Lindgre Cecilia M.
- Lindgren Cecilia M.
- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
- Loley Christina
- Loos Ruth J F
- Lorentzon Mattias
- Lotery Andrew J.
- Lua Jian'an
- Luan Jian'an
- Luben Robert N.
- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- Martínez-Larrad María Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
- Merlini Pier Angelica
- Metspalu Andres
- Meyre David
- Midthjell Kristian
- Min Josine L.
- Moffatt Miriam F.
- Mohlke Karen L.
- Mond Keri L.
- Monda Keri L
- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- Mäg Reedik
- Mägi Reedik
- Mälarstig Anders
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
- Nelson Christopher P.
- Nemes James
- Nemesh James
- Nestle Frank O.
- Neville Matt J.
- Ngwa Julius S.
- Nica Alexandra C.
- Nieminen Markku S.
- Nilesh J Samani
- Nilsson Peter
- Nisbet James
- North Kari E.
- Nyholt Dale R.
- Nöthen Markus M.
- O'Connell Jeffrey R.
- O'Donnel Christopher J.
- O'Donnell Christopher J.
- O'Rahilly Stephen
- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
- Olsson Gunnar
- Ong Ken K.
- Ongen Halit
- Oostra Ben
- Osmond Clive
- Ostenson Claes-Göran
- Ouwehand Willem H.
- Owen Katharine R.
- Palmer Colin N A
- Palmer Lyle J.
- Pankow James S.
- Par Ju Hyun
- Parish Sarah
- Park Ju-Hyun
- Parker Alex N.
- Parts Leopold
- Paré Guillaume
- Pascoe Laura
- Patel Riyaz S.
- Patterson Chris C.
- Pattou François
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Pellikka Niina
- Peltonen Leena
- Penninx Brenda W.
- Perola Markus
- Perry John R B
- Peter M Visscher
- Peters Annette
- Peters Marjolein J.
- Petersen Ann Kristin
- Peto Richard
- Petrie John R.
- Peyvandi Flora
- Pichler Irene
- Pietiläinen Kirsi H.
- Platou Carl
- Platou Carl G P
- Polasek Ozren
- Potter Simon
- Pouta Anneli
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Purcell Shaun
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rafelt Suzanne
- Raitakari Olli
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- Randal Joshua C.
- Randall Joshua C
- Rasheed Asif
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N. William
- Rayner Nigel W.
- Reilly Muredach P.
- Reinehr Thomas
- Rice Catherine
- Ridderstråel Martin
- Ridderstråle Martin
- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
- Samad Adbus
- Samani Nilesh
- Sampietro M. Lourdes
- Sampson Michael J.
- Samuel Maria
- Sanders Alan R.
- Sandholt Camilla
- Sandhu Manj S.
- Sandhu Manjinder S.
- Sanna Serena
- Saramies Jouko
- Savolainen Markku J.
- Saxena Richa
- Sayer Avan A.
- Schadt Eric
- Scherag Andre
- Scherag Susann
- Schillert Arne
- Schipf Sabine
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schwarz Peter E H
- Schäfer Arne
- Scott James
- Scott Laura J.
- Seedorf Udo
- Segrè Ayellet V.
- Sehmi Joban
- Sekowska Magdalena
- Sennblad Bengt
- Shah Nabi
- Shaun Purcell
- Shi Jianxin
- Shields Beverley M.
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- Syvänen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
- Tzenova Bell Jordana
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden Andre G.
- Uitterlinden André
- Valle Timo T.
- van Dam Rob M.
- van Duijn Cornelia M.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
- Author
- Abate Degu
- Abate Degu
- Abate Kalkidan Hassell
- Abate Kalkidan Hassell
- Abbafati Cristiana
- Abbafati Cristiana
- Abbasi Nooshin
- Abbasi Nooshin
- Abbastabar Hedayat
- Abbastabar Hedayat
- Abd-Allah Foad
- Abd-Allah Foad
- Abdela Jemal
- Abdela Jemal
- Abdelalim Ahmed
- Abdelalim Ahmed
- Abdollahpour Ibrahim
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdulkader Rizwan Suliankatchi
- Abebe Molla
- Abebe Molla
- Abebe Zegeye
- Abebe Zegeye
- Abera Semaw F.
- Abera Semaw F.
- Abil Olifan Zewdie
- Abil Olifan Zewdie
- Abraha Haftom Niguse
- Abraha Haftom Niguse
- Abrham Aklilu Roba
- Abrham Aklilu Roba
- Abu-Raddad Laith Jamal
- Abu-Raddad Laith Jamal
- Abu-Rmeileh Niveen M. E.
- Abu-Rmeileh Niveen M. E.
- Accrombessi Manfred Mario Kokou
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Acharya Dilaram
- Acharya Pawan
- Acharya Pawan
- Adamu Abdu A.
- Adamu Abdu A.
- Adane Akikw Awoke
- Adane Akikw Awoke
- Adebayo Oladimeji M.
- Adebayo Oladimeji M.
- Adedoyin Rufus Adesoji
- Adedoyin Rufus Adesoji
- Adekanmbi Victor
- Adekanmbi Victor
- Ademi Zanfina
- Ademi Zanfina
- Adetokunboh Olatunji
- Adetokunboh Olatunji
- Adib Mina G.
- Adib Mina G.
- Admasie Amha
- Admasie Amha
- Adsuar Jose C.
- Adsuar Jose C.
- Afanvi Kossivi Agbelenko
- Afanvi Kossivi Agbelenko
- Afarideh Mohsen
- Afarideh Mohsen
- Afshin Ashkan
- Afshin Ashkan
- Agarwal Gina
- Agarwal Gina
- Aggarwal Anju
- Aggarwal Anju
- Aghayan Sargis Aghast
- Aghayan Sargis Aghast
- Agrawal Anurag
- Agrawal Anurag
- Agrawal Sutapa
- Agrawal Sutapa
- Ahmadi Alireza
- Ahmadi Alireza
- Ahmadi Mehdi
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadieh Hamid
- Ahmed Muktar Beshir
- Ahmed Muktar Beshir
- Aichour Amani Nidhal
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Aichour Miloud Taki Eddine
- Akbari Mohammad Esmaeil
- Akbari Mohammad Esmaeil
- Akinyemiju Tomi
- Akinyemiju Tomi
- Akseer Nadia
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- Al-Aly Ziyad
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- Al-Eyadhy Ayman
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- Al-Mekhlafi Hesham M.
- Al-Mekhlafi Hesham M.
- Alam Khurshid
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- Alashi Alaa
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- Alavian Seyed Moayed
- Alavian Seyed Moayed
- Alene Kefyalew Addis
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- Ali Komal
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- Ali Syed Mustafa
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- Alijanzadeh Mehran
- Alijanzadeh Mehran
- Alizadeh-Navaei Reza
- Alizadeh-Navaei Reza
- Aljunid Syed Mohamed
- Aljunid Syed Mohamed
- Alkerwi Ala'a
- Alkerwi Ala'a
- Alla Francois
- Alla Francois
- Alsharif Ubai
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- Altirkawi Khalid
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- Alvis-Guzman Nelson
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- Amare Azmeraw T.
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- Amlov Johan
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- Ammar Walid
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- Anber Nahla Hamed
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- Anderson Jason A.
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- Andrei Catalina Liliana
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- Androudi Sofia
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- Ausloos Marcel
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- Bali Ayele Geleto
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- Ball Kylie
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- Ballesteros Wayra Citlali Paz
- Ballesteros Wayra Citlali Paz
- Bamighausen Till Winfried
- Bamighausen Till Winfried
- Banach Maciej
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- Banoub Joseph Adel Mattar
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- Barac Aleksandra
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- Behzadifar Meysam
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- Bejoy Yannick
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- Bekele Bayu Begashaw
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- Berhane Adugnaw
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- Beuran Mircea
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- Beyranvand Tina
- Beyranvand Tina
- Bhala Neeraj
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- Bhalla Ashish
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- Bhattarai Suraj
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- Bhutta Zulfiqar A.
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- Biadgo Belete
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- Bicer Burcu Kucuk
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- Bijani Ali
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- Bikbov Boris
- Bikbov Boris
- Bilano Ver
- Bilano Ver
- Bililign Nigus
- Bililign Nigus
- Bin Sayeed Muhamad Shandaat
- Bin Sayeed Muhamad Shandaat
- Bin Zaman Sojib
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- Bisanzio Donal
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- Bjorge Tone
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- Borschmann Rohan
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- Brugha Traolach
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- Buchbindet Rachelle
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- Burnett Richard T.
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- Campos-Nonato Ismael R.
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- Cardenas Rosario
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- Carvalho Felix
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- Castaneda-Orjuela Carlos A.
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- Catala-Lopez Ferran
- Catala-Lopez Ferran
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- Cercy Kelly M.
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- Cerin Ester
- Cerin Ester
- Chaiah Yazan
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- Chang Jung-Chen
- Chang Jung-Chen
- Chang Kai-Lan
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- Charlson Fiona J.
- Chattopadhyay Aparajita
- Chattopadhyay Aparajita
- Chattu Vijay Kumar
- Chattu Vijay Kumar
- Chee Miao Li
- Chee Miao Li
- Cheng Ching-Yu
- Cheng Ching-Yu
- Chew Adrienne
- Chew Adrienne
- Chiang Peggy Pei-Chia
- Chiang Peggy Pei-Chia
- Chimed-Ochir Odgerel
- Chimed-Ochir Odgerel
- Chin Ken Lee
- Chin Ken Lee
- Chitheer Abdulaal
- Chitheer Abdulaal
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- Chowdhury Rajiv
- Chowdhury Rajiv
- Christensen Hanne
- Christensen Hanne
- Christopher Devasahayam J.
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- Chung Sheng-Chia
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- Cicuttini Flavia M.
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- Cohen Aaron J.
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- Cooper Cyrus
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- Cooper Owen R.
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- Coresh Josef
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- Cornaby Leslie
- Cornaby Leslie
- Cortesi Paolo Angelo
- Cortesi Paolo Angelo
- Cortinovis Monica
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- Costa Megan
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- Cousin Ewerton
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- Cromwell Elizabeth A.
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- Daba Alenmeh Kabeta
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- Dadi Abel Fekadu
- Dadi Abel Fekadu
- Damasceno Alberti Antonio Moura
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- Dasa Tamirat Tesfaye
- Dasa Tamirat Tesfaye
- Dash Aditya Prasad
- Dash Aditya Prasad
- Davitoiu Dragos Virgil
- Davitoiu Dragos Virgil
- Davletov Kairat
- Davletov Kairat
- De la Cruz-Gongora Vanessa
- De la Cruz-Gongora Vanessa
- De la Hoz Fernando Pio
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- De Leo Diego
- De Leo Diego
- De Neve Jan-Walter
- De Neve Jan-Walter
- Defo Barthelemy Kuate
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- Degenhardt Louisa
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- Deiparine Selina
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- Dellavalle Robert P.
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- Dervenis Nikolaos
- Dervenis Nikolaos
- Deshpande Aniruddha
- Deshpande Aniruddha
- Dessie Getenet Ayalew
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- Deveber Gabrielle Aline
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- Dey Subhojit
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- Dharmaratne Samath Dhamminda
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- Dhimal Meghnath
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- Dinberu Mesfin Tadese
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- Eggen Anne Elise
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- El Bcheraoui Charbel
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- El-Khatib Iad
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- Elfiong Andem
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- Elyazar Iqbal Rf
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- Enayati Ahmadali
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- Endries Aman Yesuf
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- Er Benjamin
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- Eskandarieh Sharareh
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- Esteghamati Alireza
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- Estep Kara
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- Fakhim Hamed
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- Falavarjani Khalil Ghasemi
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- Faramarzi Mahbobeh
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- Foigt Nataliya A.
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- Rahman Mahfuzar
- Rahman Mahfuzar
- Rahman Mohammad Hifz Ur
- Rahman Mohammad Hifz Ur
- Rahman Muhammad Aziz
- Rahman Muhammad Aziz
- Rai Rajesh Kumar
- Rai Rajesh Kumar
- Rajati Fatemeh
- Rajati Fatemeh
- Rajsic Sasa
- Rajsic Sasa
- Raju Sree Bhushan
- Raju Sree Bhushan
- Ram Usha
- Ram Usha
- Ranabhat Chhabi Lal
- Ranabhat Chhabi Lal
- Ranjan Prabhat
- Ranjan Prabhat
- Rath Goura Kishor
- Rath Goura Kishor
- Rawaf David Laith
- Rawaf David Laith
- Rawaf Salman
- Rawaf Salman
- Reddy K. Srinath
- Reddy K. Srinath
- Rehm Colin D.
- Rehm Colin D.
- Rehm Jurgen
- Rehm Jurgen
- Reiner Robert C.
- Reiner Robert C.
- Reitsma Marissa B.
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Remuzzi Giuseppe
- Renzaho Andre M. N.
- Renzaho Andre M. N.
- Resnikoff Serge
- Resnikoff Serge
- Reynales-Shigematsu Luz Myriam
- Reynales-Shigematsu Luz Myriam
- Rezaei Satar
- Rezaei Satar
- Ribeiro Antonio Luiz P.
- Ribeiro Antonio Luiz P.
- Rivas Jacqueline Castillo
- Rivas Jacqueline Castillo
- Rivera Juan A.
- Rivera Juan A.
- Roba Kedir Teji
- Roba Kedir Teji
- Rodrigues-Ramirez Sonia
- Rodrigues-Ramirez Sonia
- Roever Leonardo
- Roever Leonardo
- Roman Yesenia
- Roman Yesenia
- Ronfani Luca
- Ronfani Luca
- Roshandel Gholamreza
- Roshandel Gholamreza
- Rostami Ali
- Rostami Ali
- Roth Gregory A.
- Roth Gregory A.
- Rothenbacher Dietrich
- Rothenbacher Dietrich
- Roy Ambuj
- Roy Ambuj
- Rubagotti Enrico
- Rubagotti Enrico
- Rushton Lesley
- Rushton Lesley
- Sabanayagam Charumathi
- Sabanayagam Charumathi
- Sachdev Perminder S.
- Sachdev Perminder S.
- Sacker Abdur Razzaque
- Sacker Abdur Razzaque
- Saddik Basema
- Saddik Basema
- Sadeghi Ehsan
- Sadeghi Ehsan
- Safari Hosein
- Safari Hosein
- Safari Yahya
- Safari Yahya
- Safari-Faramani Roya
- Safari-Faramani Roya
- Safdarian Mandi
- Safdarian Mandi
- Safi Sare
- Safi Sare
- Safiri Saeid
- Safiri Saeid
- Sagar Rajesh
- Sagar Rajesh
- Sahebkar Amirhossein
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sahraian Mohammad Ali
- Sajadi Haniye Sadat
- Sajadi Haniye Sadat
- Salam Nasir
- Salam Nasir
- Salamati Payman
- Salamati Payman
- Saleem Zikria
- Saleem Zikria
- Salimeadeh Hamideh
- Salimeadeh Hamideh
- Salimi Yahya
- Salimi Yahya
- Salomon Joshua A.
- Salomon Joshua A.
- Salvi Devashri Digvijay
- Salvi Devashri Digvijay
- Samy Abdullah M.
- Samy Abdullah M.
- Sanabria Juan
- Sanabria Juan
- Sanchez-Nino Maria Dolores
- Sanchez-Nino Maria Dolores
- Sanchez-Pimienta Tania G.
- Sanchez-Pimienta Tania G.
- Sanders Taren
- Sanders Taren
- Sang Yingying
- Sang Yingying
- Santomauro Damian Francesco
- Santomauro Damian Francesco
- Santos Itamar S.
- Santos Itamar S.
- Santos Joao Vasco
- Santos Joao Vasco
- Sardana Mayank
- Sardana Mayank
- Sarmiento-Suarez Rodrigo
- Sarmiento-Suarez Rodrigo
- Sarrafzadegan Nizal
- Sarrafzadegan Nizal
- Sartorius Benn
- Sartorius Benn
- Sarvi Shahabeddin
- Sarvi Shahabeddin
- Sathian Brifesh
- Sathian Brifesh
- Satpathy Maheswar
- Satpathy Maheswar
- Satz Inbal
- Satz Inbal
- Sawant Arundhati R.
- Sawant Arundhati R.
- Sawhney Monika
- Sawhney Monika
- Saylan Mete
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- Sayyah Mehdi
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- Schaeffner Elke
- Schaeffner Elke
- Schmidt Maria Ines
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- Schneider Ione J. C.
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- Schottker Ben
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- Schutte Aletta Elisabeth
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- Schwehel David C.
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- Schwendicke Falk
- Schwendicke Falk
- Scott James G.
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- Seedat Soraya
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- Sekerija Mario
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- Sepanlou Sadaf G.
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- Serre Marc L.
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- Servan-Mori Edson
- Servan-Mori Edson
- Seyedmousavi Seyedmojtaba
- Seyedmousavi Seyedmojtaba
- Shabaninejad Hosein
- Shabaninejad Hosein
- Shaddick Gavin
- Shaddick Gavin
- Shafieesabet Azadeh
- Shafieesabet Azadeh
- Shahbazi Mehdi
- Shahbazi Mehdi
- Shaheen Amira A.
- Shaheen Amira A.
- Shaikh Masood Ali
- Shaikh Masood Ali
- Shams-Beyranvand Mehran
- Shams-Beyranvand Mehran
- Shamsi Mohammadbagher
- Shamsi Mohammadbagher
- Sharafi Heidar
- Sharafi Heidar
- Sharafi Kiomairs
- Sharafi Kiomairs
- Sharif Mehdi
- Sharif Mehdi
- Sharif-Alhoseini Matadi
- Sharif-Alhoseini Matadi
- Sharifi Hamid
- Sharifi Hamid
- Sharma Jayendra
- Sharma Jayendra
- Sharma Meenakshi
- Sharma Meenakshi
- Sharma Rajesh
- Sharma Rajesh
- She Jun
- She Jun
- Sheikh Aziz
- Sheikh Aziz
- Shi Peilin
- Shi Peilin
- Shiadeh Malihe Nourollahpour
- Shiadeh Malihe Nourollahpour
- Shibuya Kenji
- Shibuya Kenji
- Shiferaw Mekonnen Sisay
- Shiferaw Mekonnen Sisay
- Shigematsu Mika
- Shigematsu Mika
- Shin Min-Jeong
- Shin Min-Jeong
- Shirkoohi Reza
- Shirkoohi Reza
- Shirt Rahman
- Shirt Rahman
- Shiue Ivy
- Shiue Ivy
- Shokraneh Farhad
- Shokraneh Farhad
- Shoman Haitham
- Shoman Haitham
- Shrime Mark G.
- Shrime Mark G.
- Shupler Matthew S.
- Shupler Matthew S.
- Shushtari Zahra Jorjoran
- Shushtari Zahra Jorjoran
- Si Si
- Si Si
- Siabani Soraya
- Siabani Soraya
- Sibai Abla Mehio
- Sibai Abla Mehio
- Siddiqi Tariq J.
- Siddiqi Tariq J.
- Sigfusdottir Inga Dora
- Sigfusdottir Inga Dora
- Sigurvinsdottir Rannveig
- Sigurvinsdottir Rannveig
- Silva Diego Augusto Santos
- Silva Diego Augusto Santos
- Silva Joao Pedro
- Silva Joao Pedro
- Silveira Dayane Gabriele Alves
- Silveira Dayane Gabriele Alves
- Singh Jasvinder A.
- Singh Jasvinder A.
- Singh Narinder Pal
- Singh Narinder Pal
- Singh Virendra
- Singh Virendra
- Sinha Dhirendra Narain
- Sinha Dhirendra Narain
- Skiadaresi Eirini
- Skiadaresi Eirini
- Skirbekk Vegard
- Skirbekk Vegard
- Smith David L.
- Smith David L.
- Smith Mari
- Smith Mari
- Sobaih Badr Hasan
- Sobaih Badr Hasan
- Sobhani Soheila
- Sobhani Soheila
- Somayaji Ranjani
- Somayaji Ranjani
- Soofi Moslem
- Soofi Moslem
- Sorensen Reed J. D.
- Sorensen Reed J. D.
- Soriano Joan B.
- Soriano Joan B.
- Soyiri Ireneous N.
- Soyiri Ireneous N.
- Spinelli Angela
- Spinelli Angela
- Sposato Luciano A.
- Sposato Luciano A.
- Sreeramareddy Chandrashekhar T.
- Sreeramareddy Chandrashekhar T.
- Srinivasan Vinay
- Srinivasan Vinay
- Stanaway Jeffrey D.
- Stanaway Jeffrey D.
- Starodubow Vladimir I.
- Starodubow Vladimir I.
- Steckling Nadine
- Steckling Nadine
- Stein Dan J.
- Stein Dan J.
- Stein Murray B.
- Stein Murray B.
- Stevanovic Goran
- Stevanovic Goran
- Stockfelt Leo
- Stockfelt Leo
- Stokes Mark A.
- Stokes Mark A.
- Sturua Lela
- Sturua Lela
- Subart Michelle L.
- Subart Michelle L.
- Sudaryanto Agus
- Sudaryanto Agus
- Sufiyan Mu'awiyyah Babale
- Sufiyan Mu'awiyyah Babale
- Sulo Gerhard
- Sulo Gerhard
- Sunguya Bruno F.
- Sunguya Bruno F.
- Sur Patrick John
- Sur Patrick John
- Sykes Bryan I.
- Sykes Bryan I.
- Szoeke Cassandra E. I.
- Szoeke Cassandra E. I.
- Tabares-Seisdedos Rafael
- Tabares-Seisdedos Rafael
- Tabuchi Takahiro
- Tabuchi Takahiro
- Tadakamadla Santosh Kumar
- Tadakamadla Santosh Kumar
- Takahashi Ken
- Takahashi Ken
- Tandon Nikhil
- Tandon Nikhil
- Tassew Segen Gebremeskel
- Tassew Segen Gebremeskel
- Tavakkoli Mohammad
- Tavakkoli Mohammad
- Taveira Nuno
- Taveira Nuno
- Tehrani-Banihashemi Arash
- Tehrani-Banihashemi Arash
- Tekalign Tigist Gashaw
- Tekalign Tigist Gashaw
- Tekelemedhin Shishay Wandey
- Tekelemedhin Shishay Wandey
- Tekle Merhawi Gebremedhin
- Tekle Merhawi Gebremedhin
- Temesgen Habtamu
- Temesgen Habtamu
- Temsah Mohamad-Rani
- Temsah Mohamad-Rani
- Temsah Omar
- Temsah Omar
- Terkawi Abdullah Sulieman
- Terkawi Abdullah Sulieman
- Tessema Belay
- Tessema Belay
- Teweldemedhin Mebrahtu
- Teweldemedhin Mebrahtu
- Thankappan Kavumpurathu Raman
- Thankappan Kavumpurathu Raman
- Theis Andrew
- Theis Andrew
- Thirunavukkarasu Sathish
- Thirunavukkarasu Sathish
- Thomas Hannah J.
- Thomas Hannah J.
- Thomas Matthew Lloyd
- Thomas Matthew Lloyd
- Thomas Nihal
- Thomas Nihal
- Thou Maigeng
- Thou Maigeng
- Thurston George D.
- Thurston George D.
- Tilahun Binyam
- Tilahun Binyam
- Tillmana Taavi
- Tillmana Taavi
- To Quyen G.
- To Quyen G.
- Tobollik Myriarn
- Tobollik Myriarn
- Tonelli Marcello
- Tonelli Marcello
- Topor-Madry Roman
- Topor-Madry Roman
- Torre Anna E.
- Torre Anna E.
- Tortajada-Girbes Miguel
- Tortajada-Girbes Miguel
- Touvier Mathilde
- Touvier Mathilde
- Tovani-Palone Marcos Roberto
- Tovani-Palone Marcos Roberto
- Towbin Jeffrey A.
- Towbin Jeffrey A.
- Tran Bach Xuan
- Tran Bach Xuan
- Tran Khanh Baca
- Tran Khanh Baca
- Truelsen Thomas Clement
- Truelsen Thomas Clement
- Tsadik Afewerki Gebremeskel
- Tsadik Afewerki Gebremeskel
- Tuzcu E. Murat
- Tuzcu E. Murat
- Tymeson Hayley D.
- Tymeson Hayley D.
- Tyrovolas Stefanos
- Tyrovolas Stefanos
- Ukwaja Kingsley N.
- Ukwaja Kingsley N.
- Ullah Irfan
- Ullah Irfan
- Updike Rachel L.
- Updike Rachel L.
- Usman Muhammad Shariq
- Usman Muhammad Shariq
- Uthman Olalekan A.
- Uthman Olalekan A.
- Vaduganathan Mutblab
- Vaduganathan Mutblab
- Vaezi Afsane
- Vaezi Afsane
- Valdez Pascual R.
- Valdez Pascual R.
- Van Donkelaar Aaron
- Van Donkelaar Aaron
- Varavikova Elena
- Varavikova Elena
- Varughese Santosh
- Varughese Santosh
- Vasankari Tommi Juhani
- Vasankari Tommi Juhani
- Vbsoughi Kia
- Vbsoughi Kia
- Venkateswaran Vidhya
- Venkateswaran Vidhya
- Venketasubramanian Narayanaswamy
- Venketasubramanian Narayanaswamy
- Villafaina Santos
- Villafaina Santos
- Violante Francesco S.
- Violante Francesco S.
- Vladimirov Sergey Konstantinovitch
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Vlassov Vasily
- Vollset Stein Emil
- Vollset Stein Emil
- Vos Theo
- Vos Theo
- Vu Giang Thu
- Vu Giang Thu
- Vujcic Isidora S.
- Vujcic Isidora S.
- Wagnew Fasil Shiferaw
- Wagnew Fasil Shiferaw
- Waheed Yasir
- Waheed Yasir
- Waller Stephen G.
- Waller Stephen G.
- Walson Judd L.
- Walson Judd L.
- Wang Yafeng
- Wang Yafeng
- Wang Yanping
- Wang Yanping
- Wang Yuan-Pang
- Wang Yuan-Pang
- Weiderpass Elisabete
- Weiderpass Elisabete
- Weiknah Adhena Ayaliew
- Weiknah Adhena Ayaliew
- Weintraub Robert G.
- Weintraub Robert G.
- Weldegebreal Fitsum
- Weldegebreal Fitsum
- Werdecker Andrea
- Werdecker Andrea
- West J. Jason
- West J. Jason
- Westerman Ronny
- Westerman Ronny
- Whiteford Harvey A.
- Whiteford Harvey A.
- Widecka Justyna
- Widecka Justyna
- Wijeratne Tissa
- Wijeratne Tissa
- Winkler Andrea Sylvia
- Winkler Andrea Sylvia
- Wiyeh Alison B.
- Wiyeh Alison B.
- Wiysonge Charles Shey
- Wiysonge Charles Shey
- Wolfe Charles D. A.
- Wolfe Charles D. A.
- Wong Tien Yin
- Wong Tien Yin
- Wu Shoaling
- Wu Shoaling
- Xavier Denis
- Xavier Denis
- Xu Gelin
- Xu Gelin
- Yadgir Simon
- Yadgir Simon
- Yadollahpour Ali
- Yadollahpour Ali
- Yamada Tomohide
- Yamada Tomohide
- Yan Lijing L.
- Yan Lijing L.
- Yano Yuichiro
- Yano Yuichiro
- Yaseri Mehdi
- Yaseri Mehdi
- Yasin Jemal Yasin
- Yasin Jemal Yasin
- Yeshanely Alex
- Yeshanely Alex
- Yimer Ebrahim M.
- Yimer Ebrahim M.
- Yip Paul
- Yip Paul
- Yisma Engida
- Yisma Engida
- Yonemoto Naohiro
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yoon Seok-Jun
- Yotebieng Marcel
- Yotebieng Marcel
- Younis Mustafa Z.
- Younis Mustafa Z.
- Yousefifard Mahmoud
- Yousefifard Mahmoud
- Yu Chuanhua
- Yu Chuanhua
- Zaidi Zoubida
- Zaidi Zoubida
- Zamani Mohammad
- Zamani Mohammad
- Zavala-Arciniega Luis
- Zavala-Arciniega Luis
- Zhang Anthony Lin
- Zhang Anthony Lin
- Zhang Hao
- Zhang Hao
- Zhang Kai
- Zhang Kai
- Zimsen Stephanie M.
- Zimsen Stephanie M.
- Zodpey Sanjay
- Zodpey Sanjay
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk–outcome pairs, and new data on risk exposure levels and risk–outcome associations.
Methods
We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk–outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
Findings
In 2017, 34·1 million (95% uncertainty interval [UI] 33·3–35·0) deaths and 1·21 billion (1·14–1·28) DALYs were attributable to GBD risk factors. Globally, 61·0% (59·6–62·4) of deaths and 48·3% (46·3–50·2) of DALYs were attributed to the GBD 2017 risk factors. When ranked by risk-attributable DALYs, high systolic blood pressure (SBP) was the leading risk factor, accounting for 10·4 million (9·39–11·5) deaths and 218 million (198–237) DALYs, followed by smoking (7·10 million [6·83–7·37] deaths and 182 million [173–193] DALYs), high fasting plasma glucose (6·53 million [5·23–8·23] deaths and 171 million [144–201] DALYs), high body-mass index (BMI; 4·72 million [2·99–6·70] deaths and 148 million [98·6–202] DALYs), and short gestation for birthweight (1·43 million [1·36–1·51] deaths and 139 million [131–147] DALYs). In total, risk-attributable DALYs declined by 4·9% (3·3–6·5) between 2007 and 2017. In the absence of demographic changes (ie, population growth and ageing), changes in risk exposure and risk-deleted DALYs would have led to a 23·5% decline in DALYs during that period. Conversely, in the absence of changes in risk exposure and risk-deleted DALYs, demographic changes would have led to an 18·6% increase in DALYs during that period. The ratios of observed risk exposure levels to exposure levels expected based on SDI (O/E ratios) increased globally for unsafe drinking water and household air pollution between 1990 and 2017. This result suggests that development is occurring more rapidly than are changes in the underlying risk structure in a population. Conversely, nearly universal declines in O/E ratios for smoking and alcohol use indicate that, for a given SDI, exposure to these risks is declining. In 2017, the leading Level 4 risk factor for age-standardised DALY rates was high SBP in four super-regions: central Europe, eastern Europe, and central Asia; north Africa and Middle East; south Asia; and southeast Asia, east Asia, and Oceania. The leading risk factor in the high-income super-region was smoking, in Latin America and Caribbean was high BMI, and in sub-Saharan Africa was unsafe sex. O/E ratios for unsafe sex in sub-Saharan Africa were notably high, and those for alcohol use in north Africa and the Middle East were notably low.
Interpretation
By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning
Single polyelectrolyte multilayer fabricated by covalent layer-by-layer assembly of TA and PEI and its antibacterial application via incorporated Ag particles
- Author
- Publication venue
- Publication date
- 01/01/2009
- Field of study
The purpose of this report is to provide an overview on the study of the fabrication of a multilayer by Covalent Layer-by-Layer Assembly for Antibacterial Application via incorporated silver particles. This project investigates the use of this layer-by-layer method to create multiple bilayers of terepthalaldehyde (TA) and polyethyleneimine (PEI) on glass surface, with the incorporation of silver nanoparticles in order to effectively achieve anti-bacterial effect. Bacterial contamination has all along posed as a serious problem in many areas which requires sterility to minimize microbial growth. This report highlights the combination of the use of both the aqueous layer-by-layer deposition technique, as well as the nanoparticle surface modification chemistry, to construct thin film coatings that fulfil the antibacterial function. Together with the silver ions and nanoparticles embedded within the bilayersm, they are able to achieve this objective by preventing the adhesion of bacteria on the surface through their anti-adhesive property, acting as biocides to the bacteria through contact killing, and lastly through the sustained release of the antibacterial agents from a reservoir of silver particles.
Due to the widespread adverse social and economic consequence resulted from the undesired bacterial growth on equipment, in particular medical devices, there remains much incentive to perform this work for future applications in various industries.Bachelor of Engineering (Chemical and Biomolecular Engineering
Burgernomics: the economics of the Big Mac standard
- Author
- Publication venue
- Publication date
- Field of study
Professors and hamburgers: an international comparison of real academic salaries
- Publication venue
- Publication date
- Field of study
In recent years, academic staff unions and associations have argued for higher salaries for academics on the grounds that existing salaries have not kept pace with inflation, are well below commercial salaries and, most glaringly, are much lower than the salaries of their overseas counterparts. However, most international comparisons are made based on exchange rate conversions, which is inappropriate since purchasing power differentials are only reflected in exchange rates in the long term. Furthermore, the volatility of exchange rates make such conversions highly inaccurate. A comparison is provided of real academic salaries by converting the nominal salaries in each country to their purchasing power equivalents, using the Big Mac Index. Our results show that real academic salaries are highest in Hong Kong and Singapore, relative to the developed countries, while Hong Kong tax and social security deductions are lowest. Furthermore, real salary levels, combined with intrinsic considerations such as the quality-of-life, indicate that Canada and New Zealand are unattractive places for visiting/migrating academics, while Australia and the USA are relatively attractive. It is suggested that these findings could be of use to policy-makers and academic unions in salary negotiations, as well as academics making relocation decisions.
Optimism and the Occult Octopus: Favorites Lose, Underdogs Triumph, and Spain Finally Wins the World Cup
- Publication venue
- American Statistical Association
- Publication date
- 01/01/1970
- Field of study
Optimism and the Occult Octopus: Favorites Lose, Underdogs Triumph, and Spain Finally Wins the World Cup
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/05/2014
- Field of study
- …