Exile and Petrarch’s Reinvention of Authorship

This article demonstrates a systematic connection between the novelty of Petrarch’s authorship and his self-definition as an exile. Petrarch employs the unusual term exilium/esilio to substantiate his unprecedented claim that literature is a legally valid officium (civic role). Following Dante, Petrarch grounds his exilic authorship in the Christian discourse of peregrinatio: life as pilgrimage through exile. But Petrarch’s new officium allows him a measure of control over literary creation that no prior Italian writer had enjoyed. This is especially true of the “Canzoniere,” Petrarch’s compilation of his vernacular lyrics, whose singularity functions as a proxy for its author’s selfhood

Exile and Rhetorical Order in the Vita nova

This article identifies the Augustinian motive of peregrinatio (pilgrimage/exile) as fundamental to the Vita nova, both thematically and at the level of narrative structure. Although Dante himself would not experience banishment from Florence in 1302, this early work establishes him as a vernacular poet whose authority stems from a marginal and provisional social position

Dante’s Convivio, Book 1: Metaphor, Exile, Epochē

The essay examines closely the many and varied metaphors of Convivio 1 in relation to its "content." This approach contrasts with most prior work on the Convivio, which views it as a philosophical work, and pays little attention its form or rhetoric. Instead, the article shows that the Convivio draws on a variety of disciplines in orer to emphasize its author's subjectivity. Once we appreciate that Dante's multi-disciplinary approach, the novel literary and subjective qualities of the Convivio become much clearer. Dante's metaphors do not offer a final intellectual or philosophical demonstration but rather encourage a suspension of judgment that replicates for the reader the alienation of exile from which Dante writes

‘Riacquistare la Casarsa buona’: Exile, Realism, and Authorship in Pasolini’s Atti impuri and Amado mio

This article challenges the established reading of Atti impuri and Amado mio, Pasolini’s early unfinished novels about young homosexual love, as diaristic. Previous accounts of the Friulan novels have largely ignored the fact that their final redactions were drawn up in Rome, where the author had fled from Friuli in January 1950 in the wake of a sexually tinged scandal. The present analysis suggests that the novels’ relationship to their setting should be read as nostalgic, and compares them to the poetic works on Friuli that Pasolini wrote in Rome in the early 1950s. This poetics of absence provides the backdrop for a reflection on the practice of realist authorship that engages with contemporary neorealist narrative from a position of paradoxical outsiderhood

"Un estraneo in una terra ostile": Exile and Engagement in Pasolini's Verse Dramas

Concentrates on the brief period of Pier Paolo Pasolini’s career between 1966 and 1969 when he dedicated a significant portion of his energy to the theater. Argues that these years contain Pasolini’s most direct engagement with bourgeois Italian culture: he largely drops his use of dialect in favor of Standard Italian, he sets his plays in modern urban Italy or in places related to it by analogy or allegory, and he explicitly envisages a public made up of the "advanced groups of the bourgeoisie." Once this theatrical period closes, Pasolini’s narrative works tend to create their own hermetic environment in which to play themselves out

Characterization and eschatological realism from Dante to Petrarch

This article considers the characterization of blessed souls in Dante’s Commedia (1307–21) and Petrarch’s Canzoniere (c. 1356–74) and Triumphi (c. 1352–74). It argues that eschatological realism – the detailed representation of souls in the afterlife – lies at the heart of these three works, each of which depicts a deceased beloved who now resides in Paradise. Dante’s Paradiso navigates a range of doctrinal and literary challenges to incorporate its blessed characters into the poem’s continuum of interlocutors. Although the Commedia culminates with a first-person, mystical experience, the structural importance of third-person voices to the canticle demonstrates the centrality of realist characterization to the overall project. Petrarch’s works, meanwhile, reject Dante’s broad and varied descriptions of beatitude but nonetheless assert a more restricted eschatological realism channelled through the interpersonal connection with Laura. The beloved’s combination of exemplarity and historicity sets up the paradigm that defines the other characters in Petrarch’s narrative, including the poetic ‘I’

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

BACKGROUND: Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock. METHODS AND DESIGN: The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a multicenter, double-blind, adaptive sample size, randomized, placebo-controlled trial designed to test the efficacy of combination therapy with vitamin C (1.5 g), thiamine (100 mg), and hydrocortisone (50 mg) given every 6 h for up to 16 doses in patients with respiratory or circulatory dysfunction (or both) resulting from sepsis. The primary outcome is ventilator- and vasopressor-free days with mortality as the key secondary outcome. Recruitment began in August 2018 and is ongoing; 501 participants have been enrolled to date, with a planned maximum sample size of 2000. The Data and Safety Monitoring Board reviewed interim results at N = 200, 300, 400 and 500, and has recommended continuing recruitment. The next interim analysis will occur when N = 1000. This update presents the statistical analysis plan. Specifically, we provide definitions for key treatment and outcome variables, and for intent-to-treat, per-protocol, and safety analysis datasets. We describe the planned descriptive analyses, the main analysis of the primary end point, our approach to secondary and exploratory analyses, and handling of missing data. Our goal is to provide enough detail that our approach could be replicated by an independent study group, thereby enhancing the transparency of the study. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03509350. Registered on 26 April 2018

Statewide Molecular Epidemiology of Mycobacterium tuberculosis Transmission in a Moderate- to Low-Incidence State: Are Contact Investigations Enough?

To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease <2 years after infection), we obtained DNA fingerprints for 1,172 (99%) of 1,179 Mycobacterium tuberculosis isolates collected from Maryland TB patients from 1996 to 2000. We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 114 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that eliminating diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations

Measurement invariance of the short version of the problematic mobile phone use questionnaire (PMPUQ-SV) across eight languages

The prevalence of mobile phone use across the world has increased greatly over the past two decades. Problematic Mobile Phone Use (PMPU) has been studied in relation to public health and comprises various behaviours, including dangerous, prohibited, and dependent use. These types of problematic mobile phone behaviours are typically assessed with the short version of the Problematic Mobile Phone Use Questionnaire (PMPUQ-SV). However, to date, no study has ever examined the degree to which the PMPU scale assesses the same construct across different languages. The aims of the present study were to (i) determine an optimal factor structure for the PMPUQ-SV among university populations using eight versions of the scale (i.e., French, German, Hungarian, English, Finnish, Italian, Polish, and Spanish); and (ii) simultaneously examine the measurement invariance (MI) of the PMPUQ-SV across all languages. The whole study sample comprised 3038 participants. Descriptive statistics, correlations, and Cronbach's alpha coefficients were extracted from the demographic and PMPUQ-SV items. Individual and multigroup confirmatory factor analyses alongside MI analyses were conducted. Results showed a similar pattern of PMPU across the translated scales. A three-factor model of the PMPUQ-SV fitted the data well and presented with good psychometric properties. Six languages were validated independently, and five were compared via measurement invariance for future cross-cultural comparisons. The present paper contributes to the assessment of problematic mobile phone use because it is the first study to provide a cross-cultural psychometric analysis of the PMPUQ-SV

Arm-in-cage testing of natural human-derived mosquito repellents

BACKGROUND: Individual human subjects are differentially attractive to mosquitoes and other biting insects. Previous investigations have demonstrated that this can be attributed partly to enhanced production of natural repellent chemicals by those individuals that attract few mosquitoes in the laboratory. The most important compounds in this respect include three aldehydes, octanal, nonanal and decanal, and two ketones, 6-methyl-5-hepten-2-one and geranylacetone [(E)-6,10-dimethylundeca-5,9-dien-2-one]. In olfactometer trials, these compounds interfered with attraction of mosquitoes to a host and consequently show promise as novel mosquito repellents. METHODS: To test whether these chemicals could provide protection against mosquitoes, laboratory repellency trials were carried out to test the chemicals individually at different concentrations and in different mixtures and ratios with three major disease vectors: Anopheles gambiae, Culex quinquefasciatus and Aedes aegypti. RESULTS: Up to 100% repellency was achieved depending on the type of repellent compound tested, the concentration and the relative composition of the mixture. The greatest effect was observed by mixing together two compounds, 6-methyl-5-hepten-2-one and geranylacetone in a 1:1 ratio. This mixture exceeded the repellency of DEET when presented at low concentrations. The repellent effect of this mixture was maintained over several hours. Altering the ratio of these compounds significantly affected the behavioural response of the mosquitoes, providing evidence for the ability of mosquitoes to detect and respond to specific mixtures and ratios of natural repellent compounds that are associated with host location. CONCLUSION: The optimum mixture of 6-methyl-5-hepten-2-one and geranylacetone was a 1:1 ratio and this provided the most effective protection against all species of mosquito tested. With further improvements in formulation, selected blends of these compounds have the potential to be exploited and developed as human-derived novel repellents for personal protection