6,086 research outputs found
The size-brightness correspondence:evidence for crosstalk among aligned conceptual feature dimensions
The same core set of cross-sensory correspondences connecting stimulus features across different sensory channels are observed regardless of the modality of the stimulus with which the correspondences are probed. This observation suggests that correspondences involve modality-independent representations of aligned conceptual feature dimensions, and predicts a size-brightness correspondence, in which smaller is aligned with brighter. This suggestion accommodates cross-sensory congruity effects where contrasting feature values are specified verbally rather than perceptually (e.g., where the words WHITE and BLACK interact with the classification of high and low pitch sounds). Experiment 1 brings these two issues together in assessing a conceptual basis for correspondences. The names of bright/white and dark/black substances were presented in a speeded brightness classification task in which the two alternative response keys differed in size. A size-brightness congruity effect was confirmed, with substance names classified more quickly when the relative size of the response key needing to be pressed was congruent with the brightness of the named substance (e.g., when yoghurt was classified as a bright substance by pressing the smaller of two keys). Experiment 2 assesses the proposed conceptual basis for this congruity effect by requiring the same named substances to be classified according to their edibility (with all of the bright/dark substances having been selected for their edibility/inedibility, respectively). The predicted absence of a size-brightness congruity effect, along with other aspects of the results, supports the proposed conceptual basis for correspondences and speaks against accounts in which modality-specific perceptuomotor representations are entirely responsible for correspondence-induced congruity effects
The size-brightness correspondence: evidence for crosstalk among aligned conceptual feature dimensions
Electronic transport through electron-doped Metal-Phthalocyanine Materials
We report an insulator-metal-insulator transition in films of five metal
phthalocyanines (MPc) doped with alkali atoms. Electrical conduction
measurements demonstrate that increasing the alkali concentration results in
the formation of a metallic state for all systems. Upon further doping, the
films reenter the insulating state. Structural and Raman spectroscopy studies
reveal the formation of new crystalline phases upon doping and are consistent
with the phenomena originating from charge transfer between the intercalated
alkali atoms and MPc, in a similar fashion to what has been so far observed
only in C60. Due to the presence of a molecular spin, large exchange energy,
and a two-fold orbital degeneracy in MPc, our findings are of interest in the
study of controllable magnetism in molecular materials and in the investigation
of new, recently predicted electronic phases.Comment: Replaced with published versio
Formaldehyde-releasers: relationship to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers
This is one of series of review articles on formaldehyde and formaldehyde-releasers (others: formaldehyde in cosmetics, in clothes and in metalworking fluids and miscellaneous). Thirty-five chemicals were identified as being formaldehyde-releasers. Although a further seven are listed in the literature as formaldehyde-releasers, data are inadequate to consider them as such beyond doubt. Several (nomenclature) mistakes and outdated information are discussed. Formaldehyde and formaldehyde allergy are reviewed: applications, exposure scenarios, legislation, patch testing problems, frequency of sensitization, relevance of positive patch test reactions, clinical pattern of allergic contact dermatitis from formaldehyde, prognosis, threshold for elicitation of allergic contact dermatitis, analytical tests to determine formaldehyde in products and frequency of exposure to formaldehyde and releasers. The frequency of contact allergy to formaldehyde is consistently higher in the USA (8-9%) than in Europe (2-3%). Patch testing with formaldehyde is problematic; the currently used 1% solution may result in both false-positive and false-negative (up to 40%) reactions. Determining the relevance of patch test reactions is often challenging. What concentration of formaldehyde is safe for sensitive patients remains unknown. Levels of 200-300 p.p.m. free formaldehyde in cosmetic products have been shown to induce dermatitis from short-term use on normal skin
Growth of epitaxially oriented Ag nanoislands on air-oxidized Si(111)-(7x7) surfaces: Influence of short range order on the substrate
Clean Si(111)-(7{x7) surfaces, followed by air-exposure, have been
investigated by reflection high energy electron diffraction (RHEED) and
scanning tunneling microscopy (STM). Fourier transforms (FTs) of STM images
show the presence of short range (7x7) order on the air-oxidized surface.
Comparison with FTs of STM images from a clean Si(111)-(7x7) surface shows that
only the 1/7th order spots are present on the air-oxidized surface. The oxide
layer is ~ 2-3 nm thick, as revealed by cross-sectional transmission electron
microscopy (XTEM). Growth of Ag islands on these air-oxidized Si(111)-(7x7)
surfaces has been investigated by in-situ RHEED and STM and ex-situ XTEM and
scanning electron microscopy. Ag deposition at room temperature leads to the
growth of randomly oriented Ag islands while preferred orientation evolves when
Ag is deposited at higher substrate temperatures. For deposition at 550{\deg}C
face centered cubic Ag nanoislands grow with a predominant epitaxial
orientation [1 -1 0]Ag || [1 -1 0]Si, (111)Ag || (111)Si along with its twin
[-1 1 0]Ag || [1 -1 0]Si, (111)Ag || (111)Si, as observed for epitaxial growth
of Ag on Si(111) surfaces. The twins are thus rotated by a 180{\deg} rotation
of the Ag unit cell about the Si [111] axis. It is intriguing that Ag
nanoislands follow an epitaxial relationship with the Si(111) substrate in
spite of the presence of a 2-3 nm thick oxide layer between Ag and Si.
Apparently the short range order on the oxide surface influences the
crystallographic orientation of the Ag nanoislands.Comment: 10 figure
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SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation.
SLC45A2 encodes a putative transporter expressed primarily in pigment cells. SLC45A2 mutations cause oculocutaneous albinism type 4 (OCA4) and polymorphisms are associated with pigmentation variation, but the localization, function, and regulation of SLC45A2 and its variants remain unknown. We show that SLC45A2 localizes to a cohort of mature melanosomes that only partially overlaps with the cohort expressing the chloride channel OCA2. SLC45A2 expressed ectopically in HeLa cells localizes to lysosomes and raises lysosomal pH, suggesting that in melanocytes SLC45A2 expression, like OCA2 expression, results in the deacidification of maturing melanosomes to support melanin synthesis. Interestingly, OCA2 overexpression compensates for loss of SLC45A2 expression in pigmentation. Analyses of SLC45A2- and OCA2-deficient mouse melanocytes show that SLC45A2 likely functions later during melanosome maturation than OCA2. Moreover, the light skin-associated SLC45A2 allelic F374 variant restores only moderate pigmentation to SLC45A2-deficient melanocytes due to rapid proteasome-dependent degradation resulting in lower protein expression levels in melanosomes than the dark skin-associated allelic L374 variant. Our data suggest that SLC45A2 maintains melanosome neutralization that is initially orchestrated by transient OCA2 activity to support melanization at late stages of melanosome maturation, and that a common allelic variant imparts reduced activity due to protein instability
Solution of Ge(111)-(4×4)-Ag structure using direct methods applied to X-ray diffraction data
‘When Birds of a Feather Flock Together’: Synesthetic Correspondences Modulate Audiovisual Integration in Non-Synesthetes
Parise C, Spence C. ‘When Birds of a Feather Flock Together’: Synesthetic Correspondences Modulate Audiovisual Integration in Non-Synesthetes. Presented at the 10th International Multisensory Research Forum (IMRF 2009), New York, NY
Penetrating spinal injury with wooden fragments causing cauda equina syndrome: case report and literature review
Study design: Case report Objective: To report an unusual case of cauda equina syndrome following penetrating injury to the lumbar spine by wooden fragments and to stress the importance of early magnetic resonance imaging (MRI) in similar cases. Summary of background data: A 22-year-old girl accidentally landed on wooden bannister and sustained a laceration to her back. She complained of back pain but had fully intact neurological function. The laceration in her back was explored and four large wooden pieces were removed. However 72 h later, she developed cauda equina syndrome. MRI demonstrated the presence of a foreign body between second and third lumbar spinal levels following which she underwent emergency decompressive laminectomy and the removal of the multiple wooden fragments that had penetrated the dura. Results: Post-operatively motor function in her lower limbs returned to normal but she continued to require a catheter for incontinence. At review 6 months later, she was mobilising independently but the incontinence remained unchanged. Conclusion: There are no reported cases in the literature of wooden fragments penetrating the dura from the back with or without the progression to cauda equina syndrome. The need for a high degree of suspicion and an early MRI scan to localise any embedded wooden fragments that may be separate from the site of laceration is emphasized even if initial neurology is intact
Tnni3k Modifies Disease Progression in Murine Models of Cardiomyopathy
The Calsequestrin (Csq) transgenic mouse model of cardiomyopathy exhibits wide variation in phenotypic progression dependent on genetic background. Seven heart failure modifier (Hrtfm) loci modify disease progression and outcome. Here we report Tnni3k (cardiac Troponin I-interacting kinase) as the gene underlying Hrtfm2. Strains with the more susceptible phenotype exhibit high transcript levels while less susceptible strains show dramatically reduced transcript levels. This decrease is caused by an intronic SNP in low-transcript strains that activates a cryptic splice site leading to a frameshifted transcript, followed by nonsense-mediated decay of message and an absence of detectable protein. A transgenic animal overexpressing human TNNI3K alone exhibits no cardiac phenotype. However, TNNI3K/Csq double transgenics display severely impaired systolic function and reduced survival, indicating that TNNI3K expression modifies disease progression. TNNI3K expression also accelerates disease progression in a pressure-overload model of heart failure. These combined data demonstrate that Tnni3k plays a critical role in the modulation of different forms of heart disease, and this protein may provide a novel target for therapeutic intervention
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