Parents’ experiences of health visiting for children with Down syndrome

© MA Healthcare Limited.Children with Down syndrome have an increased likelihoodof experiencing serious health conditions. Health visitors canhave an important role in monitoring and promoting healthand development for young children with Down syndrome.This study aimed to explore parents’ experiences of healthvisiting services for children with Down syndrome. Twentyfour parents of children with Down syndrome aged 0–5 yearscompleted a brief questionnaire about the number and natureof visits from health visitors in the previous 12 months andtheir support needs. Some parents commented that otherprofessionals met the needs of their child, whereas others saidthat they would like more advice and support from healthvisitors. A further exploration of broader health serviceprovision, including health visiting, for young children withDown syndrome is needed.Peer reviewedFinal Accepted Versio

Colour gradients in normal and compact early-type galaxies at 1<z<2

We have derived colour gradients for a sample of 20 early-type galaxies (ETGs) at 1 < z_spec < 2 selected from the GOODS-South field. The sample includes both normal ETGs (13) having effective radii comparable to the mean radius of local ones and compact ETGs (7) having effective radii from two to six times smaller. Colour gradients have been derived in the F606W-F850LP bands (UV-U rest-frame) taking advantage of the ultradeep HST-ACS observations covering this field and providing a spatial resolution of about 0.8 kpc at the redshift of the galaxies. Despite of the narrow wavelength baseline covered (1000 Angstrom), sampling approximatively the emission dominated by the same stellar population, we detect significant radial colour variations in 50 per cent of our sample. In particular, we find five ETGs with positive colour gradients (cores bluer than the external regions), and five galaxies with negative colour gradients (cores redder than the external regions), as commonly observed in the local Universe. These results show that at 1 < z < 2, when the Universe was only 3-4 Gyr old, ETGs constituted a composite population of galaxies whose different assembly histories have generated different stellar distributions with the bluest stellar population either in the center or in the outskirts as well as throughout the whole galaxy. Moreover, we find that compact galaxies seem to preferentially show a blue cores while moving towards normal galaxies, central stellar populations become progressively redder. Nonetheless, the narrow baseline covered together with the low statistics still prevent us to be conclusive about a possible physical connection between colour gradients and the degree of compactness of high-z ETGs.Comment: 11 pages, 8 figures, accepted for publication in MNRA

The number density of superdense early-type galaxies at 1<z<2 and the local cluster galaxies

Many of the early-type galaxies observed so far at z>1 turned out to have smaller radii with respect to that of a typical present-day early-type galaxy with comparable mass. This has generated the conviction that in the past early-type galaxies were more compact, hence denser, and that as a consequence, they should have increased their radius across the time to reconcile with the present-day ones. However, observations have not yet established whether the population of early-types in the early Universe was fully represented by compact galaxies nor if they were so much more numerous than in the present-day Universe to require an evolution of their sizes. Here we report the results of a study based on a complete sample of 34 early-type galaxies at 0.9<z_{spec}<1.92. We find a majority (62 per cent) of normal early-type galaxies similar to typical local ones, co-existing with compact early-types from ~2 to ~6 times smaller in spite of the same mass and redshift. The co-existence of normal and compact early-type galaxies at ~1.5 suggests that their build-up taken place in the first 3-4 Gyr, followed distinct paths. Also, we find that the number density of compact early-types at ~1.5 is consistent with the lower limits of the local number density of compact early-types derived from local clusters of galaxies. The similar number of compact early-types found in the early and in the present day Universe frustrates the hypothesized effective radius evolution while provides evidence that also compact ETGs were as we see them today 9-10 Gyr ago. Finally, the fact that (at least) most of the compact ETGs at high-z are accounted for by compact early-types in local cluster of galaxies implies that the former are the direct progenitors of the compact early-type cluster galaxies establishing a direct link between environment and early phases of assembly of ETGs.Comment: Published on MNRAS Letters (5 pages, 2 figures, 1 table

High-redshift elliptical galaxies: are they (all) really compact?

We investigate the properties of 12 ultra-massive passively evolving early type galaxies (ETGs) at z_phot>1.4 in the COSMOS 2 deg^2 field. These 12 ETGs were selected as pBzKs, have accurate 1.4<= z_phot <=1.7,high Sersic index profiles typical of ellipticals, no detection at 24 micron, resulting in a complete ETG sample at M*>2.5x10^11 M_sun (Chabrier IMF). Contrary to previous claims, the half light radii estimated in very high S/N imaging data from HST+ACS are found to be large for most of the sample, consistent with local ellipticals. If the high redshift ETGs with M*<2.5x10^11 M_sun are really small in size and compact as reported in previous studies, our result may suggest a "downsizing" scenario, whereby the most massive ETGs reach their final structure earlier and faster than lower mass ones. However, simulating galaxies with morphological properties fixed to those of local ETGs with the same stellar mass show that the few compact galaxies that we still recover in our sample can be understood in term of fluctuations due to noise preventing the recovery of the extended low surface brightness halos in the light profile. Such halos, typical of Sersic profiles, extending even up to 40 kpc, are indeed seen in our sample.Comment: 9 pages, 7 figures, accepted by MNRA

The AIDS and Cancer Specimen Resource: Role in HIV/AIDS scientific discovery

The AIDS Cancer and Specimen Resource (ACSR) supports scientific discovery in the area of HIV/AIDS-associated malignancies. The ACSR was established as a cooperative agreement between the NCI (Office of the Director, Division of Cancer Treatment and Diagnosis) and regional consortia, University of California, San Francisco (West Coast), George Washington University (East Coast) and Ohio State University (Mid-Region) to collect, preserve and disperse HIV-related tissues and biologic fluids and controls along with clinical data to qualified investigators. The available biological samples with clinical data and the application process are described on the ACSR web site. The ACSR tissue bank has more than 100,000 human HIV positive specimens that represent different processing (43), specimen (15), and anatomical site (50) types. The ACSR provides special biospecimen collections and prepares speciality items, e.g., tissue microarrays (TMA), DNA libraries. Requests have been greatest for Kaposi's sarcoma (32%) and non-Hodgkin's lymphoma (26%). Dispersed requests include 83% tissue (frozen and paraffin embedded), 18% plasma/serum and 9% other. ACSR also provides tissue microarrays of, e.g., Kaposi's sarcoma and non-Hodgkin's lymphoma, for biomarker assays and has developed collaborations with other groups that provide access to additional AIDS-related malignancy specimens. ACSR members and associates have completed 63 podium and poster presentations. Investigators have submitted 125 letters of intent requests. Discoveries using ACSR have been reported in 61 scientific publications in notable journals with an average impact factor of 7. The ACSR promotes the scientific exploration of the relationship between HIV/AIDS and malignancy by participation at national and international scientific meetings, contact with investigators who have productive research in this area and identifying, collecting, preserving, enhancing, and dispersing HIV/AIDS-related malignancy specimens to funded, approved researchers at no fee. Scientific discovery has been advanced by this unique biorepository. Investigators are encouraged to browse the ACSR Internet site for materials to enhance their own scientific initiatives

Post-Operative Pain After Knee Arthroscopy and Related Factors

The aim of this study was to explore the intensity of post-arthroscopy knee pain during the first 24 hours, and to study the influence of pre-operative pain, tourniquet time and amount of surgical trauma on post-arthroscopy pain. In 78 male patients that underwent elective arthroscopic menisectomy or diagnostic arthroscopy of the knee, preoperative and post-operative pain were registered using the Visual Analogue Scale. Variance for repeated measures and for independent observations was analysed. Supplementary analgesia was required for 23% of the patients, more often in the recovery room and between 2 and 8 hours postoperatively. Of all factors analyzed, only time was statistically significant in determining the level of post-operative pain. Supplementary analgesia was required only in patients that underwent operative arthroscopy, and more often in patients with tourniquet time of more than 40 minutes. In conclusions, post-operative time is the most significant factor related to the post-arthroscopy knee pain

Visions of prosperity and conspiracy in Timor-Leste

In Timor-Leste, visions of radical societal transformation and future wealth derived from gold and oil are accompanied by concerns that outsiders might be conspiring to rob the country of its riches, as well as conjuring up dystopian scenarios of sinister plots and future mayhem. Examining national narratives and local accounts, this article argues that visions of prosperity and visions of conspiracy are two sides of the same coin; both are embedded in an understanding that power works in invisible ways. In discussing these visions in relation to the literature on “conspiracy theories” and “cargo cults” (terms that have recently been imported to the study of Timor-Leste), it explores the critical potential of these visions. Whereas the labels “conspiracy theory” and “cargo cult” create distinctions between the “rational” perspective of the West and the “irrationality” of non-Western others, as practices these visions end up collapsing such distinctions by appropriating the power of the outside

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incompletely characterized. T-cell death in cultures of peripheral blood mononuclear cells (PBMC) showed 'classic' features of apoptosis following exposure to pneumococci. Conversely, purified CD3(+) T-cells cultured with pneumococci demonstrated necrosis with membrane permeabilization. The death of purified CD3(+) T-cells was not inhibited by necrostatin, but required the bacterial toxin pneumolysin. Apoptosis of CD3(+) T-cells in PBMC cultures required 'classical' CD14(+) monocytes, which enhanced T-cell activation. CD3(+) T-cell death was enhanced in HIV-seropositive individuals. Monocyte-mediated CD3(+) T-cell apoptotic death was Fas-dependent both in vitro and in vivo. In the early stages of the T-cell dependent host response to pneumococci reduced Fas ligand mediated T-cell apoptosis was associated with decreased bacterial clearance in the lung and increased bacteremia. In summary monocytes converted pathogen-associated necrosis into Fas-dependent apoptosis and regulated levels of activated T-cells at sites of acute bacterial infection. These changes were associated with enhanced bacterial clearance in the lung and reduced levels of invasive pneumococcal disease

Predicting recovery at home after Ambulatory Surgery

The correct implementation of Ambulatory Surgery must be accompanied by an accurate monitoring of the patient post-discharge state. We fit different statistical models to predict the first hours postoperative status of a discharged patient. We will also be able to predict, for any discharged patient, the probability of needing a closer follow-up, or of having a normal progress at home

Development of Danish version of child oral-health-related quality of life questionnaires (CPQ8–10 and CPQ11–14)

<p>Abstract</p> <p>Background</p> <p>The Child Perceptions Questionnaire (CPQ) is a self-reported questionnaire developed to measure oral health-related quality of life in children. The CPQ aims to improve the description of children's oral health, while taking into consideration the importance of psychological aspects in the concept of health. The CPQ exists in two versions: the CPQ_8–10for children aged 8–10 years and the CPQ_11–14for those aged 11–14 years. The aim of this study was to develop a Danish version of the CPQ_8–10and the CPQ_11–14and to evaluate its validity for use among Danish-speaking children.</p> <p>Methods</p> <p>The instruments were translated from English into Danish in accordance with a recommended translation procedure. Afterwards, they were tested among children aged 8–10 (n = 120) and 11–14 years (n = 225). The validity was expressed by the correlation between overall CPQ scores and i) self-reported assessment of the influence of oral conditions on everyday life (not at all, very little, some, a lot, very much) and ii) the self-reported rating of oral health. Furthermore, groups of children with assumed decreased oral health-related quality of life were compared with children with healthy oral conditions. Finally, we examined the internal consistency.</p> <p>Results</p> <p>The correlation between overall CPQ scores and global assessments of the influence of oral conditions on everyday life showed Spearman correlation coefficients of 0.45, <it>P < 0.001 </it>for CPQ_8–10and 0.50, <it>P < 0.001 </it>for CPQ_11–14. The correlation between overall CPQ scores and the self-reported rating of oral health showed Spearman correlation coefficients of 0.45, <it>P < 0.001 </it>for CPQ_8–10and 0.17, P = 0.010 for CPQ_11–14.</p> <p>The median overall CPQ_8–10scores were 7 for individuals with healthy oral conditions, 5 for individuals with cleft lip and palate, and 15 for individuals with rare oral diseases. The median overall CPQ_11–14scores were 9 for individuals with healthy oral conditions, 9 for individuals with cleft lip and palate, 17.0 for individuals with rare oral diseases, and 22.0 for individuals with fixed orthodontic appliances. There were statistically significant differences between the groups of children with healthy oral conditions and each of the subgroups, except for children with cleft lip and palate.</p> <p>Chronbach'α were 0.82 for CPQ_8–10and 0.87 for CPQ_11–14.</p> <p>Conclusion</p> <p>The results of this study reveal that the Danish CPQ_8–10and CPQ_11–14, seem to be valid instruments for measuring oral health-related quality of life in children although its ability to discriminate between children with cleft lip and palate and healthy children seem to be limited.</p