Linear prediction of weak records: the discrete case

We characterize the family of discrete distributions for which the best mean square error predictor of a future weak record is a linear function of a past or observed weak record

Order statistics from overlapping samples: bivariate densities and regression properties

In this paper we are interested in the joint distribution of two order statistics from overlapping samples. We give an explicit formula for the distribution of such a pair of random variables under the assumption that the parent distribution is absolutely continuous (with respect to the Lebesgue measure on the real line). The distribution is identified through the form of the density with respect to a measure which is a sum of the bivariate Lebesgue measure on R2 and the univariate Lebesgue measure on the diagonal {(x, x) : x ∈ R}. We are also interested in the question to what extent conditional expectation of one of such order statistic given another determines the parent distribution. In particular, we provide a new characterization by linearity of regression of an order statistic from the extended sample given the one from the original sample, special case of which solves a problem explicitly stated in the literature. It appears that to describe the correct parent distribution it is convenient to use quantile density functions. In several other cases of regressions of order statistics we provide new results regarding uniqueness of the distribution in the sample. Nevertheless the general question of identifiability of the parent distribution by regression of order statistics from overlapping samples remains open.Ministry of Science and Technology, TaiwanMinisterio de Economia, Industria y Competitividad (MINECO). EspañaNational Science Center, Polan

A characterization of distributions based on linear regression of order statistics and record values

We obtain the family of distributions for which the regression of one order statistic on another, not necessarily adjacent, is linear. As a consequence, we present a characterization of uniform distributions on an interval. We also characterize the distributions that appear when we impose the condition of linearity of regression for record values

Aplicación del muestreo sistemático en el diseño de encuestas

La obtención de muestras utilizando el muestreo sistemático es algo que se ha llevado a cabo desde principios del siglo XX, debido a la simplicidad de su manejo. Como inconveniente, los diseños sistemáticos clásicos no son estimables, por lo que no podemos suministrar estimadores directos del error de muestreo cometido. Este inconveniente ha tratado de salvarse a través de distintas variantes sobre la versión más simple del muestreo sistemático. En este trabajo, proponemos otra variante, en la que se hace aleatorio el paso del muestreo sistemático, siguiendo una determinada variable, lo que nos conduce a un diseño equivalente al muestreo aleatorio simple y, por tanto, estimable. Conseguimos así un procedimiento secuencial de obtención de muestras de gran utilidad en poblaciones que tienen una cierta estructura, y fácilmente implementable en la realización de encuestas

Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes

To evaluate the effectiveness of the different insulin therapies on obstetrics-fetal outcomes in women with pregestational diabetes mellitus. We enrolled 147 pregnant women with pre-existing type 1 or 2 diabetes mellitus. Clinical and biochemical parameters were analysed in relation to obstetric and fetal outcomes. 14.2% received treatment with Neutral Protamine Hagedorn insulin and short-acting insulin analogues; 19% with premixed human insulin; 40.1% with insulin glargine and lispro, 6.2% with detemir and aspart and 20% with continuous subcutaneous insulin infusion. All 5 types of treatment achieved a reduction of the mean HbA1c during pregnancy (p = 0.01). Pre-pregnancy care was carried out for 48% of patients. We found no statistically significant differences between the different insulin therapies and the obstetric-fetal outcomes. In conclusión, the different insulin therapies used in patients with pregestational diabetes mellitus does not seem to affect obstetric-fetal outcomes

Implementación de la metodología aprendizaje-servicio (ApS) como medio generador de conocimiento y reflexión en los estudiantes de los grados de Educación Infantil y Educación Primaria

Memoria ID2019/045. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2019-2020

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe