Development of commercial drag-augmentation systems for small satellites

In the framework of the ESA CleanSat programme Cranfield University is developing a family of drag augmentation system (DAS) modules to enable small satellites in Low Earth Orbit (LEO) to comply with space debris mitigation requirements. There are currently two mature Cranfield DAS designs based on deployable Kapton sails using stored energy for deployment. One concept is Icarus and it is currently on-board the UK’s TechDemoSat-1 (launched 8 July 2014) and Carbonite-1 spacecraft (launched 10 July 2015). The second concept is the de-orbit mechanism (DOM) module, which is due to fly as technological demonstrator on the upcoming ESA ESEO mission. The key drivers used during the design process were: low cost, low mass, easy testability, safety, reliability, and avoidance of additional debris production. These drivers matched with top-level requirements, from a potential customers perspective (e.g.: satellite integrators), which were defined during the CleanSat study. Other relevant requirements for the DAS included demisability, performance (in terms of orbital decay), area-to-mass ratio, functionality, lifetime, and environment compatibility. This paper discusses the compliance of the Cranfield DAS designs with the identified requirements, and illustrates the scalability via application to several case study missions (500 kg and 200 kg LEO satellites). The two most challenging aspects to assess were compliance with the lifetime required for storage on ground and pre-deployment on orbit, and the effect of the orbital environment (radiation, ATOX, debris) on the sail. The study has provided useful input to explore new concepts based on the heritage designs; these concepts are evolutions of the DOM unit and hybrid designs. The hybrid design combines aspects of the Icarus and the DOM concepts to reduce the limitations of the respective individual devices and improve scalability, adaptability and manufacturability. In addition, this work is helping to achieve commercial readiness for the technology. This will enable development of a commercial DAS offering that will be an attractive solution for small satellite integrators, allowing them to meet debris mitigation requirements

Modular, reconfigurable approach for a commercial space spacecraft programme

This thesis presents the work performed in producing a system-level design for a modular, multipurpose small satellite platform. A multipurpose platform may be applied to a wide range of missions, and, to be commercially viable, the envelope of missions for which it is suitable should be as large as possible. The research therefore addresses the particular requirements that are specific to different mission types, and produces characteristic requirement sets for each. General design requirements are also derived, such as those for enabling modularity and allowing compatibility with different launch vehicles. The commercial requirements arising from the different market and customer sectors are also examined. Industry analysis allows identification of general market trends, and predictions are made regarding the likely size and characteristics of the market in which the proposed platform would compete. It is anticipated there could be a worldwide demand for more than twenty small satellites each year, for which a flexible small spacecraft platform could potentially compete. After derivation of the necessary requirements has been performed, a system-level design of the spacecraft platform is undertaken. The resulting design is based on a multi-module, reconfigurable concept, which can be adapted to fit the different launch envelopes of Pegasus-XL, Taurus, ASAP-5 and larger launchers, and also to accommodate a wide range of payloads. The subsystems are offered in different capability variants, which may be interchanged in response to different mission requirements. The platform equipment and structure forms a 'standard parts lisf', from which the appropriate configuration can be built up. Schedule reductions are obtained due to the modular design allowing more of the integration and testing of the platform to be performed in parallel. The proposed programme for development of the platform uses up-front investment to conduct much of the detailed design of the platform in advance of any actual project. This allows the design effort to be shared across many subsequent projects, and the design phase of each new project to be minimised. The key benefits of the proposed platform and programme are adaptability, ability to rapidly reconfigure to mission requirements, suitability for future upgrading, and reduction of the project schedule.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Modular, reconfigurable approach for a commercial space spacecraft programme

This thesis presents the work performed in producing a system-level design for a modular, multipurpose small satellite platform. A multipurpose platform may be applied to a wide range of missions, and, to be commercially viable, the envelope of missions for which it is suitable should be as large as possible. The research therefore addresses the particular requirements that are specific to different mission types, and produces characteristic requirement sets for each. General design requirements are also derived, such as those for enabling modularity and allowing compatibility with different launch vehicles. The commercial requirements arising from the different market and customer sectors are also examined. Industry analysis allows identification of general market trends, and predictions are made regarding the likely size and characteristics of the market in which the proposed platform would compete. It is anticipated there could be a worldwide demand for more than twenty small satellites each year, for which a flexible small spacecraft platform could potentially compete. After derivation of the necessary requirements has been performed, a system-level design of the spacecraft platform is undertaken. The resulting design is based on a multi-module, reconfigurable concept, which can be adapted to fit the different launch envelopes of Pegasus-XL, Taurus, ASAP-5 and larger launchers, and also to accommodate a wide range of payloads. The subsystems are offered in different capability variants, which may be interchanged in response to different mission requirements. The platform equipment and structure forms a 'standard parts lisf', from which the appropriate configuration can be built up. Schedule reductions are obtained due to the modular design allowing more of the integration and testing of the platform to be performed in parallel. The proposed programme for development of the platform uses up-front investment to conduct much of the detailed design of the platform in advance of any actual project. This allows the design effort to be shared across many subsequent projects, and the design phase of each new project to be minimised. The key benefits of the proposed platform and programme are adaptability, ability to rapidly reconfigure to mission requirements, suitability for future upgrading, and reduction of the project schedule.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Community Resilience Research: UK Case Studies, Lessons and Recommendations report to the Cabinet Office and Defence Science and Technology Laboratory.

This report presents four case studies carried out for the Community Resilience project funded by DSTL and supported by the Civil Contingency Secretariat (CCS), Cabinet Office. The work for this project was carried out between September and December 2011. The aim of the Community Resilience project was to develop a better understanding of the role of community resilience in emergency response and recovery situations in order to inform Cabinet Office / Civil Contingencies Secretariat policy on community resilience and to inform the development of future work

What might sustainability of the GEO region look like?

Sustainability in space is often discussed, but as a community we are only gradually learning what it actually means. To inform this understanding, a set of three parallel projects ran at Cranfield University (Oct 2020 to Mar 2021) to develop a scenario of sustainable use of the geostationary orbit region. The three projects were to develop mission designs for (a) a Scavenger spacecraft equipped with tools, actuators and sensors to perform rendezvous with selected satellites at their end of life, to harvest selected parts and components (i.e. solar panels, radiators, antenna reflectors), store and deliver them to the Recycler for refurbishment or recycling, (b) a Recycler space station located in GEO, capable of receiving parts and materials obtained by the Scavenger spacecraft and performing a range of inspection, recycling and repurposing operations on them, and (c) a candidate customer mission: a huge communications satellite based on the Airbus VASANT (VASt ANTenna) concept, with two antenna arrays, each 35 m square, sized to be able to communicate directly from GEO to mobile phone users at Earth's surface. Some of the features highlighted by these studies are (a) the technical challenges of reusing parts from old satellites: modularity and design-for-reuse seem to be key enablers, (b) the advanced robotics and autonomy implied by the on-orbit operations, (c) the challenge of long-term orbit control without excessive propellant consumption, and (d) although the technology is challenging, there are major non-technical challenges for the business case and for aspects such as the legal use of debris, liability for accidents, and compliance with any regulations. Sustainability is challenging, but nature leaves us no alternative

Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae

Abstract Tissue-resident memory CD4 T ($T_{RM}$) cells induced by infection with Bordetella pertussis persist in respiratory tissues and confer long-term protective immunity against re-infection. However, it is not clear how they are maintained in respiratory tissues. Here we demonstrate that B. pertussis-specific CD4 $T_{RM}$ cells produce IL-17A in response to in vitro stimulation with LPS or heat-killed Klebsiella pneumoniae (HKKP) in the presence of dendritic cells. Furthermore, IL-17A-secreting CD4 $T_{RM}$ cells expand in the lung and nasal tissue of B. pertussis convalescent mice following in vivo administration of LPS or HKKP. Bystander activation of CD4 $T_{RM}$ cells was suppressed by anti-IL-12p40, but not by anti-MHCII antibodies. Furthermore, purified respiratory tissue-resident, but not circulating, CD4 T cells from convalescent mice produced IL-17A following direct stimulation with IL-23 and IL-1$\beta$ or IL-18. Intranasal immunization of mice with a whole cell pertussis vaccine induced respiratory CD4 $T_{RM}$ cells that were re-activated following stimulation with K. pneumoniae. Furthermore, the nasal pertussis vaccine conferred protective immunity against B. pertussis but also attenuated infection with K. pneumoniae. Our findings demonstrate CD4 $T_{RM}$ cells induced by respiratory infection or vaccination can undergo bystander activation and confer heterologous immunity to an unrelated respiratory pathogen

Reducing emergency hospital admissions: A population health complex intervention of an enhanced model of primary care and compassionate communities

YesBackground: Reducing emergency admissions to hospital has been a cornerstone of health care policy. There is little evidence of systematic interventions which achieved this aim across a population. We report the impact on unplanned admissions to hospital through a complex intervention over a 44 month period in Frome, Somerset. Aim: A population health complex intervention of an enhanced model of primary care and compassionate communities to improve population health and reduce emergency admissions to hospital Design: A cohort retrospective study of a complex intervention on all emergency admissions in Frome compared to Somerset from April 2013 to December 2017. Setting: Frome Medical Practice, Somerset Methods: Patients were identified using broad criteria including anyone with cause for concern. Patient centred goal setting and care planning combined with a compassionate community social approach was implemented broadly across the population of Frome. Results: There was a progressive reduction, by 7.9 cases per quarter (95% CI: 2.8, 13.1; p=0.006) in unplanned hospital admissions across the whole population of Frome, over the study period from April 2014 to December 2017. At the same time, there was sharp increase in the number of admissions per quarter, within the Somerset, with an increase in the number of unplanned admissions of 236 per quarter (95% CI: 152, 320; p<0.001). Conclusion: The complex intervention in Frome was associated with highly significant reductions in unplanned admissions to hospital with reduction of healthcare costs across the whole population of From

Prevalence and architecture of de novo mutations in developmental disorders.

The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important genes. Here we have sequenced the exomes of 4,293 families containing individuals with developmental disorders, and meta-analysed these data with data from another 3,287 individuals with similar disorders. We show that the most important factors influencing the diagnostic yield of DNMs are the sex of the affected individual, the relatedness of their parents, whether close relatives are affected and the parental ages. We identified 94 genes enriched in damaging DNMs, including 14 that previously lacked compelling evidence of involvement in developmental disorders. We have also characterized the phenotypic diversity among these disorders. We estimate that 42% of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function. We estimate that developmental disorders caused by DNMs have an average prevalence of 1 in 213 to 1 in 448 births, depending on parental age. Given current global demographics, this equates to almost 400,000 children born per year

Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease

Inherited retinal disease is a common cause of visual impairment and represents a highly heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals with inherited retinal disease, who have had whole-genome sequencing (n = 605), whole-exome sequencing (n = 72), or both (n = 45) performed, as part of the NIHR-BioResource Rare Diseases research study. We identified pathogenic variants (single-nucleotide variants, indels, or structural variants) for 404/722 (56%) individuals. Whole-genome sequencing gives unprecedented power to detect three categories of pathogenic variants in particular: structural variants, variants in GC-rich regions, which have significantly improved coverage compared to whole-exome sequencing, and variants in non-coding regulatory regions. In addition to previously reported pathogenic regulatory variants, we have identified a previously unreported pathogenic intronic variant in $\textit{CHM}$ in two males with choroideremia. We have also identified 19 genes not previously known to be associated with inherited retinal disease, which harbor biallelic predicted protein-truncating variants in unsolved cases. Whole-genome sequencing is an increasingly important comprehensive method with which to investigate the genetic causes of inherited retinal disease.This work was supported by The National Institute for Health Research England (NIHR) for the NIHR BioResource – Rare Diseases project (grant number RG65966). The Moorfields Eye Hospital cohort of patients and clinical and imaging data were ascertained and collected with the support of grants from the National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital, National Health Service Foundation Trust, and UCL Institute of Ophthalmology, Moorfields Eye Hospital Special Trustees, Moorfields Eye Charity, the Foundation Fighting Blindness (USA), and Retinitis Pigmentosa Fighting Blindness. M.M. is a recipient of an FFB Career Development Award. E.M. is supported by UCLH/UCL NIHR Biomedical Research Centre. F.L.R. and D.G. are supported by Cambridge NIHR Biomedical Research Centre

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.

BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare disease with an emerging genetic basis. Heterozygous mutations in the gene encoding the bone morphogenetic protein receptor type 2 (BMPR2) are the commonest genetic cause of PAH, whereas biallelic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF2AK4) are described in pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. Here, we determine the frequency of these mutations and define the genotype-phenotype characteristics in a large cohort of patients diagnosed clinically with PAH. METHODS: Whole-genome sequencing was performed on DNA from patients with idiopathic and heritable PAH and with pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis recruited to the National Institute of Health Research BioResource-Rare Diseases study. Heterozygous variants in BMPR2 and biallelic EIF2AK4 variants with a minor allele frequency of <1:10 000 in control data sets and predicted to be deleterious (by combined annotation-dependent depletion, PolyPhen-2, and sorting intolerant from tolerant predictions) were identified as potentially causal. Phenotype data from the time of diagnosis were also captured. RESULTS: Eight hundred sixty-four patients with idiopathic or heritable PAH and 16 with pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis were recruited. Mutations in BMPR2 were identified in 130 patients (14.8%). Biallelic mutations in EIF2AK4 were identified in 5 patients with a clinical diagnosis of pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. Furthermore, 9 patients with a clinical diagnosis of PAH carried biallelic EIF2AK4 mutations. These patients had a reduced transfer coefficient for carbon monoxide (Kco; 33% [interquartile range, 30%-35%] predicted) and younger age at diagnosis (29 years; interquartile range, 23-38 years) and more interlobular septal thickening and mediastinal lymphadenopathy on computed tomography of the chest compared with patients with PAH without EIF2AK4 mutations. However, radiological assessment alone could not accurately identify biallelic EIF2AK4 mutation carriers. Patients with PAH with biallelic EIF2AK4 mutations had a shorter survival. CONCLUSIONS: Biallelic EIF2AK4 mutations are found in patients classified clinically as having idiopathic and heritable PAH. These patients cannot be identified reliably by computed tomography, but a low Kco and a young age at diagnosis suggests the underlying molecular diagnosis. Genetic testing can identify these misclassified patients, allowing appropriate management and early referral for lung transplantation