390 research outputs found
Karl Marx: Forty years after (1883-1923)
https://stars.library.ucf.edu/prism/1348/thumbnail.jp
Vertex Operators and Soliton Time Delays in Affine Toda Field Theory
In a space-time of two dimensions the overall effect of the collision of two
solitons is a time delay (or advance) of their final trajectories relative to
their initial trajectories. For the solitons of affine Toda field theories, the
space-time displacement of the trajectories is proportional to the logarithm of
a number depending only on the species of the colliding solitons and their
rapidity difference. is the factor arising in the normal ordering of the
product of the two vertex operators associated with the solitons. is shown
to take real values between and . This means that, whenever the solitons
are distinguishable, so that transmission rather than reflection is the only
possible interpretation of the classical scattering process, the time delay is
negative and so an indication of attractive forces between the solitons.Comment: p. 24 Latex, Swansea-SWAT/93-94/3
Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration
Pharmacological manipulation of the type 5 metabotropic glutamate (mGlu5) receptor alters various addiction related behaviors such as drug self-administration and the extinction and reinstatement of drug-seeking behavior. However, the effects of pharmacological modulation of mGlu5 receptors on brain reward function have not been widely investigated. We examined the effects of acute administration of positive and negative allosteric modulators (PAMs and NAMs, respectively) on brain reward function by assessing thresholds for intracranial self-stimulation (ICSS). In addition, when acute effects were observed, we examined changes in ICSS thresholds following repeated administration. Male Sprague-Dawley rats were implanted with bipolar electrodes into the medial forebrain bundle and trained to respond for ICSS, followed by assessment of effects of mGlu5 ligands on ICSS thresholds using a discrete trials current–intensity threshold determination procedure. Acute administration of the selective mGlu5 NAMs MTEP (0, 0.3, 1, or 3 mg/kg) and fenobam (0, 3, 10, or 30 mg/kg) dose-dependently increased ICSS thresholds (∼70% at the highest dose tested), suggesting a deficit in brain reward function. Acute administration of the mGlu5 PAMs CDPPB (0, 10, 30, and 60 mg/kg) or ADX47273 (0, 10, 30, and 60 mg/kg) was without effect at any dose tested. When administered once daily for five consecutive days, the development of tolerance to the ability of threshold-elevating doses of MTEP and fenobam to increase ICSS thresholds was observed. We conclude that mGlu5 PAMs and NAMs differentially affect brain reward function, and that tolerance to the ability of mGlu5 NAMs to reduce brain reward function develops with repeated administration. These brain reward deficits should be taken into consideration when interpreting acute effects of mGlu5 NAMs on drug self-administration, and repeated administration of these ligands may be an effective method to reduce these deficits
Hierarchical Growth and Cosmic Star Formation: Enrichment, Outflows and Supernova Rates
The cosmic star formation histories are evaluated for different minimum
masses of the initial halo structures, with allowance for realistic gas
outflows. With a minimum halo mass of 10^{7} - 10^{8} M_odot and a moderate
outflow efficiency, we reproduce both the current baryon fraction and the early
chemical enrichment of the IGM. The intensity of the formation rate of
``normal'' stars is also well constrained by the observations: it has to be
dominated by star formation in elliptical galaxies, except perhaps at very low
redshift. The fraction of baryons in stars is predicted as are also the type Ia
and II supernova event rates. Comparison with SN observations in the redshift
range z=0-2 allows us to set strong constraints on the time delay of type Ia
supernovae (a total delay of \sim 4 Gyr is required to fit the data), the lower
end of the mass range of the progenitors (2 - 8 M_odot) and the fraction of
white dwarfs that reproduce the type Ia supernova (about 1 per cent). The
intensity in the initial starburst of zero metallicity stars below 270 M_\odot
must be limited in order to avoid premature overenrichment of the IGM. Only
about 10 - 20 % of the metals present in the IGM at z = 0 have been produced by
population III stars at very high z. The remaining 80 - 90 % are ejected later
by galaxies forming normal stars, with a maximum outflow efficiency occurring
at a redshift of about 5. We conclude that 10^{-3} of the mass in baryons must
lie in first massive stars in order to produce enough ionizing photons to allow
early reionization of the IGM by z \sim 15.Comment: 51 pages, 23 eps figure
Mixing of Active and Sterile Neutrinos
We investigate mixing of neutrinos in the MSM (neutrino Minimal Standard
Model), which is the MSM extended by three right-handed neutrinos. Especially,
we study elements of the mixing matrix between three
left-handed neutrinos () and two sterile
neutrinos () which are responsible to the seesaw mechanism
generating the suppressed masses of active neutrinos as well as the generation
of the baryon asymmetry of the universe (BAU). It is shown that
can be suppressed by many orders of magnitude compared with
and , when the Chooz angle is large in the
normal hierarchy of active neutrino masses. We then discuss the neutrinoless
double beta decay in this framework by taking into account the contributions
not only from active neutrinos but also from all the three sterile neutrinos.
It is shown that and give substantial, destructive contributions
when their masses are smaller than a few 100 MeV, and as a results receive no stringent constraint from the current bounds on such decay.
Finally, we discuss the impacts of the obtained results on the direct searches
of in meson decays for the case when are lighter than pion
mass. We show that there exists the allowed region for with such
small masses in the normal hierarchy case even if the current bound on the
lifetimes of from the big bang nucleosynthesis is imposed. It is also
pointed out that the direct search by using and might miss such since the branching ratios can be
extremely small due to the cancellation in , but the search by
can cover the whole allowed region by improving the
measurement of the branching ratio by a factor of 5.Comment: 30 pages, 32 figure
Strong interface-induced spin-orbit coupling in graphene on WS2
Interfacial interactions allow the electronic properties of graphene to be
modified, as recently demonstrated by the appearance of satellite Dirac cones
in the band structure of graphene on hexagonal boron nitride (hBN) substrates.
Ongoing research strives to explore interfacial interactions in a broader class
of materials in order to engineer targeted electronic properties. Here we show
that at an interface with a tungsten disulfide (WS2) substrate, the strength of
the spin-orbit interaction (SOI) in graphene is very strongly enhanced. The
induced SOI leads to a pronounced low-temperature weak anti-localization (WAL)
effect, from which we determine the spin-relaxation time. We find that
spin-relaxation time in graphene is two-to-three orders of magnitude smaller on
WS2 than on SiO2 or hBN, and that it is comparable to the intervalley
scattering time. To interpret our findings we have performed first-principle
electronic structure calculations, which both confirm that carriers in
graphene-on-WS2 experience a strong SOI and allow us to extract a
spin-dependent low-energy effective Hamiltonian. Our analysis further shows
that the use of WS2 substrates opens a possible new route to access topological
states of matter in graphene-based systems.Comment: Originally submitted version in compliance with editorial guidelines.
Final version with expanded discussion of the relation between theory and
experiments to be published in Nature Communication
Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma
Background: Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood. Methodology/Principal Findings: Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature. Conclusions/Significance: These findings provide evidence that K-rasG12D; p53R172H mice recapitulate features of human NSCLC metastasis and will provide a useful platform on which to study the biologic basis for lung adenocarcinom
Crystal Structure of PrgI-SipD: Insight into a Secretion Competent State of the Type Three Secretion System Needle Tip and its Interaction with Host Ligands
Many infectious Gram-negative bacteria, including Salmonella typhimurium, require a Type Three Secretion System (T3SS) to translocate virulence factors into host cells. The T3SS consists of a membrane protein complex and an extracellular needle together that form a continuous channel. Regulated secretion of virulence factors requires the presence of SipD at the T3SS needle tip in S. typhimurium. Here we report three-dimensional structures of individual SipD, SipD in fusion with the needle subunit PrgI, and of SipD:PrgI in complex with the bile salt, deoxycholate. Assembly of the complex involves major conformational changes in both SipD and PrgI. This rearrangement is mediated via a π bulge in the central SipD helix and is stabilized by conserved amino acids that may allow for specificity in the assembly and composition of the tip proteins. Five copies each of the needle subunit PrgI and SipD form the T3SS needle tip complex. Using surface plasmon resonance spectroscopy and crystal structure analysis we found that the T3SS needle tip complex binds deoxycholate with micromolar affinity via a cleft formed at the SipD:PrgI interface. In the structure-based three-dimensional model of the T3SS needle tip, the bound deoxycholate faces the host membrane. Recently, binding of SipD with bile salts present in the gut was shown to impede bacterial infection. Binding of bile salts to the SipD:PrgI interface in this particular arrangement may thus inhibit the T3SS function. The structures presented in this study provide insight into the open state of the T3SS needle tip. Our findings present the atomic details of the T3SS arrangement occurring at the pathogen-host interface
The N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD
The type III secretion system (T3SS) is an essential virulence factor for Shigella flexneri, providing a conduit through which host-altering effectors are injected directly into a host cell to promote uptake. The type III secretion apparatus (T3SA) is comprised of a basal body, external needle, and regulatory tip complex. The nascent needle is a polymer of MxiH capped by a pentamer of invasion plasmid antigen D (IpaD). Exposure to bile salts (e.g. deoxycholate) causes a conformational change in IpaD and promotes recruitment of IpaB to the needle tip. It has been proposed that IpaB senses contact with host cell membranes, recruiting IpaC and inducing full secretion of T3SS effectors. While the steps of T3SA maturation and their external triggers have been identified, details of specific protein interactions and mechanisms have remained difficult to study due to the hydrophobic nature of the IpaB and IpaC translocator proteins. Here we explored the ability for a series of soluble N-terminal IpaB peptides to interact with IpaD. We found that DOC is required for the interaction and that a region of IpaB between residues 11–27 is required for maximum binding, which was confirmed in vivo. Furthermore, intramolecular FRET measurements indicated that movement of the IpaD distal domain away from the protein core accompanied the binding of IpaB11-226. Together these new findings provide important new insight into the interactions and potential mechanisms that define the maturation of the Shigella T3SA needle tip complex and provide a foundation for further studies probing T3SS activation
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