Indigenous Health – Australia, Canada, New Zealand and the United States - Laying Claim to a Future that Embraces Health for Us All.

Improving the health of all peoples has been a call across the globe for many decades and unfortunately remains relevant today, particularly given the large disparities in health status of peoples found around the world. Rather than differences in health, or health inequalities, we use a different term, health inequities. This is so as mere differences in health (or inequalities ) can be common in societies and do not necessarily reflect unfair social policies or practices. For example, natural ageing implies older people are more prone to illness. Yet, when differences are systematic, socially produced and unfair, these are considered health inequities. Certainly making judgments on what is systematic, socially produced and unfair, reflects value judgments and merit open debate. We are making explicit in this paper what our judgments are, and the basis for these judgment

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Mast cell hyperplasia in Opisthorchis viverrini-associated cholecystitis

Despite significant advances in understanding the role of the immune response in Opisthorchis viverrini-associated carcinogenesis, little is known about how infection induces gall bladder disease. This study investigated whether mast cells are activated in cholecystitis associated with O. viverrini, gall bladder specimens from ninety-two patients who had undergone cholecystectomy at the Khon Kaen Regional Hospital, Khon Kaen, Thailand. Two representative sections from the body of fresh gall bladder tissue were fixed in Carnoy’s solution and embedded in paraffin wax. The paraffin sections were stained for mast cells and IgE plasma cells by the double histochemical and immunohistochemical method. The cells in the epithelium, lamina propria, muscular layer, and subserosa were counted and expressed as cells per square millimeter. The gall bladder bile was examined for the presence of O. viverrini eggs. Significantly higher mean mast cell numbers were found in the lamina propria (221.41 ± 16.01 vs 116.97 ± 14.61 cells per mm2; P < 0.005) of egg positive compared to egg negative groups, respectively. No comparable differences in mast cell number were observed in other layers. IgE plasma cells were rarely seen. The results suggest that mast cell hyperplasia occurs during cholecystitis in association with opisthorchiasis and may play a role in the pathogenesis of the disease.</p

The importance of host age and sex to patterns of reinfection with Ascaris lumbricoides following mass anthelmintic treatment in a South Indian fishing community

Analysis of egg and worm counts of Ascaris recorded at various intervals following a mass anthelmintic treatment programme in a South Indian fishing community is presented. Three indices of infection in the community are compared, namely the prevalence and intensity of egg output (at 2, 6 and 11 months following treatment) and the number of worms expelled following an 11 month period of reinfection. Detailed examination of these measurements revealed significant associations with patient sex and age. The age-prevalence profile of Ascaris infection changed little over time (except immediately following treatment) with the peak prevalence found in the 5–9 year age group. Although 85% of both males and females harboured Ascaris initially, the prevalence following 11 months reinfection was decreased, due to a significantly lower proportion of males being reinfected. By the 11th month of reinfection, the age-intensity profiles of egg output were similar to those observed at initial treatment in the older age groups (10 years and above) and in male children (< 10 years). However, a dramatic increase in the egg output of female children, greatly exceeding the initial mean, was observed within a 6 month period of reinfection. The intensity of egg output did not accurately reflect the abundance of Ascaris recovered via drug-induced expulsion following an 11 month period of reinfection. Although the egg output attained pre-intervention levels, the average worm intensity reached only half the initial value. The trends in the sex- and age-intensity profiles were consistent at the two sampling dates and showed similar patterns to the egg output curves. The relevance of the results to helminth control and the monitoring of reinfection is discussed.</p

Food-borne Trematodes

Key Points:Food-borne trematodes (FBTs), including liver, lung and intestinal flukes, are important "Neglected Tropical Diseases'(NTDs).An estimated 85 million people worldwide are infected with FBT and more than half are in Asia.Humans acquire FBT infection through ingestion of viable metacercariae in second intermediate hosts in undercooked or raw food preparation.The diseases caused by FBTs range from asymptomatic, mild disease, to fatal bile duct cancer.The drugs of choice for treatment of FBTs are praziquantel and triclabendazole

Case Study of the 2011 Garma Festival Youth Forum: Strengths, Challenges and Implications for Policy and Practice

This case study was nested within a larger project commissioned by the Commonwealth Department of Families, Housing, Community Services and Indigenous Affairs (FaCHSIA) that aims to facilitate better policy and practice in the promotion of social and emotional wellbeing among Aboriginal and Torres Strait Islander youth. The need for improvement in this area is clearly evident in their much higher prevalence of negative outcomes across most measures of health, education, employment and involvement in the justice system. These measures indicate a higher exposure of Indigenous youth to the causes and consequences of low social and emotional wellbeing, as well as a lack of opportunity to recognise and build on personal strengths and capacity to achieve their full potential. A systematic literature, policy and program review revealed both a need and an enormous opportunity to enhance understanding of the strengths and challenges faced by those working on the ground, to share their knowledge and ideas on what kind of supporting mechanisms would maximise their growth and sustainability. Six case studies were completed to harvest this information across a range of program contexts and provide practical, useful and highly supported recommendations for policy, resource allocation and practice about what works, how and why. This report describes findings from the 2011 Garma Festival Youth Forum, one of the six case studies that collectively contribute to better understanding of how the universal strengths and positive potential of young Aboriginal people, whatever their circumstances, can be successfully and sustainably fostered