1,510 research outputs found
Valine Biosynthesis: Mrub_2994 is Orthologous to \u3cem\u3eE. coli\u3c/em\u3e b3770 and Mrub_1844 is Orthologous to \u3cem\u3eE. coli\u3c/em\u3e b3771
This project is part of the Meiothermus ruber genome analysis project, which uses the bioinformatics tools associated with the Guiding Education through Novel Investigation – Annotation Collaboration Toolkit (GENI-ACT) to predict gene function. We investigated the biological function of the genes Mrub_2994 and Mrub_1844. We predict that Mrub_1884 encodes the enzyme dihydroxy-acid dehydratase (DNA coordinates 1901362..1903026 on the forward strand), which is the third step of the valine biosynthesis pathway (KEGG map number 00290). It catalyzes the conversion of 2,3-dihydroxy-3methylbutanoate to 3-methyl-2-oxobutanoate. The E. coli K12 MG1655 ortholog is predicted to be b3771, which has the gene identifier ilvD. We also predict that Mrub_2994 encodes the enzyme branched-chain amino acid transaminase. (DNA coordinates 3033210..3034169 on the forward strand), which is the fourth step of the valine biosynthesis pathway (KEGG map number 00290). It catalyzes the conversion of 3-methyl-2-oxobutanoate to L-valine. The E. coli K12 MG1655 ortholog is predicted to be b3770, which has the gene identifier ilvE
Habitable Climates: The Influence of Eccentricity
In the outer regions of the habitable zone, the risk of transitioning into a
globally frozen "snowball" state poses a threat to the habitability of planets
with the capacity to host water-based life. We use a one-dimensional energy
balance climate model (EBM) to examine how obliquity, spin rate, orbital
eccentricity, and ocean coverage might influence the onset of such a snowball
state. For an exoplanet, these parameters may be strikingly different from the
values observed for Earth. Since, for constant semimajor axis, the annual mean
stellar irradiation scales with (1-e^2)^(-1/2), one might expect the greatest
habitable semimajor axis (for fixed atmospheric composition) to scale as
(1-e^2)^(-1/4). We find that this standard ansatz provides a reasonable lower
bound on the outer boundary of the habitable zone, but the influence of
obliquity and ocean fraction can be profound in the context of planets on
eccentric orbits. For planets with eccentricity 0.5, our EBM suggests that the
greatest habitable semimajor axis can vary by more than 0.8 AU (78%!) depending
on obliquity, with higher obliquity worlds generally more stable against
snowball transitions. One might also expect that the long winter at an
eccentric planet's apoastron would render it more susceptible to global
freezing. Our models suggest that this is not a significant risk for Earth-like
planets around Sun-like stars since such planets are buffered by the thermal
inertia provided by oceans covering at least 10% of their surface. Since
planets on eccentric orbits spend much of their year particularly far from the
star, such worlds might turn out to be especially good targets for direct
observations with missions such as TPF-Darwin. Nevertheless, the extreme
temperature variations achieved on highly eccentric exo-Earths raise questions
about the adaptability of life to marginally or transiently habitable
conditions.Comment: References added, text and figures updated, accepted by Ap
Interactions between Cosmic Strings: An Analytical Study
We derive analytic expressions for the interaction energy between two general
cosmic strings as the function of their relative orientation and the
ratio of the coupling constants in the model. The results are relevant to the
statistic description of strings away from critical coupling and shed some
light on the mechanisms involved in string formation and the evolution of
string networks.Comment: 31 pages,REVTEX, Imperial/TP/93-94/3
Path Selection for Quantum Repeater Networks
Quantum networks will support long-distance quantum key distribution (QKD)
and distributed quantum computation, and are an active area of both
experimental and theoretical research. Here, we present an analysis of
topologically complex networks of quantum repeaters composed of heterogeneous
links. Quantum networks have fundamental behavioral differences from classical
networks; the delicacy of quantum states makes a practical path selection
algorithm imperative, but classical notions of resource utilization are not
directly applicable, rendering known path selection mechanisms inadequate. To
adapt Dijkstra's algorithm for quantum repeater networks that generate
entangled Bell pairs, we quantify the key differences and define a link cost
metric, seconds per Bell pair of a particular fidelity, where a single Bell
pair is the resource consumed to perform one quantum teleportation. Simulations
that include both the physical interactions and the extensive classical
messaging confirm that Dijkstra's algorithm works well in a quantum context.
Simulating about three hundred heterogeneous paths, comparing our path cost and
the total work along the path gives a coefficient of determination of 0.88 or
better.Comment: 12 pages, 8 figure
Modal Logics of Topological Relations
Logical formalisms for reasoning about relations between spatial regions play
a fundamental role in geographical information systems, spatial and constraint
databases, and spatial reasoning in AI. In analogy with Halpern and Shoham's
modal logic of time intervals based on the Allen relations, we introduce a
family of modal logics equipped with eight modal operators that are interpreted
by the Egenhofer-Franzosa (or RCC8) relations between regions in topological
spaces such as the real plane. We investigate the expressive power and
computational complexity of logics obtained in this way. It turns out that our
modal logics have the same expressive power as the two-variable fragment of
first-order logic, but are exponentially less succinct. The complexity ranges
from (undecidable and) recursively enumerable to highly undecidable, where the
recursively enumerable logics are obtained by considering substructures of
structures induced by topological spaces. As our undecidability results also
capture logics based on the real line, they improve upon undecidability results
for interval temporal logics by Halpern and Shoham. We also analyze modal
logics based on the five RCC5 relations, with similar results regarding the
expressive power, but weaker results regarding the complexity
The use of oral recombinant feline interferon omega in two cats with type II diabetes mellitus and concurrent feline chronic gingivostomatitis syndrome
Articles in International JournalsFeline Chronic Gingivostomatitis Syndrome (FCGS) is a common disease in clinical practice. Among the therapeutic
options available, long-acting corticosteroids are frequently used due to their anti-inflammatory and
immunosuppressive properties. Although they may improve the clinical symptoms, they can lead to a progressive
form of the disease that becomes refractory to treatment. Furthermore, their direct relationship with type II diabetes
mellitus (DM) is well known. Consequently, these drugs are controversial and not recommended for routine
management of FCGS. Recombinant feline interferon-omega (rFeIFN-ω) is an immunomodulatory compound.
Recently, its daily oral administration has been shown to be successful in treating refractory cases of FCGS. This case
study describes two clinical cases of type II DM complicated by FCGS. Both animals were calicivirus positive and
they had been previously treated with long-acting corticosteroids, which may have been the major cause of DM.
The two cats were treated with glargine insulin (Lantus, starting dose 1 IU/cat twice daily (BID)), achieving remission
10 and 18 weeks later respectively. Considering the difficulty with control of FCGS in these animals, an oral daily
dose of rFeIFN-ω was started as an alternative to long-acting corticosteroids. In both cats oral clinical signs
gradually improved and 60 days after the start of therapy the owners reported a significant relief of pain during
mastication. According to the authors’ knowledge, this is the first case report that describes the successful use of
rFeIFN-ω in the management of FCGS in type II diabetic cats, in which long-acting corticosteroids are
contraindicated
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals with vitiligo (cases) and 3,182 controls), an independent replication study (1,440 cases and 1,316 controls) and a meta-analysis (3,187 cases and 6,723 controls) identifying 13 additional vitiligo-associated loci. These include OCA2-HERC2 (combined P = 3.80 × 10 ), MC1R (P = 1.82 × 10 ), a region near TYR (P = 1.57 × 10 ), IFIH1 (P = 4.91 × 10 ), CD80 (P = 3.78 × 10 ), CLNK (P = 1.56 × 10 ), BACH2 (P = 2.53 × 10 ), SLA (P = 1.58 × 10 ), CASP7 (P = 3.56 × 10 ), CD44 (P = 1.78 × 10 ), IKZF4 (P = 2.75 × 10 ), SH2B3 (P = 3.54 × 10 ) and TOB2 (P = 6.81 × 10 ). Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among vitiligo, melanoma, and eye, skin and hair coloration
Applied Interventions in the Prevention and Treatment of Obesity Through the Research of Professor Jane Wardle
Purpose of Review
Obesity presents a challenge for practitioners, policy makers, researchers and for those with obesity themselves. This review focuses on psychological approaches to its management and prevention in children and adults.
Recent Findings
Through exploring the work of the late Professor Jane Wardle, we look at the earliest behavioural treatment approaches and how psychological theory has been used to develop more contemporary approaches, for example incorporating genetic feedback and habit formation theory into interventions. We also explore how Jane has challenged thinking about the causal pathways of obesity in relation to eating behaviour. Beyond academic work, Jane was an advocate of developing interventions which had real-world applications.
Summary
Therefore, we discuss how she not only developed new interventions but also made these widely available and the charity that she established
Search for contact interactions, large extra dimensions and finite quark radius in ep collisions at HERA
A search for physics beyond the Standard Model has been performed with
high-Q^2 neutral current deep inelastic scattering events recorded with the
ZEUS detector at HERA. Two data sets, e^+ p \to e^+ X and e^- p \to e^- X, with
respective integrated luminosities of 112 pb^-1 and 16 pb^-1, were analyzed.
The data reach Q^2 values as high as 40000 GeV^2. No significant deviations
from Standard Model predictions were observed. Limits were derived on the
effective mass scale in eeqq contact interactions, the ratio of leptoquark mass
to the Yukawa coupling for heavy leptoquark models and the mass scale parameter
in models with large extra dimensions. The limit on the quark charge radius, in
the classical form factor approximation, is 0.85 10^-16 cm.Comment: 28 pages, 4 figures, accepted for publication in Physics Letters
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