Poetic Individuality in Clare, Hopkins, and Edward Thomas

John Clare, Gerard Manley Hopkins, and Edward Thomas form a trio of disparate yet tantalisingly related poets. What distinguishes them also conjoins them: the desire, in Hopkins’ words, to invest their poetry with ‘an individualising touch’. The poetic achievement of all three is animated by the effort to discover an idiom that answers to the pressure of a unique cast of mind, feeling, and vision of experience. All three poets stand consciously apart from their period. They articulate a recurrent counter-voice in English poetry of the nineteenth and early twentieth centuries, grounded in an effort to imbue poetic language with an acutely personal bearing. The Introduction establishes the interrelation of their personal and poetic individuality, exploring the way their poems formulate and embody shared aims. Clare once enthused over Keats’s description in Isabella of an eye ‘Striving to be itself’. The phrase gets purchase on the spirit of embattled innovation that the three chapters on Clare’s poetry locate in his language. The first seeks to characterise the haphazard ingenuity of Clare’s style, pursuing his trust in a brand of seemingly improvisational inventiveness as a means of discovering new modes of expression. Chapter 2 concentrates on the more controlled aspects of Clare’s experimentalism, attending to his poems’ twinning of actual and literary discovery. Chapter 3 focuses more explicitly on the disarmingly personal nature of Clare’s poetry, thinking about its strange marriages of personal fervour and literary archetype. Hopkins insisted on ‘originality’ as a ‘condition of poetic genius’; but his poetry is alert to originality’s costs as well as its virtues. The concern of Chapter 4 is with how Hopkins’ valorisation of distinctiveness sits in tension with his wariness of ‘Parnassian’ – the quality of ‘being too so-and-so-all over-ish’; it contends that Hopkins is most himself at his most unpredictable. Chapter 5 extends an emphasis on Hopkins’ blend of craft and spontaneity, and the intricacy and fervour of his expression of feeling, into a consideration of the rich presence his poetry affords to the heart. Chapter 6 attends to the ways in which Hopkins’ nerviness about the potentially alienating qualities of his individual style feeds back into the distinctive tenor of his voice. Thomas thought that ‘nothing so well represents […] singularity as style’. The first chapter on his poems explores takes off from T. S. Eliot’s notion of the ‘auditory imagination’ to explore the fusion of poetic and personal ‘singularity’ in Thomas’s harnessing of the postures of speech, and experimentation with the forms and rhythms of folk song. A large part of the individuality of Thomas’s style owes to the intricacy and tenacity of his syntax, and Chapter 8 explores the way in which his poetry’s distinctive voice arises out of an effort to trace the contours of thought and feeling. A final chapter devotes itself to the way in which, for all his idiosyncrasy, Thomas, like Clare and Hopkins, strives to achieve intimacy with a reader, contending that his best poems often invite us into the confidence of a personality that remains finally elusive. A coda emphasises the inventiveness and personal candour that unites the three poets’ language

Supply chain analysis of Gabilan Manufacturing Inc.

MBA Professional ReportThe purpose of this MBA Project was to investigate and provide alternative supply chain management strategies to assist Gabilan Manufacturing Inc. in reducing supply chain costs. This project was conducted with the sponsorship and assistance of Gabilan Manufacturing Inc. There were two primary goals of this project. The first was to identify and document the impact of forecasting errors in an environment where customer forecasts are available to the vendor. The second was to investigate the costs associated with relocating cutting operations as well as the procurement impact of a new cutting machine. Both of these goals relate directly to the overall effort to reduce supply chain costs without a loss of service level to Gabilan's customer.http://archive.org/details/supplychainnalys109459821Lieutenant Commander, United States NavyLieutenant, United States NavyApproved for public release; distribution is unlimited

Climate, landscape, habitat, and woodland management associations with hazel dormouse Muscardinus avellanarius population status

Although strictly protected, populations of the hazel dormouse Muscardinus avellanarius in the UK declined by 72% from 1993 to 2014. Using National Dormouse Monitoring Programme data from 300 sites throughout England and Wales, we investigated variation in hazel dormouse population status (expressed as Indices of Abundance, Breeding, and population Trend) in relation to climate, landscape, habitat, and woodland management. Dormice were more abundant and produced more litters on sites with warmer, sunnier springs, summers, and autumns. Dormouse abundance was also higher on sites with consistently cold local climate in winter. Habitat connectivity, woodland species composition, and active site management were all correlated with greater dormouse abundance and breeding. Abundances were also higher on sites with successional habitats, whereas the abundance of early successional bramble Rubus fruticosus habitat, woodland area, and landscape connectivity were important for population stability. Diversity in the structure of woodlands in Europe has decreased over the last 100 years, and the habitats we found to be associated with more favourable dormouse status have also been in decline. The conservation status of the hazel dormouse, and that of woodland birds and butterflies, may benefit from reinstatement or increased frequency of management practices, such as coppicing and glade management, that maintain successional and diverse habitats within woodland

Isospin-breaking corrections to light leptonic decays in lattice QCD+QED at the physical point

We report on the physical-point RBC/UKQCD calculation of the leading isospin-breaking corrections to light-meson leptonic decays. This is highly relevant for future precision tests in the flavour physics sector, in particular the first-row unitarity of the Cabibbo-Kobayashi-Maskawa matrix containing the elements $V_{us}$ and $V_{ud}$. The simulations were performed using Domain-Wall fermions for $2+1$ flavours, and with isospin-breaking effects included perturbatively in the path integral through order $\alpha$ and $(m_u - m_d)/\Lambda _{\mathrm{QCD}}$. We use QED$_{\mathrm{L}}$ for the inclusion of electromagnetism, and discuss here the non-locality of this prescription which has significant impact on the infinite-volume extrapolation.Comment: Proceedings for The 39th International Symposium on Lattice Field Theory, 8th-13th August, 2022, Rheinische Friedrich-Wilhelms-Universit\"at Bonn, Bonn, German

The Genetic Structure of Pacific Islanders

Human genetic diversity in the Pacific has not been adequately sampled, particularly in Melanesia. As a result, population relationships there have been open to debate. A genome scan of autosomal markers (687 microsatellites and 203 insertions/deletions) on 952 individuals from 41 Pacific populations now provides the basis for understanding the remarkable nature of Melanesian variation, and for a more accurate comparison of these Pacific populations with previously studied groups from other regions. It also shows how textured human population variation can be in particular circumstances. Genetic diversity within individual Pacific populations is shown to be very low, while differentiation among Melanesian groups is high. Melanesian differentiation varies not only between islands, but also by island size and topographical complexity. The greatest distinctions are among the isolated groups in large island interiors, which are also the most internally homogeneous. The pattern loosely tracks language distinctions. Papuan-speaking groups are the most differentiated, and Austronesian or Oceanic-speaking groups, which tend to live along the coastlines, are more intermixed. A small “Austronesian” genetic signature (always <20%) was detected in less than half the Melanesian groups that speak Austronesian languages, and is entirely lacking in Papuan-speaking groups. Although the Polynesians are also distinctive, they tend to cluster with Micronesians, Taiwan Aborigines, and East Asians, and not Melanesians. These findings contribute to a resolution to the debates over Polynesian origins and their past interactions with Melanesians. With regard to genetics, the earlier studies had heavily relied on the evidence from single locus mitochondrial DNA or Y chromosome variation. Neither of these provided an unequivocal signal of phylogenetic relations or population intermixture proportions in the Pacific. Our analysis indicates the ancestors of Polynesians moved through Melanesia relatively rapidly and only intermixed to a very modest degree with the indigenous populations there

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility

Ion channels regulate many aspects of cell physiology, including cell proliferation, motility, and migration, and aberrant expression and activity of ion channels is associated with various stages of tumor development, with K⁺ and Cl⁻ channels now being considered the most active during tumorigenesis. Accordingly, emerging in vitro and preclinical studies have revealed that pharmacological manipulation of ion channel activity offers protection against several cancers. Merkel cell polyomavirus (MCPyV) is a major cause of Merkel cell carcinoma (MCC), primarily because of the expression of two early regulatory proteins termed small and large tumor antigens (ST and LT, respectively). Several molecular mechanisms have been attributed to MCPyV-mediated cancer formation but, thus far, no studies have investigated any potential link to cellular ion channels. Here we demonstrate that Cl⁻ channel modulation can reduce MCPyV ST-induced cell motility and invasiveness. Proteomic analysis revealed that MCPyV ST up-regulates two Cl⁻ channels, CLIC1 and CLIC4, which when silenced, inhibit MCPyV ST-induced motility and invasiveness, implicating their function as critical to MCPyV-induced metastatic processes. Consistent with these data, we confirmed that CLIC1 and CLIC4 are up-regulated in primary MCPyV-positive MCC patient samples. We therefore, for the first time, implicate cellular ion channels as a key host cell factor contributing to virus-mediated cellular transformation. Given the intense interest in ion channel modulating drugs for human disease. This highlights CLIC1 and CLIC4 activity as potential targets for MCPyV-induced MCC

Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 x 10(53)). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 x 10(-20)). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management