13 research outputs found
Parkbuddy â Find My Car Android Mobile Application
- Publication venue
- Journal of Telecommunication, Electronic and Computer Engineering (JTEC)
- Publication date
- 07/12/2017
- Field of study
As a result of technological progress, smartphones become an excellent choice for the user to make their life easier. This paper discussed how to locate parked vehicle using mobile application. The situation of forgetting where last vehicle location was parked and trying to remember it can become problem to some people especially to those who are having deterioration of memory such as a short term memory and dementia. This mobile application helps these users to locate their vehicle by utilising the global positioning system (GPS) system. This paper presents and critically analyses the system developed to solve the problem
Parkbuddy â Find My Car Android Mobile Application
- Publication venue
- Universiti Teknikal Malaysia (UTEM)
- Publication date
- 01/01/2017
- Field of study
Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between <i>Plasmodium vivax</i> PvDBP and <i>Plasmodium falciparum</i> VAR2CSA
- Author
- Publication venue
- 'American Society for Microbiology'
- Publication date
- 01/01/2019
- Field of study
Examining the generalizability of research findings from archival data
- Author
- Abd Al-Aziz Ahmad M
- Abraham Ajay T
- Adamkovic Matus
- Agadullina Elena
- Ahn Jungsoo
- Akinci Cinla
- Akkas Handan
- Albrecht David
- Alzahawi Shilaan
- Amaral-Baptista Marcio
- Anand Rahul
- Ang Kevin Francis U
- Anseel Frederik
- Aruta John Jamir Benzon R
- Ashraf Mujeeba
- Baker Bradley J
- Bao Xueqi
- Baskin Ernest
- Bathula Hanoku
- Bauman Christopher W
- Bavolar Jozef
- Bayraktar Secil
- Beckman Stephanie E
- Benjamin Aaron S
- Brown Stephanie EV
- Buckley Jeffrey
- Buitrago R. Ricardo E
- Bution Jefferson L
- Byrd Nick
- Carrera Clara
- Caruso Eugene M
- Chen Lin
- Chen Minxia
- Chen Zhaowei
- Cicerali Eyyub Ensari
- Clemente Elena Giulia
- Cohen Eric D
- Crede Marcus
- Cummins Jamie
- Dahlander Linus
- Daniels David P
- Daskalo Lea Liat
- Dawson Ian GJ
- Day Martin V
- Delios Andrew
- Dietl Erik
- Domurat Artur
- Dreber Anna
- Dsilva Jacinta
- Dubrov Dmitrii I
- Edris Sarah
- Elbaek Christian T
- Elsherif Mahmoud M
- Evans Thomas R
- Fellenz Martin R
- Fiedler Susann
- Firat Mustafa
- Freitag Raquel
- Furrer RĂ©my A
- Gautam Dhruba Kumar
- Gautam Richa
- Gearin Brian
- Gerschewski Stephan
- Ghasemi Omid
- Ghasemi Zohreh
- Ghosh Anindya
- Giani Cinzia
- Goldberg Matthew H
- Gordon Michael
- Goswami Manisha
- Graf-Vlachy Lorenz
- Griffith Jennifer A
- Grigoryev Dmitry
- Gu Jingyang
- H Rajeshwari
- Hadida Allegre L
- Hafenbrack Andrew C
- HafenbrÀdl Sebastian
- Hammersley Jonathan J
- Han Hyemin
- Harman Jason L
- Hartanto Andree
- Henkel Alexander P
- Ho Yen-Chen
- Holding Benjamin C
- Holzmeister Felix
- Horobet Alexandra
- Huang Tina S-T
- Huang Yiming
- Huntsinger Jeffrey R
- Idzikowska Katarzyna
- Imada Hirotaka
- Imran Rabia
- Ingels Michael J
- Jaeger Bastian
- Janssen Steve MJ
- Jia Fanli
- Jiménez Alfredo
- Jin Jason Lu
- Johannes Niklas
- Johannesson Magnus
- Jolles Daniel
- Jozefiakova Bibiana
- Kalandadze Tamara
- Kalimeri Kyriaki
- Kang Polly
- Kantorowicz Jaroslaw
- KaradaÄ Didar
- Karimi-Rouzbahani Hamid
- KaÄmĂĄr Pavol
- Kee Daisy Mui Hung
- Keller Lucas
- Khan Haider A
- Knutsson Mikael
- Kombeiz Olga
- Korniychuk Aleksey
- Kowal Marta
- Leder Johannes
- Liang Liang Wenhao
- Liew Taegyeong Tae
- Lin Fangwen
- Liu Bin
- Liu Chengwei
- Longo Maria Cristina
- Lovakov Andrey
- Low Mei Peng
- Lucas Gerardus JM
- Lukason Oliver
- Ly Albert L
- Ma Zhuoran
- Mafael Alexander
- Mahar Elizabeth A
- Mahmoudkalayeh Soheil
- Manheim David
- Marcus Alfred
- Marsh Melvin S
- Martin Jolie M
- Martinez Luis E
- Martinoli Mario
- MartonÄik Marcel
- Masters-Waage Theodore C
- Mata Rui
- Mazloomi Hamid
- McCarthy Randy J
- Millroth Philip
- Mishra Mahima
- Mishra Supriti
- Mohr Alexander
- Moreau David
- Myer Annalisa
- Nadler Amos
- Nair Sudhir
- Nilsonne Gustav
- Niszczota PaweĆ
- O'Mahony Aoife
- Oberhauser Marc
- Obloj Tomasz
- Orhan Mehmet A
- Oswald Flora
- Otterbring Tobias
- Otto Philipp E
- PadrĂłn-HernĂĄndez Ivar
- Pan Alan J
- Paruzel-Czachura Mariola
- Pfeiffer Thomas
- Pfuhl Gerit
- Pirrone Angelo
- Plessis Christilene du
- Porcher Simon
- Protzko John
- Prox Constantin
- Qi Shelly
- Rahal Rima-Maria
- Rahman Md Shahinoor
- Rao Gudivada Venkat
- Reina Michelle L
- Rentala Satyanarayana
- Riaz Zahid
- Ropovik Ivan
- Ross Robert M
- Rotella Amanda
- Roth Leopold HO
- Roulet Thomas J
- Rubin Matthew M
- Röseler Lukas
- Sammartino Andre
- Sanchez Johann
- Saville Adrian D
- Schaerer Michael
- Schleu Joyce Elena
- Schmallenbach Leo
- Schnabel Landon
- Schumpe Birga M
- Senanayake Tony
- Seri Raffaello
- Sheng Feng
- Snider Roary E
- Song Di
- Song Victoria
- SpĂŒntrup Frederik Schulze
- Starnawska Sylwia E
- Stern Kai A
- Stevens Samantha M
- StrĂžmland Eirik
- Su Wunhong
- Sun Hao
- Sweeney Kevin P
- Takamatsu Reina
- Tan Hongbin
- Terskova Maria
- Tey Kian Siong
- Tierney Warren
- Todorova Mariya M
- Tolstoy Daniel
- Torkkeli Lasse
- Trojan Jais
- Tybur Joshua M
- Uhlmann Eric Luis
- Valderrey Francisco J
- Vallina-Hernandez Ana Maria
- Vasudevan Ranjith P
- Vernet Antoine
- Viganola Domenico
- Vissak Tiia
- Voss Hinrich
- Wahle Thorsten
- Wai Jonathan
- Wakabayashi Lauren ET
- Wang Junnan
- Wang Peng
- Wang Yating
- Wang Yong
- Warmenhoven Robert W
- Wennberg Karl
- Wernicke Georg
- Woike Jan K
- Wollbrant Conny E
- Woodin Greg
- Wright Joshua D
- Wu Tao
- Xia Qiong
- Xie Zhenzhen
- Yoon Sangsuk
- Yuan Lin
- Yuan Wenlong
- Yucel Meltem
- Zheng Zhao
- Zhou Haibo
- Zogmaister Cristina
- Zultan Ro'i
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 19/07/2022
- Field of study
This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizabilityâfor the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso InĂȘs
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eric E Schadt
- Eriksson Johan G.
- Eriksson Per
- Esko TÔnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
- Gardezi Ali
- Gejman Pablo V.
- Geus Eco J C
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gjesing Anette P.
- Glass Daniel
- Glazer Nicole L.
- Gloyn Anna L.
- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
- Green Fiona
- Green Todd
- Greenawalt Danielle M.
- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- GrĂ€Ăler JĂŒrgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
- Hazen Stanley L.
- Heard-Costa Nancy L.
- Heath Andrew C.
- Hebebrand Johannes
- Hedman Ă sa K.
- Hei Iris M.
- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C.
- Horikoshi Momoko
- Horne Benjamin D.
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Huikuri Heikki V.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Ida Chen Yii Der
- Igl Wilmar
- Illig Thomas
- Ingelsson Erik
- Ingle Catherine
- Iribarren Carlos
- Ishaq Muhammad
- Isomaa Bo
- Jackso Anne U.
- Jackson Anne U.
- Jacobs Kevin B.
- James Alan L.
- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
- Johansson Ă sa
- John Ulrich
- Johnson Paul
- Johnson Paul R V
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- JĂžrgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
- Kajantie Eero
- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
- Kerr-Conte Julie
- Ketkar Shamika
- Kettunen Johannes
- Khaw Kay Tee
- Kiemeney Lambertus A.
- KilpelÀine Tuomas O.
- KilpelÀinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik ZoltĂĄn
- Kuulasmaa Teemu
- Kuusisto Johanna
- KvalĂžy Kirsti
- Kyriakou Theodosios
- KÀhönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
- Langenberg Claudia
- Lango Allen Hana
- Lantieri Olivier
- Lanzani Chiara
- Launer Lenore J.
- Lauritzen Torsten
- Lawlor Debbie A.
- Lawrence Robert W.
- Leander Karin
- Lecoeur Cecile
- LehtimÀki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
- Li Mingyao
- Li Shengxu
- Lian Liming
- Liang Liming
- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
- Lindgre Cecilia M.
- Lindgren Cecilia M.
- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
- Loley Christina
- Loos Ruth J F
- Lorentzon Mattias
- Lotery Andrew J.
- Lua Jian'an
- Luan Jian'an
- Luben Robert N.
- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- MartĂnez-Larrad MarĂa Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
- Merlini Pier Angelica
- Metspalu Andres
- Meyre David
- Midthjell Kristian
- Min Josine L.
- Moffatt Miriam F.
- Mohlke Karen L.
- Mond Keri L.
- Monda Keri L
- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- MĂ€g Reedik
- MĂ€gi Reedik
- MĂ€larstig Anders
- MĂ€rz Winfried
- MĂŒhleisen Thomas W.
- MĂŒnzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
- Nelson Christopher P.
- Nemes James
- Nemesh James
- Nestle Frank O.
- Neville Matt J.
- Ngwa Julius S.
- Nica Alexandra C.
- Nieminen Markku S.
- Nilesh J Samani
- Nilsson Peter
- Nisbet James
- North Kari E.
- Nyholt Dale R.
- Nöthen Markus M.
- O'Connell Jeffrey R.
- O'Donnel Christopher J.
- O'Donnell Christopher J.
- O'Rahilly Stephen
- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
- Olsson Gunnar
- Ong Ken K.
- Ongen Halit
- Oostra Ben
- Osmond Clive
- Ostenson Claes-Göran
- Ouwehand Willem H.
- Owen Katharine R.
- Palmer Colin N A
- Palmer Lyle J.
- Pankow James S.
- Par Ju Hyun
- Parish Sarah
- Park Ju-Hyun
- Parker Alex N.
- Parts Leopold
- Paré Guillaume
- Pascoe Laura
- Patel Riyaz S.
- Patterson Chris C.
- Pattou François
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Pellikka Niina
- Peltonen Leena
- Penninx Brenda W.
- Perola Markus
- Perry John R B
- Peter M Visscher
- Peters Annette
- Peters Marjolein J.
- Petersen Ann Kristin
- Peto Richard
- Petrie John R.
- Peyvandi Flora
- Pichler Irene
- PietilÀinen Kirsi H.
- Platou Carl
- Platou Carl G P
- Polasek Ozren
- Potter Simon
- Pouta Anneli
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Purcell Shaun
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rafelt Suzanne
- Raitakari Olli
- Rallidis Loukianos S.
- Randal Joshua C.
- Randall Joshua C
- Rasheed Asif
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N. William
- Rayner Nigel W.
- Reilly Muredach P.
- Reinehr Thomas
- Rice Catherine
- RidderstrÄel Martin
- RidderstrÄle Martin
- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- RĂos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
- Samad Adbus
- Samani Nilesh
- Sampietro M. Lourdes
- Sampson Michael J.
- Samuel Maria
- Sanders Alan R.
- Sandholt Camilla
- Sandhu Manj S.
- Sandhu Manjinder S.
- Sanna Serena
- Saramies Jouko
- Savolainen Markku J.
- Saxena Richa
- Sayer Avan A.
- Schadt Eric
- Scherag Andre
- Scherag Susann
- Schillert Arne
- Schipf Sabine
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir JĂŒrgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schwarz Peter E H
- SchÀfer Arne
- Scott James
- Scott Laura J.
- Seedorf Udo
- SegrĂš Ayellet V.
- Sehmi Joban
- Sekowska Magdalena
- Sennblad Bengt
- Shah Nabi
- Shaun Purcell
- Shi Jianxin
- Shields Beverley M.
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- SparsĂž Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- SyvÀnen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho LehtimÀki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
- Tzenova Bell Jordana
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden Andre G.
- Uitterlinden André
- Valle Timo T.
- van Dam Rob M.
- van Duijn Cornelia M.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber GĂ©rard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Ăhrvik John
- Ăstenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired ÎČ-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of âŒ2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 Ă 10(-4)), improved ÎČ-cell function (P = 1.1 Ă 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A.
- Ahmed Hatem
- Ahmed M.
- Ahmed O. S.
- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
- Ajayi Nnennaya A.
- Ajibaye Solomon
- Ajili F.
- Ajogbasile F.V.
- Ajogbasile Fehintola V.
- Akanbi Olusola Anuoluwapo
- Akenji Blaise MBoringong
- Akhoud Youssef
- Akinola Monilade
- Akogbeto Petas
- Akoua-Koffi Chantal G.
- Akpede George O.
- Al Onifade Fattah
- Alain Etoundi Mballa
- Alaoui Afaf
- Alaoui-Amine Sanaa
- Alarif Ahlam
- Alaruusi A. M.
- Albert MĂ©lanie
- AlEmam Adba Alfatih
- Alemayehu Dawit Hailu
- Alemu Fekadu
- Algheriani Raiva
- Ali Abraham
- Ali M.A.
- Ali Mohamed Ahmed
- Ali Mushal
- Ali Wael
- Alkarim Mona O.A.
- Allam Loubna
- Allam Mushal
- Allam Mushal
- Altamura Settimia
- Amar Narjis
- Amenga-Etego Lucas N.
- Amer K. E.
- Amer Khaled
- Amira Souissi
- Amoako Daniel G.
- Amoo Olufemi Samuel
- Amoth Patrick
- Amougou Marie
- Ampofo William K.
- Amuri Adrienne A.
- Amuzu Dominic S. Y.
- Amzazi SaaĂŻd
- Anang Abraham Kwabena
- Anas Abbad
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- Andersen Kristian
- Andersson Hana Sofia
- Andika Brian
- Andres Moreira-Soto
- Andriam Soa Fy
- Andriamandimby Soa Fy
- Anga Latifa
- Ange Dossou
- Angelov Angel
- Anna-Lena Sander
- Annajr B.
- Anoh Etilé A.
- Anscombe Catherine
- Antwerpen Markus H.
- Anu Campbell
- Anyaneji Ugochukwu J.
- Anyika Chinyere
- Aouni M.
- Appiah Vincent
- Appiah-Kubi Joyce
- Arena Fabio
- Arjaquah Augustina
- Arjarquah A.
- Armand Edang-Minko
- Armanious Riad Mounir
- Armoo Samuel
- Arnaldo Paulo
- Arnold Catherine E.
- Arrouchi Housna
- Artesi Maria
- Aryeetey Sherihane
- Asamoah Jesse Addo
- Asante Ivy A.
- Asare K.M.
- Ashton Philip
- Ashton Phillip
- Asiedu Ernest
- Asiedu-Bekoe Franklyn Egbe
- Asiimwe Stephen
- Askander Omar
- Asmamaw Kominist
- Assane Hamadi
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- Ayoade F.
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- Ayouba Ahidjo
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- Babatunde Sunday
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- Badou Yvette
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- Baker David
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- Bates Matthew
- Batra Dhwani
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- Bayih Abebe Genetu
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- Bedford Trevor
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- Bejon Philip
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- Ben Kahla Alia
- Ben Khelil Jalila
- Ben Moussa Mohamed
- Ben Othman Roua
- Ben Romdhane Habiba
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- Bitrou S.M.
- Bizard MĂ©line
- Bióté Simão Tchuda
- Blackmore Timothy
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- Bloomfield Max
- Bnouyahia Ikram
- Boatemaa Linda
- Bolajoko Bankole
- Bonney Evelyn Y.
- Bonney Joseph H. K.
- Bonney Kofi
- Bontems SĂ©bastien
- Bootsma Sacha
- Borrmann Steffen
- Boter Marjan
- Boujemla Bouchra
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- Bouzid Amal
- Bouzid Jawad
- Bracchitta Fiorenza
- Brechar Ludivine
- Bridges Daniel J.
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- Brisebarre Angela
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- BUHARI Mikhail Olayinka
- Bulimo Wallace D
- Bunga Sudhir
- Butel Christelle
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- Candé Adul
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- Cer Regina Z.
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- Chtourou A.
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- Cigolo Jean-Claude Makangara
- Cisse Barada
- Clarisse Murebwayire
- Colson Philippe
- Comas Iñaki
- Combe Patrice
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- Cortes Carlos
- Cotten Matthew
- Crawford M.
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- CĂĄ Milanca Agostinho
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- D'Aprile Annamaria
- Dadi Hailu
- Daghfous Riadh
- Dagnran Anoumou
- Dakka Hanae
- Dal Monego Simeone
- Damaris Matoke-Muhia
- Damena D.
- Damilari Dabiri
- Daniels Rodney S.
- Dao Sounkalo
- Daou Amadou
- Dara Antoine
- Daubenberger Claudia
- David Kumbelembe
- Davids Micheala
- Davies Mary-Ann
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- de Ligt Joep
- De Nittis Rosella
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- de Oliveira Martins Leonardo
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- De Sanctis R.
- de Silva Thushan I
- DeAlmeida Mary
- Debela Alemu Tike
- Delaney Kayla
- Delaporte Eric
- Delerce Jeremy
- Dellagi Koussay
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- Deng Lul Lojok
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- Derrar Fawzi
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- Deschenes Michael V.
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- Detweiler Angela M.
- Devatchagni Syntyche
- Devaux Christian A.
- Dhaala Beatrice
- Dia Aminata
- Dia Ndongo
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- Diab A.
- Diagne Diabou
- Diagne Moussa M.
- Diakite Mandiou
- Diallo Amadou
- Diallo Haby
- Diallo Penda Malhado
- Diallo Sada
- Diarra B.
- Diarra Bassirou
- Diaw Papa Alassane
- Diawara Idrissa
- Dieng Alle Baba
- Dieng Assane
- Diergaardt Azaria
- Diop Mamadou
- Diop Oumy
- Djimde Abdoulaye
- Djingarey Mamoudou Harouna
- Djomsi Dowbiss Meta
- Djontu Jean Claude
- Dobi Paul
- Donati Flora
- Dorkenoo Ameyo
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- El ansari Fatima Zahra
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- Enouf Vincent
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- Farawyla H.
- Fares Wasfi
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- GeurtsvanKessel Corine H.
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- Ghassan Adib
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- Girgis Samia Abdou
- Gismondo Maria Rita
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- Hellemans Jorn
- Helmy Sherine
- Hemlali Mouhssine
- Henson Sondes
- Heraud Jean-Michel
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- Hicham Elannaz
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- Hilali Abderraouf
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- Hoornaert Laurien
- Hope Virginia
- Hosch Salome
- Houda Harmak
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- Howard Julia
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- Iyanu Fred-Akintunwa
- Jain Komal
- Jalal D.
- Jalal Nourlil
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- Jannoo N.
- Jefferies Sarah
- Jegede-Williams Anu
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- Kabanda Alice
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- Kandeil Ahmed
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- Kidane Eleni
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- Kiiza Ronald
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- Kirimunda Samuel
- Kiritu Edward
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- Koivogui Joel
- Koka Hellen
- Kolomoets E.V.
- Kone Amadou
- Konou Abla A.
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- Wulf Ben
- Wurie I.
- Wurie Isatta
- Xavier Joicymara S.
- Xiang Zuzheng
- Xie Hong
- Yadouleton Anges
- Yadouleton Yahya
- Yakout Mostfa
- Yandoko Rivalyn Nakoune
- Yang Qi
- Yao Kouadio T.
- Yassine Kasmi
- Yassine Zouheir
- Yasuda Jiro
- Yatassaye Bouna
- Yeboah C.
- Yeboah Richmond
- Yeboah-Manu Dorothy
- Yemi Bright K.
- Yiaba Cyrus
- Yiaba Warren Cyrus
- Yu Popova A.
- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo ArsĂšne
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Another history of museums: from the discourse to the museum-piece
- Author
- ADAM Thomas
- ALSOP Joseph
- ALTICK Richard D
- ANDERSON Benedict
- APPADURAI Arjun
- AULANIER Christiane
- BAILKIN Jordana
- BAL Mieke
- BARRINGER Tim J
- BAYNE SiĂąn
- BAZIN Germain
- BENNETT Tony
- BENNETT Tony
- BERGVELT Ellinor
- BERGVELT Ellinor
- BESSY Christian
- BOUQUET Mary
- BREWER John
- BROWN Bill
- BYRNE Sarah
- CAHN Walter
- CANDLIN Fiona
- CONLIN Jonathan
- CONLIN Jonathan
- CONLIN Jonathan
- CRANE Susan A
- CRARY Jonathan
- CRARY Jonathan
- CUNO James B
- CUNO James B
- DANTO Arthur
- DARIAN-SMITH Kate
- DASTON Lorraine
- DEAZLEY Ronan
- DEBARY Octave
- DENEKE Bernward
- DIAS NĂ©lia
- Dominique Poulot
- DUDLEY Sandra
- DUNCAN Carol
- DUNCAN Sally Anne
- EDWARDS Elizabeth
- EFFROS Bonnie
- ELKINS James
- EMERY Elizabeth Nicole
- EMERY Elizabeth Nicole
- FALSER Michael
- FINDLEN Paula
- FREEDBERG David
- FYFE Gordon
- GAEHTGENS Thomas W
- GELL Alfred
- HALL Stuart
- HALL Stuart
- HASKELL Francis
- HENARE Amiria
- HENNION Antoine
- HIGONNET Anne
- HILL Kate
- HOSKINS Janet
- HUDSON Kenneth
- JENKINS Ian
- JENSEN Lote
- JENSEN Lote
- KAPLAN Flora E. S
- KESNER Ladislav
- KNELL Simon J
- KOPYTOFF Igor
- LASC Anca I
- LATOUR Bruno
- LATOUR Bruno
- LAYTON Robert
- LEHMANN-BRAUNS Susanne
- LENAIN Thierry
- LEWIS Geoffrey
- LOIR Christophe
- LONG VĂ©ronique
- LORENTE JesĂșs Pedro
- MACDONALD Sharon
- MACGREGOR Neil
- MACLEOD Dianne Sachko
- MAROSI Erno
- MCCAULEY Anne
- MINIHAN Janet
- MOSER Stephanie
- MURRAY David
- NELSON Robert S
- NOORDEGRAAF Julia
- ORLANDO Francesco
- PATEY Caroline
- PAUL Carole
- PERGAM Elizabeth A
- PETY Dominique
- POINTON Marcia R
- POINTON Marcia R
- POINTON Marcia R
- POMMIER Edouard
- POULOT Dominique
- POULOT Dominique
- POULOT Dominique
- RIONNET Florence
- SALLES Georges
- SHAW Wendy M. K
- SHAYA Gregory
- SHEEHAN James J
- SHERMAN Daniel J
- SMITH Anthony D
- SMITH Anthony D
- STANISZEWSKI Mary Anne
- STANISZEWSKI Mary Anne
- STARN Randolph
- STOCKING George W
- TAMEN Miguel
- TAYLOR Brandon
- THOMAS Nicholas
- VAN KALCK MichĂšle
- VERHOOGT Robert Maarten
- VERMEULEN Ingrid R
- VINCENT Odile
- WATSON Watson Janell
- WHITEHEAD Christopher
- WRIGHT Gwendolyn
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2013
- Field of study
The history of museums could get inspired on the procedures of material studies and of Anthropology in order to take a new stand and move away from the institutional approach and consider the approach of objects traditionally labelled as museum objects. The socalled âmuseum piecesâ are supposed to have a number of characteristics, particularly some great historical and artistic qualities, sometimes an heritage quality, but above all the ability to make âfriendsâ around the community or around the world. In all these respects, it is proposed here a number of research procedures that may supplement or enrich the directions usually assigned to the history of institutions
Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1
- Author
- Abecasis G.R. (Gonçalo R.)
- Abecasis Gonçalo
- Absher D. (Devin)
- Adrienne Cupples L.
- Aherrahrou Zouhair
- Allayee Hooman
- Allione Alessandra
- Altshuler David
- Altshuler David
- Altshuler David
- Amin Najaf
- Anand Sonia
- Andersen Karl
- Anderson J.L. (Jeffrey L.)
- Angelica Merlini Pier
- Ardissino Diego
- Ardlie Kristin
- Assimes T.L. (Themistocles L.)
- Assimes Themistocles
- Aulchenko Yurii
- Baas Annette
- Badger Jonathan
- Balkau Beverley
- Ball Stephen
- Balmforth Anthony
- Bandinelli Stefania
- Barbalic maja
- Barnes Timothy
- Barroso InĂȘs
- Barroso InĂȘs
- Becker Diane
- Becker Lewis
- Beckmann Jacques
- Benediktsson Rafn
- Bengtsson Boström Kristina
- Bennett Amanda
- Berger Klaus
- Berglund G.
- Bergman R.N. (Richard N.)
- Bergman Richard N.
- Bergmann S. (Sven)
- Bingham Sheila
- Bis Joshua
- Blagieva Roza
- Blair R.D. (Ross D.)
- Blankenberg Stefan
- Blankensteijn Jan
- Bochud Murielle
- Bockxmeer Frank
- Boehm Bernhard
- Boehnke Michael
- Boehnke Michael
- Boekholdt Matthijs
- Boerwinkle E. (Eric)
- Boerwinkle Eric
- Bonnycastle L.L. (Lori L.)
- Bonnycastle Lori
- Bots Michiel
- Bown N.
- Bradley Declan
- Bragi Walters G.
- Braund Peter
- Bravenboer Bert
- Brown M.J. (Morris J.)
- Brown Morris
- Bumpstead Suzannah
- Bumpstead Suzannah
- Burnand Kevin
- Burton Paul
- Burtt Noël
- Buysschaert Ian
- Cambien François
- Campbell Harry
- Carlquist John
- Cauchi Stephane
- Caulfield Mark
- Chambers John
- Charpentier Guillaume
- Chen L. (Li)
- Child Anne
- Chines Peter
- Cichon Sven
- Clarke Robert
- Clough Rachel
- Cockerill Gillian
- Codd Veryan
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins Francis
- Connell John
- Cornelis Marilyn
- Couper David
- Crawford G.J. (Gabriel J.)
- Crawford Gabe
- Daly Mark
- Dam Rob
- Davies Robert
- de Jong P.E. (Paul E.)
- Dedoussis George
- Dehghan Abbas
- Deloukas P. (Panos)
- Deloukas P. (Panos)
- Deloukas Panagiotis
- Demissie Serkalem
- Devaney Joseph
- Di Gregorio Alessandra
- Diemert Patrick
- Dina Christian
- Do Ron
- Doering Angela
- Dominiczak Anna
- Doney Alex
- Duijn Cornelia
- Dupuis Josée
- Döring Angela
- Dörr Marcus
- Edkins Ted
- Eifert Sandra
- El Mokhtari Nour Eddine
- Elliott Amanda
- Elliott K.S. (Katherine S.)
- Elliott Katherine
- Elliott P. (Paul)
- Ellis Stephen
- Elosua R. (Roberto)
- Elosua Roberto
- Engert J.C. (James C.)
- Epstein Stephen
- Erdmann Jeanette
- Erdos Michael
- Eriksson Per
- Ernst F. (Florian)
- Eyheramendy Susana
- Faire Ulf
- Farrall Martin
- Felix Stephan
- Ferreira Teresa
- Ferrucci Luigi
- Fischer M. (Marcus)
- Florez J.C. (Jose C.)
- Folkersen Lasse
- Folsom Aaron
- Forouhi Nita
- Fox Caroline
- Franco-Cereceda Anders
- Franklin Christopher
- Frayling Timothy
- Freimer Nelson B.
- Freyer Jennifer
- Frikke-Schmidt Ruth
- Froguel Philippe
- Futers Simon
- Galan Pilar
- Ganser Martha
- Gateva Vesela
- Gerry Hill B.
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger Christian
- Gigante Bruna
- Gilst Wiek
- Girelli Domenico
- Gloyn Anna
- Goel A. (Anuj)
- Golledge Jonathan
- Goodall Alison
- Graaf Jacqueline
- Grallert Harald
- Grarup Niels
- Green T. (Todd)
- Gretarsdottir S. (Solveig)
- Gretarsdottir Solveig
- Griffin Simon
- Grobbee Diederick
- Groop Leif
- Groop Leif
- Groves Christopher
- Guarrera Simonetta
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey
- Gut Ivo
- Gwilliam Rhian
- Gyllensten U. (Ulf)
- Hadjadj Samy
- Hadley D. (David)
- Haeften Timon
- Hafez Hany
- Hall Alistair
- Halperin Eran
- Hammond Naomi
- Hamsten Anders
- Hansen T. (Torben)
- Harrison Seamus
- Harst Pim
- Hartikainen A.L.
- Hassanali Neelam
- Hattersley Andrew
- Hazen Stanley
- Heath Simon
- Hengstenberg Christian
- Hercberg Serge
- Herder Christian
- Herpt Thijs
- Hide Winston
- Hill A.A. (Andrew A.)
- Hitman Graham
- Hoek Mandy
- Hofman A. (Albert)
- Hofman Albert
- Hofmann Oliver
- Holm Hilma
- Homuth Georg
- Horne Benjamin
- Hu Frank
- Hua Zhao J. (Jing)
- Hughes Anne
- Humphries Steve
- Hunt Sarah
- Hunter D.J. (David J.)
- Huth Cornelia
- Hveem Kristian
- Illig Thomas
- Illig Thomas
- Illig Thomas
- Iribarren Carlos
- Isomaa Bo
- Jackson Anne
- Jackson Anne
- Jarvelin Marjo-Riitta
- Johnson A. (Anne)
- Johnson P.R.V. (Paul R. V.)
- Johnson Toby
- Jones G.T. (Gregory T.)
- Jones Gregory
- Jorgensen Torben
- Jousilahti Pekka
- Jukema Jan Wouter
- Kaiser Michael
- Kao Wen
- Kaplan Lee
- Kastelein John
- Kathiresan S. (Sekar)
- Kathiresan S. (Sekar)
- Khaw K.T.
- Khaw Kay-Tee
- Kiemeney Bart
- Klopp Norman
- Knowles Joshua
- Kolovou G. (Genovefa)
- Kong Augustine
- Kong Augustine
- Kooner Jaspal S.
- Kraft Peter
- Kuusisto Johanna
- König Inke
- Laakso M. (Markku)
- Laakso Markku
- Laaksonen Reijo
- Laan Maris
- Lakatta Edward
- Lambrechts Diether
- Langenberg Claudia
- Lathrop Mark
- Lauritzen Torsten
- Leander Karin
- Lettre Guillaume
- Lewis David
- Li Man
- Li X.
- Lieb Wolfgang
- Lieverse Aloysius
- Lim Noha
- Lindgren Cecilia
- Lindholt Jes
- Loley Christina
- Loos Ruth
- Lorbeer Roberto
- Lotery Andrew
- Lourdes Sampietro M.
- Luan J.
- Luben Robert
- Lucas G. (Gavin)
- Lyssenko Valeriya
- Mannucci Pier
- Maouche Seraya
- Marre Michel
- Marrugat Jaume
- Martinelli Nicola
- Matthiasson S.E. (Stefan E.)
- Matullo G.
- McArdle Wendy
- McCarroll Steve
- McCarthy Mark
- McCarthy Mark I.
- McCulloch Laura
- McKeown Pascal
- McNoe Les
- McPherson R. (Ruth)
- McPherson Ruth
- Meigs James
- Meisinger Christa
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Meitinger Thomas
- Melander O. (Olle)
- Melander Olle
- Meneton Pierre
- Merriman T.R. (Tony R.)
- Midthjell Kristian
- Mohlke Karen
- Mohlke Karen L.
- Mooser V. (Vincent)
- Mooser Vincent
- Morgan Thomas
- Morken M.A. (Mario A.)
- Morken Mario
- Morris Andrew
- Morris Andrew
- Muhlestein Joseph
- Munroe Patricia
- Munzel Thomas
- Musunuru Kiran
- MĂ€rz Winfried
- MĂŒhleisen Thomas
- Nahrstaedt Janja
- Naik D.K. (Dilip K.)
- Najjar Samer
- Narisu Narisu
- Navarro Pau
- Navis Gerjan
- Nelson Christopher P.
- Newhouse Stephen
- Newton-Cheh Christopher
- Nilsson P. (Peter)
- Nilsson P. (Peter)
- Norman Paul E.
- Numans Mattijs
- Nöthen Markus
- O'Donnell Christopher
- O'Donnell Christopher J.
- O'Reilly Paul
- Olivieri O. (Oliviero)
- Onland-Moret N.C. (N. Charlotte)
- Org Elin
- Orho-Melander Marju
- Ouwehand Willem
- Owen Katharine
- Palmen Jutta
- Palmer Colin
- Panico Salvatore
- Pankow James
- Papadakis K. (Konstantinos)
- Patel Riyaz
- Patterson Chris
- Payne Felicity
- Peden John
- Pedersen Oluf
- Peltonen Leena Johanna
- Perola Markus
- Perry John
- Peters Annette
- Petersen A.K.
- Peyvandi Flora
- Pfeufer Arne
- Platou Carl
- Polidoro Silvia
- Potter Simon
- Pouta Anneli
- Powell Janet
- Pramstaller Peter Paul
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed
- Rader Daniel
- Rallidis Loukianos
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner Nigel William
- Reffelmann Thorsten
- Refstrup Mette
- Reilly M.P. (Muredach P.)
- Rettig Rainer
- Ricceri Fulvio
- Rice Catherine
- Rij Andre
- Roberts Robert
- Robertson Neil
- Rocheleau Ghislain
- Roden Michael
- Romanazzi Valeria
- Rosendaal Frits
- Rubin Diana
- Rudan Igor
- Sacerdote Carlotta
- Salomaa Veikko
- Salomaa Veikko
- Samani N.J. (Nilesh J.)
- Samani Nilesh
- Samani Nilesh
- Sampson M.J. (Michael J.)
- Sandhu Manjinder
- Sandhu Manjinder
- Sanna Serena
- Saxena Richa
- Sayers Ian
- Schadt Eric
- Scheet Paul
- Schillert Arne
- Schlessinger D. (David)
- Schouw Yvonne
- Schreiber S. (Stefan)
- Schrezenmeir J. (JĂŒrgen)
- Schunkert Heribert
- Schwartz S.M. (Stephen M.)
- Schwartz S.M. (Stephen M.)
- SchÀfer A. (Arne)
- Scott D Julian
- Scott L.J. (Laura J.)
- Scott Laura
- Scuteri Angelo
- Seedorf U. (Udo)
- SegrĂš Ayellet
- Shields Beverley
- Shrader Peter
- Sigurdsson G. (Gunnar)
- Sijbrands Eric
- Siscovick D.S. (David S.)
- Siscovick David
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Smith A. (Alberto)
- Smith A.J.P.
- Smith Albert Vernon
- Smith T.B. (Tamara B.)
- Snieder Harold
- Snoep Jaapjan
- Sohrabi Soroush
- Song Kijoung
- Soranzo N. (Nicole)
- Soranzo Nicole
- SparsĂž Thomas
- Spector Timothy
- Spertus John
- Stark K. (Klaus)
- Stefansson K. (Kari)
- Stefansson K. (Kari)
- Stein Lincoln
- Steinthorsdottir Valgerdur
- Stewart Alexandre F.
- Stirrups Kathy
- Stoll Monika
- Strachan David
- Strassburger Klaus
- Stringham H.M. (Heather M.)
- Stringham Heather
- Subirana Isaac
- Sun Qi
- Susan Burnett Mary
- Swift Amy
- Sylvius Nicolas
- SyvÀnen A.C.
- Tanaka Toshiko
- Tang W.
- Teijink J. A W
- Tennstedt Stephanie
- Teumer Alexander
- Thompson John
- Thompson John
- Thompson Matthew
- Thomson I.A. (Ian A.)
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorleifsson Gudmar
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir Unnur
- Tichet Jean
- Tobin Martin
- Tognoni G. (Giovanni)
- Tomaszewski Maciej
- Topless Ruth
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tuomilehto Jaakko
- Tybjaerg-Hansen A.
- Uda Manuela
- Uiterwaal Cuno
- Uitterlinden A. (Andre)
- Uitterlinden André
- Valle T.T. (Timo T.)
- van Rij A. (Andre)
- Vasudevan Thodur
- Vicky Phillips L.
- Vineis Paolo
- Vliet-Ostaptchouk Jana
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin F.)
- Voight Benjamin
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Waeber GĂ©rard
- Wain Louise
- Walker M. (Mark)
- Wallace Chris
- Waltham Matthew
- Wareham N.J. (Nicholas J.)
- Wareham Nick
- Wareham Nick
- Watanabe R.M. (Richard M.)
- Waterworth Dawn
- Watkins Hugh
- Webster J. (John)
- Weedon Michael
- Welch Ryan
- Wells George
- Wichmann H.E. (H. Erich)
- Wichmann Heinz Erich
- Wichmann Heinz Erich
- Wijmenga C. (Cisca)
- Wijmenga Cisca
- Wild John
- Wild Philipp
- Willenborg Christina
- Willer C.J. (Cristen J.)
- Willer Cristen
- Williams Frances
- Wilson J.F. (James F.)
- Witteman J. (Jacqueline)
- Witteman Jacqueline
- Wright Benjamin
- Wright Benjamin
- Wu Guanming
- Ye S. (Shu)
- Yu Grace
- Yuan Xin
- Zeggini Eleftheria
- Zeggini Eleftheria
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Ziegler A. (Andreas)
- Zwart John-Anker
- Publication venue
- Elsevier
- Publication date
- 01/01/2011
- Field of study
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1Â Ă 10â5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1Â Ă 10â5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52Â Ă 10â10, odds ratio 1.15 [1.10â1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04â1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Absher D. (Devin)
- Absher D. (Devin)
- Aherrahrou Z. (Zouhair)
- Ahlqvist E. (Emma)
- Ahmadi K.R. (Kourosh)
- Ahmed N. (Nabeel)
- Alavere H. (Helene)
- Alibrandi M.T.S. (Maria)
- Allayee H. (Hooman)
- Allen H.L.
- Almgren P. (Peter)
- Altshuler D. (David)
- Amin N. (Najaf)
- Anand S.S. (Sonia)
- Andersen K.K. (Karl)
- Ardissino D. (Diego)
- Ardlie K.G. (Kristin)
- Armitage J. (Jane)
- Arnold A.M. (Alice)
- Aspelund T. (Thor)
- Assimes T.L. (Themistocles)
- Assmann G. (Gerd)
- Aulchenko Y.S. (Yurii)
- Azhar M. (Muhammad)
- Balkau B. (Beverley)
- Ball S.G. (Stephen G.)
- Barbalic M. (maja)
- Barker A.M. (Adam)
- Barlassina C. (Christina)
- Barlera S. (Simona)
- Barnes D. (Daniel)
- Barnes T.A. (Timothy)
- Barrett A. (Angela)
- Barroso I.E. (InĂȘs)
- Bataille V. (Veronique)
- Becker D.M. (Diane)
- Becker L.C. (Lewis)
- Beckmann J.S. (Jacques)
- Beckmann J.S. (Jacques)
- Beilby J.P. (John)
- Bell J.T. (Jordana)
- Ben-Shlomo Y.
- Ben-Shlomo Y. (Yoav)
- Bennett A.J. (Amanda)
- Berger K. (Klaus)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Berndt S.I. (Sonja)
- Biebermann H. (Heike)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Blakemore A.I.F. (Alexandra)
- Blankenberg S. (Stefan)
- Boehm B.O. (Bernhard)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boeing H. (Heiner)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E.A. (Eric)
- Boes T. (Tanja)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret)
- Borecki I.B. (Ingrid)
- Bornstein S.R. (Stefan R.)
- Bornstein S.R. (Stefan)
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- Coin L. (Lachlan)
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- MĂ€gi R. (Reedik)
- MĂ€larstig A. (Anders)
- MĂ€rz W. (Winfried)
- Nahrstaedt J. (Janja)
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- Nelson C.P. (Christopher P.)
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- Neville M.J. (Matthew)
- Ngwa J.S.
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- Nieminen M.S. (Markku)
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- OÂŽConnell J.R.
- Palmer C.N.A. (Colin)
- Pankow J.S. (James)
- Pare G. (Guillame)
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- Parker A.N. (Alex)
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- Payne F. (Felicity)
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- Peters A. (Annette)
- Peters M.J. (Marjolein)
- Petersen A.K.
- Peto R. (R.)
- Petrie J.R. (John)
- Peyvandi F. (Flora)
- Pichler I. (Irene)
- Pietilainen K.H. (Kirsi Hannele)
- Platou C. (Carl)
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- Pramstaller P.P. (Peter P.)
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- Qi L. (Lu)
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- Quyyumi A.A. (Arshed)
- Rader D.J. (Daniel)
- Rafelt S. (Suzanne)
- Raitakari O. (Olli)
- Raitakari O.T. (Olli T.)
- Rallidis L.S. (Loukianos)
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- Rayner N.W. (N. William)
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- Ripatti S. (Samuli)
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- Saxena R. (Richa)
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- Schipf S. (Sabine)
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- Schunkert H. (Heribert)
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- Sehmi J.S. (Joban)
- Sekowska M. (Magdalena)
- Sennblad B. (Bengt)
- Serrano-RĂos M. (Manuel)
- Shah N. (Nisha)
- Shi J. (Jianxin)
- Shi J. (Jianxin)
- Shields B.M. (Beverley)
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- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
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- Sivapalaratnam S. (Suthesh)
- Sladek R. (Rob)
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- Smit J.H. (Jan)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- SparsĂž T. (Thomas)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth)
- Spertus J.A. (John)
- StanÄcĂĄkovĂĄ A. (Alena)
- Stark K. (Klaus)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Stephens J. (Jonathan)
- Stewart A.F. (Alexandre F.)
- Stirrups K. (Kathy)
- Stoll M. (Monika)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- SyvÀnen A.C.
- Tammesoo M.L.
- Taneera J. (Jalal)
- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas)
- Tognoni G.
- Tomaszewski M. (Maciej)
- Travers M.E. (Mary E.)
- Travers M.E. (Mary)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Turrini F. (Fabiola)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- Van Dam R.M. (Rob M.)
- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (GĂ©rard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Ăhrvik J. (John)
- Ăstenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 Ă 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
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Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two: Genoa, Italy. 28 September â 01 October 2016
- Author
- Aalto Kristiina
- Abdalla Eiman
- Abdawani Reem
- Abdelrahman Nagla
- Abduragimova Farida
- Abinun Mario
- Acar Banu
- Acikel Cengizhan
- Adrovic Amra
- Agostoni Carlo
- Aguiar Francisca
- Aikawa Nadia E.
- Ailioaie Constantin
- Akikusa Jonathan D.
- Akman Sema
- Al Shaqshi Laila
- Al Zakwani Ibrahim
- Al Zuhbi Sana
- Albani Salvatore
- Alberdi-Saugstrup Mikel
- Albrecht Julia
- Albu Adriana
- Alcobendas Rosa
- Alekseeva Ekaterina
- Alexeev D.
- Alexeeva Ekaterina
- Alhemairi Mohammad
- Alikasifoglu Mehmet
- Alizzi Clotilde
- Allen Roger C.
- Alongi Alessandra
- Alpigiani M. G.
- Alpigiani Maria Giannina
- Altaye Mekibib
- Alves Andressa G. F.
- Alvey Christine
- Amarilyo Gil
- Amin Tania
- Amira Dhouib
- Ammann Sandra
- Amorim Rita A.
- Ang Elizabeth
- Anton Jordi
- Arango Christine
- Arıcı Zehra S.
- AricĂČ Maurizio
- Arkachaisri Thaschawee
- Arman Nilay
- Arnstad Ellen D.
- Arostegui Juan I.
- Arroyo Ivonne
- Arsenyeva S.
- Arslan Nur
- Avcin Tadej
- Aviel Yonatan Butbul
- AvramoviÄ Mojca Zajc
- AvÄin Tadej
- Ayaz Nuray Aktay
- Ayyildiz-Civan Hasret
- Badot Valérie
- Baheti A.
- Bale Peter
- Ballabio Maria
- Barbé-Tuana Florencia
- Baris Ezgi
- Barnicoat Angela
- Barone P.
- Barral Estefania
- Barrense-Dias Yara
- Barril Sara Marsal
- Barros Myrthes T.
- BartholomÀ Nora
- Barut Kenan
- Basbozkurt Gokalp
- Basic Jelena
- Bathi Loshinidevi D/O Thana
- Batu Ezgi
- Batu Ezgi D.
- Batu Ezgi Deniz
- Bava Cecilia
- Beckmann Jessica
- Behrens Edward M.
- Bell Samantha
- Belli Riccardo
- Bellucci Eleonora
- Belyaeva Lyudmila
- Benavente Belen Serrano
- Benseler Susanne
- Benseler Susanne M.
- Beresford Michael W
- Beresford Michael W.
- Berntson Lillemor
- Best Brian
- Beukelman Timothy
- Beutel Karin
- Bhattad Sagar
- Bhatti Parveen
- Bianco Anna Monica
- Bijl M.
- Bilginer Yelda
- Bingham Clifton
- BirkiÄ Ika
- Bohnsack J.
- Bohnsack John
- Boltjes Arjan
- Bonafini Barbara
- Bonafé Luisa
- Bonfa Eloisa
- BonfĂĄ Eloisa
- Bonhoeffer Jan
- Borrell Ricardo Pujol
- Bosak Edi Paleka
- Boteanu Alina Lucica
- Boulter Emily
- Bovis Francesca
- Bracaglia Claudia
- Bracci-Laudiero Luisa
- Braga Alfésio L. F.
- Braga VinĂcius L.
- Branco Jaime C.
- Breda L.
- Brice Nicky
- Brik Riva
- Bristow Helen
- Brito Iva
- Brodszky Valentin
- Brogan P. A.
- Brogan Paul
- Brogan Paul A.
- Brucato Antonio
- Brunner H. I.
- Brunner Hermine
- Brunner Hermine I.
- Brunner Juergen
- Bukovac Lana TambiÄ
- Bukowski Jack
- Bultink I. E. M.
- Burgos-Vargas Ruben
- Burrell Grendel
- Byelyaeva Lyudmyla M.
- Bzarova Tatiana
- Bzarova Tatyana
- BÄrziĆa Dace
- C Claudia Saad-MagalhĂŁes
- Caballero Consuelo Modesto
- Caiello Ivan
- Campanilho-Marques Raquel
- Campione Elena
- Campos LĂșcia M. D. A.
- Candotti Fabio
- Canham Nathalie
- CanhĂŁo Helena
- Cant Andrew
- Caorsi Roberta
- Carenini Laura
- Carlomagno Raffaella
- Carobbio Alessandra
- Carr Shannon
- Carraro Mara
- Carrasco Ruy
- Caspers Laure
- Cassidy Samuel
- Castagnola Elio
- Castiglione Maria Cristina
- Castro Fabio M.
- Castro Tania M.
- Cattalini M.
- Cattalini Marco
- Ceccherini Isabella
- Ceci Maria
- Celikel Banu Acar
- Chalom E.
- Chan Mercedes
- Charuvanij Sirirat
- Chatel Laurence
- Chiaroni-Clarke Rachel
- Chiesa Sabrina
- Chistyakova Evgeniya
- Chyzheuskaya Iryna
- Cimaz R.
- Cimaz Rolando
- Civino A.
- Civino Adele
- Coda Andrea
- Collante Ma. Theresa M.
- Consolaro A.
- Consolaro Alessandro
- Consolini R.
- Constantin Tamas
- Conte Umberto
- Conti G.
- Corazza Francis
- Cordeiro Ana
- Corkhill Rachel
- Corona F.
- Corona Fabrizia
- Corpora Umberto
- Corral Sandra Garrote
- Corsello Giovanni
- Cortis E.
- Costa José
- Costa Manuela
- Costa-Filho Ivan
- Craig Jeffrey M.
- Cressoni Paolo
- Cristina de Min
- Cron Randy Q.
- Crow Yanick
- Cullu-Cokugras Fugen
- Cumetti Davide
- Damian Laura O.
- Danilko Kseniia V.
- Danzmann Luiz C.
- Dare J.
- Dare Jason
- Davidson Joyce
- Daviâ Sergio
- DavĂŹ S.
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- De Benedetti Fabrizio
- de Benedetti Fabrizio
- De Fanti A.
- de Graaf Kathy
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- de Leeuw K.
- de Min Cristina
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- Dolhain R. J. E. M.
- DolĆŸan Vita
- Donnelly Ryan F.
- Dossetter Lee
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- Duarte Ana Catarina
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- Durrant Karen L.
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- Ellis Justine A.
- Enders Felicitas Bellutti
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- Esteves Gladys C. C.
- Eusébio Mónica
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- Falcini Fernanda
- Fall Ndate
- Farhat Juliana
- Farhat Sylvia C. L.
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- Fedorov Evgeny
- Ferlin Walter
- Ferlin Walter G.
- Fernanda Falcini
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- Filonovich Rostislav M.
- Finetti Martina
- Fingerhutova Sarka
- Fisher Antony C.
- FlatĂž Berit
- Flood Terence
- Foeldvari I.
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- Fonseca JoĂŁo E.
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- Gallo MĂłnica MartĂnez
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- Gerschman Tommy
- Giacomin Maria F. D. A.
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- Gok Faysal
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- Gomez Pilar
- Gonzalez Tatiana
- Gonzalez-Roca Eva
- Gorio Chiara
- Gormezano Natali W.
- Gorospe Juan I. Arostegui
- Grech Debra
- Gregory Antonarakis
- Grein Ingrid H. R.
- Grevich Sriharsha
- Grewal Davinder Singh
- Griffin Thomas
- Grigelioniene Giedre
- Groll Andreas
- Grom Alexei
- Grom Alexei A
- Grom Alexi A.
- Groot N.
- Groot Noortje
- Grossi Alice
- Grun Lucas K.
- Guarnizo Pilar
- Gucenmez Ozge Altug
- Guelbert Norberto
- Guerra Liana
- Guilhot Florence
- GuimarĂŁes HercĂlia
- Gulati Gaurav
- Gunduz Zubeyde
- Guo Z.
- Gupta Anju
- GĂĄmir Mariluz GĂĄmir
- GĂŒr Gökçe
- GĂŒrses Dolunay
- Haas J-Peter
- Haas Johannes Peter
- Haas Johannes-Peter
- Hackl Lukas
- Hadipour Fatemeh
- Hadipour Zahra
- Hambleton Sophie
- Hansmann Sandra
- Harel Liora
- HarjaÄek Miroslav
- Hasegawa Shunji
- Hashkes Phillip J
- Haug Iris
- Hausmann Jonathan S.
- Hawke Fiona
- Hawkins Philip
- Hazra Anasuya
- Heard Clare
- Heinrich M.
- Hendry Gordon
- Henneke Philipp
- Henter Jan-Inge
- Hentgen VĂ©ronique
- Herlin Troels
- Herresthal Stefanie
- Hinnershitz Tina
- Hirano Reiji
- Hirotsu Camila
- Hlavackova Eva
- Hofer M.
- Hofer Michael
- Hofer Michaël
- Holzinger Dirk
- Horne Anna
- Horne AnnaCarin
- Horneff G.
- Horneff Gerd
- Horonjeff Jennifer
- Hospach Anton
- Hotten Henny G.
- Hoza Jozef
- Huegle Boris
- Huppertz Hans-Iko
- Hurst Jane
- Hussain Khalid
- Hyrich Kimme L.
- HĂŒgle Boris
- Ilisson Jaanika
- Ilowite Norm
- Ilowite Norman T.
- Imai Chihaya
- Imazio Massimo
- Insalaco A.
- Insalaco Antonella
- Isayeva Kseniya
- Ito Shuichi
- IĆĄtuk Karla
- Jacqmin Philippe
- Janda Ales
- Jandial Sharmila
- Januskeviciute Giedre
- JeluĆĄiÄ Marija
- Jeyaratnam Jerold
- Job-Deslandre Chantal
- Johnson Nicole
- Johnson Zoë
- Jones Caroline
- Jones Jordan T.
- Jones Julie
- Jones Marcus H.
- Jorge Liliana
- Jorgensen Andrea
- Jorgensen Andrea L.
- Jorini M.
- Junior Edson Amaro
- Kacar Ayla
- Kaiser Daniela
- Kalabic J.
- Kaleda M.
- Kaleda Maria
- Kalil Jorge
- Kamenets Elena
- Kamphuis S. S. M.
- Kamphuis Sylvia
- Kanakoudi-Tsakalidou Florence
- Kaneko Utako
- Kanetaka Taichi
- Kaneva Radka
- Kaneyasu Hidenobu
- Kangas Salla
- Kardolus A.
- Kariminejad Ariana
- Karsioglu Yildirim
- Karslioglu Yildirim
- Kasapcopur Ozgur
- Kaschenko Elena
- Katsicas MarĂa M.
- Kaufmann Rachel
- Kawano Yoshifumi
- Kearsley-Fleet Lianne
- Keppeke Livia
- Kern David
- Keskin Dilek
- Keskindemirci Gonca
- Keskitalo Paula
- Kessel Christoph
- Khrustaleva Helena
- Khrustaleva Helena K.
- Khubchandani Raju
- Killeen Orla
- Kimura Yuki
- Kingsbury D.
- Kingsbury Daniel
- Kiper Nural
- Kısaarslan Aysenur Pac
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- Kitoh Toshiyuki
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- Kubota Tomohiro
- Kuchinskaya Ekaterina
- Kuemmerle-Deschner J. B.
- Kuemmerle-Deschner Jasmin
- Kuester R. M.
- Kupper H.
- Kutlu Tufan
- La Torre F.
- La CĂ©line
- Lacassagne Sandrine
- Lachmann Helen
- Ladino Mabel
- Lahey Lauren
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- Lamba Manisha
- Lamot Lovro
- Lamot Mirta
- Lancini Francesca
- Lang Michael
- Lanni Stefano
- Lapeyre GeneviĂšve
- Lauwerys B.
- Laxer R. M.
- Lazar Calin
- Lazareva Arina
- Lazarevic Dragana S.
- Lazaros George
- Lazea Cecilia
- Leahey Hannah
- Lee Peggy
- Leelayuwattanakul Isree
- Lehmberg Kai
- Lelubre Christophe
- Len Claudio A.
- Leon K.
- Leone Valentina
- Leong Jingyao
- Lepri Gemma
- Lerkvaleekul Butsabong
- Leroux Brian
- Lewandowski Laura
- Licciardi Francesco
- Lichtenfels Ana J. D. F. C.
- Ligostaeva Elena
- Linkova Lenka
- Lira Luis
- Liston Adrian
- Lomakina Olga
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- LĂȘ Phu-Quoc
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- MacGregor Ishbel
- Maestroni Silvia
- Maggio M. C.
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- Magnusson Bo
- Maillard Susan
- Makay Balahan
- Malagon Clara
- Maletin Alexey
- Malievsky Viktor A.
- Malighetti Giorgia
- Marafon Denise Pires
- Marasco Emiliano
- Marcolongo Renzo
- Maritsi Despoina
- Marks Stephen
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- Martini A.
- Martini Alberto
- Martino David
- Martins Fernando
- Marzan K.
- Marzetti Valentina
- Matucci-Cerinic Marco
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- McLellan Kirsty
- Mebus Charles
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- Mendelson Amir
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- Menendez-Castro Ricardo
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- Messia Virginia
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- Mieszkalski Kelly
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- Mihaylova Dimitrina
- Milojevic D.
- Minden K.
- Minden Kirsten
- Minoia Francesca
- Minute Marta
- Mitchell John
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- Modaressi Mohammadreza
- Molina Juliana
- Moneta Gian Marco
- Mongini Federica
- Montesano Paola
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- Montin Davide
- Moradinejad Mohammad-Hassan
- Moreira Gustavo
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- Morgan Esi
- Moshe Veronica
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- Nelson Lee
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- Newland Paul
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- Nichols Kim E
- Nicolai Rebecca
- Nielsen Susan
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- Nikishina I.
- Nikishina Irina
- Nistala Kiran
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- Nordal Ellen
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- Nourse Peter
- Novelli Antonio
- Nozawa Tomo
- Nykvist Ulrika JĂ€rpemo
- NĂžrgaard Mette
- Ohga Shouichi
- Okamoto Nami
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- Pastore S.
- Pastore Serena
- Pastorino Claudia
- Pederson Ronald
- Peltoniemi Suvi
- Penades Inmaculada Calvo
- Pereira Luiz A. A.
- Pereira Oriany L.
- Pereira Rosa M.
- Pereira Rosa M. R.
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- Picco Paolo
- Pileggi Gecilmara
- Pilkington Clarissa
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- Pino Sally
- Pinto NatĂĄlia B. F.
- Pisaneschi Elisa
- Pistorio Angela
- Podda R.
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- Pontillo Alessandra
- Popp David
- Poyrazoglu Hakan
- Prakken Berent
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- Pruunsild Chris
- Puri Ratna
- Pushkov Alexander
- Putterman Chaim
- Quarmby Rachael
- Quartier P.
- Quartulli Lorenzo
- Quesada-Masachs Estefania
- Quilis Neus
- Rabinovich C.
- Rabinowicz Noa
- Radstake Timothy R.
- Raeeskarami Seid-Reza
- Rafiq Nadia K.
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- Ralph Elizabeth
- Ramanan Athimalaipet V.
- Ramchurn Navdha R.
- Ramos Filipa O.
- Rapley Tim
- Ravelli A.
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- Rawat Amit
- Ray N.
- Rednic Simona
- Reis Yonit
- Remesal Agustin
- Ricci Francesca
- Rice Gillian
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- Rigante D.
- Rigante Donato
- Rimini Alessandro
- Ringold Sarah
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- Robinson Emily
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- Rocha Gustavo
- Rodionovskaya S.
- Rodionovskaya Svetlana
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- Rubinstein Tamar
- Rumba-Rozenfelde Ingrida
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- RĂŒhle Frank
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- Saffrey Richard
- Sahin Sezgin
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- Saitoh Akihiko
- Sakamoto Ana P.
- Salgado Manuel
- Sallum Adriana E. M.
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- Salzer Ulrich
- Sanner Helga
- Santarelli Francesca
- Santori Elettra
- Santos FlĂĄvia H.
- Santos Maria Jose
- Santos Maria José
- Santos MÂȘ JosĂ©
- Saraeva Radoslava
- Savostyanov Kirill
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- Schinzel Vania
- Schmeling Heinrike
- Schmid Jana Pachlopnik
- Schneider Elvira Cannizzaro
- Schneider Rayfel
- Schuchman Edward
- Schulert Grant
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- Schultz Andre
- Schultze Joachim
- Schwarz Tobias
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- Scott Christiaan
- Seraya Valentina
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- Severini Giovanni Maria
- Shabana Kousuke
- Shaikhani D.
- Shapiro Ari
- Shenoi Susan
- Shimizu Masaki
- Shokry Salah
- Shoop Stephanie J. W.
- Signa Sara
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- Silva Marco F. C. D.
- Silva Vanessa M.
- Simon T. A.
- Simon Teresa
- Simonini Gabriele
- Simou Stefania
- Simsek Dogan
- Singh Surjit
- Sinoplu Ada B.
- Slatter Mary
- Sleptsova Tatiana
- Smith Eve M.
- Smith Nicola
- Smolewska Elzbieta
- Sokolove Jeremy
- Soloshenko Margarita
- Solyom Alexander
- Soponkanaporn Sirisucha
- Sormani Maria Pia
- Sousa Sandra
- Sozeri Betul
- Sparchez Mihaela
- Speziale A.
- Srp Radoslav
- SrĆĄen SaĆĄa
- Stagi Stefano
- Stanevica Valda
- Stanevicha Valda
- Stavrakidou Maria
- StaĆÄviÄa Valda
- Stefanov Stefan
- Sterba Gary
- Stevens Anne
- Stock Thomas
- Stoll Monika
- Strand Vibeke
- Strippoli Raffaele
- Sugita Yuko
- Sundberg Erik
- Superti-Furga Andrea
- Suri Deepti
- Susic Gordana
- Suårez Raul Gutiérrez
- Swart Joost
- Sylviane Hanquinet
- Sztajnbok Flavio
- SĂĄnchez Ana M. MarĂn
- Sönmez Hafize E.
- Taddio Andrea
- Taggart Cliff
- Tahghighi Fatemeh
- Taiani Jaymi
- Takei Syuji
- Talim Beril
- Tamai Hiroshi
- Tanpaiboon Pranoot
- Taparkou Anna
- Tarakci Ela
- Taskiran Ekim
- Teixeira LĂdia
- Teixeira Vitor A.
- Tekko Ismaiel A.
- Telcharova Albena
- Temelkova Katya
- Tenbrock Klaus
- Teng Y. K. O.
- ter Haar Nienke
- Terreri Maria T.
- Terreri Maria Teresa
- Terreri Maria Teresa R.
- Tesser Alessandra
- Tezcaner Aysen
- Thomson Wendy
- Tiewsoh Kaara
- Tommasini Alberto
- Topdemir Mesut
- Toplak NataĆĄa
- Toppino Claudia
- Torcoletti Marta
- Torreggiani Sofia
- Toth M.
- Trachana Maria
- Tricarico Alessandra
- Tsakova Adelina
- Tsinti Maria
- Tsitsami Elena
- Tsolia Maria
- Tsurikova Nadezhda
- Tufik Sergio
- Tullus Kjell
- Turco Marco
- TuÄcu Gökçen D.
- Tzaribachev Nikolay
- Tziavas Panagiotis
- Tzimouli Vasiliki
- Tzveova Reni
- Uettwiller Florence
- Uher Michal
- Uncu Nermin
- Unsal Erbil
- Unsal Sevket Erbil
- Uziel Yosef
- Vairo Donatella
- Valencia Raul A. Chavez
- Valenti Anna
- Valieva Sania
- Valieva Saniya
- Vallipakorn Sakda A.-O.
- van den Hoogen Lucas L.
- van Dijk W.
- van Dijkhuizen Pieter
- Van Dijkhuizen Pieter
- Van Nieuwenhove Erika
- van Royen-Kerkhof Annet
- van Wijk Femke
- Vanoni Federica
- Vargas Camilo
- Varnier Giulia Camilla
- Vastert Sebastiaan
- Veale Douglas
- Vehe Richard
- Vehe Richard K.
- Vele Paulina
- Venhoff Nils
- Verazza S.
- Vergara Beatrice
- Verstappen Suzanne M. M.
- Vidal Adriana Rodriguez
- VidoviÄ Mandica
- Viglizzo Gianmaria
- Viktorova Tatiana V.
- Vilaiyuk Soamarat
- Vitebskaya Alisa
- Vlahos Bonnie
- Vogl Thomas
- Vojinovic Jelena
- Volpi Stefano
- Vougiouka Olga
- VÀhÀsalo Paula
- Wahezi Dawn
- Wakiguchi Hiroyuki
- Wallace C.
- Wallace Carol
- Wang Min
- Wang Ronnie
- Wedderburn Lucy
- Wedderburn Lucy R.
- Wei X.
- Weitzman Sheila
- Weller-Heinemann Frank
- West Kerry
- Wicksell Rikard
- Wiener Anastasia
- Wienke Judith
- Willermain François
- Woerner Andreas
- Wolfs Tom
- Wouters Carine
- Wright Rachael D.
- Wu Qiong
- Wulffraat Nico
- Wynne Karen
- WĂŒrzner Reinhard
- Yachie Akihiro
- Yalcinkaya Fatos
- Yalçınkaya FatoĆ
- Yamasaki Yuichi
- Yamatou Tsuyoshi
- Yamazaki Kazuko
- Yashiro Masato
- Yasumura Junko
- Yazici Fatih
- Yeo Joo Guan
- Yepez Ricardo
- Yin Peng
- Yokota Shumpei
- Yuasa Megan
- Yucel Gozde
- Yuraga Tamara M.
- YĂŒksel Selçuk
- Zaffarano Silvia
- Zaharova Ekaterina
- Zajtseva Larisa
- Zajtseva Larisa I.
- Zak Marek
- Zak Marek S.
- Zani Giulia
- Zeft Andrew
- Zholobova Elena
- Ziaee Vahid
- Zirkzee E.
- Zuber Zbigniew
- Zulian F.
- Zumbrunn Thomas
- Ăakan Mustafa
- Ăakar NilgĂŒn
- Ăzdel Semanur
- Ăzen Seza
- Ăzçakar Zeynep Birsin
- Ćahin Sezgin
- Ć antere Ruta
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 24/07/2017
- Field of study