A Review of the Welfare Impact on Pinnipeds of Plastic Marine Debris

Uncounted, and usually unobserved, numbers of pinnipeds find themselves entangled in lost fishing gear, monofilament line, nets, rope, plastic packaging in the ocean or on the shoreline. These animals may carry debris wrapped around themselves for long periods, and often die as a result, sometimes from deep chronic wounds. The pinniped species most affected by this modern and manmade phenomenon are fur seals, monk seals, and California sea lions, and to a lesser extent grey, common and monk seals. Entanglement rates described range up to 7.9% of local populations annually, and the common entangling materials; packing bands, fragments of lost net, rope, monofilament line, fishery flashers and lures, long-line fishing gear, hooks and line, and bait hooks are discussed. Awareness of this issue is increasing, and local action is reported to have made measurable differences in entanglement rates, however, plastic material in the ocean is likely to be long lived, and will leave many entangled pinnpeds unreported and result in a hidden and potentially significant effect on wild animal welfare

Systematic event generator tuning for the LHC

In this article we describe Professor, a new program for tuning model parameters of Monte Carlo event generators to experimental data by parameterising the per-bin generator response to parameter variations and numerically optimising the parameterised behaviour. Simulated experimental analysis data is obtained using the Rivet analysis toolkit. This paper presents the Professor procedure and implementation, illustrated with the application of the method to tunes of the Pythia 6 event generator to data from the LEP/SLD and Tevatron experiments. These tunes are substantial improvements on existing standard choices, and are recommended as base tunes for LHC experiments, to be themselves systematically improved upon when early LHC data is available.Comment: 28 pages. Submitted to European Physical Journal C. Program sources and extra information are available from http://projects.hepforge.org/professor

“Dogged” Search of Fresh Nakhla Surfaces Reveals New Alteration Textures

Special Issue: 74th Annual Meeting of the Meteoritical Society, August 8-12, 2011, London, U.K.International audienceCarbonaceous chondrites are considered as amongst the most primitive Solar System samples available. One of their primitive characteristics is their enrichment in volatile elements.This includes hydrogen, which is present in hydrated and hydroxylated minerals. More precisely, the mineralogy is expected to be dominated by phyllosilicates in the case of CM chondrites, and by Montmorillonite type clays in the case of CI. Here, in order to characterize and quantify the abundance of lowtemperature minerals in carbonaceous chondrites, we performed thermogravimetric analysis of matrix fragments of Tagish Lake, Murchison and Orgueil

Collider constraints on electroweakinos in the presence of a light gravitino

Using the GAMBIT global fitting framework, we constrain the MSSM with an eV-scale gravitino as the lightest supersymmetric particle, and the six electroweakinos (neutralinos and charginos) as the only other light new states. We combine 15 ATLAS and 12 CMS searches at 13 TeV, along with a large collection of ATLAS and CMS measurements of Standard Model signatures. This model, which we refer to as the G~-EWMSSM, exhibits quite varied collider phenomenology due to its many permitted electroweakino production processes and decay modes. Characteristic G~-EWMSSM signal events have two or more Standard Model bosons and missing energy due to the escaping gravitinos. While much of the G~-EWMSSM parameter space is excluded, we find several viable parameter regions that predict phenomenologically rich scenarios with multiple neutralinos and charginos within the kinematic reach of the LHC during Run 3, or the High Luminosity LHC. In particular, we identify scenarios with Higgsino-dominated electroweakinos as light as 140 GeV that are consistent with our combined set of collider searches and measurements. The full set of G~-EWMSSM parameter samples and GAMBIT input files generated for this work is available via Zenodo

A horizon scan of issues affecting UK forest management within 50 years

Forests are in the spotlight: they are expected to play a pivotal role in our response to society’s greatest challenges, such as the climate and biodiversity crises. Yet, the forests themselves, and the sector that manages them, face a range of interrelated threats and opportunities. Many of these are well understood, even if the solutions remain elusive. However, there are also emerging trends that are currently less widely appreciated. We report here the results of a horizon scan to identify developing issues likely to affect UK forest management within the next 50 years. These are issues that are presently under-recognized but have potential for significant impact across the sector and beyond. As the forest management sector naturally operates over long timescales, the importance of using good foresight is self-evident. We followed a tried-and-tested horizon scanning methodology involving a diverse Expert Panel to collate and prioritize a longlist of 180 issues. The top 15 issues identified are presented in the Graphical Abstract. The issues represent a diverse range of themes, within a spectrum of influences from environmental shocks and perturbations to changing political and socio-economic drivers, with complex emerging interactions between them. The most highly ranked issue was ‘Catastrophic forest ecosystem collapse’, reflecting agreement that not only is such collapse a likely prospect but it would also have huge implications across the sector and wider society. These and many of the other issues are large scale, with far-reaching implications. We must be careful to avoid inaction through being overwhelmed, or indeed to merely focus on ‘easy wins’ without considering broader ramifications. Our responses to each of the challenges and opportunities highlighted must be synergistic and coherent, involving landscape-scale planning. A more adaptive approach to forest management will be essential, encouraging continual innovation and learning. The 15 horizon scan issues presented here are a starting point on which to build further research, prompt debate and action, and develop evidence-based policy and practice. We hope that this stimulates greater recognition of how our forests and sector may need to change to be fit for the future. In some cases, these changes will need to be fundamental and momentous

Collider constraints on electroweakinos in the presence of a light gravitino

Using the GAMBIT global fitting framework, we constrain the MSSM with an eV-scale gravitino as the lightest supersymmetric particle, and the six electroweakinos (neutralinos and charginos) as the only other light new states. We combine 15 ATLAS and 12 CMS searches at 13 TeV, along with a large collection of ATLAS and CMS measurements of Standard Model signatures. This model, which we refer to as the G~-EWMSSM, exhibits quite varied collider phenomenology due to its many permitted electroweakino production processes and decay modes. Characteristic G~-EWMSSM signal events have two or more Standard Model bosons and missing energy due to the escaping gravitinos. While much of the G~-EWMSSM parameter space is excluded, we find several viable parameter regions that predict phenomenologically rich scenarios with multiple neutralinos and charginos within the kinematic reach of the LHC during Run 3, or the High Luminosity LHC. In particular, we identify scenarios with Higgsino-dominated electroweakinos as light as 140 GeV that are consistent with our combined set of collider searches and measurements. The full set of G~-EWMSSM parameter samples and GAMBIT input files generated for this work is available via Zenodo

Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource

Objective: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn’s disease (CD), including their impact on need for surgery. Design: Outcomes were assessed in 11 928 patients (4968 UC, 6960 CD) in the UK IBD BioResource initiated on thiopurine monotherapy with the intention of maintaining medically induced remission. Effectiveness was assessed retrospectively using patient-level data and a definition that required avoidance of escalation to biological therapy or surgery while on thiopurines. Analyses included overall effectiveness, time-to-event analysis for treatment escalation and comparison of surgery rates in patients tolerant or intolerant of thiopurines. Results: Using 68 132 patient-years of exposure, thiopurine monotherapy appeared effective for the duration of treatment in 2617/4968 (52.7%) patients with UC compared with 2378/6960 (34.2%) patients with CD (p<0.0001). This difference was corroborated in a multivariable analysis: after adjusting for variables including treatment era, thiopurine monotherapy was less effective in CD than UC (OR 0.47, 95% CI 0.43 to 0.51, p<0.0001). Thiopurine intolerance was associated with increased risk of surgery in UC (HR 2.44, p<0.0001); with a more modest impact on need for surgery in CD (HR=1.23, p=0.0015). Conclusion: Thiopurine monotherapy is an effective long-term treatment for UC but significantly less effective in CD

Reinterpretation of LHC Results for New Physics: Status and recommendations after Run 2

We report on the status of efforts to improve the reinterpretation of searches and measurements at the LHC in terms of models for new physics, in the context of the LHC Reinterpretation Forum. We detail current experimental offerings in direct searches for new particles, measurements, technical implementations and Open Data, and provide a set of recommendations for further improving the presentation of LHC results in order to better enable reinterpretation in the future. We also provide a brief description of existing software reinterpretation frameworks and recent global analyses of new physics that make use of the current data

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist