Petrology and structure of Campanario-La Haba pluton and Los Berrocales stock (Badajoz): preliminary dates

[Abstract] The Campanario-La Haba pluton and Los Berrocales stock are situated in the southern part ofthe Central-Iberian zone. They form part ofthe late-Hercynian alignement named Caceres-Linares or Pedroches-Alburquerque. During the last years these two granitoids have been related, based on spatial and/or genetic criteria, with Los Pedroches Batholith. These igneous bodies are different. Campanario-La Haba pluton is a coarse grained peraluminous granite with large megaphenocrysts ofcordierite. Three facies are differenciated based on petrographic criteria: coarse grained porfiric granite with megaphenocryst of cordierite, fine grained porfiric granite with megaphenocryst of cordierire and fine-medium granite. Los Berrocales is a zoned stock formed by granodiorites graded to granites in the center. Structure-studies indicates that the Campanario-La Haba pluton has been structurated in magmatic state. The magmatic foliation and lineation direction show the orientation ofN12üE, parallel to the pluton lenghtening. The magnetic susceptibility values show that the magnetic behaviour of the granites is dominated by paramagnetic minerals, fine for apply the Anisotropy ofthe Magnetic Susceptibility. The magnetic structure is rather homogeneous and the magnetic lineation and foliation show the N12üE direction. This paper shows premier dates and conclusions of the work that Mineralogy and Petrology department (University of Basque Country) has being done in conjunction with the Geodinamic department (University ofBasque Country) on the westhern end of the Los Pedroches Batholith

Effects of isothermal crystallization on the mechanical properties of a elastomeric medium chain length polyhydroxyalkanoate

In the present study, the relationship between molecular structure and mechanical properties for a medium chain length polyhydroxyalkanoate (mcl-PHA) composed of 3-hydroxyoctanoate and 3-hydroxyhexanoate was elucidated. The mcl-PHA was crystallized from the melt at four different temperatures between its glass transition and melting point (37, 21, 3 and −21 °C) and its molecular structure was analysed by means of differential scanning calorimetry (DSC) and wide-angle X-ray diffractometry (WAXD). The mechanical properties, which were analysed via tensile-tests and dynamic mechanical analysis (DMA), were clearly affected by the selected crystallization temperature and corresponding molecular structure of the polymer. In this sense, samples crystallized at 37, 21 and 3 °C displayed higher secant moduli calculated at 2% (E2% ∼ 20 MPa) than the sample crystallized at −21 °C (E2% ∼ 7 MPa) due to their higher crystallinity. Even if samples crystallized at 37, 21 and 3 °C had very similar degree of crystallinity, their secant moduli calculated at 50, 100 and 200% (E50%, E100% and E200%) and yield strength (σy) were clearly affected by the selected crystallization temperature, showing a positive correlation (i.e., higher crystallization temperatures and corresponding more ordered crystalline domains with narrower crystal distributions resulted in higher E50%, E100% and E200% values).The authors are thankful for funds from the Basque Government, Department of Education, Universities and Research (GIC12/161-IT-632-13) and the Spanish Ministry of Innovation and Competitiveness MINECO (MAT2013-45559-P)

Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regeneration

Producción CientíficaBone tissue engineering demands alternatives overcoming the limitations of traditional approaches in the context of a constantly aging global population. In the present study, elastin-like recombinamers hydrogels were produced by means of carbodiimide-catalyzed crosslinking with citric acid, a molecule suggested to be essential for bone nanostructure. By systematically studying the effect of the relative abundance of reactive species on gelation and hydrogel properties such as functional groups content, degradation and structure, we were able to understand and to control the crosslinking reaction to achieve hydrogels mimicking the fibrillary nature of the extracellular matrix. By studying the effect of polymer concentration on scaffold mechanical properties, we were able to produce hydrogels with a stiffness value of 36.13 ± 10.72 kPa, previously suggested to be osteoinductive. Microstructured and mechanically-tailored hydrogels supported the growth of human mesenchymal stem cells and led to higher osteopontin expression in comparison to their non-tailored counterparts. Additionally, tailored hydrogels were able to rapidly self-mineralize in biomimetic conditions, evidencing that citric acid was successfully used both as a crosslinker and a bioactive molecule providing polymers with calcium phosphate nucleation capacity.Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13

Smart on-chip Fourier-transform spectrometers harnessing machine learning algorithms

Miniaturized silicon photonics spectrometers have great potential for mass market applications like medicine and hazard detection. However, the performance of state-of-the-art silicon spectrometers is limited by fabrication imperfections and temperature variations. In this work, we present a fundamentally new strategy that combines machine learning algorithms and on-chip spatial heterodyne Fourier-transform spectroscopy to identify specific absorption features operated under a wide range of temperatures in the presence of fabrication imperfections. We experimentally show differentiation of four different input spectra with unknown temperature variations as large as 10 °C. This is about 100x increase in operational range, compared to state-of-the-art retrieval techniques

Increasing the Resolution and Spectral Range of Measured Direct Irradiance Spectra for PV Applications

The spectral distribution of the solar irradiance incident on photovoltaic (PV) modules is a key variable controlling their power production. It is required to properly simulate the production and performance of PV plants based on technologies with different spectral characteristics. Spectroradiometers can only sense the solar spectrum within a wavelength range that is usually too short compared to the actual spectral response of some PV technologies. In this work, a new methodology based on the Simple Model of the Atmospheric Radiative Transfer of Sunshine (SMARTS) spectral code is proposed to extend the spectral range of measured direct irradiance spectra and to increase the spectral resolution of such experimental measurements. Satisfactory results were obtained for both clear and hazy sky conditions at a radiometric station in southern Spain. This approach constitutes the starting point of a general methodology to obtain the instantaneous spectral irradiance incident on the plane of array of PV modules and its temporal variations, while evaluating the magnitude and variability of the abundance of atmospheric constituents with the most impact on surface irradiance, most particularly aerosols and water vapor

Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling

BACKGROUND: Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this pathology, leading to the discovery of prognostic factors based on gene expression data, genomic rearrangements and mutational subgroups. Nevertheless, additional efforts are needed in order to enable survival predictions at the patient level. In this study we investigated new machine learning-based models of survival using transcriptomic and clinical data. METHODS: Gene expression profiling (GEP) of in 2 different publicly available retrospective DLBCL cohorts were analyzed. Cox regression and unsupervised clustering were performed in order to identify probes associated with overall survival on the largest cohort. Random forests were created to model survival using combinations of GEP data, COO classification and clinical information. Cross-validation was used to compare model results in the training set, and Harrel's concordance index (c-index) was used to assess model's predictability. Results were validated in an independent test set. RESULTS: Two hundred thirty-three and sixty-four patients were included in the training and test set, respectively. Initially we derived and validated a 4-gene expression clusterization that was independently associated with lower survival in 20% of patients. This pattern included the following genes: TNFRSF9, BIRC3, BCL2L1 and G3BP2. Thereafter, we applied machine-learning models to predict survival. A set of 102 genes was highly predictive of disease outcome, outperforming available clinical information and COO classification. The final best model integrated clinical information, COO classification, 4-gene-based clusterization and the expression levels of 50 individual genes (training set c-index, 0.8404, test set c-index, 0.7942). CONCLUSION: Our results indicate that DLBCL survival models based on the application of machine learning algorithms to gene expression and clinical data can largely outperform other important prognostic variables such as disease stage and COO. Head-to-head comparisons with other risk stratification models are needed to compare its usefulness

Estudios sefardíes dedicados a la memoria de Iacob M. Hassán (ź"l)

Elena Romero y Aitor García Moreno son los editores de este volumen.[EN] This work aims to honour Iacob. M. Hassán, who set up, promoted, and for decades maintained, the CSIC's School of Sephardic studies (Escuela de Estudios Sefardíes) in Madrid. It comprises a collection of articles on the Jews in the medieval Spanish kingdoms, along with other articles on a wide variety of language issues, and the study and publication of literary works produced or handed down by the Sephardim of the Balkans and Morocco between the sixteenth and the twentieth centuries, such as biblical commentaries and lexicons, liturgical poetry, rabbinic literature, biographies, folk tales, popular folk songs, ballads, and modern songs ... These studies also include an article by Iacob. M. Hassán published here for the first time in the form of a facsimile of his original typed manuscript. The work is preceded by a foreword and an unpublished text of one of his lectures, which contains a wealth of autobiographical information, as well as his views on the vicissitudes of Sephardic Studies as an academic discipline.[ES] Con esta obra se quiere honrar al creador, impulsor y mantenedor durante decenios de la llamada Escuela de Estudios Sefardíes del CSIC (Madrid). Se recogen en ella artículos relativos a los judíos en los reinos hispanos medievales, y otros dedicados a muy variados temas de lengua, y al estudio y edición de obras literarias producidas o transmitidas por los sefardíes de los Balcanes y de Marruecos entre el siglo XVI y el XX: comentarios y léxicos bíblicos, poesía litúrgica, literatura rabínica, biografías, cuentos tradicionales, coplas, romances, cancionero moderno, etc., etc. Entre los estudios se incluye además, como primicia, un artículo mecanografiado de Iacob. M. Hassán que se publica por primera vez en edición facsímil. La obra va precedida de un Prólogo y del texto inédito de una de sus conferencias, en la que aporta numerosos datos autobiográficos, así como su visión sobre los avatares de los Estudios Sefardíes como disciplina académica

The labor market effects of technology shocks

We analyze the effects of neutral and investment-specific technology shocks on hours worked and unemployment. We characterize the response of unemployment in terms of job separation and job finding rates. We find that job separation rates mainly account for the impact response of unemployment while job finding rates for movements along its adjustment path. Neutral shocks increase unemployment and explain a substantial portion of unemployment and output volatilityinvestment-specific shocks expand employment and hours worked and mostly contribute to hours worked volatility. We show that this evidence is consistent with the view that neutral technological progress prompts Schumpeterian creative destruction, while investment specific technological progress has standard neoclassical feature

Silicon photonic mode multiplexers based on subwavelength metamaterials and on-chip beam forming

4 pags., 1 fig. -- Event: SPIE OPTO, 2023, San Francisco, California, United StatesIntegration of photonic circuits on silicon offers a unique opportunity to address the scaling of inter- and intra-chip communications in an energy-efficient and cost-effective manner. Mode-division multiplexing (MDM) is deemed as one of the most promising technologies to increase aggregated data bandwidth and avoid a communication capacity crunch. In this invited talk, we review our latest advances on integrated silicon mode multiplexers, including new topologies based on subwavelength grating (SWG) metamaterials for extended broadband operation and higher-order mode support. Specifically, we report on an ultra-broadband multiplexer based on a phase shifter and a multimode interference (MMI) coupler both engineered with subwavelength metamaterials. Experimental measurements of a complete multiplexer-demultiplexer link show losses lower than 2 dB and crosstalk below -17 dB over a bandwidth of 245 nm (1427 – 1672 nm).This work has been funded in part by the French Industry Ministry (Nano2022 project under IPCEI program); the Agence Nationale de la Recherche (ANR-MIRSPEC-17- CE09-0041); the European Union’s Horizon Europe (Marie SklodowskaCurie grant agreement Nº 101062518); the Spanish Ministry of Science and Innovation (MICINN) under grants RTI2018-097957-B-C33 and PID2020-115353RA-I00; the Spanish State Research Agency under grant MCIN/AEI/10.13039/501100011033 (PTQ2021-011974); the Community of Madrid – FEDER funds (S2018/NMT4326); the European Union – NextGenerationEU through the Recovery, Transformation and Resilience Plan (DIN2020-011488). The fabrication of the device was performed at the Plateforme de Micro-NanoTechnologie/C2N, which is partially funded by the Conseil General de l’Essonne. This work was partly supported by the French RENATECH network.Peer reviewe