I Take My Place in the Ranks of Revolutionary Youth

Typed resignation letter addressed to the Young Communist League. Serves as a political flyer in support of the Young Peoples Socialist League. Student Publications: The Campus Newspaper Collectio

Anomalies in a waterlike model confined between plates

Using molecular dynamic simulations we study a waterlike model confined between two fixed hydrophobic plates. The system is tested for density, diffusion and structural anomalous behavior and compared with the bulk results. Within the range of confining distances we had explored we observe that in the pressure-temperature phase diagram the temperature of maximum density (TMD line), the temperature of maximum and minimum diffusion occur at lower temperatures when compared with the bulk values. For distances between the two layers below a certain threshold ,$d\le d_c$, only two layers of particles are formed, for $d\ge d_c$ three or more layers are formed. In the case of three layers the central layer stays liquid while the contact layers crystallize. This result is in agreement with simulations for atomistic models

Diagnostyka przerzutów nowotworowych do tarczycy za pomocą biopsji aspiracyjnej cienkoigłowej

Introduction: Malignant metastases are rarely found in the thyroid gland, the incidence reaching approximately 2% of all thyroid malignant neoplasms. They are most often caused by tumours of the kidneys, lungs, mammary glands, ovary, and colon or by melanomas. The aim of the study was to evaluate the usefulness of fine needle aspiration biopsy (FNA) for diagnosing tumour metastases to thyroid glands. Material and methods: A total of 15122 patients were operated between 1990 and 2009 for goitres. Malignant neoplasm was diagnosed in 733 (4.8%) patients. Malignant metastases to the thyroid gland were detected in 10 patients, namely 2 men and 8 women aged 48–89 years. The group made up 1.4% of all patients operated for malignant thyroid tumour. Preoperative diagnostic procedure consisted of thyroid scintigraphy, thyroid ultrasonography, and cytology of the material obtained through FNA. In addition, the hormonal activity of the thyroid gland was examined. The range of operation was established through clinical assessment of the tumour, preoperative cytology, and intra-operative histopathology. Results: Among 7 patients with thyroid metastases from renal clear cell carcinoma, as diagnosed postoperatively, cytology of the thyroid material obtained through FNA revealed follicular tumour in 3 (43%) patients, tumour cells in 2 (28.5%) and atypical cells in the other 2 (28.5%). Intraoperative histopathology confirmed the presence of metastasis from renal clear cell carcinoma (1) and indicated thyroid medullary cancer (1), follicular tumour (4), or trabecular adenoma with necrosis (1). Among two patients with thyroid metastases from breast cancer, cytology confirmed a metastasis from breast cancer in one (the woman was disqualified for surgical treatment) and indicated follicular tumour in one. Intraoperative histopathology suggested thyroid anaplastic cancer. Examination of biopsy specimen revealed epithelial cells accompanied by cell atypia in one patient with thyroid metastasis from lung cancer. Intra-operative examination also indicated cellular atypia in the same patient. Conclusions: Follicular tumour diagnosed by fine needle aspiration biopsy in patients after treatment for other cancers, especially renal clear cell carcinoma, should alert the surgeon to the possibility that it could be a metastasis of this cancer to the thyroid gland. (Pol J Endocrinol 2010; 61 (5): 427-429)Wstęp: Tarczyca może być miejscem odległych przerzutów nowotworowych. Są to zmiany rzadkie stanowiące około 2% wszystkich nowotworów tarczycy. Najczęściej ich przyczyną są nowotwory nerki, płuca, sutka, jajnika, jelita grubego oraz czerniak. Celem pracy była ocena przydatności biopsji aspiracyjnej cienkoigłowej (BAC) w rozpoznawaniu przerzutów nowotworowych do tarczycy. Materiał i metody: W latach 1990–2009 operowano 15122 chorych z powodu różnych postaci wola. Nowotwór złośliwy rozpoznano u 733 (4,8%) chorych. Przerzuty nowotworowe do tarczycy stwierdzono u 10 chorych (2 mężczyzn i 8 kobiet w wieku od 48-89 lat) - 1,4% nowotworów złośliwych tarczycy. Diagnostyka przedoperacyjna obejmowała badania scyntygraficzne, ultrasonograficzne tarczycy, ocenę cytologiczną materiału pobranego drogą BAC. Badano czynność hormonalną gruczołu tarczowego. Zakres operacji ustalano na podstawie oceny klinicznej guza, wyników badań przedoperacyjnego cytologicznego oraz śródoperacyjnego histopatologicznego. Wyniki: W wyniku BAC tarczycy u 7 chorych z rozpoznanym pooperacyjnie przerzutem raka jasnokomórkowego nerki do gruczołu stwierdzono guz pęcherzykowy (3), komórki nowotworowe (2), komórki atypowe u pozostałych (2). Doraźne badanie histopatologiczne potwierdziło przerzut raka jasnokomórkowego nerki (1), wskazywało na raka rdzeniastego tarczycy (1), nowotwór pęcherzykowy (4) i gruczolak beleczkowaty z martwicą (1). U 2 chorych z przerzutem raka piersi do tarczycy badanie cytologiczne (1) potwierdziło przerzut raka piersi (chora zdyskwalifikowana onkologicznie do leczenia operacyjnego) i wskazywało na guz pęcherzykowy (1). Doraźne badanie histopatologiczne sugerowało występowanie raka anaplastycznego tarczycy. U 1 chorej z przerzutem raka płuca do tarczycy w badaniu bioptatu stwierdzono obecność komórek nabłonkowych i atypię, zaś w badaniu śródoperacyjnym rozległe zmiany martwicze z atypią komórkową. Wnioski: Rozpoznanie w BAC guza pęcherzykowego u chorych po leczeniu innych nowotworów, szczególnie raka jasnokomórkowego nerki powinno wzmóc czujność lekarza w kierunku poszukiwania ewentualnego przerzutu tego nowotworu do tarczycy. (Endokrynol Pol 2010; 61 (5): 427-429

A rare case of follicular carcinoma of the thyroid gland — simultaneous surgery of primary tumour and metastatic tumour of frontal bone

Autorzy przedstawiają rzadki przypadek raka pęcherzykowego tarczycy z obecnością przerzutu do kości czołowej czaszki. Zwracają uwagę na obraz kliniczny oraz wartość badań obrazowych - scyntygrafii i tomografii komputerowej - dla rozpoznania przerzutów odległych raka pęcherzykowego tarczycy. Podkreślają znaczenie radykalnego leczenia chirurgicznego, polegającego na całkowitym wycięciu gruczołu tarczowego, połączonego z jednoczesnym wycięciem przerzutu do kości czołowej i uzupełnionego o terapię jodem radioaktywnym, dla osiągnięcia dobrych wyników odległych leczenia raka pęcherzykowego tarczycy.The authors present a rare case of follicular carcinoma of the thyroid gland with metastasis to the frontal bone. Attention is drawn in particular to the clinical picture as well as to the value of imaging examinations - scintigraphy and computer tomography - for diagnosing the remote metastases of follicular carcinoma of the thyroid gland. The authors emphasise the importance of radical surgery treatment, based on total resection of the thyroid gland combined with simultaneous excision of the metastasis from the frontal bone, supplemented by radioactive iodine therapy to achieve good distant results of the thyroid’s follicular carcinoma treatment

Diffusion Anomaly in a three dimensional lattice gas

We investigate the relation between thermodynamic and dynamic properties of an associating lattice gas (ALG) model. The ALG combines a three dimensional lattice gas with particles interacting through a soft core potential and orientational degrees of freedom. From the competition between the directional attractive forces and the soft core potential results two liquid phases, double criticality and density anomaly. We study the mobility of the molecules in this model by calculating the diffusion constant at a constant temperature, $D$. We show that $D$ has a maximum at a density $\rho_{max}$ and a minimum at a density $\rho_{min}<\rho_{max}$. Between these densities the diffusivity differs from the one expected for normal liquids. We also show that in the pressure-temperature phase-diagram the line of extrema in diffusivity is close to the liquid-liquid critical point and it is partially inside the temperature of maximum density (TMD) line

Cores in warm dark matter haloes: a Catch 22 problem

The free streaming of warm dark matter particles dampens the fluctuation spectrum, flattens the mass function of haloes and imprints a fine grained phase density limit for dark matter structures. The phase space density limit is expected to imprint a constant density core at the halo center on the contrary to what happens for cold dark matter. We explore these effects using high resolution simulations of structure formation in different warm dark matter scenarios. We find that the size of the core we obtain in simulated haloes is in good agreement with theoretical expectations based on Liouville's theorem. However, our simulations show that in order to create a significant core, (r_c~1 kpc), in a dwarf galaxy (M~1e10 Msun), a thermal candidate with a mass as low as 0.1 keV is required. This would fully prevent the formation of the dwarf galaxy in the first place. For candidates satisfying large scale structure constrains (m_wdm larger than 1-2 keV) the expected size of the core is of the order of 10 (20) pc for a dark matter halo with a mass of 1e10 (1e8) Msun. We conclude that "standard" warm dark matter is not viable solution for explaining the presence of cored density profiles in low mass galaxies.Comment: 9 pages, 8 figures, new theory section, fig 8 updated, conclusions unchanged, accepted for publication on MNRA

Structure and anomalous solubility for hard spheres in an associating lattice gas model

In this paper we investigate the solubility of a hard-sphere gas in a solvent modeled as an associating lattice gas. The solution phase diagram for solute at 5% is compared with the phase diagram of the original solute free model. Model properties are investigated both through Monte Carlo simulations and a cluster approximation. The model solubility is computed via simulations and is shown to exhibit a minimum as a function of temperature. The line of minimum solubility (TmS) coincides with the line of maximum density (TMD) for different solvent chemical potentials, in accordance with the literature on continuous realistic models and on the "cavity" picture. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4743635]Conselho Nacional de Pesquisas (CNPq)Conselho Nacional de Pesquisas (CNPq) [475039/2010-6, 472210/2011-4]CAPESCapesInstituto Nacional de Ciencia e Tecnologia de Fluidos Complexos (INCTFCx)Instituto Nacional de Ciencia e Tecnologia de FLUIDOS COMPLEXOS (INCT-FCx)Universidade Federal de Santa CatarinaUniversidade Federal de Santa Catarin

Prenatal whole exome sequencing:the views of clinicians, scientists, genetic counsellors and patient representatives

Objective Focus groups were conducted with individuals involved in prenatal diagnosis to determine their opinions relating to whole exome sequencing in fetuses with structural anomalies. Method Five representatives of patient groups/charities (PRGs) and eight clinical professionals (CPs) participated. Three focus groups occurred (the two groups separately and then combined). Framework analysis was performed to elicit themes. A thematic coding frame was identified based on emerging themes. Results Seven main themes (consent, analysis, interpretation/reinterpretation of results, prenatal issues, uncertainty, incidental findings and information access) with subthemes emerged. The main themes were raised by both groups, apart from ‘analysis’, which was raised by CPs only. Some subthemes were raised by PRGs and CPs (with different perspectives). Others were raised either by PRGs or CPs, showing differences in patient/clinician agendas. Conclusions Prenatal consent for whole exome sequencing is not a ‘perfect’ process, but consent takers should be fully educated regarding the test. PRGs highlighted issues involving access to results, feeling that women want to know all information. PRGs also felt that patients want reinterpretation of results over time, whilst CPs felt that interpretation should be performed at the point of testing only

Towards sustainable development through the perspective of eco-efficiency - A systematic literature review

© 2017 Elsevier Ltd. Sustainability concerns have increasingly gained importance among organizations and their stakeholders around the world. In this context, eco-efficiency has become a consistent tool towards the transition to sustainable development and the efforts of eco-efficiency indicators have been used for comparative studies and decision-making tasks, providing better financial, environmental, and social performance. The aim of this paper is to provide a systematic literature review on the theme of sustainable development from the perspective of eco-efficiency, with the adaptation of the Knowledge Development Process intervention instrument - constructivist (ProKnow-C). The paper identifies and structures the state-of-the-art between Eco-Efficiency and Sustainable Development with a view to: (i) selecting a Bibliographic Portfolio (BP) that is aligned with the perception of the researchers on the theme; (ii) performing a bibliometric analysis of the selected BP; (iii) performing a thematic synthesis; (iv) finding the integration of eco-efficiency and sustainable development with other approaches; (v) proposing an innovative framework to achieve sustainable development through eco-efficiency indicators; and (vi) finding paths for further research. This research makes multiple new contributions, providing both academics and practitioners a better panorama to achieve sustainable development through eco-efficiency by expanding the literature review, highlighting the synergies and barriers between eco-efficiency and sustainable development and by comparing and analysing them, showing its relevant features. In addition, we synthesized the contributions of the BP according to the BASF indicators, sustainable dimensions and four measurement levels: industry, organization, project and process to better describe the current academic scenario on the subject