Active Pixel Sensor Architectures for High Resolution Large Area Digital Imaging

This work extends the technology of amorphous silicon (a-Si) thin film transistors (TFTs) from traditional switching applications to on-pixel signal amplification for large area digital imaging and in particular, is aimed towards enabling emerging low noise, high resolution and high frame rate medical diagnostic imaging modalities such as digital tomosynthesis. A two transistor (2T) pixel amplifier circuit based on a novel charge-gate thin film transistor (TFT) device architecture is introduced to shrink the TFT based pixel readout circuit size and complexity and thus, improve the imaging array resolution and reliability of the TFT fabrication process. The high resolution pixel amplifier results in improved electrical performance such as on-pixel amplification gain, input referred noise and faster readouts. In this research, a charge-gated TFT that operates as both a switched amplifier and driver is used to replace two transistors (the addressing switch and the amplifier transistor) of previously reported three transistor (3T) APS pixel circuits.. In addition to enabling smaller pixels, the proposed 2T pixel amplifier results in better signal-to-noise (SNR) by removing the large flicker noise source associated with the switched TFT and increased pixel transconductance gain since the large ON-state resistance of the switched TFT is removed from the source of the amplifier TFT. Alternate configurations of 2T APS architectures based on source or drain switched TFTs are also investigated, compared, and contrasted to the gate switched architecture using charge-gated TFT. A new driving scheme based on multiple row resetting is introduced which combined with the on-pixel gain of the APS, offers considerable improvements in imaging frame rates beyond those feasible for PPS based pixels. The novel developed 2T APS architectures is implemented in single pixel test structures and in 88 pixel test arrays with a pixel pitch of 100 µm. The devices were fabricated using an in-house developed top-gate TFT fabrication process. Measured characteristics of the test devices confirm the performance expectations of the 2T architecture design. Based on parameters extracted from fabricated TFTs, the input referred noise is calculated, and the instability in pixel transconductance gain over prolonged operation tine is projected for different imaging frame rates. 2T APS test arrays were packaged and integrated with an amorphous selenium (a-Se) direct x-ray detector, and the x-ray response of the a-Se detector integrated with the novel readout circuit was evaluated. The special features of the APS such as non-destructive readout and voltage programmable on-pixel gain control are verified. The research presented in this thesis extends amorphous silicon pixel amplifier technology into the area of high density pixel arrays such as large area medical X-ray imagers for digital mammography tomosynthesis. It underscores novel device and circuit design as an effective method of overcoming the inherent shortcomings of the a-Si material . Although the developed device and circuit ideas were implemented and tested using a-Si TFTs, the scope of the device and circuit designs is not limited to amorphous silicon technology and has the potential to be applied to more mainstream technologies, for example, in CMOS active pixel sensor (APS) based digital cameras

Comparison of thiobarbituric acid reacting substances and total antioxidant capacity in saliva of smokers and nonsmokers

Introduction: The aim of this study was to evaluate thiobarbituric acid reactive substances (TBARS) as lipid peroxidation marker and total antioxidant capacity(TAC) in saliva of smoker and non-smoker men. Materials & Methods: This case-control study was performed on 104 men including smoker (52) and non-smoker (52) men, referred to the Oral Medicine Department in Babol Faculty of Dentistry. 2 ml of unstimulated saliva was collected and specimens were transferred to the Biochemistry Laboratory using dry ice and freezed. Data were analyzed using SPSS 18 and Mann Whitney test. Results: Findings indicated that the levels of TBARS and TAC in saliva of smokers were significantly higher than control group. Conclusion: Higher level of TBARS in smokers can show the evident and dangerous role of cigarette and its chemical compounds, and increased level of TAC in smokers can prove the hypothesis of compensatory mechanism of antioxidant system

Selective Change Driven Imaging: A Biomimetic Visual Sensing Strategy

Selective Change Driven (SCD) Vision is a biologically inspired strategy for acquiring, transmitting and processing images that significantly speeds up image sensing. SCD vision is based on a new CMOS image sensor which delivers, ordered by the absolute magnitude of its change, the pixels that have changed after the last time they were read out. Moreover, the traditional full frame processing hardware and programming methodology has to be changed, as a part of this biomimetic approach, to a new processing paradigm based on pixel processing in a data flow manner, instead of full frame image processing

Amorphous and Polycrystalline Photoconductors for Direct Conversion Flat Panel X-Ray Image Sensors

In the last ten to fifteen years there has been much research in using amorphous and polycrystalline semiconductors as x-ray photoconductors in various x-ray image sensor applications, most notably in flat panel x-ray imagers (FPXIs). We first outline the essential requirements for an ideal large area photoconductor for use in a FPXI, and discuss how some of the current amorphous and polycrystalline semiconductors fulfill these requirements. At present, only stabilized amorphous selenium (doped and alloyed a-Se) has been commercialized, and FPXIs based on a-Se are particularly suitable for mammography, operating at the ideal limit of high detective quantum efficiency (DQE). Further, these FPXIs can also be used in real-time, and have already been used in such applications as tomosynthesis. We discuss some of the important attributes of amorphous and polycrystalline x-ray photoconductors such as their large area deposition ability, charge collection efficiency, x-ray sensitivity, DQE, modulation transfer function (MTF) and the importance of the dark current. We show the importance of charge trapping in limiting not only the sensitivity but also the resolution of these detectors. Limitations on the maximum acceptable dark current and the corresponding charge collection efficiency jointly impose a practical constraint that many photoconductors fail to satisfy. We discuss the case of a-Se in which the dark current was brought down by three orders of magnitude by the use of special blocking layers to satisfy the dark current constraint. There are also a number of polycrystalline photoconductors, HgI2 and PbO being good examples, that show potential for commercialization in the same way that multilayer stabilized a-Se x-ray photoconductors were developed for commercial applications. We highlight the unique nature of avalanche multiplication in a-Se and how it has led to the development of the commercial HARP video-tube. An all solid state version of the HARP has been recently demonstrated with excellent avalanche gains; the latter is expected to lead to a number of novel imaging device applications that would be quantum noise limited. While passive pixel sensors use one TFT (thin film transistor) as a switch at the pixel, active pixel sensors (APSs) have two or more transistors and provide gain at the pixel level. The advantages of APS based x-ray imagers are also discussed with examples