Multiobjective evolutionary algorithms for multivariable PI controller design

A multiobjective optimisation engineering design (MOED) methodology for PI controller tuning in multivariable processes is presented. The MOED procedure is a natural approach for facing multiobjective problems where several requirements and specifications need to be fulfilled. An algorithm based on the differential evolution technique and spherical pruning is used for this purpose. To evaluate the methodology, a multivariable control benchmark is used. The obtained results validate the MOED procedure as a practical and useful technique for parametric controller tuning in multivariable processes.This work was partially supported by the FPI-2010/19 grant and the project PAID-06-11 from the Universitat Politecnica de Valencia and the projects DPI2008-02133, TIN2011-28082 and ENE2011-25900 from the Spanish Ministry of Science and Innovation.Reynoso Meza, G.; Sanchís Saez, J.; Blasco Ferragud, FX.; Herrero Durá, JM. (2012). Multiobjective evolutionary algorithms for multivariable PI controller design. Expert Systems with Applications. 39(9):7895-7907. https://doi.org/10.1016/j.eswa.2012.01.111S7895790739

Regioselective synthesis of 3-hydroxyorthanilic acid and its biotransformation into a novel phenoxazinone dye by use of laccase

A natural phenoxazinone derivative, cinnabarinic acid (2, CA, R = CO2H), could be obtained in vitro with the aid of purified laccase from the fungi Pycnoporus cinnabarinus by oxidative dimerization of 3-hydroxyanthranilic acid (1, 3-HAA, R = CO2H). With the aim of gaining access to a new class of water-soluble chromophores and potential bioactive molecules, the regioselective sulfonation of 2-hydroxyanihne was investigated. Straightforward insertion of a sulfonate group into a carbon-metal bond provided an efficient and selective process for the synthesis of 3-hydroxyorthanilic acid (3, 3-HOA, R = SO3H). This sulfonated compound was then subjected to laccase oxidation in order to mimic the cinnabarinic acid synthesis. A practical HPLC method to study the oxidized products was developed, and the major product of biotransformation - namely 2-aniino-3-oxo-3H-phenoxazin-1,9-disulfonic acid (4, LAO, R = SO3H) - was isolated and identified as the sulfonate analogue of cinnabarinic acid. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)