Mentoring beim Übergang in die berufliche Ausbildung am Beispiel des Ada-Lovelace-Projekts

"In Deutschland erzielen Mädchen inzwischen durchschnittlich bessere Schulabschlüsse und weisen zumindest bis in die Hochschule etwas erfolgreichere Bildungsverläufe auf als Jungen. Allerdings scheinen Mädchen und junge Frauen ihre erworbenen Qualifikationen und Kompetenzen beim Übergang in den Arbeitsmarkt nicht so gut nutzen zu können. Ihr Berufswahlspektrum ist deutlich enger und sie wählen eher Berufe mit schlechteren Karrierechancen und geringerer Bezahlung als Jungen. Hier setzen Berufseinstiegsmentorings an, die allerdings meistens beim Übergang von der Hochschule in den Beruf und selten beim Übergang in eine berufliche Ausbildung unterstützen. Genau das ist aber die Zielsetzung des Zweigs 'Ausbildung' im 'Ada-Lovelace- Projekt', in dem es darum geht, Mädchen insbesondere zur Wahl eines Berufs im naturwissenschaftlich-technischen und IT-Bereich zu ermutigen. Besonderheiten, Chancen und Grenzen eines solchen Mentoring-Angebots sollen anhand dieses Beispiels dargestellt und über Ergebnisse zweier durchgeführter Evaluationsstudien soll berichtet werden." (Autorenreferat)"In Germany, girls achieve better average results in their final school examinations and are more successful than boys in their college and university courses. It appears, however, that girls and young women are unable to take full advantage of their superior educational credentials when entering the job market. Women are faced with a narrower field of career choices and they tend to select occupations with lower salaries and fewer opportunities for career advancement. At the transitional point between college or university and work, job entry mentoring is often used to help people get jobs, but it is rarely used to support the transitions involving occupational training. This article presents the latter type by the example of the 'occupational education' branch of the 'Ada-Lovelace-Project', professional mentoring designed to encourage girls to choose a job in a scientific, technical or IT-related field. Special features, prospects and limitations of this form of mentoring will be described, and accounts of two studies currently in progress will be given." (author's abstract

How do individuals with Williams syndrome learn a route in a real-world environment?

Individuals with Williams syndrome (WS) show a specific deficit in visuo-spatial abilities. This finding, however, is mainly based on performance on small-scale laboratory-based tasks. This study investigated large-scale route learning in individuals with WS and two matched control groups (moderate learning difficulty group [MLD], typically developing group [TD]). In a non-labelling and a labelling (verbal information provided along the route) condition, participants were guided along one of two unfamiliar 1 km routes with 20 junctions, and then retraced the route themselves (two trials). The WS participants performed less well than the other groups, but given verbal information and repeated experience they learnt nearly all of the turns along the route. The extent of improvement in route knowledge (correct turns) in WS was comparable to that of the control groups. Relational knowledge (correctly identifying spatial relationships between landmarks), compared to the TD group, remained poor for both the WS and MLD groups. Assessment of the relationship between performance on the large-scale route learning task to that on three small-scale tasks (maze learning, perspective taking, map use) showed no relationship for the TD controls, and only a few non-specific associations in the MLD and WS groups

Advanced Flow Cytometry Assays for Immune Monitoring of CAR-T Cell Applications

Adoptive immunotherapy using chimeric antigen receptor (CAR)-T cells has achieved successful remissions in refractory B-cell leukemia and B-cell lymphomas. In order to estimate both success and severe side effects of CAR-T cell therapies, longitudinal monitoring of the patient’s immune system including CAR-T cells is desirable to accompany clinical staging. To conduct research on the fate and immunological impact of infused CAR-T cells, we established standardized 13-colour/15-parameter flow cytometry assays that are suitable to characterize immune cell subpopulations in the peripheral blood during CAR-T cell treatment. The respective staining technology is based on pre-formulated dry antibody panels in a uniform format. Additionally, further antibodies of choice can be added to address specific clinical or research questions. We designed panels for the anti-CD19 CAR-T therapy and, as a proof of concept, we assessed a healthy individual and three B-cell lymphoma patients treated with anti-CD19 CAR-T cells. We analyzed the presence of anti-CD19 CAR-T cells as well as residual CD19+ B cells, the activation status of the T-cell compartment, the expression of co-stimulatory signaling molecules and cytotoxic agents such as perforin and granzyme B. In summary, this work introduces standardized and modular flow cytometry assays for CAR-T cell clinical research, which could also be adapted in the future as quality controls during the CART cell manufacturing process

Virtual Blocks: a serious game for spatial ability improvement on mobile devices

This paper presents a novel spatial instruction system for improving spatial abilities of engineering students. A 3D mobile game application called Virtual Blocks has been designed to provide a 3D virtual environment to build models with cubes that help students to perform visualization tasks to promote the development of their spatial ability during a short remedial course. A validation study with 26 freshman engineering students at La Laguna University (Spain) has concluded that the training had a measurable and positive impact on students spatial ability. In addition, the results obtained using a satisfaction questionnaire show that Virtual Blocks is considered an easy to use and stimulating application.This work has been partially supported by the (Spanish) National Program for Studies and Analysis project "Evaluation and development of competencies associated to the spatial ability in the new engineering undergraduate courses" (Ref. EA2009-0025) and the (Spanish) National Science Project "Enhancing Spatial REasoning and VIsual Cognition with advanced technological tools (ESREVIC)" (Ref TIN2010-21296-C02-02)Martín Dorta, NN.; Sanchez Berriel, I.; Bravo, M.; Hernández, J.; Saorin, JL.; Contero, M. (2014). Virtual Blocks: a serious game for spatial ability improvement on mobile devices. Multimedia Tools and Applications. 73(3):1575-1595. https://doi.org/10.1007/s11042-013-1652-0S15751595733Baartmans BG, Sorby SA (1996) Introduction to 3-D spatial visualization. Prentice Hall, Englewood CliffsClements D, Battista M (1992) Geometry and spatial reasoning. In: Grouws DA (ed) Handbook of research on mathematics teaching and learning. New York, pp 420–464Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Erlbaum, HillsdaleDe Lisi R, Cammarano DM (1996) Computer experience and gender differences in undergraduate mental rotation performance. 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Route knowledge and configural knowledge in typical and atypical development: a comparison of sparse and rich environments

Background: Individuals with Down syndrome (DS) and individuals with Williams syndrome (WS) have poor navigation skills, which impact their potential to become independent. Two aspects of navigation were investigated in these groups, using virtual environments (VE): route knowledge (the ability to learn the way from A to B by following a fixed sequence of turns) and configural knowledge (knowledge of the spatial relationships between places within an environment). Methods: Typically developing (TD) children aged 5 to 11 years (N = 93), individuals with DS (N = 29) and individuals with WS (N = 20) were presented with a sparse and a rich VE grid maze. Within each maze, participants were asked to learn a route from A to B and a route from A to C before being asked to find a novel shortcut from B to C. Results: Performance was broadly similar across sparse and rich mazes. The majority of participants were able to learn novel routes, with poorest performance in the DS group, but the ability to find a shortcut, our measure of configural knowledge, was limited for all three groups. That is, 59 % TD participants successfully found a shortcut, compared to 10 % participants with DS and 35 % participants with WS. Differences in the underlying mechanisms associated with route knowledge and configural knowledge and in the developmental trajectories of performance across groups were observed. Only the TD participants walked a shorter distance in the last shortcut trial compared to the first, indicative of increased configural knowledge across trials. The DS group often used an alternative strategy to get from B to C, summing the two taught routes together. Conclusions: Our findings demonstrate impaired configural knowledge in DS and in WS, with the strongest deficit in DS. This suggests that these groups rely on a rigid route knowledge based method for navigating and as a result are likely to get lost easily. Route knowledge was also impaired in both DS and WS groups and was related to different underlying processes across all three groups. These are discussed with reference to limitations in attention and/or visuo-spatial processing in the atypical groups

Cubes or Pellets in Mental-Rotation Tests: Effects on Gender Differences and on the Performance in a Subsequent Math Test

In mental rotation, males consistently outperform females in performance and confidence. Both can affect math anxiety. In the present study, 107 undergraduate students (85 female) solved a mental-rotation test either with cube (C-MRT) or pellet (P-MRT) figures as stimulus material, then reported their confidence in their ability in the test, and solved a math test. Males performed better than females in both test versions: In the C-MRT, with a large effect, and in the P-MRT, with a small effect, and reported higher scores in their confidence. In math test performance, males scored higher than females when they solved the math test after the C-MRT but not after the P-MRT. The interactions of gender and stimulus material were not significant. Correlations between confidence and math test performance were large for males and not significant for females. Stereotype threat and lift effects are discussed as possible reasons for the varying effects of the stimulus material on the MRT performance of male and female participants

Suffering from problematic smartphone use? Why not use grayscale setting as an intervention! – An experimental study

Increasingly, problematic smartphone use behavior (PSU) and excessive consumption are reported. In this study, an experiment was developed to investigate the influence of screen coloration using the grayscale setting on smartphone usage time in repeated measurements. We also investigated how individuals perceived suffering correlates with smartphone usage time and PSU, and whether differences exist by smartphone usage type (social, process, habitual). 240 subjects completed a questionnaire about smartphone usage time, PSU, perceived suffering, and smartphone usage types. Afterward, their smartphones were switched to grayscale setting for at least 24h, and thereafter 92 of these participants completed the second questionnaire. Analyses showed that grayscale setting decreases usage time and that there is a positive correlation between PSU, smartphone usage duration, and perceived suffering. The types of use (process and habitual) influence one's perceived suffering. Thus, it shows that individuals are aware of their PSU and suffer from it. Using grayscale setting is effective in reducing smartphone use time